Vb-1 Vitexin Promotes Hair Growth May Study

[ALightInTheDark]

https://www.ncbi.nlm.nih.gov/pubmed/29761053

VB-1 significantly promotes the proliferation of hDPCs in a concentration-dependent manner [...] dkk1was clearly down-regulated in hDPCs treated with VB-1. The increased active β-Catenin and decreased AXIN2 protein levels suggest that VB-1 facilitates Wnt/β-catenin signaling in hDPCs in vitro. The expression of DP signature genes was also upregulated after VB-1 treatment.

 

[Toddskii]

 

[mr_robot]

DP = Dermal Papillia, the more DP cells you have the thicker the hair shaft. Minoxidil works by increasing the number of DP cells in the follicle.

VB-1 is found in a number of plants that you can get essential oil from, however I have no idea what the concentrations would be.

 

[ALightInTheDark]

https://www.ncbi.nlm.nih.gov/m/pubmed/22358062/

Dickkopf 1 (DKK-1) is a pathogenic mediator involved in male pattern baldness.
Dickkopf 1 promotes regression of hair follicles.

-> dkk1was clearly down-regulated in hDPCs treated with VB-1

@Toddski
Just one among other things VB-1 seems to do
For the rest, you can search by yourself


For concentrations VB-1 was used at (0–10 µM) in cells

So nobody knows actually. But it rather seems to be very low concentration (ng/mg)

 

[timberman]

Pretty interesting stuff. Here you can read some more about Vitexin, http://blog.lifeextension.com/2017/06/7-health-benefits-of-vitexin-remarkable.html

 

[bboy]

What's kind of jumped out at me as being interesting in that study is that a dose of 0.1 uM was more effective than both 1.0 uM and 10.0 uM. So increasing the dose by 10 and even 100 fold made it less effective... I wonder why that was?

 

[ALightInTheDark]

https://www.researchgate.net/figure...5dlrF1YuUXc-mSXNYDzDs65-HNM0NHxIhoesv7ryhnJUQ

In this study you can see the diagram linked to PG pathway.

We need to increase :
- PGE synthases (mPGES-1: microsomal prostaglandin E synthase-1 (extremely important), mPGES-2: prostaglandin E synthase-2, cPGES: cytosolic prostaglandin E synthase)
- AKR1C1

We need to mess or downregulate :
-
CBR1
- 15-PGDH
- PGD2 synthase
- 15-KetoProstaglandin D2

 

[Trichosan]

Interesting. How do we approach this for self-experimentation? Pharm grades?
Lovely plant:
https://www.crimson-sage.com/store/chinese-herbs/vitexnegundo-cannabifolia-328-detail

Edited:

Hmm,...http://www.adooq.com/vitexin.html

 

[ALightInTheDark]

Interesting. How do we approach this for self-experimentation? Pharm grades?
Lovely plant:
https://www.crimson-sage.com/store/chinese-herbs/vitexnegundo-cannabifolia-328-detail

Edited:

Hmm,...http://www.adooq.com/vitexin.html

I think thoose seems to be good but let me avise you to use liposamal topical if you can. Vehicle is almost as important as the compound itself.
https://web.archive.org/web/2003070...ine.com/archives/2000/032/05/r0269-0281re.pdf


Btw
https://www.hairlosscure2020.com/2018-american-hair-research-summit/

Aclaris Samumed Dr.Christiano/Torso and Cotsarelis are present.
(From the site : Update: One of my inside sources e-mailed me today and said that there was some excitement about the results presented by Cassiopeia in relation to Breezula)

 

[kiwipilu]

I think thoose seems to be good but let me avise you to use liposamal topical if you can. Vehicle is almost as important as the compound itself.
https://web.archive.org/web/2003070...ine.com/archives/2000/032/05/r0269-0281re.pdf


Btw
https://www.hairlosscure2020.com/2018-american-hair-research-summit/

Aclaris Samummed De.Christiano/Torsion and Cotsarelis are present.
(From the site : Update: One of my inside sources e-mailed me today and said that there was some excitement about the results presented by Cassiopeia in relation to Breezula)

https://2018ahrs.org/2018ahrs/wp-content/uploads/2017/04/AbstractBook_2018AHRS_May2018-Orlando.pdf
see page 10, it beats minoxidil ?! : o need a groupbuy asap : p

 

[ALightInTheDark]

https://2018ahrs.org/2018ahrs/wp-content/uploads/2017/04/AbstractBook_2018AHRS_May2018-Orlando.pdf
see page 10, it beats minoxidil ?! : o need a groupbuy asap : p

Of course there is already numerous reported use of CB-03-01. Says weaker than RU,at least 2x stronger than fina and with no side effects


Edit :
A) These results inspire a new strategy that can restore morphological transitions and rescue the hair-forming
ability of adult organoids:
1) continuous PKC inhibition; and
2) timely supply of growth factors (IGF, VEGF), Wnts, and MMPs.

B) Vitamin D deficiency was present in 64.8% of patients, with 32.96% having mild, 17.60% moderate and 14.25% severe deficiency. Vitamin D values were significantly associated with all hair loss type (p=0.02), with
central centrifugal scarring alopecia having lowest vitamin D levels, and Androgenetic Alopecia the highest.
-> This is confusing me. Does it means Androgenetic Alopecia people have too much VitD levels?

C) The novel humanized mouse model of Androgenetic Alopecia holds great potential to systematically explore new candidate anti-Androgenetic Alopecia agents at the preclinical level and to better characterize the as yet incompletely understood mechanisms of action of traditional agents such as minoxidil.

-> Mouse : 1 / Human : 0

D) Our data revealed upstream first responses of KATP channel in HDPC induced by minoxidil sulfate.
The opening of KATP channel by minoxidil sulfate critically contributes to the promotion of therapeutic potency for
hair growth. The amplification of signaling via KATP channel activation may be essential and effective strategy for AAG

E) More specifically, genes involved in the monounsaturated fatty acid and triglyceride synthesis were proven fundamental for proper hair development. In
addition, more evidence has been advocating that essential dietary fatty acids, their metabolites and their nuclear receptors are influencing the hair follicle and fur in several preclinical models

F) Our data identify WNT10A
as a critical ligand controlling hair follicle progenitor cell proliferation. Together with the observation that hair
follicle stem cells are maintained in the absence of WNT10A and in balding scalp, our results suggest downstream
β-catenin pathway activation as a potential approach to ameliorate androgenetic alopecia in patients who carry a WNT10A variant.

-> Revelant with Vitexin VB-1

G) The elevated levels of plasma MMP activity in Androgenetic Alopecia patients could be consistent with hair follicle miniaturization and perifollicular fibrosis. Whether increased MMP activity puts Androgenetic Alopecia patients at risk for subclinical heart tissue remodeling is unknown.

H) Traction caused by the habit of wearing hats may facilitate colonization of the scalp by Staphylococcus aureus (Sa). Sa secreted cytotoxic proteins,
frequently detected in active DCS lesions, can act as superantigens, activating the secretion of inflammatory
cytokines, which may induce thickening of collagen. These cytokines activate the fibroblasts, causing
overproduction of the extracellular matrix, which leads to fibrosis due to its progressive accumulation.

I) Intralesional Triamcinolone Acetonide For Treatment Of Traction Alopecia
None of the patients reported any adverse effects due to the ILK. ILK
injections are usually done at a concentration of 5mg/mL

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