Who has stopped frontal loss?

[HairlossCA]

SO I have tried a variety of combinations to supplement my daily finasteride and Nizoral (twice weekly). I have tried spironolactone 5% once a day for about a year (no results) and so then I tried Revivogen once a day for about a year (no results).

My goal is simply to maintain the frontal area but I continue to steadily lose hair in the frontal area, despite very diligently sticking to my regimen.

Has anyone had success maintaining with folligen or azelaic acid?? Suggestions are welcomed as I am open to try a different topical--although I don't want to use minoxidil at this point...

Thanks for any feedback...

 

[Cornholio]

I was going to say Xanadrox 12.5% which has minoxidil+azelaic acid and is easy to apply to thin areas, but you say you dont want minoxidil... Shame, because I think Xanadrox is showing some fine hair growth (slightly visible) at my temples....

spironolactone %5 makes sense but is not really proven for regrowth as minoxidil is. It wouldnt hurt to continue it as it may add something to finasteride, but that isnt proven. Still, I would trust spironolactone more than azelaic acid if I had a choice (and couldnt use minoxidil).

Nizoral shampoo and tricomin spray may help a little thickening things up a little, and both have been shown to thicken hair shafts.

Folligen, like tricomin, is a copper peptide spray (but doesnt have the clinical study behind it)...

 

[Lizzad]

Folligen and azelaic acid ain't gonna maintain shiat, especially if spironolactone & revivogen didn't help as they were more likely to. Try minoxidil 5%, its given me some decent results up-front...

 

[Dice_Has_Hair]

SO I have tried a variety of combinations to supplement my daily finasteride and Nizoral (twice weekly). I have tried spironolactone 5% once a day for about a year (no results) and so then I tried Revivogen once a day for about a year (no results).

My goal is simply to maintain the frontal area but I continue to steadily lose hair in the frontal area, despite very diligently sticking to my regimen.

Has anyone had success maintaining with folligen or azelaic acid?? Suggestions are welcomed as I am open to try a different topical--although I don't want to use minoxidil at this point...

Thanks for any feedback...

I have had success! If I were you, I would get back on the spironolactone 5% lotion and apply it like anywhere from 2 to 3 times a day to the frontal hairline. Atleast twice a day. The way I would do it would be in the morning before I go to work, then do it again either on lunch break or after work in the afternoon....whatever falls about midday, then do it again before bedtime. I know it sounds excessive, but the frontal hairline/temporal area has always been a very stubborn area to treat, so you really have to stick to it and keep on it.
Why don't you want to use minoxidil? That too could help you keep it, actually help it grow. If you want to use revivogen again, I would still make your spironolactone the number 1 weapon, then look to revivogen as a follow up. You could apply the spironolactone first then let it dry and soak in, then apply the revivogen.
If you would like to use another anti androgen instead of spironolactone, look to fluridil. But with the fluridil, it doesn't like water............apply all water based applications first, let it dry then apply the fluridil. If you put it on when scalp is still wet, it willl degrade. Even after fluridil application.....avoid getting your head wet.
Another anti androgen worth mentioning is topical flutamide. It is a very powerful anti androgen. I would just apply some to frontal hairline, if you decide to use it. Some people are afraid to use it, for fear that it might be systematically absorbed and giving bad sides. Well, from what I have heard from people taking it, they didn't have any sides. So it probably won't systematically absorb, unless you use some potent vehicle to drive it in.......like DMSO. I would not apply anything designed to shove more of it in.....even emu oil. The users also reported that it stopped the hairloss.
Folligen and azelaic acid? I use both,LOL!! I like folligen. It has some growth properties, although I have never used it by itself. I think it really enhances the minoxes growth properties. It is a good anti-inflammatory and may be a good SOD too. I use xandrox 5% and xandrox 15% and they contain azelaic acid. I cannot say for sure if the azelaic acid will work as a 5 alpha-reductase inhibitor or not. I like Dr. Lee's xandrox. I really believe that the xandrox 15% really rocks when it comes to growth. It has really thickened up my hairline( temporal and frontal).
But to answer your question about if folligen or azelaic acid alone to "maintain" your hair ............................I wouldn't hold my breath if I were you. You'll pass out if you do. But they would make a great addition.

 

[explife157]

I think it might have more opportunities to maintain or regrow frontal hair by combing with proven and helpful treatments just as kalika says.
Good luck to you!!!

 

[Lizzad]

Another anti androgen worth mentioning is topical flutamide. It is a very powerful anti androgen. I would just apply some to frontal hairline, if you decide to use it. Some people are afraid to use it, for fear that it might be systematically absorbed and giving bad sides. Well, from what I have heard from people taking it, they didn't have any sides. So it probably won't systematically absorb

Nonsense, it only works due to systematic absorbtion. Read any study on it.

 

[Dice_Has_Hair]

Another anti androgen worth mentioning is topical flutamide. It is a very powerful anti androgen. I would just apply some to frontal hairline, if you decide to use it. Some people are afraid to use it, for fear that it might be systematically absorbed and giving bad sides. Well, from what I have heard from people taking it, they didn't have any sides. So it probably won't systematically absorb

Nonsense, it only works due to systematic absorbtion. Read any study on it.

Okay......give me a link to the study that you read and I'd like to read it.

 

[Lizzad]

Local and systemic reduction by topical finasteride or flutamide of hamster flank organ size and enzyme activity.



Title
Local and systemic reduction by topical finasteride or flutamide of hamster flank organ size and enzyme activity.
Author
Chen C; Puy LA; Simard J; Li X; Singh SM; Labrie F
Address
MRC Group in Molecular Endocrinology, CHUL Research Center, Québec, Canada.
Source
J Invest Dermatol, 105: 5, 1995 Nov, 678-82
Abstract
The hamster flank organ is a widely used model of the control of sebaceous gland activity by androgens and anti-androgens. Finasteride, a 5 alpha-reductase inhibitor, was administered locally on the surface of the right flank organ and right ear twice daily for 4 weeks. The treatment caused similar 12% to 30% reductions in the size of the sebaceous glands in both flank organs. Moreover, relative mRNA levels of the androgen-regulated FAR-17a gene measured by in situ hybridization as well as [3H]-thymidine incorporation and 5 alpha-reductase activity were similarly decreased in the two flank organs after topical application. The pure anti-androgen flutamide, at the same doses, exerted a more potent effect on all the same parameters, and the effect was also comparable on both the treated and untreated sides of flank organs. Finasteride and flutamide significantly decreased ventral and dorsal prostatic weights after topical application. The present data show that the topical administration of finasteride, in analogy with flutamide, causes local inhibition of sebaceous gland growth in both the costovertebral organs and ears. However, as demonstrated by the similar inhibitory effect in the contralateral untreated side and the reduced weight of the dorsal and ventral lobes of the prostate and seminal vesicles, finasteride and flutamide both exert significant systemic effects.

Also, "The Effects of a Nonsteroid Antiandrogen, Flutamide, on Sebaceous Gland Growth", Barry N. Lutsky et al, The Journal of Investigative Dermatology, 64:412-417, 1975. This study also applied widely varying doses of topical flutamide to only one of the flank organs in a group of hamsters, but both flank organs in all the animals were reduced by roughly the same amount at all doses.

 

[Dice_Has_Hair]

Local and systemic reduction by topical finasteride or flutamide of hamster flank organ size and enzyme activity.



Title
Local and systemic reduction by topical finasteride or flutamide of hamster flank organ size and enzyme activity.
Author
Chen C; Puy LA; Simard J; Li X; Singh SM; Labrie F
Address
MRC Group in Molecular Endocrinology, CHUL Research Center, Québec, Canada.
Source
J Invest Dermatol, 105: 5, 1995 Nov, 678-82
Abstract
The hamster flank organ is a widely used model of the control of sebaceous gland activity by androgens and anti-androgens. Finasteride, a 5 alpha-reductase inhibitor, was administered locally on the surface of the right flank organ and right ear twice daily for 4 weeks. The treatment caused similar 12% to 30% reductions in the size of the sebaceous glands in both flank organs. Moreover, relative mRNA levels of the androgen-regulated FAR-17a gene measured by in situ hybridization as well as [3H]-thymidine incorporation and 5 alpha-reductase activity were similarly decreased in the two flank organs after topical application. The pure anti-androgen flutamide, at the same doses, exerted a more potent effect on all the same parameters, and the effect was also comparable on both the treated and untreated sides of flank organs. Finasteride and flutamide significantly decreased ventral and dorsal prostatic weights after topical application. The present data show that the topical administration of finasteride, in analogy with flutamide, causes local inhibition of sebaceous gland growth in both the costovertebral organs and ears. However, as demonstrated by the similar inhibitory effect in the contralateral untreated side and the reduced weight of the dorsal and ventral lobes of the prostate and seminal vesicles, finasteride and flutamide both exert significant systemic effects.

Uh oh!! So basically.......even if flutamide is applied topically, it will be absorbed and allowed to work systematically? Thats scary :freaked: !! Well, I do know you can get flutamide on http://www.lipoxidil.com and they use the liposome technology. Supposedly, with the liposome formula, it is supposed to stay at the skin barrier and is not supposed to go beyond that. What is your opinion on this? What do you think? :?

Also, "The Effects of a Nonsteroid Antiandrogen, Flutamide, on Sebaceous Gland Growth", Barry N. Lutsky et al, The Journal of Investigative Dermatology, 64:412-417, 1975. This study also applied widely varying doses of topical flutamide to only one of the flank organs in a group of hamsters, but both flank organs in all the animals were reduced by roughly the same amount at all doses.

 

[Lizzad]

Flutamide is definately not a good choice of treatment for anyone not wishing to have some feminizing effects. spironolactone, Fluridil, RU are all much better choices. Thing is, some tolerate the sides better and some experience less side effects, but that dosen't mean it's not being systematically absorbed.

Flutamide has been around for a long time and there's a good reason why very few companies offer it as a hairloss treatment. I'm not familiar with liposome technology but i'm very dubious of lipoxidil in general, i hope their products are what they are advertised to be. :wink:

 

[Dice_Has_Hair]

Flutamide is definately not a good choice of treatment for anyone not wishing to have some feminizing effects. spironolactone, Fluridil, RU are all much better choices. Thing is, some tolerate the sides better and some experience less side effects, but that dosen't mean it's not being systematically absorbed.

Flutamide has been around for a long time and there's a good reason why very few companies offer it as a hairloss treatment. I'm not familiar with liposome technology but i'm very dubious of lipoxidil in general, i hope their products are what they are advertised to be. :wink:

I do agree with you on the lipoxidil thing. It is kinda skeptical. But the people that use their products are happy with them. Ya know, the only thing that really makes one think twice is the fact that they sell those "experimental" hairloss products. Kinda weird,LOL!!! And some of the formulas that they come up with look like they just throw a bunch of sh*t together and hope that it works. Makes one think, but if people buy from them and are happy, then I guess the company atleast has some potential. Wouldn't hurt to try, if you have the spare cash I suppose.

 

[iamnaked]

I've had what I reckon are good results with the stuff I'm using, but It's such a rollercoaster man - some days I'm up, some days I'm down. The cosmetic effects of the stuff I use really confuse me sometimes. Overall, I think it's definitely had a positive effect though. Be diligent in your regimen though - if only for the placebo effect

 

[HairlossCA]

Hey guys--muchos gracias for all of your responses!

Kalika: You have had success with spironolactone, huh--have you maintained your hairline and temples? I was only applying once a day but it really seemed like I lost hair FASTER with that stuff! That stuff makes my hair so greasy that it would be hard to apply at work...Maybe I will try Xandrox, but the fear is that if I stop using it the crash and burn will be substantial...

I gotta do something to slow this shiite down--the back is maintaining nicely (finasteride) but the front is slowly going, going--

 

[Dice_Has_Hair]

Hey guys--muchos gracias for all of your responses!

Kalika: You have had success with spironolactone, huh--have you maintained your hairline and temples? I was only applying once a day but it really seemed like I lost hair FASTER with that stuff! That stuff makes my hair so greasy that it would be hard to apply at work...Maybe I will try Xandrox, but the fear is that if I stop using it the crash and burn will be substantial...

I gotta do something to slow this shiite down--the back is maintaining nicely (finasteride) but the front is slowly going, going--

Yes, I have had great success. I have held onto what I have and regrew some too. If you don't think the spironolactone 5% lotion will due to its greasiness, you should try the 2% spironolactone solution. It is nongreasy and dries quickly. I would apply the spironolactone 2% morning and midday and then apply the 5% spironolactone lotion at night before bed. I would also recommend using the xandrox 15% too, if you would. Try that on the hairline. Apply the xandrox 15% first at night, then after it dries thoroughly, apply the spironolactone 5% lotion. Try that.