squeegee
Banned
- Reaction score
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Fight Your Genes said:Squeegee nice post there. so what your saying is that D6D Functional Deficiency is a potential male pattern baldness pathway as it results in a Prostaglandin imbalance and raised inflammation that results in hair loss and other chronic disorders.
So its quite simple to reverse this imbalance via supplementation with GLA?
It could be a dysfunctional D6D or overactive Delta-5-desaturase (D5D) enzyme. Delta-5-desaturase (D5D) is the enzyme that converts DGLA into AA. This is the critical enzyme in the entire equation. Insulin is a potent activator of D5D..see there is a bunch of studies out there with Hyperinsulinemia or insuline resistance and male pattern baldness.
Sesamin oil is a potent inhibitor of D5D.
Sesamin is a potent and specific inhibitor of delta 5 desaturase in polyunsaturated fatty acid biosynthesis.
Shimizu S, Akimoto K, Shinmen Y, Kawashima H, Sugano M, Yamada H.
Source
Department of Agricultural Chemistry, Kyoto University, Japan.
Abstract
Incubation with sesame oil increases the mycelial dihomo-gamma-linolenic acid content of an arachidonic acid-producing fungus, Mortierella alpina, but decreases its arachidonic acid content [Shimizu, S., K. Akimoto, H. Kawashima, Y. Shinmen and H. Yamada (1989) J. Am. Oil Chem. Soc. 66, 237-241]. The factor causing these effects was isolated and identified to be (+)-sesamin. The results obtained in experiments with both a cell-free extract of the fungus and with rat liver microsomes demonstrated that (+)-sesamin specifically inhibits delta 5 desaturase at low concentrations, but does not inhibit delta 6, delta 9 and delta 12 desaturases. Kinetic analysis showed that (+)-sesamin is a noncompetitive inhibitor (Ki for rat liver delta 5 desaturase, 155 microM). (+)-Sesamolin, (+)-sesaminol and (+)-episesamin also inhibited only delta 5 desaturases of the fungus and liver. These results demonstrate that (+)-sesamin and related lignan compounds present in sesame seeds or its oil are specific inhibitors of delta 5 desaturase in polyunsaturated fatty acid biosynthesis in both microorganisms and animals.