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All that is correct but to make things easier, if you bald from a young age, you are way too fucked and you shouldn't spread your genetic, so taking hrt and a vasectomy (because there are reports of mtf getting cis women pregnant) would eliminate the shitty genetics. Every young balding man should do that, same for woman who start thinning at young age. For us? It is too f*****g over but we can choose to not be selfish and stop spreading this genetics. Unfortunately humans are horrible creatures that wants to spread their genetics regardless if it is good or not, then their descendants will suffer because their parents were f*****g selfish and only care about them and what they want.IMO, androgen degrador wont help the majority of people who already tried HRT. If you're a young balder, it usually means that you already have mutated sebaceous glands and therefore hair follicles since utero, meaning they are super sensitive to not just steroid hormones, but also peptide ones like prolactin or insulin, just via defferent pathways. With those kind of mutations you need to dig a little deeper and counter direct sources of hair cycle disruption and inflammation. And the main sources are Wnt signaling pathway and PGD2.
PGD2 is both the main source of inflammation and Wnt activator. Like other prostaglandins, it can be easily countered by NSAIDs like aspirin without a need of using corticosteroids in most cases. I think the reduction of it must be a priority for most people with hairloss.
Wnt, which can also cause cancer and diabetes btw, unfortunately, cannot be inhibited directly apart from lowering PGD2. There is a direct Inhibitor, but it was only tested on rats, but successfully, which is good news.
I rly f*****g hate when a bald f*** says 'oh no I dont want to take dutasteride might affect my fertility' just stfu up and get a vasectomy and stop that miserable genetic once and for all
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