Exploring The Hormonal Route. Hair=life.

[BeardCombover]

Fck I hope not worse than mine. Although my DHEAS has lowered till last time, rest of androgens(except T and free T) has increased (DHT and DHEA being the ones that increased the most vs last blood test). My hair is massacred btw and having more body hair out of nowhere.

If all your adrenal androgens increased and ACTH as well. that's probably high E levels overstimulate adrenal gland.

 

[BeardCombover]

Im so desperate about my situation that I am prob take some oral hydrocortisone low dosage (5 mg) to see if it does something

I'd start with reducing E2 dose. Probably gonna do the same. Corticoids aren't a joke, they might ruin you.

 

[Adri23]

If all your adrenal androgens increased and ACTH as well. that's probably high E levels overstimulate adrenal gland.

My E2 at trough is 374.1 pg/ml at trough. U have been with higher estradiol in the past for month without any issue (up to 451 pg/ml for months). Thing is I have now reduced my dosage from 6 to 5 mg and I am getting severe anxiety out of nowhere, mostly in the afternoon and night( I have severe anxiety right now and nothing happened)

 

[Adri23]

I'd start with reducing E2 dose. Probably gonna do the same. Corticoids aren't a joke, they might ruin you.

I'm def ruined atp, idk if it can make it worse haha

 

[Adri23]

Tbh everything is bad after I killed my balls. It's like the typical scenario of androgen issues after orchiectomy( at the end of the day mine is like an orchi). Like I had high dht before but rest of androgens were good. Now everything is increasing(not by a lot tho still in range)

 

[BeardCombover]

Tbh everything is bad after I killed my balls. It's like the typical scenario of androgen issues after orchiectomy( at the end of the day mine is like an orchi)

IMO, orchi requires hard reset of everything. Take low dose of E, you don't even need more than 200pg/ml. And FK all AAs, there's noone i know who could manage on them more than 10years w/o any troubles, so they're the worst long time solution.
But again, I'm not the one to advise anything atp. =(

 

[Adri23]

IMO, orchi requires hard reset of everything. Take low dose of E, you don't even need more than 200pg/ml. And FK all AAs, there's noone i know who could manage on them more than 10years w/o any troubles, so they're the worst long time solution.

I lowered my E and feel so anxious. Like idk how to cope with this but I cant manage the anxiety lol. I will try to cope and see if it improves with days. Idk if bica at low dosages is causing this, but idk what would I do with minoxidil hypertrichosis if I stop bica

But again, I'm not the one to advise anything atp. =(

Neither I am. We are too fucked to even recommend anything cause nothing seems to work

 

[BeardCombover]

I wonder whether for those of us with NCAH, high E is actually bad, because E increases corticosteroid-binding globulin, which would lead to more acth. Low levels with bica might be better

Ye, I also think that high E is bad for many reasons, especially if you have low aromatase enzyme like me (my aromatase was marked as poor on test) and Adri (and some others here too, although It happens to be a pretty rare disorder), because with low aromatase, your body is just not used to any significant doses of E, and all the RNA transciption that existed without E, will have to be recalibrated to have E as co-factor. And this is gonna be even more shocking to the system the later you start.
And indeed, thats true about corticosteroid-binding globulin and upregulated cortisol production as a result, furthermore E increases all the axis globulins including SHBG and the thyroid one (Thyroxine-Binding Globulin). This effect on all the globulins means that E can up(down)regulate tons of sh*t.
I'm honestly starting to believe that min-maxing (like in games) just doesn't work with living organisms, there's a very delicate balance, that can be easily broken if smth is blocked or elevated. If you block smth, you need to replace it with smth, if smth is elevated, smth else will be deficient or elevated.
In case of E (especially for ppl with bad aromatase), I think that high E just needs to be mediated with progestin (or prog), which helps with regulation of those globulins, as well as E-induced cell proliferation in some tissues. Moreover, high estrogen actually lowers progesterone, and imbalance in these hormones lead to improper functioning of the thyroid (and adrenal gland as a result).

 

[BeardCombover]

I lowered my E and feel so anxious. Like idk how to cope with this but I cant manage the anxiety lol. I will try to cope and see if it improves with days.

It will with time, had the same issue.

Idk if bica at low dosages is causing this, but idk what would I do with minoxidil hypertrichosis if I stop bica

Mb lower minoxidil dose? I'm not an expert in minoxidil tho..
And ye, prog is still relevant IMO. Ok, ima go chill. My advises are worth 0. =)

 

[Adri23]

It will with time, had the same issue.

Yeah. i also bought some phosphatidylserine, idk if it will work but I bought it because I've seen it recomended

Mb lower minoxidil dose? I'm not an expert in minoxidil tho..

Prolly. I will lose more hair but well my hair is terribly bad at this point.

Even with min I have this sh*t hair so...

 

[foy]

I think this can be useful to many here.

https://www.reddit.com/r/DrWillPowers/s/drbaoaYfLI

 

[sg2000]

He is cute because he is young. All young people are cute. Most anyways.

youre so cute when youre jelous about foy

 

[losingbattle88]

youre so cute when youre jelous about foy

What jealous about what?

 

[sg2000]

nothing i was joking bro

 

[foy]

youre so cute when youre jelous about foy

He was talking about almas not about me

 

[foy]

By the way, my breasts don't hurt at all anymore, I'm going crazy, it seems the e2 wasn't doing anything to me like I suspected

 

[sg2000]

Ye, I also think that high E is bad for many reasons, especially if you have low aromatase enzyme like me (my aromatase was marked as poor on test) and Adri (and some others here too, although It happens to be a pretty rare disorder), because with low aromatase, your body is just not used to any significant doses of E, and all the RNA transciption that existed without E, will have to be recalibrated to have E as co-factor. And this is gonna be even more shocking to the system the later you start.
And indeed, thats true about corticosteroid-binding globulin and upregulated cortisol production as a result, furthermore E increases all the axis globulins including SHBG and the thyroid one (Thyroxine-Binding Globulin). This effect on all the globulins means that E can up(down)regulate tons of sh*t.
I'm honestly starting to believe that min-maxing (like in games) just doesn't work with living organisms, there's a very delicate balance, that can be easily broken if smth is blocked or elevated. If you block smth, you need to replace it with smth, if smth is elevated, smth else will be deficient or elevated.
In case of E (especially for ppl with bad aromatase), I think that high E just needs to be mediated with progestin (or prog), which helps with regulation of those globulins, as well as E-induced cell proliferation in some tissues. Moreover, high estrogen actually lowers progesterone, and imbalance in these hormones lead to improper functioning of the thyroid (and adrenal gland as a result).

by high E levels you mean more than 500 pg ml?

 

[sg2000]

He was talking about almas not about me

he was talking about me he said that im cute only cause im young

 

[foy]

he was talking about me he said that im cute only cause im young

A , true

 

[sg2000]

hi gays