Updated (i Think?) Tsuji Article Interstitial Stuff

[yep78]

Ok so I remember reading the kyocera article in July on the news about them partnering and their method. Well I just read it again today, and I could swear it's updated and formated differently. Here's the link:

http://global.kyocera.com/news/2016/0702_nfid.html


This news release is intended for media purposes, and is current of the date of publication. Information is subject to change without notice.

KYOCERA, RIKEN and Organ Technologies Launch Joint Research in Regenerative Medicine to Treat Hair Loss
Organ regeneration technology shows promise for regenerating hair follicles

July 12, 2016
Kyocera Corporation (President: Goro Yamaguchi),RIKEN

national science institute (President: Hiroshi Matsumoto) and Organ Technologies Inc.

(President: Yasuhiro Sugimura) announced today a partnership to develop technologies and products for treating alopecia (hair loss) through the regeneration of hair follicles. The companies aim to put the technologies into practical use in 2020.

Background
Common types of hair loss include androgenic alopecia, congenital alopecia, cicatricial or “scarring” alopecia, and telogen effluvium alopecia among women. Currently, it is said that there are more than 18 million patients with alopecia in Japan alone*1. Because alopecia can influence the quality of life, many diverse treatments, including hair growth formulas, hair loss inhibitors and autografting of individual hair follicles*2, have been utilized with mixed results. Because no existing treatment — not even surgical autografting — can increase the number of hair follicles, any viable method of regenerating hair follicles has great potential to succeed where other methods fail.

Success of Hair Follicle Regeneration in Mice
The Laboratory for Organ Regeneration (Team Leader: Takashi Tsuji) of the RIKEN Center for Developmental Biology (CDB)

has demonstrated that the regeneration of many organs, including teeth, hair follicles and secretory glands, is functionally possible. The hair follicle is the only organ known to regenerate repeatedly after birth (hair cycles*3). In 2012, the research team isolated epithelial stem cells and follicle dermal papilla cells (mesenchymal stem cells)*4 from the follicles of mature mouse whiskers and body hair and used them to develop a technology for the regeneration of follicular primordium by utilizing an “organ primordium technology*5” previously developed by the same team. Transplanting the regenerated follicular primordium into hairless mice results in the growth of regenerative follicles, thus demonstrating the feasibility of hair shaft regeneration. The transplanted primordium also forms connections with surrounding tissues (arrector pili muscle and nerves) and repeats normal hair cycles. Furthermore, this method allows control of the hair color by adding pigment stem cells, and the number of hair follicles regenerated, elevating its potential for the aesthetic treatment of alopecia. In addition, the RIKEN research team has succeeded in using iPS cells*6 to regenerate functional skin organ systems*7 in mice

, including all follicles, sebaceous glands, and skin tissues, thus leading the world in organ regeneration technology*.

*RIKEN Press Release “Growing skin in the lab”http://www.riken.jp/en/pr/press/2016/20160402_1/

Joint Partnership Aims for New Treatment in 2020
Kyocera, RIKEN and Organ Technologies plan to establish cell culture and transplant technologies and develop devices for transplantation, aiming to put the technologies into practical use for the treatment of human alopecia in 2020 in Japan. The RIKEN Integrated Innovation Building

*8 (Kobe City, Hyogo Prefecture) will serve as a base for this joint research.

Kyocera will lead technical aspects such as the development of cell processing devices, by utilizing its microfabrication and manufacturing technologies which have been cultivated for over 50 years. RIKEN and Organ Technologies will be responsible for the development of follicle-derived stem cell culture / amplification technologies and cell manipulation technologies for clinical application in humans, establishment of production processes, implementation of preclinical studies and other roles.

Major roles of participating companies
Kyocera Development of cell processing devices, etc.
RIKEN and
Organ Technologies Development of stem cell culture / amplification technologies, development of cell manipulation technologies, establishment of production processes, implementation of preclinical studies, etc.

Outline of Business Model
Follicular regenerative medicine will focus on the collection of stem cells from the patient’s own hair follicles, followed by the processing of these follicles and autografting on the same patient. For the treatment of androgenic alopecia (the most common type), a small number of hair follicles will be collected, from which stem cells will be isolated, cultured and amplified to produce hair follicle germ by the established organ primordium method. The regenerated hair follicle germ will be packaged and delivered to a medical facility for use in transplantation therapy for the patient.

With the goal of Kyocera becoming the commissioned manufacturer for this method through cooperation with Organ Technologies, the joint research partnership plans to pave the way for commercial viability within a research period of two years, followed by the materialization of the business model of commissioned manufacturing.

 

[That Guy]

I dunno. Looks as I remember it

 

[resu]

This is the cure right here, I reckon the density won't be the same as it originally was since they can't pack the grafts too close but it should look dense either way.

 

[Gone]

Was there any statement regarding the limit
of the density achieved? Who says they can't pack them closely?

It's been said that they could probably adjust the number of hairs per follicular unit, so that should be totally attainable if it works, but in terms of spacing I'm not sure

 

[MeMoZa313]

NEW HOPE!!

 

[Xander94]

Can some1 explain how is this different than shisheido?

 

[Captain Rex]

Can some1 explain how is this different than shisheido?

common Xander94

tsuji is replicating hair follicles from the scratch
shiseido is replicating the DP cells and DSC thing

DP- Dermal Papilla
DSC- Dermal Sheath Cups

TSUJI
tsuji will create a lot of hair follicles in lab and then transplant or graft them into scalp just like FUT or FUE
PROS= there is no need to take hair follicles from donor region just only few needed and then replicated in labs.
CONS= its gonna be the same fut and fue method which will be little irritating and painful

my belief transplant is not a solution or cure its a cover up.(u will never get back the same density of hair)

SHESEIDO/ REPLICEL
They are going to take a biopsy from the back of your head( a small segment of skin) and then retrieve some of the DP cells and DSC and then replicate to inject them back to affected areas which will stimulate hair to grow

PROS= this is the perfect way to treat male pattern baldness i think ( its a cure from the root of the problem not cover up like transplant plus u grow hair from your skin, it will look natural no doubt in that)
CONS= there is no con if it works out

 

[Xander94]

common Xander94

tsuji is replicating hair follicles from the scratch
shiseido is replicating the DP cells and DSC thing

DP- Dermal Papilla
DSC- Dermal Sheath Cups

TSUJI
tsuji will create a lot of hair follicles in lab and then transplant or graft them into scalp just like FUT or FUE
PROS= there is no need to take hair follicles from donor region just only few needed and then replicated in labs.
CONS= its gonna be the same fut and fue method which will be little irritating and painful

my belief transplant is not a solution or cure its a cover up.(u will never get back the same density of hair)

SHESEIDO/ REPLICEL
They are going to take a biopsy from the back of your head( a small segment of skin) and then retrieve some of the DP cells and DSC and then replicate to inject them back to affected areas which will stimulate hair to grow

PROS= this is the perfect way to treat male pattern baldness i think ( its a cure from the root of the problem not cover up like transplant plus u grow hair from your skin, it will look natural no doubt in that)
CONS= there is no con if it works out

Then for a guy like me that only needs density all around Tsuji is basicly useless for now.

 

[Captain Rex]

Then for a guy like me that only needs density all around Tsuji is basicly useless for now.

sry to break it up in this way but yes u can't graft hair follicles that close so as to get hair density like ur teenage hair
so when anyone says transplant is a cure i don't like it.( just false hopes).

Histogen and Replicel are our best shot now.

 

[Blackber]

sry to break it up in this way but yes u can't graft hair follicles that close so as to get hair density like ur teenage hair
so when anyone says transplant is a cure i don't like it.( just false hopes).

Histogen and Replicel are our best shot now.

Tsuji's team already said they can control density and their follicle germs are much smaller than traditional grafts.

 

[buckthorn]

sry to break it up in this way but yes u can't graft hair follicles that close so as to get hair density like ur teenage hair

you could get them close enough. With unlimited donor, you can have perceivably a full head of hair. we've seen HAIR TRANSPLANTS, with limited donor where the hair lines created look almost like full density (when a sh*t ton of grafts are used)

 

[kiwipilu]

"a doctor from Europe showed a high survival rate of 100 FU's in a cm2, but the grafts were put in absolutely perpendicular, which is about the only way you can accomplish that - but the aesthetic result of grafts placed in an upright angle is horrendous and very abnormal."
Mike Beehner, M.D.
Anyway most of the best doctor easily achieve 60-65 FU'S/cm² which is perfect density and make it look natural

 

[Captain Rex]

Tsuji's team already said they can control density and their follicle germs are much smaller than traditional grafts.

the smaller the merrier
but still look at Rooney he needs further hair transplant
so hair transplant is not a solution or cure
grafting hair doesn't solve the root cause of male pattern baldness
the process will continue and will take over after certain time.
if we take a closer look on our scalp, we will see our skin has lost its thickness ( a connection to DP cells). Well, grafting doesn't increase the thickness. But stem therapy will for sure( they just need to thicken it up)
DHT is not the sole reason behind male pattern baldness (but yea its a driving factor) and skull expansion has a major role in that.( and hey i'm not selling any massage book, ok)

i hope these stem cell therapies come out in the market as soon as possible

you could get them close enough. With unlimited donor, you can have perceivably a full head of hair. we've seen HAIR TRANSPLANTS, with limited donor where the hair lines created look almost like full density (when a sh*t ton of grafts are used)

i wish this to happen but still u can easily figure out a guy with hair transplant. It doesn't fit in man. Doesn't do the job. If there's any treatment that grows hair on your scalp and makes the skin thick like we had it before then that will be a cure.

i am waiting for replicel to show their work

 

[That Guy]

i wish this to happen but still u can easily figure out a guy with hair transplant.

You can

90% of the human population cannot

 

[Trouse]

You can

90% of the human population cannot

This. Transplants can be completely undetectable to the untrained eye. Just because we're Norwood savants who are obsessed with looking at other mens' hair density doesn't mean anyone else will spot a good transplant, unless it's just brought down way too far and looks absurd.

At any rate, after reading Tsuji's answers from that teleconference I came away with the perception that not only would you be able to get your normal density back, you could conceivably have greater density than your pre-balding head. I personally never had a ton of hair, it was always very soft and silky but also thin. If they have what amounts to an unlimited donor supply of germ follicles I don't see why they can't pack them as dense as the person is willing to pay for. I mean obviously some people's scalps allow for this just based on their genetics, so what's to prevent Tsuji and his team from doing this manually?

 

[resu]

If they use cultured grafts with 3 or more hairs they won't need to pack them too close then use the nape hairs for the hairline. Some hair transplant Doctor also mention the limitation of the number of blood vessels but I can't find the video on youtube at the moment.

My natural hair direction already looked like a bad hair transplant before balding, in the mid-scalp there's a couple of whirlpools and in the nape area as well, if I could change the direction in the mid-scalp to have them faced forward then it would be much easier to comb the hair but this is so far ahead in the future that it's not even a worry at this point. With the thinning in the middle the whirlpools naturally form a faux hawk, that's my current combover and I can't do anything else until I get my hair back.

 

[Captain Rex]

don't know whether it is related to hair loss but i read somewhere iPS cells can be used for hair multiplication.
here is a new update from RIKEN -

Green light for launch of clinical research using donor iPS cells
http://www.riken.jp/en/pr/topics/2017/20170207_1/

edit: "In the trials, patients will be transplanted with cell suspensions of retinal pigment epithelial (RPE) cells made from iPS cells generated from other donors and stockpiled by CiRA. The RPE cells, prepared at CDB, will be transplanted into patients at Kobe City Medical Center General Hospital and Osaka University Hospital."

so they are trialing it for some eye related problems as of now but who knows if they find it useful, hair regeneration will be their next goal.

 

[lemoncloak]

Correct me if I'm wrong but hair transplants need light packing because the grafts don't heal well otherwise, not because they can't fit. Here they're using a clump of cells, not a piece of scalp with a follicle in the middle. Also, Toyoshima said they can reach 120 hairs/cm^2, perhaps more. Have you seen the article he bases this statement on? They just injected a mouse about 30 times, grew a bunch of hair and said "ok we can do this much density for sure". I wouldn't be surprised if they can greatly exceed 120 (which is already double the hair transplant standard). Besides, look at Tissuse. Granted, they're using a special needle, but they seem to aim for original, pre-balding density.
"The microorganoid follicles are incorporated into the openings of previously depilated, miniaturized hair follicles (isthmus) of affected skin areas. Preferably, the de novo papillae and hair microfollicles are injected, more preferably by means of a specially constructed device of about 150 μm in size."
I really wish Tsuji would use such a tiny needle but don't forget germs can have up to 4 hairs each.