Why Is It That Finasteride Just Maintains Most Of The Time But Dutasteride Causes Regrowth/thinken
- Thread starter coalfire
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You mean more testosterone, i understand in some men, they get man boobs and low libido but in most they get increasted libido and slighty stronger.
i thought estrogen would rise in those who have too much testosterone when taking a dht inhibitor, but for those with low to moderate amounts of testosterone to begin with, i thought they'd gain testosterone.
nate30
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The body tries to preserve the normal T/E ratio so a rise in testosterone also means a rise in Estrogen. Finasteride users typically experience a 15% rise in Total T due to 5ar not converting it to DHT, but some men experience a drop in Free T in the long term, which is the more important measure. This coupled with the fact that DHT inhibits the effects of Estrogen on certain tissues makes gyno and Estrogen dominance a possibility.
Finasteride isn't going to make you more manly. Just the opposite.
Finasteride isn't going to make you more manly. Just the opposite.
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It doesn't have much to do with how much testosterone you have, just with the fact that by inhibiting 5-AR, there is more testosterone available to be converted by the other enzymes, and aromatase is the next one in line.
I am not sure why everyone is saying estrogen is causing the regrowth. Dutasteride inhibits more type 2 5ar. Type 2 5ar is highly involved in hair loss, so removing more of it results in greater effectiveness. If I remember correctly dutasteride is 3 times as potent at inhibiting type 2 5ar. This doesn't mean it is 3 times more effective than finasteride by any means. I am not sure where you heard that dutasteride causes a lot of regrowth while finasteride doesn't. The efficacy difference between the two drugs is minimal for most people. Some people actual claim to have better results on finasteride than dutasteride. Looking at anecdotal reports is useless though. Look at the studies, they show dutasteride is slightly more effective than finasteride at keeping/regrowing hair.
nate30
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I don't believe the 5ar2 enzyme itself is directly responsible for hair loss, but one of its metabolites, DHT, is. It is the serum DHT level (95% reduction for Duta vs 70% for Fina) that is relevant. I agree that Duta doesn't have a reputation for causing substantially more regrowth than Finasteride.
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wrong as hell , i have low DHT now thanks to finasteride. I got rewarded with great regrowth that was followed hitting baseline in a month , Did blood test and found out that my estradiol almost doubled. I even got gyno. i have had Telogen Effluvium effect overall my scalp for last 4 month. And i think its due to the hormonal imbalance.
Dutasteride lowers the same exact enzyme finasteride does almost 100 percent. finasteride is only like 70 so that probably accounts for the biggest difference why dutasteride works so much better. Although I wouldnt rule out the estrogen spike as some kind of contributing factor.
Its such a shame dutasteride and finasteride have such sides. I mean they work so well its a shame we all cant try dutasteride because it would prevent male pattern baldness for most people.
Its such a shame dutasteride and finasteride have such sides. I mean they work so well its a shame we all cant try dutasteride because it would prevent male pattern baldness for most people.