the most potent anti androgen or dht blocker

[Rocky V]

aside from finasteride and dutasteride and ru, what are the most potent dht blockers and/or anti androgens? For example: keto cream, topical spironolactone, revivogen, or any other that work.

 

[ukmale24]

None, that i can think of.

 

[John979]

Potent medications also risk the chance of side effects, for example Flutamide which is even too potent for topical use.

 

[ukmale24]

What about Flutamel? Are they pretty much the same?

 

[Ende]

CB-03-01. As potent as cyproterone acetate when it comes to blocking the androgen receptors, and apparently without any systemic side effects. Besides from CB, RU58841 is as close as you get to an ideal, topical anti-androgen.

 

[ripple-effect]

Revivogen was proven in an in vitro study to inhibit more DHT than propecia and dutasteride.

Propecia inhibited 67%
dutasteride inhibited ~80%
Revivogen 90%

 

[Rocky V]

[Propecia inhibited 67%
dutasteride inhibited ~80%
Revivogen 90%

yeah but thats in no way true for humans. Have you seen the success stories of finasteride compared to revivogen? They're not even comparable.

 

[ripple-effect]

That's because Revivogen is not as popular as Propecia. Propecia has the backing of the FDA. So you hear alot more success stories because you have a larger pool of people using Propecia than Revivogen. You go to the doctor and that's the only option they know for hair loss. I myself used finasteride for a year....it did preserve my hair **I guess** but it made my hair look like sh1t, dry, thin looking, and killed my energy. If you want to try it out then go for it but remember the effectiveness of Propecia will die out after 2 years. Revivogen will keep working as long as you use it. Good luck.

 

[abcdefg]

Well propecia has the backing of the FDA but most importantly it has been proven in the most rigorous costly way possible that is works. Its safety is well studied. That is actually a pretty huge deal as you will find out when you take revivogen for 2 years only to see you are balding at same speed as before minus the 500 dollars you wasted.
Also I never hear anyone question the safety of topicals. I mean any topical could just as easily cause tumors or cancer just as well as any other foreign substance. No one knows what causes those things to start so rubbing some weird mixture of stuff on there everyday for 5 years I mean who knows.

 

[Rocky V]

ripple effect,

dude I would choose a topical over a pill anyday. But revivogen studies have in no way comparison with propecia because propecia has met the vigorous fda regulations. Revivogen is 90% in vitro not in vivo. I use revivogen but I can't question the effectiveness compared to propecia because propecia is more efficient. Theres many people who have used revivogen and they just get mild success at best.

And propecia has side effects in less than 10% of people but the side effects are the reason why I would never mess with propecia because pills go through the digestive tract and it may damage organs if too harsh.

 

[Bryan]

Potent medications also risk the chance of side effects, for example Flutamide which is even too potent for topical use.

Let's be careful about what we're talking about: flutamide isn't "too potent for topical use", its problem is merely that it's absorbed systemically when it's applied topically.

 

[Bryan]

If you want to try it out then go for it but remember the effectiveness of Propecia will die out after 2 years.

Where'd you get THAT weird idea?? The difference in haircounts between finasteride users and placebo users continues to increase with each succeeding year, it doesn't decrease.

 

[ripple-effect]

http://www.regrowshair.com/non-surgical- ... ing-chart/

After year 2 the effectiveness of propecia starts to decrease

 

[Bryan]

http://www.regrowshair.com/non-surgical-hair-loss-treatments/propecia-finasteride-dosing-chart/

After year 2 the effectiveness of propecia starts to decrease

Yes, it decreases a bit after a few years, but not NEARLY as much as people who don't use Propecia at all.

 

[ripple-effect]

Yes, but it goes along with what I said originally. Propecia's effectiveness dies out after 2 years. At around 8-10 year period you reach baseline and it stops working. You can even google users who noted at around 6-10 years it stops working for them. I believe it is because the body becomes tolerant to the drug.

 

[ripple-effect]

As to why this happens, here is a theory:

"With Reflex Hyperandrogenicity, our bodies will adjust to the anti-DHT medicines (Finasteride, Dutasteride) over time and thus the effectiveness with disappear, along with our hair.

Our bodies are masters at adaptation, and over time, while it gets used to the lack of DHT in the system, the androgen receptors will re-adjust themselves to be more sensitive to DHT and/or the body will incorporate more androgen receptors. This is how the body will re-balance itself after a period of reduced DHT (with Finasteride/Dutasterde). The common time period for this to happen is about 3-5 years (or more). This is when Finasteride (Propecia) and soon to be Dutasteride (Avodart) will be rendered useless and our hairloss will pick up where it left off. "

http://www.hairlosshelp.com/forums/mess ... ight_key=y

 

[Kev123]

If Finasteride loses effectiveness after just 2 years, then how come in the 5 year Propecia study it showed an increase throughout the 5 years, with only the 4th and 5th years being similar but still higher hair count than the first 3 years?

:dunno:

 

[Kev123]

As to why this happens, here is a theory:

"With Reflex Hyperandrogenicity, our bodies will adjust to the anti-DHT medicines (Finasteride, Dutasteride) over time and thus the effectiveness with disappear, along with our hair.

Our bodies are masters at adaptation, and over time, while it gets used to the lack of DHT in the system, the androgen receptors will re-adjust themselves to be more sensitive to DHT and/or the body will incorporate more androgen receptors. This is how the body will re-balance itself after a period of reduced DHT (with Finasteride/Dutasterde). The common time period for this to happen is about 3-5 years (or more). This is when Finasteride (Propecia) and soon to be Dutasteride (Avodart) will be rendered useless and our hairloss will pick up where it left off. "

http://www.hairlosshelp.com/forums/mess ... ight_key=y

Okay that's much better and way different than "2 years".

 

[ripple-effect]

Look at the chart please. It begins at year 2....you might start noticing it at year 3-5.

 

[Bryan]

Yes, but it goes along with what I said originally. Propecia's effectiveness dies out after 2 years. At around 8-10 year period you reach baseline and it stops working.

Propecia's effectiveness doesn't "die out" after 2 years. LOOK AT YOUR OWN CHART!! As I said earlier, the difference in haircounts between Propecia users and placebo users continued to INCREASE over a full FIVE YEARS, and there was no indication at all that the trend was about to start suddenly and mysteriously going in the opposite direction during subsequent years (year 6 and beyond).

You may think that you're Nostradamus and can predict what's going to happen at 6+ years, but your silly fantasies don't mean a thing to me. Keep your unscientific predictions to yourself, and don't try to scare Propecia users with your garbage.