I'm new to this site but I need to share what is happening on my bald head now. Following the suggestion of a friend I started since about one month the “Double A†method with topical dutasteride in an Aloe Vera gel base, and since 10 days hair fall nearly stopped. I can’t really believe what’s happening. Let’s see whether the treatment will give side effects (I took oral dutasteride for a few weeks and I know the side effects of the drug). For the time being I can’t find a defect in this treatment. I’ll keep you updated.
Topical dutas once a day WORKS!
- Thread starter twohair
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dorianyates
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Interesting.....yes..pls keep us posted.
hairhaircomeagain
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two hair...Thanks for your inputs.
what is topical dutasteride? Does it not have negative effects like procepia ?
Thanks
what is topical dutasteride? Does it not have negative effects like procepia ?
Thanks
Bryan, I'm not saying this is the best tratment for you...only this is the best for me. Finasteride can not inibith the type 1 ar, while dutas is very effectively in doing it. Most of the dht in the scalp can be attributed to type 1 5ar. Anyway, you are right, dutasteride comes in a capsule, dissolved in an oil base. Make the compress with Aloe to use briefly (few minutes) under the shower and you'll see.
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twohair said:
I really don't think you can tell that for sure, after only a month. Besides, even if it really is working for you after all, it _may_ be doing so only because it's being absorbed systemically. That was the main point I was trying to make.
twohair said:
I don't know if I'd say that it's VERY effective at that. At the standard dose of 1 Avodart capsule per day, it inhibits about half of the type 1 enzyme (or maybe a bit more).
twohair said:
Yes, but we don't CARE about most of the DHT in the scalp, which comes from sebaceous glands. What we care about is the DHT that's generated INSIDE THE HAIR FOLLICLE. That seems to come almost exclusively from the type 2 enzyme.
Bryan
I'm sure that after only one month no treatment i had used previously (I tryed nearly everything) come close to results obtained with this one. No itching, no hair loss at all. I previously used also oral dutasteride and i know the side effects of the drug, but using it topically that side effects disappear so I belive that its effectiveness can be attributed to the topical action.
Yes is true..the drugs, taken orally at 0,5 mg per day, can inhibit 90% of dht in bloodstream and 54% of dht in the scalp, but what about his action on contact? Directly on 5ar enzyme? Maybe it is closer to a TOTAL suppression of dht.
Last answer: the sebaceous glands are INSIDE THE HAIR FOLLICLE and type 1 5 ar was also found in dermal papilla and hair sheaths and dutasteride inhibit also type 2 much better than finasteride.
Anyway this is the link where all started http://www.realbooks.net ---Double A
Yes is true..the drugs, taken orally at 0,5 mg per day, can inhibit 90% of dht in bloodstream and 54% of dht in the scalp, but what about his action on contact? Directly on 5ar enzyme? Maybe it is closer to a TOTAL suppression of dht.
Last answer: the sebaceous glands are INSIDE THE HAIR FOLLICLE and type 1 5 ar was also found in dermal papilla and hair sheaths and dutasteride inhibit also type 2 much better than finasteride.
Anyway this is the link where all started http://www.realbooks.net ---Double A
Guys do not trust that guy. If you try topical dutasteride you will feel a lot of pain. I had tried it 1 year ago. I think thwohair is just joking.
More specifically, upon breaking the first pill and applying it on my temples, back then, I got a severe skin irritation which lasted for many days. If you dont trust me, just google for skin/dermal irritation due to dutasteride. Apart from this, if you break an avodart pill, you are putting in risk pregnant women, who may touch the leacked substance (google for teratogenic effects on fetuses, due to dutasteride). Note that teratogeneses apply to broken finasteride pills as well.
In any case, mark my words: These two powerful drugs (dutasteride and finasteride) have been approved for oral use, not for topical application. Follow the rules as established by FDA, the pharmaceytical companies and the scientists associated with the specific research. If you make experiments on your own with these two drugs, you are setting both yourself and others into high risk.
Thylax
More specifically, upon breaking the first pill and applying it on my temples, back then, I got a severe skin irritation which lasted for many days. If you dont trust me, just google for skin/dermal irritation due to dutasteride. Apart from this, if you break an avodart pill, you are putting in risk pregnant women, who may touch the leacked substance (google for teratogenic effects on fetuses, due to dutasteride). Note that teratogeneses apply to broken finasteride pills as well.
In any case, mark my words: These two powerful drugs (dutasteride and finasteride) have been approved for oral use, not for topical application. Follow the rules as established by FDA, the pharmaceytical companies and the scientists associated with the specific research. If you make experiments on your own with these two drugs, you are setting both yourself and others into high risk.
Thylax
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twohair said:
The sebaceous glands and the hair follicle are both part of the pilosebaceous unit, but the seb glands aren't inside the hair follicle.
Furthermore, I suggest that you actually READ the study I cited about finasteride being the main inhibitor of 5a-reductase in human hair follicle dermal papillae.
The only accurate thing you said was that dutasteride is a better inhibiter of the type 2 enzyme than finasteride.
Bryan
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thylax : "If you try topical dutasteride you will feel a lot of pain"
what do you mean PAIN??? what kinda pain
ANd can this actually work as a topical? any study on it?
what do you mean PAIN??? what kinda pain
ANd can this actually work as a topical? any study on it?
Thylax I'm not joking. Why should I? I'm 29 years old and I don't have time to waste. I'm trying to share what I learned...belive me or not.
Bryan, a study is only "one study" and everybody out there know that dutasteride is about 10 time stronger then finasteride in his inibitory effect on human 5ar (lot of study). It seems to me you want to dispute...just to do it...really don't understand you...belive what you want---peace---
Bryan, a study is only "one study" and everybody out there know that dutasteride is about 10 time stronger then finasteride in his inibitory effect on human 5ar (lot of study). It seems to me you want to dispute...just to do it...really don't understand you...belive what you want---peace---
powersam
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twohair i dont know who you are or what your pushing, although i suspect it may be that 19euro book. but coming into this forum and posting junkscience bullshite isn't going to get you anywhere. If in fact you do use avodart topically (which i doubt), any positive effect you get is probably from the systemic absorption of it through your scalp, so you may as well swallow it.
someone else on this board tried it awhile back, and said putting dutasteride on his scalp caused him physical pain. moreover you've tried this method for 10 days?? come back in a year and then we might listen, or stay here for a year so noone thinks your a shill when your 7th post is "OMG TOPICAL dutasteride GREW BACK ALL MY HAIR".
i'm sorry if i sound negative but if you took the time to read up on this subject and this forum, you'd know just how ridiculous AND suspect you sound.
someone else on this board tried it awhile back, and said putting dutasteride on his scalp caused him physical pain. moreover you've tried this method for 10 days?? come back in a year and then we might listen, or stay here for a year so noone thinks your a shill when your 7th post is "OMG TOPICAL dutasteride GREW BACK ALL MY HAIR".
i'm sorry if i sound negative but if you took the time to read up on this subject and this forum, you'd know just how ridiculous AND suspect you sound.
oh yes PowerSam, maybe also I'm a stock olders of GlaxoWellcome and I'm trying to make out profit with your hair loss. Maybe that Kennedy was killed by ufo. Do you really think that if someone write that something works is going to push it? In that case please tell me: what are you doing here? Does not this newsgroup serves to relate experiences?
Dutasteride is not "junkscience"...and you should know that fact. I used every kind of treatment and no one had worked for me but dutas...this is the truth...you too, belive me or not...
I never said that dutas gives me back a full head of hair in 4 weeks... only I feel it's gonna work
and what do you mean for "physical pain"? This is true "junkscience bullshite"
Dutasteride is not "junkscience"...and you should know that fact. I used every kind of treatment and no one had worked for me but dutas...this is the truth...you too, belive me or not...
I never said that dutas gives me back a full head of hair in 4 weeks... only I feel it's gonna work
and what do you mean for "physical pain"? This is true "junkscience bullshite"