Vitamin A overdose

[lacaz]

But this atRAS level being high is something permanent or something that subside with time?
Accutane itself is proven to cause diffuse hairloss through tellogen effluvium
by what u said we can conclude that, accutane can induce hairloss and by inducing hairloss it can worsen AAG what is evident, everything that cause hairloss will worsen the aag state of a person, meaning that the hairs that felt maybe wont comeback because theyre being attacked by DHT while they fall for another reason beside dht
i didnt understand right but u said that accutane can induce alopecia areata too?

Yes on studies it tells that it can change permanently the genes expression in the cells. Means that the aldh1a3 (who is transforming enzymes in atRAs and so determinate the level of atRA) will be more active for life longterm

then it depend on how strong accutane alterated our RA metabolism. Every metabolism react in different proportion. Maybe it's possible that the atRAs are really high for the first years post accutane and then decreased, but still if it's too high it will have the negative conséquences. they say on the studies that precise level is really important for evertyhing work well about the hair follicle

In my case, since accutane I never see one little white sebum acne again for years, my skin never react the same as before under the sun (more sunburns and more difficult to tan (tan process is related to the ALDHs family!), so I'm pretty sure accutane have done his 'job' well in my skin cells

For your last question, no alopecia areata and universalis are non cicatricial alopecias
Alteration of the vitaminA metabolism is linked to cicatricial alopecias (CCCA, PCA, LLP, FFA), a kind of inflammation that destroy the follicle and the stem cells. Look in the msg, i put the different studies that explain how altered vitA metabolism (higher RA metabolism activity) lead to hair destruction ( less wnt, less anti inflammation protectors, less growth factors, etc)
And this can work in synergy with the Androgenetic Alopecia factors, all of that kill the follicles faster logically

 

[stressftw]

Yes on studies it tells that it can change permanently the genes expression in the cells. Means that the aldh1a3 (who is transforming enzymes in atRAs and so determinate the level of atRA) will be more active for life longterm

then it depend on how strong accutane alterated our RA metabolism. Every metabolism react in different proportion. Maybe it's possible that the atRAs are really high for the first years post accutane and then decreased, but still if it's too high it will have the negative conséquences. they say on the studies that precise level is really important for evertyhing work well about the hair follicle

In my case, since accutane I never see one little white sebum acne again for years, my skin never react the same as before under the sun (more sunburns and more difficult to tan (tan process is related to the ALDHs family!), so I'm pretty sure accutane have done his 'job' well in my skin cells

For your last question, no alopecia areata and universalis are non cicatricial alopecias
Alteration of the vitaminA metabolism is linked to cicatricial alopecias (CCCA, PCA, LLP, FFA), a kind of inflammation that destroy the follicle and the stem cells. Look in the msg, i put the different studies that explain how altered vitA metabolism (higher RA metabolism activity) lead to hair destruction ( less wnt, less anti inflammation protectors, less growth factors, etc)
And this can work in synergy with the Androgenetic Alopecia factors, all of that kill the follicles faster logically

thank you for your answers.
well, thats very disappointing to see that this drug cause this amount of harm especially in our gene expression..
after 1 month off accutane my skin if full of oil again though, my acne did came back already, but less severe, and im managing to keep it under control with creams and salycilic acid, my hair at moment is getting back to normal, but i dont know what is going to happen, but one thing is a fact, hair loss in a pattern = AAG,
random hairloss could maybe something else, i noticed that ive lost tons and tons of hair in the back of my hair too(donor area) and its regrowing slowly


look how it was affected there some baldspots that wasnt there, it was full of hair before.

 

[lacaz]

yeah it surely some of the temporary hair loss from the medication that will come back.

But for the high atRAs, it's aggravating factors for the long term' process. To Image the thing for exemple a guy will develop his entire predisposed baldness in 10/15 years instead of 30/40.

the balding process will begin sooner, be faster, and if the man is for ex predisposed to become norwood3, it's possible he will hit higher norwoods than he should

cause simply : high atRAs in our HF cells = Higher 5ARdht formation, higher WNT desactivation, less inflammations protection, less growth factors production, negative interaction with TGFbeta pathway. So all of that deadly combination accelerate for years the balding process

 

[stressftw]

and how to inhibit these high retinoic acid levels in our organism in a non synthethic way? If there is a way..

have you tried liver flush, somekind of detox? Does body adjust itself with time?

And you mentioned that accutane have 4 triggers that can fuk up with hair, there is more than that.
chronic telogen effluvium is seen in patients who taken isotretinoin, it fragilize hair making it dry and susceptible to environmental damage, breakage, etc.
accutane is a poison for hair

 

[Baylad]

I ate papaw for 6 weeks twice a day on an organic farm and my hands , feet and face went yellow- total overdose on Vit A