Gadgetine

The Concept Behind Follica Has Been Known Since The 1950s, Why The Heck Is A Product Taking So Long

NewUser

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George Cotsarelis said in 2015 he thinks there will be multiple treatments available in a few years. The treatments are coming, he said. But he added that what may work for some may not work for everyone. All of us here are anticipating the release of one treatment or another as it stands now. It's the waiting that is the frustrating part.

Aubrey de Grey said, in 2005, “Living forever or postponing death is possible in our lifetimes.” He obviously believes the scientific theory exists or is within reach that could solve longevity. Scientists are encouraged by findings for life extension because of the work being done with mice models. Science is now able to extend the lifespans of mice by 17 to 35%. New mice models are giving hope to developing cancer immunotherapies.

Another exciting area of research is hearing loss. There are clinical trials happening now for gene therapy and stem cells. Another company has a license agreement with a university to test a cocktail of drugs to treat deafness due to age related and nerve damaged hearing loss. They hope to begin human trials in 2018.

And with Androgenetic Alopecia, there are new and existing drugs being tested in clinical trials right now. Additionally, new science is uncovering the secrets of stem cell activation in mouse HF. The cell functions of mice and human beings have many similarities and enough to be the basis of research for many existing and hopefully future drug therapies in humans. There exist now several mouse models for AA and at least one for Androgenetic Alopecia since 2009. Scientists are able to mimic DHT sensitivity in mice causing them to lose hair. What all this means is that the science likely exists to solve baldness. The scientific theory for solving baldness has made great strides. Where the science ends is in the labs of a few publicly-funded cancer researchers.

Tsuji, Follica, Replicel-Shiseido are hopefuls for the near to mid term, one to three years. But if they don't produce practical technologies, then we have to look toward publicly funded research to solve the mysteries of age related disease, that 3 to 4% of GDP plowed back into innovation and basic research by the taxpaying public. Then it's a matter of politics as to where the money goes. Scientists would love to be able to do basic research into high risk areas of disease, but the politicians and their constituents are watching. Scientists speak publicly of what their doing in areas of medical research popular with the public and voters, like cancer and AIDS. Slowly but surely the aging western world is becoming concerned with aging. But the researchers They never talk about the research they'd like to be doing.

The science behind hair loss and hair growth has come a long way, but the technology to grow hair in people lags much further behind. We have cancer researchers to thank for the recent findings for SCF and Krox20 protein discoveries which may lead to better understanding of baldness and graying hair in people. And we have publicly-funded cancer research at UCLA to thank for stumbling on stem cell activation for HF in mice. This all needs further research and testing beyond the test tubes and mice. The science is here, but the spinoff technologies lag behind.
 
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NewUser

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If you want an absolute cure, you'll probably have to wait for gene editing.

Let's say we're approaching the problem from a crude engineering point of view. Imagine that there dozens of genes that affect balding. Different people may have X number of "wonkee" genes causing them to go bald. But let's imagine it's the same genes and exact same number of them required for balding to occur in everyone suffering Androgenetic Alopecia. Now imagine we are plumbers, and the bad genes are holes in a garden hose 400 metres long. We're losing all of the water before it ever gets to the vegetable garden, which we can't see because it's, well, 400 metres away behind some shrubs.

How do we solve the problem?
 
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H

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Tsuji's method is more of "cell" transplant with amazing potential results.

If you want an absolute cure, you'll probably have to wait for gene editing
I think of it as baby follicle transplant. Replicel would be more of a "cell transplant". Gene editing won't give back hairs that have been permanently lost.
 

cocona

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H

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Not sure what you mean. Sorry. :(
that was in the title of his last update. His story sounds extremely similar to the book "The Game" like very similar only with private hair loss forums and not and underground PUA society.
 

cocona

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that was in the title of his last update. His story sounds extremely similar to the book "The Game" like very similar only with private hair loss forums and not and underground PUA society.

Oh I'm not familiar with his story outside of the information on his "my story" page. It's not really my interest. I mostly care about what I need to do to get back to a nw0. I've kind of past the point where I can use stuff that isn't experimental. Prostaglandin protocol is where I am headed next. Getting there, slowly.
 

coolio

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There is no gene therapy for crooked teeth, or body odor, or fingernails that grow too long.

We don't need a 100% perfect cure for hair loss. We just need a treatment option that isn't ridiculously bad. So far all we've had is pills with sexual side effects, messy topicals, and no real regrowth to show for it.
 
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