What Will Happen If Transplant Frontal Hair To The Back Or Other Site?

[Jamesallenliwei]

What will happen if transplant frontal hair to the back or other site?
As we know, the frontal hair are sensitive to DHT, so it's seasy to loose the hair in frontal hairline, and the hair will progressively miniature.
What if we transplant the frontal miniatured hair follicle to the back of the head, or transplant the hair to other site of the body, for example to the leg.
Will the hair follicle continue to shrink, miniature, or not ?
Is there any scientific reseach for this question?
Thank you for sharing your opion on this question.

 

[Javell]

You absolutely have no clue how hair transplant works.
Think logically.
Why it is called a hair transplant, because hair is a f*****g, living organ.
Why hair transplant is an option, because transplanted hairs are not sensitive to DHT. Transplant your shitty frontal pubes to the donor area and it still won't be resistant.

 

[kiwipilu]

why do you want to do that? these follicles are just genetically programmed to fall with presence of dht...and this hormone is present all over the body.

 

[Jamesallenliwei]

are you sure? is there any scientific research? some theory say the frontal scalp is different from the back and sides.

You absolutely have no clue how hair transplant works.
Think logically.
Why it is called a hair transplant, because hair is a f*****g, living organ.
Why hair transplant is an option, because transplanted hairs are not sensitive to DHT. Transplant your shitty frontal pubes to the donor area and it still won't be resistant.

 

[Jamesallenliwei]

why do you want to do that? these follicles are just genetically programmed to fall with presence of dht...and this hormone is present all over the body.

the scalp DHT is elevated in the bald area, not in the nonbald area.

 

[kiwipilu]

the scalp DHT is elevated in the bald area, not in the nonbald area.

dht is dht how do you think body hairs grow?

 

[Jamesallenliwei]

dht is dht how do you think body hairs grow?

the fontal bald area has an elevated DHT level, so the frontal hair are more likely to shrink, but other site of the body DHT level are not elevated .
I know what you mean, just want to know if there is any scientific reseach about this.

 

[kiwipilu]

well when someone make a beard transplant..... surgeons take follicles from safe donor area(back of the head).
So this is your answer.. case closed.. ; )

 

[ZenHead]

What will happen if transplant frontal hair to the back or other site?
As we know, the frontal hair are sensitive to DHT, so it's seasy to loose the hair in frontal hairline, and the hair will progressively miniature.
What if we transplant the frontal miniatured hair follicle to the back of the head, or transplant the hair to other site of the body, for example to the leg.
Will the hair follicle continue to shrink, miniature, or not ?
Is there any scientific reseach for this question?
Thank you for sharing your opion on this question.

This is actually a very good question. The answer I am about to give will probably not be widely accepted, but I'll try my best to justify it. The hair in the classic male pattern baldness "zone" is not the only hair "sensitive" to DHT - all scalp hair is sensitive to DHT. The reason why DHT "kills" follicles is due to the chronic inflammation it causes - this inflammation in turn negatively impacts circulation which causes fibrosis / calcification, donwregulates growth factors (chemicals that send signals to the body to repair itself via stem cells) preventing the hair follicle from repairing itself (like a normal healthy organ would) to produce healthy hair. The reason why hair in the "horseshoe" shape remains, is because, quite simply, it is not on the galea - the bare bone with no muscle attached. The hair on the "horseshoe" has a bit more cushion, resting on more muscle below the follicle. Chronic inflammation due to DHT does not affect these follicles as much as the hair on the galea, so these hairs do not experience downregulation of growth factors. Contrary to popular belief, transplanted hairs do eventually miniaturize after decades of DHT inflammation, but at a much slower rate (as you age, you produce less testosterone and therefore less DHT).

Simply put, if you transplant the hair in the male pattern baldness zone to the back of your head, DHT's negative effects will not stop "killing" the follicle. The follicle itself is not programmed to "die off" - The area where the hair is located is responsible for this.

 

[Jamesallenliwei]

This is actually a very good question. The answer I am about to give will probably not be widely accepted, but I'll try my best to justify it. The hair in the classic male pattern baldness "zone" is not the only hair "sensitive" to DHT - all scalp hair is sensitive to DHT. The reason why DHT "kills" follicles is due to the chronic inflammation it causes - this inflammation in turn negatively impacts circulation which causes fibrosis / calcification, donwregulates growth factors (chemicals that send signals to the body to repair itself via stem cells) preventing the hair follicle from repairing itself (like a normal healthy organ would) to produce healthy hair. The reason why hair in the "horseshoe" shape remains, is because, quite simply, it is not on the galea - the bare bone with no muscle attached. The hair on the "horseshoe" has a bit more cushion, resting on more muscle below the follicle. Chronic inflammation due to DHT does not affect these follicles as much as the hair on the galea, so these hairs do not experience downregulation of growth factors. Contrary to popular belief, transplanted hairs do eventually miniaturize after decades of DHT inflammation, but at a much slower rate (as you age, you produce less testosterone and therefore less DHT).

Simply put, if you transplant the hair in the male pattern baldness zone to the back of your head, DHT's negative effects will not stop "killing" the follicle. The follicle itself is not programmed to "die off" - The area where the hair is located is responsible for this.

Yes, this is exactly what I mean, but the theory is not that scientific.
Sometimes the theory is different from the fact, so here scientific research and experiment are very important.
I don't know if there is any scientific literature or experiment on this.

 

[JeanLucBB]

This is actually a very good question. The answer I am about to give will probably not be widely accepted, but I'll try my best to justify it. The hair in the classic male pattern baldness "zone" is not the only hair "sensitive" to DHT - all scalp hair is sensitive to DHT. The reason why DHT "kills" follicles is due to the chronic inflammation it causes - this inflammation in turn negatively impacts circulation which causes fibrosis / calcification, donwregulates growth factors (chemicals that send signals to the body to repair itself via stem cells) preventing the hair follicle from repairing itself (like a normal healthy organ would) to produce healthy hair. The reason why hair in the "horseshoe" shape remains, is because, quite simply, it is not on the galea - the bare bone with no muscle attached. The hair on the "horseshoe" has a bit more cushion, resting on more muscle below the follicle. Chronic inflammation due to DHT does not affect these follicles as much as the hair on the galea, so these hairs do not experience downregulation of growth factors. Contrary to popular belief, transplanted hairs do eventually miniaturize after decades of DHT inflammation, but at a much slower rate (as you age, you produce less testosterone and therefore less DHT).

Simply put, if you transplant the hair in the male pattern baldness zone to the back of your head, DHT's negative effects will not stop "killing" the follicle. The follicle itself is not programmed to "die off" - The area where the hair is located is responsible for this.

The evidence that strongly suggests this theory isn’t based in reality to me (although it is intriguing and open for debate) is that there are men who have had hair plug surgery as far back into the 70s, 80s and 90s, many of these cases can be seen today and their plugs haven’t miniaturized in the recipient. A substantial amount of modern FU transplants that are 15-20 years old in which cases miniturisation isn’t present also. None in which it is present to an extent that would render this theory plausible.

I’ve seen interesting points made on this idea but it clearly doesn’t hold water in full. One could suggest the incredibly difficult to prove “as long as it doesn’t develop in the galeal zone it will be fine” and call it game set match, but I don’t buy it.

 

[InBeforeTheCure]

Yeah, these experiments have been done.

Transplants from hairy occipital scalp to bald frontal scalp stays hairy (that's what a hair transplant does of course). Transplants from bald scalp to hairy occipital scalp stays bald.

Source: Orentreich

If you transplant terminal occipital hair to your arm, it stays terminal. If you transplant miniaturized hair from the bald area to your arm, it stays bald. If you transplant hair from just behind the receding hairline (which will soon be hit), the hair follicles miniaturize at the same time and speed as they would if they were in the original site.

The author transplanted composite skin grafts from balding, non-balding, and bald areas of the scalp, to the skin of the arm. The galea aponeurotica was trimmed away from the grafts. The patient was a 29-yr-old male with progresive male pattern baldness (male pattern baldness). The transplants from the balding area became bald at the same rate as the balding donor site in the receding frontal, hairline, whereas the transplants taken from the non-balding area in the occiput continued to grow the same amount and quality of terminal hairs. Bald grafts taken in front of the receding hairline remained bald. This shows that the cause of male pattern baldness lies in the follicle itself or in its very close surrounding and does not depend on the galea aponeurotica, the increased tension of the scalp or of its muscles, the diminished vascular supply to the scalp or any other regional factor localized to the head area. It also shows that the 'balding clock' keeps time even when the follicle is transplanted to another region of the body.

Source: Nordstrom

And in stumptailed macaques (monkeys that have A.G.A like we do), what happens if you transplant A.G.A-resistant follicles from occipital scalp to frontal scalp and A.G.A-susceptible follicles from frontal scalp to occipital scalp and then give them testosterone? You guessed it. The occipital-to-frontal transplants survive while the frontal-to-occipital transplants quickly miniaturize.

Baldness was induced by long-term injections of testosterone. Baldness in these animals is pre-determined, and only those parts of the scalp that normally become bald are affected by androgen even when transplanted in foreign sites. In vitro studies of the metabolism of testosterone by hair follicles and by the epidermis showed the same regional and age variation. The rate of total metabolism of testosterone was higher in frontal than in occipital areas, and was higher in younger than in adult animals. The ratio of metabolites to unmetabolized testosterone was higher in the frontal area. The amount of 5α-dihydrotestosterone was highest in the frontal scalp of young animals.

Source: Takashima & Montagna

If you transplant miniaturized hairs onto mice though, they can become terminal again, while transplanted terminal human hair follicles shrink a bit.

Human hair follicles were grafted onto 2 strains of immunodeficient mice to compare the regeneration potential of vellus (miniaturized, balding) and terminal (hairy, nonbalding) follicles from males and a female exhibiting pattern baldness. Each mouse had transplants of both types of follicles from a single donor for direct comparison. Grafted follicles from 2 male donors resulted in nonsignificant differences in mean length (52 mm vs 54 mm) and mean diameter (99 μm vs 93 μm) at 22 weeks for hairs originating from balding and hairy scalp, respectively, corresponding to 400% versus 62% of the mean pretransplantation diameters. Follicles from the female donor transplanted to several mice also resulted in nonsignificant differences in length (43 mm vs 37 mm) for hairs from balding and hairy scalp, respectively, during a period of 22 weeks. The mean diameter of the originally vellus hairs increased 3-fold, whereas the terminal hairs plateaued at approximately 50% of pretransplantation diameter, resulting in a final balding hair volume double that of the nonbalding hairs. This report shows that miniaturized hair follicles of pattern alopecia can quickly regenerate once removed from the human scalp and can grow as well as or better than terminal follicles from the same individual. (J Am Acad Dermatol 2003;48:752-9.)

Source: Krajcik et al.