Wholllly Shiaat This Gyno On Bicalutamide, Help!!!

[justbeconfident]

Minor shed at 3rd week. Went on for about a week. Since then nothing special. Its been I guess 4 months, my hair still looks/feels the same as before, no regrowth. Only positive outcome is I shed much much less from the top (where I put minoxidil) compared to the back. (I have zero hair loss on the back though)
No side effects at all.

how do u apply minoxidil to scalp? in my experience its very hard to get any product to get to your skin through mid or longer length hair, it just gets stuck in the hair, makes it greasy and very little gets to actual skin
Do you have any specific technique how you apply it? What brand you are using now? Foam/liquid? It doesnt get on your face after you sleep and your hair touches pillow where you face lies?
Sorry for too many questions. Im planning to give a minoxidil a sh*t, since finasteride didnt work for me, so trying to understand how to approach it

 

[baba_yaga]

how do u apply minoxidil to scalp? in my experience its very hard to get any product to get to your skin through mid or longer length hair, it just gets stuck in the hair, makes it greasy and very little gets to actual skin
Do you have any specific technique how you apply it? What brand you are using now? Foam/liquid? It doesnt get on your face after you sleep and your hair touches pillow where you face lies?
Sorry for too many questions. Im planning to give a minoxidil a sh*t, since finasteride didnt work for me, so trying to understand how to approach it

I have long hair. I part my hair and put minoxidil in the exposed skin. I part my head several times, and each part is a little away from the preceding one. This way my whole head is covered.
Yes my hair gets greasy while rubbing minoxidil a little bit. I use liquid minoxidil, named Alopexy. No it does not get on my pillow, I put it 10 minutes before bed. It dries in an hour.

How did finasteride not work? What was your experience with it?

 

[Jacob Williams]

Do you think raloxifene at 60mg has hindered your regrowth at all? I ended up buying an 80 day supply of raloxifene even though I said I was just gonna let my boobs grow then get surgery. I’m still anxiously waiting for my drugs to arrive, do you think it would be better to stagger when I start taking each? I’ve heard antiandrogens take time to take effect, I wouldn’t want raloxifene to go ham on my hairline before bicalutamide has a chance to catchup.

UPDATE: decided to reduce my raloxifene dose back down to 60mg from 90mg.

If you do research on raloxifene, tamoxifen. They are basically bicalutamide but for estrogen.

Raloxifene/tamoxifen bind to the estrogen receptor in the same ligand binding site as estradiol, but causes the estrogen receptor to fold in such a way that prevents coactivators from forming a complex with the estrogen receptor. And as a result, estrogen-responsive genes that depend on the presence of the coactivator are not expressed. Additionally, raloxifene promotes the recruitment of corepressors to the ER.

This only happens on tissues that rely on ERα expression such as hair follicles and breast tissue.

So mathematically speaking, Raloxifene/Tamoxifen definitely have a negative impact on hair. BUT this is dependent on the dose of the drug. AND even a low dose of the drug can CAUSE damage to hair follicles since low doses can cause upregulation of HPG-axis via increases in testosterone

To confirm this I bring up PSA again.

"Raloxifene significantly increased serum concentrations of LH and FSH (by 29% and 21%), total testosterone (20%), free testosterone (16%) and bioavailable testosterone (not bound to sex hormone-binding globulin (SHBG; 20%). In parallel with testosterone, 17 beta-oestradiol also increased by 21%. SHBG increased by 7%. ... Total PSA increased by 17% without significant changes in free PSA or free/total PSA ratio."

Tamoxifen increases PSA by around 50% though so its a lot worse for hair follicles.

This is similar to the increase in total testosterone from Raloxifene (20%) and Tamoxifen (50%) (increase in testosterone is regardless of dose)

CONCLUSION: I will stay on the 60mg dose until I get my PSA and testosterone level tested to see where my hormonal profile lies in late September, thank you all.

,

 

[DHTcel]

Do you think raloxifene at 60mg has hindered your regrowth at all? I ended up buying an 80 day supply of raloxifene even though I said I was just gonna let my boobs grow then get surgery. I’m still anxiously waiting for my drugs to arrive, do you think it would be better to stagger when I start taking each? I’ve heard antiandrogens take time to take effect, I wouldn’t want raloxifene to go ham on my hairline before bicalutamide has a chance to catchup.



,

I dont think 60mg will hurt your hairline. in studies the 60mg raloxifine dose = 20mg tamoxifen didn't reduce effectiveness of bicalutamide

so im gonna stay on 60mg from now on

but I do think that higher than 60mg can really damage hair. at least in my experience

 

[DHTcel]

I have long hair. I part my hair and put minoxidil in the exposed skin. I part my head several times, and each part is a little away from the preceding one. This way my whole head is covered.
Yes my hair gets greasy while rubbing minoxidil a little bit. I use liquid minoxidil, named Alopexy. No it does not get on my pillow, I put it 10 minutes before bed. It dries in an hour.

How did finasteride not work? What was your experience with it?

Finasteride only reduces PSA by around 25%, its the weakest antiandrogen

 

[baba_yaga]

Finasteride only reduces PSA by around 25%, its the weakest antiandrogen

Banned again? For what?

 

[BRezende]

dropped raloxifene today guys, so rn I'm only on 150mg bicalutamide and 0.5mg dutasteride

decided that raloxifene isn't gonna prevent my gyno and its only hurting my hair by preventing the negative feedback estrogens give on my HPG-axis

ill get the gyno surgery later anyways

How bad that gyno can be? The problems isnt just aesthetics, pain in nipples isnt a nice thing :/

 

[AndrewBarnes]

Lol what did you expect kid. I remember you writing that you don't care about sides if you can keep your hair. So I recommend you to start research on bras.

lmfao

 

[coco_304]

If duta doesnt work, this indicates T is the problem. Bica is relatively safe, unless you really fear gyno (which can be reduced/removed). If bica doesnt work for you (nearly impossible), then you can give up.

Hi,
Can u explain this?

 

[AndrewBarnes]

Can't people that are on oral spironolactone or oral CPA just take test to maintain their test levels and also retain the androgen blocking effects of the AA drug?

 

[baba_yaga]

Hi,
Can u explain this?

Duta stops DHT almost completely, and around ~50-70% in scalp tissue. It is the best you can do to remove DHT. If you still have hairloss on duta, it means that the remaining DHT, as well as T, are still doing the damage. T is an androgen afterall.

and a quick note, bica apparently would make you sterile as it reduces the amount of semen by a lot, and you cant come off it as it doubles androgens levels. So, for who ever reads my earlier posts, proceed with caution and do your research.

 

[coco_304]

Duta stops DHT almost completely, and around ~50-70% in scalp tissue. It is the best you can do to remove DHT. If you still have hairloss on duta, it means that the remaining DHT, as well as T, are still doing the damage. T is an androgen afterall.

and a quick note, bica apparently would make you sterile as it reduces the amount of semen by a lot, and you cant come off it as it doubles androgens levels. So, for who ever reads my earlier posts, proceed with caution and do your research.

So if duta or bica, we have to do something with the remaining dht/t..?

 

[baba_yaga]

So if duta or bica, we have to do something with the remaining dht/t..?

If you are still experiencing hair loss on duta, then the remaining T and DHT are still doing the damage. If you're willing to sacrifice, this damage process can be stopped by using bica or E.