- Reaction score
- 1,026
I still don't understand why not use it topical....
Use Biopiperine With Oral Seti Possible Increase 2000% ...
- Thread starter proscar2
- Start date
He had told me his lyphar's seti is tasteless too.
About bioperine, would you recommend people to take with seti?
use it carefully to increase effects.
as maestro Swiss pointed out its the liver enzyme that causes Seti to lose approx 50% its effects. so inhibiting that (at your own risk) is the point it seems. Biopiperine as i have stated before allows extra bio-availability of supplements through digestion. But it would seem through way that of liver enzyme inhibition also. This means that it would have a double effect of not only allowing more Seti to get into the bloodstream originally but also would stop the liver breaking down a lot of the seti
when I'm right- I'm really right. Swiss can have the Oscar at week-ends!
BIO-PIPERINE
http://nutrientjournal.com/black-pe...sorption-of-nutrients-antioxidant-properties/
Bio-enhancing Ability
It has been shown that piperine can dramatically increase absorption of selenium, vitamin B, vitamin C, coenzyme Q10 [1] and beta-carotene, [2]. Piperine also increases the bioavailability of herbal and conventional drugs such as resveratrol and curcumin [12]. Piperine favorably stimulates the digestive enzymes of pancreas which enhances the digestive capacity and significantly reduces the gastrointestinal food transit time.[3] The results of clinical studies of piperine with drugs indicate that piperine administered orally at a single dose ranging from 20 to 50 mg may significantly increase serum drug levels by reducing the clearance of drugs, from natural or synthetic source.[1] The mechanisms by which piperine increases the absorption may involve increased gastrointestinal blood supply [4], postulated thermogenic properties [5] and the increase in bioenergetic processes [6].
Piperine can also attenuate free radicals and reactive oxygen species and has been shown to protect against oxidative damage in vitro.[7]
Safety and Side Effects
Piperin has been shown to inhibit both human drug-metabolizing enzymes P-glycoprotein and CYP3A4 (possibly others too)[8] which may lead to grapefruit-like effect. Inhibition of these enzymes decreases their ability to break down drugs which in turn increases drug blood levels and which causes worse side effects etc. Therefore, black pepper should not be consumed in combination with any drugs. For example, it was shown that a single administration of 1 g of black pepper more than doubled area under the plasma concentration-time curve and elimination half-life of phenytoin [9].
Piperine can be toxic for the central nervous and reproductive systems at high concentrations [11].
as maestro Swiss pointed out its the liver enzyme that causes Seti to lose approx 50% its effects. so inhibiting that (at your own risk) is the point it seems. Biopiperine as i have stated before allows extra bio-availability of supplements through digestion. But it would seem through way that of liver enzyme inhibition also. This means that it would have a double effect of not only allowing more Seti to get into the bloodstream originally but also would stop the liver breaking down a lot of the seti
when I'm right- I'm really right. Swiss can have the Oscar at week-ends!
BIO-PIPERINE
http://nutrientjournal.com/black-pe...sorption-of-nutrients-antioxidant-properties/
Bio-enhancing Ability
It has been shown that piperine can dramatically increase absorption of selenium, vitamin B, vitamin C, coenzyme Q10 [1] and beta-carotene, [2]. Piperine also increases the bioavailability of herbal and conventional drugs such as resveratrol and curcumin [12]. Piperine favorably stimulates the digestive enzymes of pancreas which enhances the digestive capacity and significantly reduces the gastrointestinal food transit time.[3] The results of clinical studies of piperine with drugs indicate that piperine administered orally at a single dose ranging from 20 to 50 mg may significantly increase serum drug levels by reducing the clearance of drugs, from natural or synthetic source.[1] The mechanisms by which piperine increases the absorption may involve increased gastrointestinal blood supply [4], postulated thermogenic properties [5] and the increase in bioenergetic processes [6].
Piperine can also attenuate free radicals and reactive oxygen species and has been shown to protect against oxidative damage in vitro.[7]
Safety and Side Effects
Piperin has been shown to inhibit both human drug-metabolizing enzymes P-glycoprotein and CYP3A4 (possibly others too)[8] which may lead to grapefruit-like effect. Inhibition of these enzymes decreases their ability to break down drugs which in turn increases drug blood levels and which causes worse side effects etc. Therefore, black pepper should not be consumed in combination with any drugs. For example, it was shown that a single administration of 1 g of black pepper more than doubled area under the plasma concentration-time curve and elimination half-life of phenytoin [9].
Piperine can be toxic for the central nervous and reproductive systems at high concentrations [11].
mowingdown
Member
- Reaction score
- 17
Where did you buy it from?
- Reaction score
- 8
I thought this way, until I realized I could chew my vitamins, rather than skipping first 2 digestive steps of mastication and saliva. So, more study is needed.
Disgusting tasting vitamins can be chewed at least twice before washing down.... Sure, probably time released stuff should not be liquid nor chewed.