What are the strongest Anti Androgens?
- Thread starter DontWant2BeBald
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1. Yes maintenance primarily. However thickening too + a bit of regrowth. I had a constant improvement for 1 year then it stabilized
2. Primarily thickening existing hair and a bit of regrowth (not much regrowth though)
3. Well, it competes for the androgen receptor with androgens that want to bind to the androgen receptor;
Assuming that DHT has way higher affinity and potency to the androgen receptor than testosterone my guess would be that testosterone wouldn't have much chance of binding when RU is active. However I don't know for sure.
4. I don't suffer from any side effects. Sides are obviously possible though as gauged by user experience.
5. 1x a day 60-75MG currently.
No problem.
Lets pretend RU went systemic and its metabolites it breaks down into that might last longer than RU molecules themselves. Where are androgen receptors in the body then besides skin, hair, and prostate? Are they found in places like the heart or anywhere else that could effect? One guy claimed his heart problems were directly from RU
gmiller09
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im not sure the danger. you arent going to become a woman rubbing RU on your head, but i msure its getting intothe body to some degree. I dont feel castrated men or woman really face any serious health problems. maybe just a longer life? i would rather risk RU than destroy enzymes that do several functions in the body.
I agree knocking out enzymes is not a smart idea, but RU molecules shutting down critical receptors that are part of your heart or other vital organs might not do you well either. Who knows what shutting down receptors all over your skin might do long term.
Someday I hope CB puts all these hard decisions into the history books so no one ever has to mess with this stuff again
gmiller09
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im not sure if what im about to say makes medical sense because im no doctor. but say a boy castrated . he will live an abnormal life but his life wouldnt be endangered. he has no androgens to bind to his receptors. but in the end we dont have enough meidcal evidence about RU to say anything with certainity. Ive never experinced sides and have used 150mg once. hopfully cb turns out to be safe and effective(more so) and replace propecia
DontWant2BeBald
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Why the hell did RU get this amazing reputation on this site. Post me one guy who used only RU and got success. I've searched quite a bit and found no one. Most likely it is a chemical which does not work otherwise the trails on it would not have stopped
Im not defending RU, but I think if the chemical was correctly made it would be among the most potent AAs if you wanted to experiment on yourself. Some people are and I dont know how the results are.
DontWant2BeBald
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If it was made correcltly and was one of the most potent AA's than the trails probably would not have stopped.
Try a different AA, but the real porblem is that these drugs have active metabolites which are actually what is AAic so I'm really not sure if applying it to the skin would work
Your guessing. No one knows why trials stopped but there are lots of possible reasons. Not the least of which is simply the cost of trials for something that arguably is not worlds better than propecia was. I dont know if applying to skin works either. Without anything done on it who is to say really. I was just saying in theory its a pretty potent AA from the preliminary studies they did do before it got canned. That is what this thread is about potent AAs. I never said I used it or plan on taking it. I thought about it but I think I am going to try finasteride first if anything
DontWant2BeBald
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Well if you havent tried finasteride because of fear of the sides then you have n business using a "research chemical" which could be anything and possibly have worse side effects than finasteride
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I thought the strongest was Androcur (Cyproterone acetate) but according to Wikipedia -
"Compared to cyproterone acetate, spironolactone is considerably less potent as an antiandrogen by weight and binding affinity to the androgen receptor. However, despite this, at the doses in which they are typically used, spironolactone and cyproterone acetate have been found to be generally equivalent in terms of effectiveness for a variety of androgen-related conditions; though, cyproterone acetate has shown a slight though non-statistically significant advantage in some studies."
THEN
"Flutamide, another frequently employed antiandrogen which is a pure, selective androgen receptor antagonist, though much less potent by weight and binding affinity than either spironolactone or cyproterone acetate, has been found to be more effective than either of them as an antiandrogen when it is used at the typical treatment doses."
Recently I've been doing research on Flutamide and the newer Bicalutamide. Unfortunately, I haven't seen guys who tried those orally.
Links:
http://en.wikipedia.org/wiki/Spironolactone
http://en.wikipedia.org/wiki/Cyproterone_acetate
http://drugs.webmd.boots.com/drugs/d...e-Acetate.aspx
"Compared to cyproterone acetate, spironolactone is considerably less potent as an antiandrogen by weight and binding affinity to the androgen receptor. However, despite this, at the doses in which they are typically used, spironolactone and cyproterone acetate have been found to be generally equivalent in terms of effectiveness for a variety of androgen-related conditions; though, cyproterone acetate has shown a slight though non-statistically significant advantage in some studies."
THEN
"Flutamide, another frequently employed antiandrogen which is a pure, selective androgen receptor antagonist, though much less potent by weight and binding affinity than either spironolactone or cyproterone acetate, has been found to be more effective than either of them as an antiandrogen when it is used at the typical treatment doses."
Recently I've been doing research on Flutamide and the newer Bicalutamide. Unfortunately, I haven't seen guys who tried those orally.
Links:
http://en.wikipedia.org/wiki/Spironolactone
http://en.wikipedia.org/wiki/Cyproterone_acetate
http://drugs.webmd.boots.com/drugs/d...e-Acetate.aspx
massa
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Well the strongest would be androcur, flutamide and spironolactone, however its pointless as a man to take these as your pretty much guaranteed to get gyno and dick problems so unless you want breast and a shrunken numb dick then stay away. The strongest 'safest' anti androgens for men would be dutasteride combined with RU or CB.
DontWant2BeBald
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Yeah thx guys. I want to use one of them as a topical. But I want to use something that kills testosterone when it comes into contact with it but only gets absorbed in the scalp.
My main concern howver is that these drugs are designed to be used orally so they have to be digested for them to turn into their final form. Like the acids and bases you body releases on them changes their chemical structure to make their active metabolite. So I am not sure if they would work if you apply them topically.
Anyone know?