Topical spironolactone & Finasteride/Dutasteride

[hairrific]

Well they use that method here as a test to see how other certain products work but ironically I don't ever see anything mentioned on the "inverse reaction testing" using spironolactone. Since scalp hair is in many ways linked to body hair then you would think more discussion of body hair symptoms would be important and discussed.

I personally know that Propecia and dutasteride can be absorbed through the skin because it says so right on the FDA regulated bottle label and the Rx literature.

Now look at the label on the ORAL Rx spironolactone bottle or the Rx literature that comes with it and tell me if it says it can be absorb through the skin. Behold! Might that be our answer?

Anyone have a Rx bottle or the FDA required literature that can please tell us?

 

[hairrific]

Yep see what I mean?

"Because it metabolizes totally and rapidly in the skin where it is applied, there are no systemic effects." "metabolizes"? What does that exactly all mean? Not very specific.

I am thinking that not only is it a weak androgen as a topical, I dare to think that it does not do anything to go where it needs to be going in the skin. Everything else poor consumers put on are skin, dandy lion root, soy, poly this poly that, vit. b 12 ginseng, give me a break, stop putting my back yard in my shampoo, its not the 70s anymore. Might be better going in our mouths or asses, hello!

Now I think I saw a study that showed happy hamsters though I smell a rat soaking the spironolactone stuff on their flanks but I am not a scientist and if Byan post it, I or the masses probably won't be able to understand most of it or even begin to use it in a helpful way. If a stereo salesman shows me a study that shows the speaker system produces 10 dep at an 34.44u output per quad at 50 decibels then how will that help me decided that I need this for my ears?

Therefore I must assume and do allot of assuming about spironolactone and hope the dudes who did the study were reputable and that the happy hamsters wore plastic funnel collars that did not rub off and lick the spironolactone off the cage or glass or each others asses and the experiment was done properly. I also have to assume the amounts of spironolactone rubbed on the flank organs were similar to the amount in the retail product everyone here is buying or thinking of trying.

Now if we could just get over this b**ch tit paranoid attitude (that is another can of worms), then we would find that like dutasteride and finasteride, spironolactone works best as an oral if done in the right amounts.

 

[Bryan]

"Because it metabolizes totally and rapidly in the skin where it is applied, there are no systemic effects." "metabolizes"? What does that exactly all mean? Not very specific.

It means that enzymes in the skin rapidly convert it to another compound that doesn't have the same properties as the original; therefore, there's none of that original compound to be absorbed systemically and cause problems.

 

[Hecfield]

Now I think I saw a study that showed happy hamsters though I smell a rat soaking the spironolactone stuff on their flanks but I am not a scientist and if Byan post it, I or the masses probably won't be able to understand most of it or even begin to use it in a helpful way. If a stereo salesman shows me a study that shows the speaker system produces 10 dep at an 34.44u output per quad at 50 decibels then how will that help me decided that I need this for my ears?

Only thing is your not on a website thats concerned with stereos.

Its a biological issue, peer reviewed journals and studies will have scientific language. They aren't designed to be simple to understand, they're designed for experts in the field to interpret and examine. But they show statistics pretty clearly, and there's usually a brief abstract which is simple to understand.

 

[hairrific]

Thanks for the replies, yes I see your points. I always benefit the most from the study summery, after that I am left with allot of questions. And thank god for Bryan too.

I am now assuming the spironolactone conversion to another compound that doesn't have the same properties as the original is going to help with me with hair loss in some way(s).

OK, nothing is sacred here, lets find something that prevents hair loss! unk:

 

[Bryan]

I am now assuming the spironolactone conversion to another compound that doesn't have the same properties as the original is going to help with me with hair loss in some way(s).

Just as an example, one of the main metabolites of spironolactone is a substance called canrenone, which is itself an antiandrogen; but it's not as potent an antiandrogen as spironolactone.