Jacob
Senior Member
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Bald scalp in men with androgenetic alopecia retains hair fo
- Thread starter squeegee
- Start date
I want to buy cats claw extract, but the problem is I can't find a good source. There are different compounds in it, some of which render it ineffective. The cheap ones have the bad compounds. The ones with the good compounds have just tiny doses that are way smaller than those used in the study.
The problem with Resveratrol is the liver destroys it before you can get any into the blood. And because it is not water soluble, you can't inject it. Fortunately the vitamins on that list do get absorbed.
The problem with Resveratrol is the liver destroys it before you can get any into the blood. And because it is not water soluble, you can't inject it. Fortunately the vitamins on that list do get absorbed.
squeegee
Banned
- Reaction score
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idontwanttobebalding said:
http://www.revgenetics.com/store/c-6-astral-fruit.aspx
Good post guys! Keep them coming!
squeegee
Banned
- Reaction score
- 132
http://bmb.oxfordjournals.org/content/55/3/578.full.pdf
Folic acid deficiency in humans has been linked with megaloblastic anaemia,
neural tube defects in the neonate, and heart disease. Folate has also been
implicated in the development of cancer, especially cancer of the colorectum.
There appear to be two principal mechanisms through which low folate status
may increase the risk of malignancy. Folate deficiency, by reducing intracellular
S-adenosylmethionine (SAM), can alter cytosine methylation in DNA, leading to
inappropriate activation of proto-oncogenes and induction of malignant
transformation. Alternatively, folic acid is crucial for normal DNA synthesis and
repair. Folate deficiency may cause an imbalance in DNA precursors, uracil
misincorporation into DNA, and chromosome breakage. This chapter briefly
describes the epidemiological data supporting the involvement of folic acid in
the aetiology of cancer. It also assesses the evidence from cellular, animal and
human studies that folic acid can modulate DNA by such mechanisms.
Folic acid supplements could boost DNA repair, says study
By Stephen Daniells, 21-Jun-2006
Related topics: Research, Vitamins & premixes, Cancer risk reduction
Daily folic acid supplements could improve DNA stability and reduce the risk of certain cancers linked to faults in the genetic code, suggests new research.
"To our knowledge, this is the first human study to determine the effects of folate supplementation on DNA repair. DNA repair is crucial in maintaining genomic stability and compromised DNA repair is associated with increased risk of malignancy," wrote lead author Graham Basten from the University of Sheffield.
Folate deficiency has previously been linked to an increased risk of precancerous lesions that could lead to a variety of cancers, including breast, colorectal, pancreatic, and lung.
The randomised, double-blind, placebo-controlled study, published in the British Journal of Cancer (Vol. 94, pp. 1942-1947), was carried out with 61 healthy volunteers (31 women) with an average age of 41.
Volunteers were assigned to receive daily folic acid supplements of 1.2 milligrams or a glucose placebo for 12 weeks. The folic acid dose is significantly higher than the RDI in both the UK and the US (200 micrograms), but significantly lower than the pharmacological doses used in many clinical trials.
Blood samples were taken to measure the red cell folate (RCF) levels, and all subjects had RCF levels of between 250 and 650 nanomoles per litre, meaning no-one was folate deficient (less than 200 nanomoles per litre).
The blood samples were also used to measure the stability of DNA in lymphocytes.
In agreement with previous work by the same group, the folic acid supplementation resulted in significant increases in the RCF levels, as well as the folate derivative 5-methyltetrahydrofolate (5-MeTHF). They also reported increases in S-adenosylmethionine (SAM) levels, a compound that is involved in the stability of DNA.
The researchers also made a link between RCF levels and misincorporation of the DNA base, uracil. Misincorporation of uracil is associated with the formation of DNA fragments that are said to promote cancer development.
"There was a strong correlation between the magnitude of lymphocyte total folate and reduction in lymphocyte DNA uracil misincorporation," reported the researchers.
The most significant effects were observed for those with the lowest RCF values, leading the researchers to say that the activity of DNA repair may not be altered by upping the folate intakes for people with adequate folate levels.
However, the intervention appeared to have no impact on other markers of DNA instability, namely DNA strand breaks and global DNA methylation.
"Uracil misincorporation is evidently more sensitive to improved folate status in healthy individuals than other putative biomarkers of DNA damage or repair, and may, therefore, be considered a valid and functional biomarker for the influence of folate on genomic stability in health people," concluded the researchers.
The mechanism behind the observed effects is not currently known and remains to be established, said the researchers.
Josephine Querido, science information officer at Cancer Research UK, told NutraIngredients.com that although there was relatively strong eveidence that folate-rich foods were linked to a lower risk of certain cancer, it is still not clear if supplements could give the same benefits.
"Folate is a B vitamin found in green and leafy vegetables. It is needed in the body to make and repair DNA. This is important as damage to a cell's DNA can lead to cancer," she said.
Folate, the natural form of the B vitamin, can be found in foods such as liver, eggs, beans, whole grains, and green leafy vegetables. Folic acid is the synthetic form used for food fortification and in supplements.
Studies have shown that folic acid is more easily absorbed from fortified foods (85 percent) and supplements (100 percent) than the folate found naturally in foods (50 percent).
Folic acid deficiency in humans has been linked with megaloblastic anaemia,
neural tube defects in the neonate, and heart disease. Folate has also been
implicated in the development of cancer, especially cancer of the colorectum.
There appear to be two principal mechanisms through which low folate status
may increase the risk of malignancy. Folate deficiency, by reducing intracellular
S-adenosylmethionine (SAM), can alter cytosine methylation in DNA, leading to
inappropriate activation of proto-oncogenes and induction of malignant
transformation. Alternatively, folic acid is crucial for normal DNA synthesis and
repair. Folate deficiency may cause an imbalance in DNA precursors, uracil
misincorporation into DNA, and chromosome breakage. This chapter briefly
describes the epidemiological data supporting the involvement of folic acid in
the aetiology of cancer. It also assesses the evidence from cellular, animal and
human studies that folic acid can modulate DNA by such mechanisms.
Folic acid supplements could boost DNA repair, says study
By Stephen Daniells, 21-Jun-2006
Related topics: Research, Vitamins & premixes, Cancer risk reduction
Daily folic acid supplements could improve DNA stability and reduce the risk of certain cancers linked to faults in the genetic code, suggests new research.
"To our knowledge, this is the first human study to determine the effects of folate supplementation on DNA repair. DNA repair is crucial in maintaining genomic stability and compromised DNA repair is associated with increased risk of malignancy," wrote lead author Graham Basten from the University of Sheffield.
Folate deficiency has previously been linked to an increased risk of precancerous lesions that could lead to a variety of cancers, including breast, colorectal, pancreatic, and lung.
The randomised, double-blind, placebo-controlled study, published in the British Journal of Cancer (Vol. 94, pp. 1942-1947), was carried out with 61 healthy volunteers (31 women) with an average age of 41.
Volunteers were assigned to receive daily folic acid supplements of 1.2 milligrams or a glucose placebo for 12 weeks. The folic acid dose is significantly higher than the RDI in both the UK and the US (200 micrograms), but significantly lower than the pharmacological doses used in many clinical trials.
Blood samples were taken to measure the red cell folate (RCF) levels, and all subjects had RCF levels of between 250 and 650 nanomoles per litre, meaning no-one was folate deficient (less than 200 nanomoles per litre).
The blood samples were also used to measure the stability of DNA in lymphocytes.
In agreement with previous work by the same group, the folic acid supplementation resulted in significant increases in the RCF levels, as well as the folate derivative 5-methyltetrahydrofolate (5-MeTHF). They also reported increases in S-adenosylmethionine (SAM) levels, a compound that is involved in the stability of DNA.
The researchers also made a link between RCF levels and misincorporation of the DNA base, uracil. Misincorporation of uracil is associated with the formation of DNA fragments that are said to promote cancer development.
"There was a strong correlation between the magnitude of lymphocyte total folate and reduction in lymphocyte DNA uracil misincorporation," reported the researchers.
The most significant effects were observed for those with the lowest RCF values, leading the researchers to say that the activity of DNA repair may not be altered by upping the folate intakes for people with adequate folate levels.
However, the intervention appeared to have no impact on other markers of DNA instability, namely DNA strand breaks and global DNA methylation.
"Uracil misincorporation is evidently more sensitive to improved folate status in healthy individuals than other putative biomarkers of DNA damage or repair, and may, therefore, be considered a valid and functional biomarker for the influence of folate on genomic stability in health people," concluded the researchers.
The mechanism behind the observed effects is not currently known and remains to be established, said the researchers.
Josephine Querido, science information officer at Cancer Research UK, told NutraIngredients.com that although there was relatively strong eveidence that folate-rich foods were linked to a lower risk of certain cancer, it is still not clear if supplements could give the same benefits.
"Folate is a B vitamin found in green and leafy vegetables. It is needed in the body to make and repair DNA. This is important as damage to a cell's DNA can lead to cancer," she said.
Folate, the natural form of the B vitamin, can be found in foods such as liver, eggs, beans, whole grains, and green leafy vegetables. Folic acid is the synthetic form used for food fortification and in supplements.
Studies have shown that folic acid is more easily absorbed from fortified foods (85 percent) and supplements (100 percent) than the folate found naturally in foods (50 percent).
squeegee
Banned
- Reaction score
- 132
*Endothil-CR: $52.95
Serving Size: 1 Tablet
Servings Per Container: 30
Amount Per Serving:
Calories 0
Total Carbohydrates 0g
Sugars 0g
Riboflavin 6.8mg 400%
Proprietary Blend 9mg
-Green Tomato SE
-Grape Seed SE
-Grean Tea SE
-Quercetin
-Rutin
Other Ingredients:
Cane sugar, tomato powder, mono-and diglycerides, salt stearic acid, natural flavors, FD&C red #40 lake, magnesium stearate, and silica.
Serving Size: 1 Tablet
Servings Per Container: 30
Amount Per Serving:
Calories 0
Total Carbohydrates 0g
Sugars 0g
Riboflavin 6.8mg 400%
Proprietary Blend 9mg
-Green Tomato SE
-Grape Seed SE
-Grean Tea SE
-Quercetin
-Rutin
Other Ingredients:
Cane sugar, tomato powder, mono-and diglycerides, salt stearic acid, natural flavors, FD&C red #40 lake, magnesium stearate, and silica.
Jacob
Senior Member
- Reaction score
- 44
squeegee said:
MLM= Multi-level-marketing..and yeah, anyone can purchase it. It's just that they can be agressive in trying to get you to sell the stuff. This place sells it: http://naturallynakedskincare.ecrater.com/c/1160757/dietary-supplements and was told by them that one does not have to become a sales associate to purchase it..and that there won't be any phone calls. Which is what I always ask for before purchasing MLM products.
It's seems the company is somehow affiliated with NeoStem..which is interesting.
The AC-11/Cat's Claw product itself and in hair products can be seen here: http://www.rephairbypierremichel.com/ Solgar also makes the supplement http://www.solgar.com/SolgarProducts/AC-11-Vegetable-Capsules.htm
The product in that link does not say how much you get. Here is another link, with another problem.
http://www.easycart.net/BeyondACenturyI ... .html#8446
Cat's Claw 10:1 Powdered extract (replaces 844.1). From the inner bark of the Uncaria tomentosa vine, a powerful antioxidant used for years to promote a healthy immune system, response to inflammation and other properties. ** Used by traditional Peruvian herbalists for centuries. 10:1 extract is concentrated 10 times over our previous powdered bark with good solubility. Typical use is about 1 gram per day with some suggesting 2-4 grams per day. 100 grams powder, Code 844.0
See Also Bulk Size:
Cat's Claw 10:1 Powdered extract Bulk Size, 1000 grams
Price $8.50
Quantity desired
Samento® Cat's Claw
CAT’S CLAW, Samento® extract. Most research on the ability of Cat’s Claw to support critical immune function** has focused on the content of pentacyclic oxindole alkaloids (POAs). Presence of even 1% tetracyclic oxindole alkaloids (TOAs) can inhibit much of the good effects of POAs; and while some Cat’s Claw contain up to 80% TOAs, Samento® is a POAs concentrate certified to be free of TOAs, allowing dose to be 1 to 5 drops 2-3 times per day. 1 fl oz (30ml) contains 120 servings. Liquid extract is more bioavailable and cost-efficient than dry capsules. 1 fluid oz, 120 doses, Code 844.6
View label, image, or more info for this product
Price $36.50
In the AC-11 study posted on this site before, subjects took 750 mg of the stuff orally, and as a result could go out in the sun much longer with no signs of skin damage. The stuff works, but I don't know where to get 750 mg of the stuff wtihout TOA's.
What do you guys think?
The stuff works topically too, but why not take it internally.
http://www.easycart.net/BeyondACenturyI ... .html#8446
Cat's Claw 10:1 Powdered extract (replaces 844.1). From the inner bark of the Uncaria tomentosa vine, a powerful antioxidant used for years to promote a healthy immune system, response to inflammation and other properties. ** Used by traditional Peruvian herbalists for centuries. 10:1 extract is concentrated 10 times over our previous powdered bark with good solubility. Typical use is about 1 gram per day with some suggesting 2-4 grams per day. 100 grams powder, Code 844.0
See Also Bulk Size:
Cat's Claw 10:1 Powdered extract Bulk Size, 1000 grams
Price $8.50
Quantity desired
Samento® Cat's Claw
CAT’S CLAW, Samento® extract. Most research on the ability of Cat’s Claw to support critical immune function** has focused on the content of pentacyclic oxindole alkaloids (POAs). Presence of even 1% tetracyclic oxindole alkaloids (TOAs) can inhibit much of the good effects of POAs; and while some Cat’s Claw contain up to 80% TOAs, Samento® is a POAs concentrate certified to be free of TOAs, allowing dose to be 1 to 5 drops 2-3 times per day. 1 fl oz (30ml) contains 120 servings. Liquid extract is more bioavailable and cost-efficient than dry capsules. 1 fluid oz, 120 doses, Code 844.6
View label, image, or more info for this product
Price $36.50
In the AC-11 study posted on this site before, subjects took 750 mg of the stuff orally, and as a result could go out in the sun much longer with no signs of skin damage. The stuff works, but I don't know where to get 750 mg of the stuff wtihout TOA's.
What do you guys think?
The stuff works topically too, but why not take it internally.
dresden said:
The found out that balding scalp is similar to non-balding scalp, but one of the big differences is we have fewer stem cells repairing the hair follicle each cycle, so it can't keep up. It keeps getting smaller. I don't see what that has to do with DNA damage, though they seem to think repairing DNA will help with hair regrowth. I'm just searching for AC-11 for general anti-aging purposes. Maybe they will find me some good stuff that is affordable.
They also found out that many vitamins and supplements might help with DNA repair or inflammation reduction, though their list does not say how much. I already take some of those, so I'm not going to add the rest of the list unless someone proves than one of the things on the list is much better than the rest.
http://www.rain-tree.com/toa-poa-article.htm
We need to find research articles specifying what we need. That link might shed some light.
The cliffs for that link are it does not matter what cat's claw extract you guy. There are no bad brands. And the recommended dose is about 300 mg per day.
Warning: the biggest customers of cats claw are HIV patients wanting to boost their immune system. I would avoid the topical route.
We need to find research articles specifying what we need. That link might shed some light.
The cliffs for that link are it does not matter what cat's claw extract you guy. There are no bad brands. And the recommended dose is about 300 mg per day.
Warning: the biggest customers of cats claw are HIV patients wanting to boost their immune system. I would avoid the topical route.
Jacob
Senior Member
- Reaction score
- 44
CCS said:
The Solgar one is 350mg. My guess is the Rephair is similar(I'll ask). LEF used to carry it..I bought tons of it way back when they had their sale...so I did take it for quite awhile. As well as the Rephair shampoo and spray product. I think products like this are better for sun protection if that's what one is looking for: http://search.lef.org/cgi-src-bin/MsmGo.exe?grab_id=0&page_id=5603&query=uv&hiword=uv
There IS a difference between AC-11 and all the other cat's claw out there. Each probably has their own benefits or at least they'll all claim them..but here's their take on it: http://www.optigenex.com/ac11.htm
There are some products in Japan that contain it...such as http://en.kenko.com/shop/en-us/commodity/X684150H/
thinninghairsucks
Established Member
- Reaction score
- 3
Warning: the biggest customers of cats claw are HIV patients wanting to boost their immune system. I would avoid the topical route.
what do u mean by this ? i dont get it sorry ?
what do u mean by this ? i dont get it sorry ?
thinninghairsucks
Established Member
- Reaction score
- 3
http://findarticles.com/p/articles/mi_m ... _20097503/
Trouble Signs
Recent studies have shown that there is a significant problem associated with the consumption of the plant that has been collected at random in the Peruvian jungle. It turns out that there are two kinds of Uncaria tomentosa that are distinguishable one from another only on the basis of their chemical constituents. Such plants which look alike but differ markedly in their composition are referred to as chemotypes (chemical types) or chemovars (chemical varieties).
The constituents of the other chemotype of U. tomentosa are quite different. It contains the tetracyclic (4-ring) oxindole alkaloids rhynchophylline and isorhynchophylline, which counteract the immunomodulating action of the pentacyclic alkaloids found in the other variety. They also exert negative chronotropic and inotropic activities, slowing and decreasing the force of the heartbeat. addition, they have a sedative effect which in chemical high doses depresses one respiration and produces ataxia (lack of muscular you. coordination).
Because the two varieties are not readily separated at the point of collection, it is difficult to prevent contamination of the potentially useful pentacyclic variety with at least some of the negative-acting tetracyclic one. Consequently, on practical grounds it is recommended that the content of the latter type oxindole alkaloids be limited to less than 0.02%.
scare tacticts ?
Trouble Signs
Recent studies have shown that there is a significant problem associated with the consumption of the plant that has been collected at random in the Peruvian jungle. It turns out that there are two kinds of Uncaria tomentosa that are distinguishable one from another only on the basis of their chemical constituents. Such plants which look alike but differ markedly in their composition are referred to as chemotypes (chemical types) or chemovars (chemical varieties).
The constituents of the other chemotype of U. tomentosa are quite different. It contains the tetracyclic (4-ring) oxindole alkaloids rhynchophylline and isorhynchophylline, which counteract the immunomodulating action of the pentacyclic alkaloids found in the other variety. They also exert negative chronotropic and inotropic activities, slowing and decreasing the force of the heartbeat. addition, they have a sedative effect which in chemical high doses depresses one respiration and produces ataxia (lack of muscular you. coordination).
Because the two varieties are not readily separated at the point of collection, it is difficult to prevent contamination of the potentially useful pentacyclic variety with at least some of the negative-acting tetracyclic one. Consequently, on practical grounds it is recommended that the content of the latter type oxindole alkaloids be limited to less than 0.02%.
scare tacticts ?
Jacob
Senior Member
- Reaction score
- 44
If you're worried about that get one that states it's free of Tetracyclic oxindoles: http://www.iherb.com/Enzymatic-Therapy-Saventaro-Max-Strength-Cat-s-Claw-90-UltraCaps/2231?at=0
thinninghairsucks
Established Member
- Reaction score
- 3
jeez been doing more reading..
this sh*t sounds like the new wonderdrug. do you think it will live up to expectations ? you going to give it a go jacob ?
id like to run:
miconazole £2.50 ( last about a month )
keto Shampoo = £4 (last 1-3 month)
vit D3 = £7.99 (lasts half a year)
Ultra Colostrum (30% IgG) = £22 (25 days
)
Trans-Resveratrol 50% = £13.79 (90 days )
AC-11 = ??? (??)
need help picking ac-11 brand and website... i live in uk anyone help ?
thinkin about not doing colostrum as its fairly pricey and i have feeling ac-11 is pricey so its one or the other please help me find some i will test run.
this sh*t sounds like the new wonderdrug. do you think it will live up to expectations ? you going to give it a go jacob ?
id like to run:
miconazole £2.50 ( last about a month )
keto Shampoo = £4 (last 1-3 month)
vit D3 = £7.99 (lasts half a year)
Ultra Colostrum (30% IgG) = £22 (25 days
)Trans-Resveratrol 50% = £13.79 (90 days )
AC-11 = ??? (??)
need help picking ac-11 brand and website... i live in uk anyone help ?
thinkin about not doing colostrum as its fairly pricey and i have feeling ac-11 is pricey so its one or the other please help me find some i will test run.
Jacob
Senior Member
- Reaction score
- 44
I just got a response from AC-11 that theirs does not contain the Tetracyclic oxindoles either.
You should be able to find the Solgar brand in the UK. I would imagine colostrum would be cheaper..especially in "bulk" powder- if you can stick with taking a powder consistently. But both have their benefits..of course.
I really wish I'd have stocked up even more on the LEF AC-11 some years ago. Maybe someone can find the Solgar or another brand at a good price. Iherb has it http://www.iherb.com/Solgar-AC-11-Uncaria-Tomentosa-Extract-60-Veggie-Caps/9659?at=1 ..VIP discounts at checkout if you're able to get 'em.
You should be able to find the Solgar brand in the UK. I would imagine colostrum would be cheaper..especially in "bulk" powder- if you can stick with taking a powder consistently. But both have their benefits..of course.
I really wish I'd have stocked up even more on the LEF AC-11 some years ago. Maybe someone can find the Solgar or another brand at a good price. Iherb has it http://www.iherb.com/Solgar-AC-11-Uncaria-Tomentosa-Extract-60-Veggie-Caps/9659?at=1 ..VIP discounts at checkout if you're able to get 'em.