Italian Hair Loss Lotion To Hit The Market In 2016

[BootyWarrior]

Mind you it hasn't done much in terms of regrowth for me, more just maintaining. Not using finasteride atm.

You are one of my favourite posters in this thread. Always with your positive and helpful attitude. I truly hope this lotion works and you get the most benefit out of it my young friend

 

[SteveTabernack]

Page 840 was the turning point of this thread. We're def gonna reach 900 before the presentation

This thread has had more turning points than Game of Thrones man

 

[17AndBalding]

You are one of my favourite posters in this thread. Always with your positive and helpful attitude. I truly hope this lotion works and you get the most benefit out of it my young friend

This made me smile, not gonna lie. I'm trying to make the best out of a pretty bad situation, and I try to make my activity on this thread useful, trying to keep up morale and share what I know. Of course, there has been moments where I used the forum as a way to blow off steam or to go full "oh woe is me", but I try to keep that at a minimum because it's not going to help anybody. I hope for us all that this lotion can help us out: For the recent receders I hope full recovery, the diffuse thinners better coverage and for the veterans at least a bridge for better treatments. We will make it boys and girls, this will be the start of a hair loss revolution, and I bet you we will be having some glorious locks going into the 2020s!

/end speech

 

[Bigbone]

Yeah I don’t know if the liposomes are there for a better delivery or to make a «surface» so it doesn’t get in the blood..

Hasson & Wongs topical finasteride has liposomes though, and there are still people who get sides. Let’s hope Brotzu knows more about this subject than H&W.

That's for penetration purposes I believe. Also the reason why I think the Morr F 5% won't work and those who experience results get it from min.

Regarding the lotion, if it works, do you guys think it would be able to bind to body hair follicles as well? If that's the case and it's able to reduce/slow body hair growth there's a huge market for that too.

 

[Toby0823]

What do you guys expect to learn from the presentation? I mean, this Italian hair lotion announcement is roughly 3yrs old now. Will you still give this much hope on this if you don’t get a definitive release date and/or actual proof of it working on people?

 

[TK421]

This made me smile, not gonna lie. I'm trying to make the best out of a pretty bad situation, and I try to make my activity on this thread useful, trying to keep up morale and share what I know. Of course, there has been moments where I used the forum as a way to blow off steam or to go full "oh woe is me", but I try to keep that at a minimum because it's not going to help anybody. I hope for us all that this lotion can help us out: For the recent receders I hope full recovery, the diffuse thinners better coverage and for the veterans at least a bridge for better treatments. We will make it boys and girls, this will be the start of a hair loss revolution, and I bet you we will be having some glorious locks going into the 2020s!

/end speech

 

[cuprous]

How are we going to know what's said at the conference on Sat? Is someone from here attending? Are the results going to be published?

 

[Francky85]

How are we going to know what's said at the conference on Sat? Is someone from here attending? Are the results going to be published?

Yes to both and Beps is going to post the power point presentation on here.

 

[Jnix]

This thread has had more turning points than Game of Thrones man

I read the books and went through all of that sh*t in the early 2000's.

 

[Goodsend]

If it works they have to release it immediately after the conference, f*** at october....what the hell

 

[Jimm]

The endless cycles of shedding are even more endless without min..

Not according to the lot that claim their hair the worse for minoxidil use. They’re quite frequent to come by. Much more so than people who have good things to say.

 

[The 7TH Sense]

How are we going to know what's said at the conference on Sat? Is someone from here attending? Are the results going to be published?

I have some friends on the forums who will attend SITRI and they will try to record the presentation. Is a bummer that they aren't officially allowed to do that though, so I'm not sure if I'll get anything fully understandable. Anyways, if they'll succeed, I'll do a translation of the entire presentation like I did with 2016's SITRI.

Oh yeah, many of you could have missed it, so here is the post, if you want to kill the time in the waiting for saturday, I suggest to play the video on your PC and the translation in your phone so you'll understand practically everything he said:

Today I had the time to translate the second essay of Brotzu at SITRI, the actual source is this video:

I got the idea this morning, reading the thread of @That Guy that was missing the SITRI parts.


So:


- " A lot of works published recently brought a lot to the hairloss matter. Many things are said in a lot of researches, but nobody says PRECISELY what is the MAIN and the LAST factor that causes all types of Alopecia. I said "all types", not a particular one. "

( Comments the slide "Factors that act on the microcirculation )

- " There was this research, conducted in 2008, which says that fundamentally many problems were found on the level of microcirculation of the hair bulbs. It talks about ICAM and ELAM, two molecules that may block microcirculation at all levels. When we debate with biomedical engineers who always pretend to find formulas regarding the circulation's parameters - I remember once when a bunch of them came to held a lesson regarding the mathematical aspects of the problems of the blood stream in the vessel, I let him finish, and then I asked him: 'and ELAM? And ICAM? What do they do in this?', and he answered: 'What are those?'. Well, he didn't know, but they are one of the factors that may completely shift all of those parameters. "

( Positively Charged (...) slide is now presented )

- "Well, we thought the molecules that we wanted to use { refers to his first speak in that morning } could have been incapsulated in liposomes positively charged. On this, a research exists, that I have reported here, and that says if we put a generic molecule into a liposome, on the order of 100nm, 100NM, and if we positively charge it, that attaches to the skin and carries beyond the substances. Our researches were made using radioactive compounds, so they were totally re-trackable after penetrating the skin, revealing their attachment and adhesion. "

( Slide PROMOTING EFFECT (...) comes up )

- " So, let's now see what we developed. Our first researches were carried using PGE1, which has the effect to stimulate endothelial cells, in particular their reproduction, bettering the local microcirculation. Is normally a molecule used in vascular surgeries. It just has a flaw, terrible: if I inject it intra-vena, when it reaches the polmones, the 80% of it gets metabolized and so lost. In our first experiments on ulceras, we directly injected PGE1 in-arteria, and in the follow-up of the patients we noticed that, if PGE1 survived, was able to dilate the vessel and the case went good, if PGE1 wasn't able to do that and got lost, the case went bad. "

( Shifts slide to the scheme )

- "Fast forward to the next experimentations, at that time we had a situation. First thing is, we had a product that was a drug. Being a drug, for its release, it would have had to pass phase 1, phase 2 and phase 3 experimentations. That means that we could have talked here only in 5-6 years from now on, if not more, with a pharmaceutical company that must have spent 20-30 millions of Euro. So we asked ourselves: 'from where does PGE1 originate from?'. It forms itself into our bodies, through the action of a bunch of enzymes, starting from well known fatty acids. The fact is we produce too low of it to be beneficial for the matter. In particular, if we take Linoleic Acid, that normally has 16 Carboniums { noise in the audio } (...) and if we take DGLA, with a simple cyclooxigenasis it can become PGE1. So if we tried to put DGLA into the liposomes - oh, and, note that the experimentation on PGE1 into those was made by myself something like 6 years ago - we noticed that this system worked well. And the thing became bigger because a person put the remedy on his head and reported that his hairs were not falling anymore: this story became more and more famous and the entire Policlinico was literally obsessed with it. We prepared a topical remedy of it in our labs for a small bunch of people when we were preparing other products, but we didn't care much of this story because we knew for the reasons exposed before that PGE1 was practically unusable. Then we thought of using DGLA, which figures in good quantities in mais oil, it is a molecule that is not considered as a drug. Then we treated with that more and more patients - oh, and logically, all of these things, before being tested on humans, were tested on rats. I'm convinced that the quantities needed were very small - note that when we injected PGE1 intra-vena on diabethic patients, when carried into cathionic liposomes, only 1/7 of the canonical dose was needed. We were on the order of nanos, quantities used were extremely low compared to canonical doses. So, I was saying, we then used DGLA, carrying it into cathionic liposomes, and we used it to treat various people afflicted by all types of Alopecia. (...) "

( Shows "Quando La Lozione funziona!" )

- " (...) and after our experimentations, we gathered all kind of observations. First, alive follicles are needed for the hairs to grow; if follicles are dead we could apply even high doses, but only road in this case remains hair transplant, as your colleague presented before. Response of patients may vary: maximum efficacy is when patients are younger than 25 - this comes from the fact that we initially used the remedy on people affected by Androgenetic Alopecia, not on children affected by areata. We observed that in people over 30 years, the response was more variable to the time passed since the hair loss occurred. Focusing now on Alopecia Areata, if there are small problems, the response is always rapid and immediate. We treated a bunch of children and they responded after just 3 or 4 months. "

( now it's 9:48 of the video, changes slide to some tables )

- " So I carried an experimentation for a pharmaceutical company, so these are the results, comprehensive of pull test, videodermoscopy and trichogram, and we registered also the grade of satisfaction of the patients treated. A main problem was reported: the lotions needs to be stored into the fridge. Once the bottle is opened and the treatment begins, the liquid may decay and becomes unusable. "

( We are at 10:26, shows the first pic of the child )

- " This is the first child treated. I am a surgeon, when they brought her to me I didn't even want to treat her, I admit. But..."

( Shows next slide )

- " After 4 months..."

(Shows the rest of slides and the photos in range of 2 months each)

( Then, at 11:03 )

- " This is another child, brought to us in May, in this condition, I absolutely did not know how he would have reacted to the treatment. He was from PerdasDeFogu, historical city of Sardinia created near coal mines, and { shifts slide } this is how he is now. "

( Changes slide, 11:32, to show another patient )

- " This is a 20 years old woman, { changes } how was after 4 months, { changes } how she is now { changes }. She went the other day, on Friday, for the final checkup, now this woman does no more use a wig, and she got her hairs long approximately 5 centimetres. "

( 12:01, changes again to show another )

- " And this is a 40 years old woman, after having a kid she caught this Androgenetic Totalis syndrome. [Corrects himself] Oh, Areata, sorry, lapsus. { changes slide } This was her skin zoomed on the microscope, there was absolutely nothing. Since I am not an expert, videodermoscopy was conducted by dermatologists - when I was analyzing the first patients using the dermoscope I didn't even know what were they doing, then they even teached it to me. { changes slide } So, after 4 months, { changes } her situation changed. { changes again } How she is now, { changes } and how the situation evolved. { changes again but made a mistake and goes back } so this is how some of our patients evolved to give you a concrete example. After this congress to which I was invited, I didn't absolutely know such things you all presented because it is not my field and it didn't interested me before my discoveries, { points to a colleague, joking } when I listened to your exposition, those things regarding the brain and the scalp were the only that I knew, because I'm a close friend of a brain surgeon and he taught me them - Oh, and also, the practical exams. "

( 13:54 , goes back to the slides and shifts to the overview )

- " These are the results, see, overall it was an excellent experimentation. Just 2 patients were not satisfied, but since they were not from Sardinia but instead from Sicily, we firmly believe that the remedy got deteriorated due to the high temperatures - it was middle summer - and to the travel by plane. As you can see we have always positive results, I insist on the first child because she didn't have a single hair and regrew all of them. This product as I said was first tested on Androgenetic Alopecia, then in a particular case of post menopausal women afflicted by Androgenetic Alopecia and for that one was published an arcticle on the paper Il Dermatologo, that I didn't even know since I didn't publish on dermalogy papers, the last year on the first number. So, these are the results and there is nothing left to say for me, thank you all. "

( Applauded, Dr. Marliani comes back at 15:22 to moderate the public, people start askingnhim questions but the microphone was already shut down, a woman shouts for the mic, but the problem persists, diffcult to hear what the doctor says next, but I understood some)

- " (...) The only thing I know aside, is that a company is currently trialing the lotion on Androgenetic Alopecia in Milan, but I don't know much more."

( The woman then asks for the product's name)

- " It does not have a name, it will have it, after the commercial release for sure { unheareable speech } (...) - Oh, and a thing I did not mention: we added Equol to the formulation, which blocks the 5 alpha reductase, and so limiting the % of usable DHT circulating. The two molecules together, DGLA and Equol, work way better. We tested with only PGE1, then only DGLA, then we combined the products and put them into cathionic liposomes, so into them there is DGLA and Equol in the final formulation in the quantities of { couldn't understand } (...) , we used very small quantities. There is no effect of inflammation, no effect of inhibition on the functioning of any other organ, we did not experience any side effect at all in all of our experiments. Thank you for the attention. "

Sorry for grammar errors.

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I wonder if DGLA could cause similar side effects as minoxidil, which for some reason I really noticed. Hope it stays completely local. I’m not sure that liposomal delivery really keeps topicals from getting into the blood stream. I don’t know sh*t though

Again... Brotzu himself told to me in the second Bellicapelli interview that DGLA is "just" a fatty acid and 100% natural. Even at 10x or more the doses used in the lotion, there's no any side effect known.

Also, they would never be allowed to use the lotion on 5 year old kids if there was even remotely the possibility it could cause sides.

Beps actually responded to someones question on here a couple weeks back and said liposomes are for penetration purposes. Not to say without it wont work though because Wuwui had really good results and I'm not sure if he used liposomes - although he was a Dr so might have a better idea on preparation.

WuWei used a lotion of S-Equol incapsulated in liposomes.
While Brotzu said that DGLA and Equol couldn't penetrate the skin by themselves, he didn't motivate this claim; however he always said that those compounds are needed in the nearest area of the hair bulb, and there was no possibility to reach the bulb without incapsulating in liposomes.

 

[Dat5Years]

You are one of my favourite posters in this thread. Always with your positive and helpful attitude. I truly hope this lotion works and you get the most benefit out of it my young friend

Yeah I'm rooting for 17 big time man. Really hope this sh*t works for him. Sound guy and in a sh*t situation.

 

[NW2.5372846]

Yeah I'm rooting for 17 big time man. Really hope this sh*t works for him. Sound guy and in a sh*t situation.

100% agree.. a 17 year old kid shouldn't have to be subjected to being on a forum like this at his age. It truly hurts me seeing it... especially since at 17, I didn't even know what balding was and sure as hell didn't ever think that I'd ever compulsively check out forums on it. This condition is so sh*t, and its not being taken seriously, and people underestimate the mental implications it causes (yes it's not life-threatening, but it sure doesn't help a person's mental health...) It's really one of the very few things that you have no control over, and changes your life. If the majority of women were hit with androgenic alopecia instead of men, we'd be living in a completely different world in terms of hair loss... that's just a fact

 

[17AndBalding]

In the meantime I'm almost 19 now, so that in itself is pretty sad been on these forums for over a year haha. But thanks for the kind comments everyone, I wish you all the best!

 

[Jimm]

Guys, I would like some sympathy here too. I'm 23 and--let me assure you--a standup guy. I know I'm not a teenager anymore, so I have that counted against me, but I would still really appreciate your support. If anyone is interested in helping support me I will send links to a Patreon that I will setup.

 

[alebaba]

In the meantime I'm almost 19 now, so that in itself is pretty sad been on these forums for over a year haha. But thanks for the kind comments everyone, I wish you all the best!

Bruh, just go enjoy life, your hair loss is probably not even that noticeable at your age. Come back later when there's a cure.

 

[DVXYZ]

In the meantime I'm almost 19 now, so that in itself is pretty sad been on these forums for over a year haha. But thanks for the kind comments everyone, I wish you all the best!

Keep your chin up buddy, I know it sucks but both Brotzu lotion and Shiseido have a strong possibility of coming out this year. So although you are young this could very well be the last year you ever have to worry about this and you'll be a much stronger person for going through it. That's a beautiful feeling, again assuming both of this products work as advertised. I joined this forum about a year ago as well. I'm 22 at the moment, my birthday is in October so if this lotion works and releases in October then it'll be the greatest birthday gift I could have ever asked for!

 

[Bitless]

Why can’t i check Jumanji’s post what happened to this thread

 

[Ollie]

Why can’t i check Jumanji’s post what happened to this thread

Well polish my nuts and serve me a milkshake you're right. He's gone.