Targeting Of Cxxc5 By A Competing Peptide Stimulates Hair Re-growth And Wound-induced Hairneogenesis

[westonci]

https://www.ncbi.nlm.nih.gov/pubmed/28595998

The Wnt/β-catenin pathway has been implicated in hair follicle development and hair regeneration in adults. We discovered that CXXC-type zinc finger protein 5 (CXXC5) is a negative regulator of the Wnt/β-catenin pathway involved in hair re-growth and wound-induced hair follicle neogenesis (WIHN) via an interaction with Dishevelled (Dvl). CXXC5 was up-regulated in miniaturized hair follicles and arrector pili muscles in human balding scalps. The inhibitory effects of CXXC5 on alkaline phosphatase activity and cell proliferation were demonstrated using human hair follicle dermal papilla cells. Moreover, CXXC5-/- mice displayed accelerated hair re-growth and treatment with valproic acid, a glycogen synthase kinase 3β inhibitor that activates the Wnt/β-catenin pathway, further induced hair re-growth in the CXXC5-/- mice. Disrupting the CXXC5-Dvl interaction with a competitor peptide activated the Wnt/β-catenin pathway and accelerated hair re-growth and WIHN. Overall, these findings suggest that the CXXC5-Dvl interaction is a potential target for treatment of hair loss.

 

[SamFT]

https://www.ncbi.nlm.nih.gov/pubmed/28595998

The Wnt/β-catenin pathway has been implicated in hair follicle development and hair regeneration in adults. We discovered that CXXC-type zinc finger protein 5 (CXXC5) is a negative regulator of the Wnt/β-catenin pathway involved in hair re-growth and wound-induced hair follicle neogenesis (WIHN) via an interaction with Dishevelled (Dvl). CXXC5 was up-regulated in miniaturized hair follicles and arrector pili muscles in human balding scalps. The inhibitory effects of CXXC5 on alkaline phosphatase activity and cell proliferation were demonstrated using human hair follicle dermal papilla cells. Moreover, CXXC5-/- mice displayed accelerated hair re-growth and treatment with valproic acid, a glycogen synthase kinase 3β inhibitor that activates the Wnt/β-catenin pathway, further induced hair re-growth in the CXXC5-/- mice. Disrupting the CXXC5-Dvl interaction with a competitor peptide activated the Wnt/β-catenin pathway and accelerated hair re-growth and WIHN. Overall, these findings suggest that the CXXC5-Dvl interaction is a potential target for treatment of hair loss.

Have you gotten fevi yet?

 

[Afro_Vacancy]

I've pointed out before, but hair loss is regularly cured by Korean scientists.

For example laminaria japonica, rice bran oil, etc.

 

[pegasus2]

I've pointed out before, but hair loss is regularly cured by Korean scientists.

For example laminaria japonica, rice bran oil, etc.

What are you saying, Korean mice are even more blessed than American mice?

 

[Afro_Vacancy]

What are you saying, Korean mice are even more blessed than American mice?

I have no idea why so many of these articles come from Korea.

 

[westonci]

This study identified KY-02327 as an inhibitor of the CXXC5 interaction (IC50 = 3.1 uM). Instructions for synthesis start on pg. 3 of the supporting info.

 

[texish]

https://www.ncbi.nlm.nih.gov/pubmed/24533507

 

[Jk1]

https://www.ncbi.nlm.nih.gov/pubmed/24533507

http://www.anti-agingfirewalls.com/2010/09/07/valproic-acid-the-phoenix-drug-arises-again/

so could topical valerian achieve the same things it seems !!

 

[texish]

According to your article, valproic acid is an analogue of valeric acid (from valerian). Analogues are chemically similar in structure, but they are often functionally different. The only way to find out would be to try it, since there probably aren't any studies on it. Valerian is certainly cheap enough and available OTC. Of course valerian smells like stinky feet, so a topical could be problematic. Not sure how long the smell would last.

 

[kadaif]

http://www.anti-agingfirewalls.com/2010/09/07/valproic-acid-the-phoenix-drug-arises-again/

so could topical valerian achieve the same things it seems !!

https://pubchem.ncbi.nlm.nih.gov/compound/7991#section=BioAssay-Results

"Inhibitors of the EP2 Prostaglandin E2 Receptor - Primary Screen"

 

[brohawk]

https://pubchem.ncbi.nlm.nih.gov/compound/7991#section=BioAssay-Results

"Inhibitors of the EP2 Prostaglandin E2 Receptor - Primary Screen"

7% inhibition isn't exactly something to worry about. Even valproic acid's 12% inhibition is pretty moot, considering its other benefits.

 

[Jk1]

7% inhibition isn't exactly something to worry about. Even valproic acid's 12% inhibition is pretty moot, considering its other benefits.

i see you can buy valerian root oil essential online is thay worth a try ?

 

[kadaif]

i see you can buy valerian root oil essential online is thay worth a try ?

I'll start tomorrow, using ethanol extract of this root (topical), with dermarolling.

 

[Armando Jose]

https://pubchem.ncbi.nlm.nih.gov/compound/7991#section=BioAssay-Results

"Inhibitors of the EP2 Prostaglandin E2 Receptor - Primary Screen"

Very interesting, Thank you.

 

[Jk1]

I'll start tomorrow, using ethanol extract of this root (topical), with dermarolling.

cool i have added valetian root essential oil to my cayenne pepper olive and peppermint oil topical. i dont dermarol yet but i will soon.

 

[jake_b]

I've pointed out before, but hair loss is regularly cured by Korean scientists.

For example laminaria japonica, rice bran oil, etc.

What is up with that? Are there different standards for trials there? If you believe the published papers, hair loss has been cured in Korea like 25 times already. And yet here we are.

 

[Trichosan]

Nice to see the article was very current and brought an additional approach to similar research. We could see a complete cure in as little as ........................................................?

 

[kadaif]

cool i have added valetian root essential oil to my cayenne pepper olive and peppermint oil topical. i dont dermarol yet but i will soon.

http://www.hairsite.com/hair-loss/board_entry-id-104878.html