Exploring The Hormonal Route. Hair=life.

[sg2000]

any smoker here whos on hrt?
Can smoking block/reduce the effects of injectable estradiol??

 

[GRme11]

any smoker here whos on hrt?
Can smoking block/reduce the effects of injectable estradiol??

Are you smoking? Definitely drop that cancer…. It affects hair as well…

 

[sg2000]

Are you smoking? Definitely drop that cancer…. It affects hair as well…

yes i will.
I will chew gums instead lol

 

[GRme11]

yes i will.
I will chew gums instead lol

Well, no wonder… Smoking, high prolactin… Makes sense for your hair to be even more fucked on top of Androgenetic Alopecia…

 

[All Might]

This is why you should never start with topical treatments to treat hairloss lmao dumbass. I never trusted topicals thats why I always use oral.

https://www.reddit.com/r/Hairloss/comments/1l4fa0v

i think using duta topically is what gave me the type 4 allergy to it

 

[sg2000]

View attachment 190424

Ok, so my DHT is crazy, but I decided just to live with it atp.
Hard to tell why it is like that, because my ACTH, 17-OHP, Cortisol, Aldosterone, Androstenedione, 3a-diol are all near low reference and DHEA-S is somehow even lower than month ago. Also, I've no clue why prolactin didn't affect anything, as well as where it came from.
Overall, I feel good, my hair doesn't fall out, skin is good, bobs are sensitive, fat is redistributed well, all even considering very high SHBG. The only downsides are more sebum on scalp (especially on forehead) and hair is kinda coarse and less soft, which makes the texture a bit weird.
DHT, tho, is definitely there, but finding out what causes it is (IMO) not worth it for me atp. I guess it's either one of CAH variations, or sort of DHT inactivation issue like 3a-HSD deficiency, or its inhibition by bile acids. I honesly blame the bile acids, because noticing some short-lived scalp inflammation from time to time when my diet is too high on fats and hair getting worse too. Regardless, even if its CAH, I have no way of treating it, because my tolerance to corticosteroids is just no bueno. Gonna just reduce my E dose a lil bit and... well, just move on with my worthless DHT mutant life.

what do you mean by high fats?which are so i can avoid it thanks

 

[sg2000]

About this much.

how old were you in the first pohtos?
Are the last 2 from today??

 

[sg2000]

also where is the balding gene?From mom side?

 

[sg2000]

Definitely moms.

All are from around 26 years old after I started finasteride. It was even worse before, but I've no photos of that period.

aand i mean were you started balding young like at 15 16 17? do you have a photo of 18 yrs old? btw veery impressive congrats <3

 

[sg2000]

Definitely moms.

All are from around 26 years old after I started finasteride. It was even worse before, but I've no photos of that period.

wait were the last 2 hair growth results from HRT?

 

[sg2000]

Around 20-21.

daamn in my case i started way earlier like 17 or maybe even 16

 

[Adri23]

Twinsies... yay =)

Yeah unfortunately it's DHT related...

Yep, they definitely have some similarities, but tbh, my SHBG was always kinda proportional to E and I actually had the same SHBG as now with 11ng/dl DHT with almost same E dose.

I think time matters too, the more time you spend with high shbg the more androgen deprived you get so the more your body try to upregulate the lack of T, but yeah it is not a proven theory either, but if you see many cancer patients the body tends to do stuff to change stuff in order to androgens to keep reaching the receptors.

but yours spiked for no reason if i'm not mistaken.

I increased bica for no reason... That might had lower my circulating T even more, then DHT started to spike and shbg started to increase. After that I had a period of big anxiety and depression and I was barely eating (lost 7 kg within 3 months) so yea SHBG increased even more from lack of calories...

Regarding my high SHBG btw, I think it has smth to do with high E metabolisation. There's a good chance that my E peaks with huge levels far earlier than trough and SHBG accumulates from that peaks, because of its long half life of about 2 weeks. And, again, because of high metabolism, E doesn't accumulate too well and trough levels turn out to be just tiny amounts of peak levels, if that makes sense. I think that because when I was on sublingual pills, they usually lasted for about 3-4 hours and I was getting menopausal symptoms after that.

Could be, that is why I think lowering e2 is important. You need to be around 300 pg/ml at trough, like trough is what really matters.

Some also say that high SHBG with moderate E = good responder, but I honestly think that there's nothing good about that, just huge fluctuations in E levels and SHBG elevation. Considering this, think I'm gonna try injecting more frequently, like 4mg/6days.

High SHBG like anything else is never good. Body needs homeostasis, if something is too low or too high it starts to give issues. Lowering your dosage is a good call!

Ye, 300pg/ml, thats actually the number I'm going for, seems like a decent amount.

Definitely. Want to go even lower when I get the orchi, like 230-250 pg/ml at trough.

Sore breasts are a very good sign IMO, mb sticking to your current dose is the answer. =)

Yeah. I always had sore nipples even with my old dosage but now it got even more intense, kinda annoying tho.

It definitely could be. Brain reacts to lack of hormones by stimulating one of axis organs (adrenal, thyroid, or gonads) to produce their own hormones and if deficiency doesn't resolve, some organ might become malfunction and when brain finds out about that via nerve impulses, it might start acting funny and do things like hormonal stress response via HPA. And if this stress is prolonged, and adrenal is overstimulated for a long time, might even cause CAH, afaik. Alongside with that, some pathways and co-factors might change and functionality of some other organs as a result, which will also contribute to hormonal imbalance.

I'm scared my body would never function like before even if I fix things...

Regarding my free T, honestly no idea (guess I need to measure it too), might as well be my issue, but I bet Bica does far more in terms of systemic T deprivation, than SHBG.

Yeah u def has to measure, and yeah bica does far more. Im not using high dosages, I am using the minimum dosage that is effective imo but if you combine that with shbg of 91.4 pmol/l the T suppression increases even more.

 

[Adri23]

Definitely moms.

Seems like when mother side is the issue we get extra fucked

 

[sg2000]

2mg is kinda a big step, I'd better reduce by 1 mg per week.

lol what?you mean 0.1 ml instead of 0.2 ml?

 

[losingbattle88]

yes i will.
I will chew gums instead lol

Or become a woman, you live in west Europe it's very easy for you.

I rather die than to become a woman. Just a little gyno would put me in deep depression.

 

[sg2000]

No, I meant reduce to 7mg first, then to 6mg next week.

why? why cant i just go to 5 or 6 mg today?my e2 levels were ridiculous 900 pg ml today is my injection day.

 

[Adri23]

I actually think that body can't just decide to exchange some androgen with another one, it kinda happens by itself with some complex variation of natural selection via stress response. I'm not 100% sure tho, need to do more research.

Yeah. Also making DHT is easy for the body because there are so many pathways and it is the most potent androgen.

Ye, all this could totally conribute to stress response, especially diet IMO.

Yeah. I have been with this issue for a whole year. I even stopped bica for a month and now I eat more, but nothing got solved. My last chance is to lower e2

I mean, I just need to find the perfect day to measure my trough. And that's totally not the 7th day. =)

Yeah, but day 7 is somewhat important too to know the trough

I'm sure we'll somehow find a way outa this. =)

I hope so....

Ok, I'm gonna measure next month.

That would be great

 

[sg2000]

btw already injected 5/5.5 mg

 

[losingbattle88]

btw already injected 5/5.5 m

How is the nicotine gum working for ya boi? xD

 

[losingbattle88]

Quitting smoking is harder than you think. Its like me saying that I will stop alcohol but here we are again with two 10.2% beers in the sun.