Why Does Topical Spironolactone Not Affect Serum Hormone Levels..

[Hairlinetesticles]

But topical testosterone gel gets absorbed systemically? Is the dosing the reason or is there another mechanism between testosterone gel and topical spironolactone cream?

 

[Zoro]

Different vehicles since testosterone gel is made to go systemic, testosterone has a lower molecular weight which might help it absorb easier, spironolactone is a relatively weak antiandrogen so you need high doses of it for antiandrogenic effects, etc

 

[Beatle Gregor]

Spironelectone blocks the androgene receptors, lessoning the effects of androgens including testosterone. As far as I know it does get absorbed systemically thought, but I might be wrong.

 

[arnoldd]

Different vehicles since testosterone gel is made to go systemic, testosterone has a lower molecular weight which might help it absorb easier, spironolactone is a relatively weak antiandrogen so you need high doses of it for antiandrogenic effects, etc

Exactly. You need 150/200mg of spironolactone for the best antiandrogen effects. If you apply topical what goes systemic is insignificant