Why is Nizerol such a big deal?

[LooseItAll]

I added nizoral to my regimen because of the scalp irritation spironolactone and minoxidil have been giving me for some time. I had to stop my regimen for about a month. Now I am on it + nizoral for a month again and I really had a massive shed. My scalp feels great after applying nizoral.

My regimen:
spironolactone 2% x2 day
nizoral 2% x2 day
minoxidil 5% x1 day

 

[Ende]

Enden can you tell me why you wouldn't use it?

It's medication, it has a tendency to dry out both scalp and hair, and it doesn't really take care of the problem. RU58841 does that, alone.

What is RU58841? Can you buy it anywhere?

It's a potent, topical anti-androgen without systemic side effects when used at the correct dose. It's possible to get severe side effects from it, but I'm currently using a 2.5% solution - 50 mg a day without any problems. It's only available as a research chemical.

 

[grove12345]

i actually believe harmful or harsh shampoos like nizoral or anything with SLS can mess up pH balance in your scalp. Produces more sebum

I used baby shampoos only once a week, at first greasy and lots of shedding. But after about 2 weeks, once a week was enough. My hair was no longer greasy and shedding dropped by ALOTTTT. Plus the texture was softer and thicker.

Start shampooing 2-4 times a week or use nizoral and everything goes straight to hell. I have to shampoo constantly to avoid sheddings and greasy scalp.

Problem is going the 2 weeks of shedding. I used to shave my head for about 2 weeks with a razor. Rinse with alchohol and apply vit E. And then it came back it was thick and my scalp was healthy. I dont expect this to work for everyone. Some people who have hairloss have thick healthy hair.
Me i dont. Its either dry, or too thin, or greasy. So....

 

[Kev123]

The only reason i'm not using Nizoral is because I can't find it any where.

Amazon has some for 4oz but too expensive for so little.

 

[rwGourmetStyleWellness]

you missed this study.
Ketocazole as an adjunct to finasteride in the treatment of androgenetic alopecia in men.
Hugo Perez BS.
Source
California College of Podiatric Medicine, 371 Columbus Avenue, San Francisco, CA 94133, USA. Hugo2002@yahoo.com
Abstract
Dihydrotestosterone (DHT) binding to androgen receptors (AR) in hair follicles is commonly accepted as the first step leading to the miniaturizing of follicles associated with androgenetic alopecia (Androgenetic Alopecia). Testosterone is converted to DHT by the enzyme 5alpha-reductase. Finasateride a 5alpha-reducase inhibitor blocks the production of DHT and is currently used to treat Androgenetic Alopecia. The inhibition is not complete but a reduction of DHT systemically and in the scalp is accomplished. Ketoconazole has been clinically shown to be effective in the treatment of Androgenetic Alopecia. In this paper, evidence is presented to support the hypothesis that ketoconazole 2% shampoo has a local disruption of the DHT pathway. It is proposed that using ketoconazole 2% shampoo as an adjunct to finasteride treatment could lead to a more complete inhibition of DHT and thus better treat Androgenetic Alopecia.

Naw I didn't miss it.

I just got lazy.

lol and broke.

 

[rwGourmetStyleWellness]

What is RU58841? Can you buy it anywhere?

It's a potent, topical anti-androgen without systemic side effects when used at the correct dose. It's possible to get severe side effects from it, but I'm currently using a 2.5% solution - 50 mg a day without any problems. It's only available as a research chemical.

So RU58841 isn't avail for commercial distribution and customer use?

Is it oil, cream or alcohol based? I hope not the later because thus the reason why I cant use rogaine its to drying.

I'm in the US. Would love to get my hands on this RU58841 if it works that good.

I hate having to wash my naturally dry hair and scalp every 3 days.

 

[abcdefg]

Nizoral is highly overrated in my opinion. I doubt anyone with male pattern baldness has regrown or prevented significant hair loss on that alone. I quit using it because it just made my head itch worse and made my dandruff worse. Maybe I will start using once in a while again, but all its validity comes from a study on its active ingredient in some small study where it helped with hair growth. I would need 8 hands to count all the products herbs and lotions that have a small study backing up the claim they grow hair.
In my opinion there is the big 2 propecia and rogaine. Anything else is unproven, experimental, and very likely a waste of your time and money like everyone says.
I would love an RU or ascj 9 or some other powerful topical that I could actually afford to use without worrying about safety or cost then I will be a happy man. It looks like its going to be a very long wait before its FDA approved and at the local store.

 

[rwGourmetStyleWellness]

Nizoral is highly overrated in my opinion. I doubt anyone with male pattern baldness has regrown or prevented significant hair loss on that alone...

i think its based on what you have (i have androg al) and how badly your regimin depends on it (I ONLY take spironolactone 25mg so when I don't do nizoral i shed like a cheap wig. When i took 100mg spironolactone i didn't have to have nizoral).

 

[WillNotLetItHappen]

My regimen:
spironolactone 2% x2 day
nizoral 2% x2 day
minoxidil 5% x1 day

Sorry but what? nizoral 2 times daily?

 

[sapinho]

I think it's biggest impact is at the start of tackling your hairloss problem, where some men have a red itchy scalp due to DHT sensitivity. I remember one guy on the forum who said he put Nizoral in his hair for 1/2 hour on the first day.

I've associated such redness with massive shedding. If I have a dry, normal scalp, my problems seem to be at bay. It's up to you to decide if you should use it based on whether your hair is oily or itching.

Some people claim it has anti-androgen properties (as opposed to anti-fungal only), but not sure if that's backed up.

 

[Primo]

It does have anti androgen properities you silly goose! Read the contents of the study posted above on this thread.

It's not finasteride, but it is still a mild anti-androgen and will make a difference as many studies show.

People don't like it because they don't know how to use it properly. They shampoo with it every day or every second day and then wonder why their scalp gets itchy :shakehead:

The instructions clearly state not to use it more than once a fortnight after successive applications or these sides can occur, so really twice a week is more than enough! I use it once every 4days.

 

[sapinho]

I did read the contents, one seems to support your opinion, but the stress is as an adjunct to finasteride:

In this paper, evidence is presented to support the hypothesis that ketoconazole 2% shampoo has a local disruption of the DHT pathway. It is proposed that using ketoconazole 2% shampoo as an adjunct to finasteride treatment could lead to a more complete inhibition of DHT and thus better treat Androgenetic Alopecia.

But then the other quoted study says:

Although the therapeutic mechanism of topical KCZ for hair growth is unclear, our results suggest that topical applications of the substance are useful for treating seborrheic dermatitis accompanied by hair regression or male pattern hair loss.

Whatever, let's just suppose it is, it stops hair loss is what matters when used per you additional advice.

 

[TheGrayMan2001]

It's not finasteride, but it is still a mild anti-androgen and will make a difference as many studies show.

there are not very many ketacozanal studies that showed anything other than minor improvement over placebo. It really doesn't make much of a difference, if at all.

 

[Primo]

What about that Korean study, where hair treated with Keto regrew at the same rate as 2% Minoxidil?

It may not be a dramatic improvement, but given the low price and the positive effect it has on the scalp, it's still a very worthy addition to the regimen.

 

[TheGrayMan2001]

What about that Korean study, where hair treated with Keto regrew at the same rate as 2% Minoxidil?

It may not be a dramatic improvement, but given the low price and the positive effect it has on the scalp, it's still a very worthy addition to the regimen.

I haven't seen that one. What was the keto doseage and how was it applied? The only study I've seen with Nizoral amounts was a French study that pretty much made it seem like a worthless effort to even use it.

 

[Primo]

This one...

http://www.gourmetstylewellness.com/hair-loss-p ... -study.pdf