Bald scalp in men with androgenetic alopecia retains hair fo

[squeegee]

So you're going to send me 4 bottles? Cool! :woot:

BTW.. PQQ has really PQ'd my interest:

http://www.lef.org/magazine/mag2010/ss2010_Rejuvenate-Your-Cells-Growing-New-Mitochondria_01.htm

PQQ’s potential to stimulate mitochondrial biogenesis was foreshadowed by early findings indicating its central role in growth and development across multiple forms of life.
PQQ Is an Essential Micronutrient

PQQ has been shown to be a potent growth factor in plants, bacteria, and higher organisms.21,24,25 Pre-clinical studies reveal that when deprived of dietary PQQ, animals exhibit stunted growth, compromised immunity, impaired reproductive capability, and most importantly, fewer mitochondria in their tissue. Rates of conception, the number of offspring, and survival rates in juvenile animals are also significantly reduced in the absence of PQQ.26-28

When PQQ is introduced back into the diet, it reverses these effects, restoring systemic function while simultaneously increasing mitochondrial number and energy efficiency.

These compelling data prompted a team of researchers at the University of California-Davis to specifically analyze PQQ’s influence on cell signaling pathways involved in the formation of new mitochondria.14

Their work, published last year, led to several extraordinary discoveries. They found that PQQ’s critical biological roles stem from its ability to activate genes directly involved in cellular energy metabolism, development, and function.14

[quote:3kxb7ga1]Mitochondrial biogenesis can be defined as the growth and division of pre-existing mitochondria. This phenomenon is not only accompanied by increased mitochondria numbers, but also their size and mass.

Mitochondrial biogenesis requires the coordinated synthesis and import of 1,000-1,500 proteins where they facilitate the production of healthy new mitochondria.

Mitochondrial biogenesis occurs through the combined effects of genes activated by PQQ via the following three mechanisms:

* PQQ increases expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha or PGC-1?. PGC-1? is a “master regulatorâ€￾ gene that mobilizes your cells’ response to various external triggers. It directly activates genes that boost mitochondrial and cellular respiration, growth, and reproduction. Its capacity to modulate cellular metabolism at the genetic level favorably affects blood pressure, cholesterol and triglyceride breakdown, and the onset of obesity.29
* PQQ activates a signaling protein known as cAMP-response element-binding protein or CREB. The CREB gene plays a pivotal role in embryonic development and growth. It also beneficially interacts with histones, molecular compounds shown to protect and repair cellular DNA. CREB also stimulates the growth of new mitochondria.30
* PQQ regulates a recently discovered gene called DJ-1. As with PGC-1? and CREB, DJ-1 is intrinsically involved in cell function and survival. It has been shown to prevent cell death by combating intensive antioxidant stress and is of particular importance to brain health and function. DJ-1 damage and mutation have been conclusively linked to the onset of Parkinson’s disease and other neurological disorders.31-34

[/quote:3kxb7ga1]


Is this compound available? f***! this is really interesting!

 

[squeegee]

http://www.regensci.org/twiki/pub/IGEM2007/ImmuneSignaling/C-Reactive_Protein_Comes_of_Age.pdf

and so this brings us back to the insulin threads..gluten free...Brains and Broons...statins are not the best for us:
http://www.marksdailyapple.com/statin-insanity/

couple this with my epigenetics post (explains why some younger men can start with male pattern baldness earlier than others and how male pattern baldness can progress faster in some than others)...

we have got to find the f****ing atrial fibulator for these f****ing follicles nfire: ...
why do some of our current (lame ***) treatments work a little.... for some anyway.

reduce inflammation (keto and other anti-fungle, anti yeast)
limit hormone damage (finasteride. and it's diff. forms)
heal skin wounds (copper peptides)

none of the above matter one bit if you have enough progenitor cells to take care of all that sh*t...guys with full heads of hair have the same sh*t going on in their scalp as we do...how does nitric oxide, miconazole, H2O2, ACV....derma rolling (wounding) help?...are these the paddles?

Yep.progenitor cells!

 

[Jacob]

So you're going to send me 4 bottles? Cool! :woot:

BTW.. PQQ has really PQ'd my interest:

http://www.lef.org/magazine/mag2010/ss2010_Rejuvenate-Your-Cells-Growing-New-Mitochondria_01.htm

PQQ’s potential to stimulate mitochondrial biogenesis was foreshadowed by early findings indicating its central role in growth and development across multiple forms of life.
PQQ Is an Essential Micronutrient

PQQ has been shown to be a potent growth factor in plants, bacteria, and higher organisms.21,24,25 Pre-clinical studies reveal that when deprived of dietary PQQ, animals exhibit stunted growth, compromised immunity, impaired reproductive capability, and most importantly, fewer mitochondria in their tissue. Rates of conception, the number of offspring, and survival rates in juvenile animals are also significantly reduced in the absence of PQQ.26-28

When PQQ is introduced back into the diet, it reverses these effects, restoring systemic function while simultaneously increasing mitochondrial number and energy efficiency.

These compelling data prompted a team of researchers at the University of California-Davis to specifically analyze PQQ’s influence on cell signaling pathways involved in the formation of new mitochondria.14

Their work, published last year, led to several extraordinary discoveries. They found that PQQ’s critical biological roles stem from its ability to activate genes directly involved in cellular energy metabolism, development, and function.14

[quote:2uumsal1]Mitochondrial biogenesis can be defined as the growth and division of pre-existing mitochondria. This phenomenon is not only accompanied by increased mitochondria numbers, but also their size and mass.

Mitochondrial biogenesis requires the coordinated synthesis and import of 1,000-1,500 proteins where they facilitate the production of healthy new mitochondria.

Mitochondrial biogenesis occurs through the combined effects of genes activated by PQQ via the following three mechanisms:

* PQQ increases expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha or PGC-1?. PGC-1? is a “master regulatorâ€￾ gene that mobilizes your cells’ response to various external triggers. It directly activates genes that boost mitochondrial and cellular respiration, growth, and reproduction. Its capacity to modulate cellular metabolism at the genetic level favorably affects blood pressure, cholesterol and triglyceride breakdown, and the onset of obesity.29
* PQQ activates a signaling protein known as cAMP-response element-binding protein or CREB. The CREB gene plays a pivotal role in embryonic development and growth. It also beneficially interacts with histones, molecular compounds shown to protect and repair cellular DNA. CREB also stimulates the growth of new mitochondria.30
* PQQ regulates a recently discovered gene called DJ-1. As with PGC-1? and CREB, DJ-1 is intrinsically involved in cell function and survival. It has been shown to prevent cell death by combating intensive antioxidant stress and is of particular importance to brain health and function. DJ-1 damage and mutation have been conclusively linked to the onset of Parkinson’s disease and other neurological disorders.31-34

Is this compound available? f*ck! this is really interesting![/quote:2uumsal1]

Yep...might be more out there than these:

http://www.lef.org/Vitamins-Supplements/Item01500/PQQ-Caps-with-BioPQQ.html

http://www.lef.org/Vitamins-Supplements/Item01568/Mitochondrial-Energy-Optimizer-with-BioPQQ.html

http://www.purecaps.com/itemdy00.asp?T1=CQP6

http://www.pureencapsulations.com/itemdy00.asp?T1=BPQ6

 

[Letac]

Hey guys, is this the same as Bio-Biloba? Meaning that it will transport/give energy to the smaller bloodvains in the body? Or what does these news really mean? Prognitor cells? How does this work?

 

[squeegee]

High-dose folic acid supplementation effects on endothelial function and blood pressure in hypertensive patients: a meta-analysis of randomized controlled clinical trials

Marc P. McRae, MSc, DC, FACN, DACBNCorresponding Author Informationemail address

Received 2 May 2008; received in revised form 7 September 2008; accepted 10 September 2008.
Abstract
Objective

Folic acid supplementation has been shown to be an effective agent for improving endothelial function, a prognostic factor for cardiovascular disease; but its effects on systolic and diastolic blood pressure in hypertensive individuals has been met with mixed results. Therefore, the purpose of this study was to provide a comprehensive meta-analysis of randomized controlled trials to investigate the effect of high-dose folic acid supplementation on blood pressure and endothelial function in hypertensive patients.
Methods

Twelve randomized controlled trials published between 1970 and December 2007 were identified using Medline and a manual search. All 12 studies used hypertensive subjects who were supplemented with at least 5000 ?g/d of folic acid for between 2 and 16 weeks. Three separate meta-analyses were carried out using a random-effects model, and the overall effect sizes were calculated for changes in systolic and diastolic blood pressures and for changes in endothelial function as measured through the percentage of change in flow-mediated dilation.
Results

The pooled estimate of effect of folic acid supplementation on systolic and diastolic blood pressure was ?2.03 mm Hg (95% confidence interval [CI], ?3.63 to ?0.43; P = .04) and 0.01 mm Hg (95% CI, ?1.12 to 1.13; not significant), respectively. The pooled estimate of effect of folic acid supplementation on change in flow-mediated dilation was 1.61% (95% CI, 1.27 to 1.96; P = .000).
Conclusion

Based upon the studies used in this meta-analysis, supplementation with at least 5000 ?g/d of folic acid, for a minimum of 6 weeks, can lower systolic blood pressure slightly; but the real clinical benefit is achieved through improved endothelial function.

 

[squeegee]

List of food/supplements to Improve Endothelial Function..

Walnuts
Low Fat-Diet
Soy Isoflavones
Wine Polyphenols
Vitamin C & E
Pycnogenol
L-Carnitine
Vitamin D
l-Arginine
Rich flavonoid rich dark chocolate
Omega-3
Alpha lipoic acid
Coq10
Taurine
Magnesium

 

[squeegee]

WOW JACOB! the PQQ is not that expensive as well!!! good damn find!

 

[squeegee]

Not much ingredients in the stem-kine formula.. I bet we can achieve the same results buy buying the supplements separately.

Thomas E. Ichim from Medistem Incorporated, USA worked with a team of 13 researchers from industry and academia to further investigate whether this supplement, containing a cocktail of green tea, astralagus, goji berry extracts, 'good' bacteria Lactobacillus fermentum, antioxidant ellagic acid, immune enhancer beta 1,3 glucan and vitamin D3, was able to increase the number of stem cells circulating in the blood. They recruited 18 healthy adults aged between 20 and 72 who stopped any other dietary supplements 4-5 days before starting a two-week course of this supplement, taking it twice daily. The researchers took blood from the participants before they started the course and on days 1, 2, 7 and 14 to test for signs of stem cell activity by looking for cells expressing the genetic stem cell markers CD133, CD34 and KDR. They then confirmed whether taking the supplement changed the overall levels of hematopoietic stem cells and endothelial progenitor cells in the blood by using HALO (Hematopoietic Assay via Luminescent Output) and colony forming assays respectively.

 

[squeegee]

Hyperbaric Oxygenation Increases Patients own Stem Cells By Eight-Fold

*

2 hours HBOT at 2 ATA; doubles the patients own circulating stem cells
*

40-60 hours HBOT increases circulating stem cells by 8-fold (800%)

A scientific study completed at the University of Pennsylvania School of Medicine reports that Hyperbaric Oxygen Therapy (HBOT) are a safe and effective way to mobilize the patients own stem cells providing immediate benefit and further preparing the patient for future stem cell implantation related therapies.

In fact the population of CD34+ cells in the peripheral circulation of humans doubled in response to a single exposure to 2.0 atmospheres absolute (ATA) HBOT for 2 hours. Over a course of twenty treatments, circulating CD34+ cells increased eight-fold!

Stem cells, also called progenitor cells, are crucial to the repair of injured tissues and organs. Hyperbaric Oxygenation increases by eight-fold the number of circulating stem cells throughout the body. Healthy recovery of injured and diseased tissues is the ultimate goal and stem cells play an essential role.

In response to injury, stem cells are mobilized out of the bone marrow to the injured sites, where they differentiate into specialized cells that are important to the healing process. Stem cells from bone marrow are capable of providing specialized functions in many different organs and tissues throughout the body. This movement, or mobilization, of stem cells can be triggered by a variety of stimuli—including Hyperbaric Oxygenation.

While drugs are associated with a host of side effects, Hyperbaric Oxygenation treatments carry a significantly lower risk of such effects.

"This is the safest way clinically to increase stem cell circulation, far safer than any of the pharmaceutical options," said Stephen Thom, MD, Ph.D., Professor at the University of Pennsylvania School of Medicine and lead author of the study.

"This study provides information on the fundamental mechanisms for hyperbaric oxygen therapy and offers a new therapeutic option for mobilizing stem cells."

"We reproduced the observations from humans in animals in order to identify the mechanism for the hyperbaric oxygen effect," added Thom. "We found that hyperbaric oxygen mobilizes stem/progenitor cells because it increases synthesis of a molecule called nitric oxide in the bone marrow. This synthesis is thought to trigger enzymes that mediate stem/progenitor cell release."

Hyperbaric Oxygenation not only causes the release of the patients circulating stem cells but greatly facilitates future endeavors using stem cell related therapies which is costly and not an automatic guarantee in every patient.

It is hoped that future study of hyperbaric oxygen's role in mobilizing stem cells will provide a wide array of treatments for combating injury and chronic progressive disease.

The completed study is scheduled for publication in the April 2006 edition of the American Journal of Physiology – Heart and Circulatory Physiology.



Submitted on August 19, 2005; Accepted on November 7, 2005


Stem cell mobilization by hyperbaric oxygenation

Stephen R Thom1, Veena M Bhopale2, Omaida C Velazquez3, Lee J Goldstein3, Lynne H Thom2*, and Donald G Buerk4

1 Emergency Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Environmental Medicine, University of Pennsylvania, Philadelphia, PA, USA
2 Emergency Medicine, University of Pennsylvania, Philadelphia, PA, USA
3 Surgery, University of Pennsylvania, Philadelphia, PA, USA
4 Physiology, University of Pennsylvania, Philadelphia, PA, USA


We hypothesized that exposure to hyperbaric oxygen (HBO2) would mobilize stem/progenitor cells from the bone marrow by a nitric oxide (.NO) dependent mechanism.

The population of CD34+ cells in the peripheral circulation of humans doubled in response to a single exposure to 2.0 atmospheres absolute (ATA) O2 for 2 hours. Over a course of twenty treatments, circulating CD34+ cells increased eight-fold, although the over-all circulating white cell count was not significantly increased.

The number of colony-forming cells (CFCs) increased from 16 ± 2 to 26 ± 3 CFCs/100,000 monocytes plated. Elevations in CFCs were entirely due to the CD34+ sub-population, but increased cell growth only occurred in samples obtained immediately post-treatment. A high proportion of progeny cells express receptors for vascular endothelial growth factor-2 and for stromal derived growth factor.

In mice, HBO2 increased circulating stem cell factor by 50%, increased the number of circulating cells expressing stem cell antigen-1 and CD34 by 3.4-fold, and doubled the number of CFCs. Bone marrow .NO concentration increased by 1008 ± 255 nM in association with HBO2. Stem cell mobilization did not occur in knock out mice lacking genes for endothelial .NO synthase. Moreover, pre-treatment of wild type mice with a nitric oxide (.NO) synthase inhibitor prevented the HBO2-induced elevation in stem cell factor and circulating stem cells.

We conclude that HBO2 mobilizes stem/progenitor cells by stimulating .NO synthesis.

 

[Jacob]

Not much ingredients in the stem-kine formula.. I bet we can achieve the same results buy buying the supplements separately.

That's what I wondered over at HLF. I thought this was a bit more interesting: http://www.healthbeyondhype.com/gold360-12-oz-preserves-p-213.html

Or this http://www.enzymedica.com/products/NaturaCell#tabsection

http://newstemcells.stemtechbiz.com/StemEnhance.aspx

 

[lazman]

this could be interesting. it provenly increases circulating progenitor cell CD34+ levels. and does it all naturally.

http://www.stem-kine.com/science2.asp

 

[CCS]

I really hope something comes of this but I'm skeptical. Every few years they make some discovery and nothing ever happens.

Nene , this study is a solid proof that Oxidation/Inflammation does the damage when it comes to male pattern baldness.. The progenitor cells just need to be activated and we have enough remaining stem cells to make the problem reversible.. This is the best study ever.. unk:

---gets up, rubs nizoral on his head, but wishes it has some anti-oxidant properties too----

 

[CCS]

reduce inflammation (keto and other anti-fungle, anti yeast)
limit hormone damage (finasteride. and it's diff. forms)
heal skin wounds (copper peptides)

none of the above matter one bit if you have enough progenitor cells to take care of all that sh*t...guys with full heads of hair have the same sh*t going on in their scalp as we do...how does nitric oxide, miconazole, H2O2, ACV....derma rolling (wounding) help?...are these the paddles?

Wait, are you saying the number of progenator cells stays the same throughout life, but they just don't keep up with the damage? They don't decrease over time? My computer has no sound, so I missed those news updates.

 

[CCS]

COLUMBUS, Ohio – Ohio State University medical researchers have demonstrated that reactive oxygen species at appropriate levels can support the healing of wounds, and specifically that wounds can generate their own low concentration of hydrogen peroxide, which has a role in healing.
A recent Ohio State study showed that at the site of injury, cells of wound tissue convert oxygen to reactive oxygen species, triggering oxidation-reduction, or redox driven mechanisms. Excess levels of reactive oxygen species, such as during chronic inflammation, may impair healing, but low levels offer healing benefits.

So then how much anti-oxidant should I add to my scalp? Or should I just worry about inflammation and assume that once that is taken care of, the oxidant level will be the right amount?

 

[thinninghairsucks]

i can get :

Ultra Colostrum (30% IgG)

Nutritional Information
Per 10g serving:
Energy: 146kJ
Energy: 35Kcal
Protein (as-is): 6.85g
Carbohydrates: 3g
Lactose: 1.5g
Fat: 0.2g

Also provides:
Total Immunoglobulins: 30%
IGF I & II: 2.8mcg/g
EGF: 1.6mcg/g

250 grams for £22.99

should i ? would it be effective if i made it into topical ?

 

[CCS]

IGF 1 is a huge protein molecule, like 100 amino acids long or something like that. I doubt it would make it through your skin. And it has to be kept near but above freezing.

As for the PGG, I'd find it hard to believe than an over the counter would stimulate stem cells to circulate your body. I also wonder if they would actually come to the aid of your hair follicle, and if they would cause problems elsewhere. If it does work, you would be making some big changes/effects to your body, so you better be sure you are doing a good thing.

 

[squeegee]

Arterioscler Thromb Vasc Biol. 2009 Jun 4.
Dickkopf-1 Enhances Inflammatory Interaction Between Platelets and Endothelial Cells and Shows Increased Expression in Atherosclerosis.
Ueland T, Otterdal K, Lekva T, Halvorsen B, Gabrielsen A, Sandberg WJ, Paulsson-Berne G, Pedersen TM, Folkersen L, Gullestad L, Oie E, Hansson GK, Aukrust P.

Research Institute for Internal Medicine, the Department of Endocrinology, the Department of Cardiology, and the Section of Clinical Immunology and Infectious Diseases, Rikshospitalet, Oslo University Hospital, and the Faculty of Medicine, University of Oslo, Norway; and the Centre for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.

OBJECTIVE: Based on the emerging importance of the wingless (Wnt) pathways in inflammation and vascular biology, we hypothesized a role for Dickkopf-1 (DKK-1), a major modulator of Wnt signaling, in atherogenesis and plaque destabilization. METHODS AND RESULTS: We report increased levels of DKK-1 in experimental (ApoE(-/-) mice) and clinical (patients with coronary artery disease [n=80] and patients with carotid plaque [n=47]) atherosclerosis, both systemically (serum) and within the lesion, with particularly high levels in advanced and unstable disease. We identified platelets as an important cellular source of DKK-1 as shown by in vitro experiments and by immunostaining of thrombus material obtained at the site of plaque rupture in patients with acute ST-elevation myocardial infarction, with strong immunoreactivity in platelet aggregates. Our in vitro experiments identified a role for platelet- and endothelial-derived DKK-1 in platelet-dependent endothelial activation, promoting enhanced release of inflammatory cytokines. These inflammatory effects of DKK-1 involved inhibition of the Wnt/beta-catenin pathway and activation of nuclear factor kappaB. CONCLUSIONS: Our findings identify DKK-1 as a novel mediator in platelet-mediated endothelial cell activation. The demonstration of enhanced DKK-1 expression within advanced carotid plaques may suggest that this DKK-1-driven inflammatory loop could be operating within the atherosclerotic lesion.

 

[squeegee]

Hairloss is all about inflammation period.. CRP facilitates endothelial cell
apoptosis and blocks angiogenesis by inhibiting
NO production,30 and inhibits bone-marrowderived
endothelial progenitor cell survival
and differentiation.

These results suggest that inflammation leads to decreased circulating EPCs in patients with diabetes, which might be related to the pathogenesis of diabetic vascular disease.

High cholesterol causes increased oxidative stress, impairing the function of EPCs. In addition to being implicated in cardiovascular diseases, oxidative stress is also a factor in diabetes.

 

[CCS]

Exercising will lower your cholesterol levels a bit. What else can we do? Soy? B vitamins?

As for inflammation, there is nizoral shampoo, and there also is ingestion of fish oil, borageseed oil, and sesamin. Sesamin is small and fat soluble, so we might be able to put it on our head if you think that would help.

How do we get our oxidative stress levels checked so we know if we need to take that supplement LE is selling?

Even if inflammation is the cause, there still is other stuff that causes the inflammation. We know that reducing androgens helps a lot. And proctor found a link between arginine and NO levels. Maybe we should put a pinch of arginine in our shampoo?

It is interesting though that we don't want to inhibit all the peroxide, or healing does not occur. So topical anti-oxidiants might not be the best route. Instead, calm the immune system up there, and do its job for it with anti-bacterials.

 

[Jacob]

THE PILL: Pierre Michel RepHair THE CLAIM: AC-11, a proprietary extract of Uncaria tomentosa (the cat's-claw plant from the rain forest), repairs damaged DNA in hair cells to reduce dryness, thinning, and breakage while increasing shine and thickness.

Two new substances, AC-11 and Dimericine, appear to enhance the DNA repair capacity of cells. These substances might have use in treating patients with xeroderma pigmentosa and in enhancing the ability of sun blocks to prevent ultraviolet-induced cellular damage.

AC-11 is the successor compound to C-MED-100[R] the first nutraceutical having FDA permission to claim natural DNA repair activity. AC-11 is a Cat's Claw (Uncaria tomentosa) water extract that is claimed to be a highly effective antiaging treatment of skin because of several mechanisms: NF-kB inhibition blocking inflammatory cytokine production (eg, TNF alpha), antioxidant properties via electrophilic scavenging and NF-kB inhibition reducing surface peroxides, and enhancement of DNA repair by reducing macromolecular expression and damage and decreasing cellular replication of damaged DNA. When AC-11 is applied topically to skin it decreases the number of "sun burnt cells" and pathogenic DNA dimers induced by ultraviolet light. AC-11 can be taken orally or applied topically. It is made by Optigenex Inc