Exploring The Hormonal Route. Hair=life.

[Capone]

I know, i always feared it to be the case with me, i have had issues with my heart since i was 14, where it beats irregularly,,, heart palpitations, beat..beat..beat..pause.....hard beat.. beat, every so often, and heart pains, but doctors said my heart was perfectly fine in 2015 when i went to find out what was going on, and then 15 months or so later, hair loss started and so began the nightmare lol. Might be related, might be coincidence.

I have something similar.. the pause and then a harder beat.. fks me off big time. I could have a really bad episode if I mess with my electrolytes. I’m convinced lowering or blocking my DHT can cause them. Propranolol works but it causes hair loss, typical

 

[Yar]

[QUOTE = "LEXUS, post: 1836026, member: 139951"] Не может быть. без финастерида или дутастерида волосы не будут расти. Вы не могли отрастить волосы на CPA и эстрадиоле. cypro не блокирует dht. без блока DHT невозможно лечить волосы. [/ QUOTE]

I do not use any dht inhibitors. Against this, by inhibiting 5a you inhibit other metabolites. Example: 5a dihydroprogesterone because it acts on 5a reductase which makes other hormone metabolites. Progesterone - 5a - dihydroprogesterone. Study all the hormones and their metabolites that pass through 5a. Inhibit 5a, you inhibit other metabolites. Transits using only testosterone inhibitors and using estradiol grow very beautiful hair. At the moment, I generally switched to Shemale mode.

 

[Yar]

[QUOTE = "LEXUS, post: 1836026, member: 139951"] Не может быть. без финастерида или дутастерида волосы не будут расти. Вы не могли отрастить волосы на CPA и эстрадиоле. cypro не блокирует dht. без блока DHT невозможно лечить волосы. [/ QUOTE]

 

[Yar]

this is what my travel kit looks like

 

[omega]

Hey,

I used 5mg finasteride and 1,5mg topical estradiol for 1y. (2018 aug. - 2019 sep.), but it doesn't work.
I don't want to use Dutasteride because of the negative stronger sexual effects. The exact role of hormones is uncertain. + Dutasteride doesn't work for everyone.

There may be a correlation between higher testosterone levels and hair loss in Androgenetic Alopecia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419033/

"It is logical that some reduction in hair loss and miniaturization may occur if the conversion of testosterone to its stronger androgen, DHT, is prevented......."

"Spironolactone is a potassium-sparing diuretic that functions as a competitive aldosterone antagonist and inhibits the interaction of testosterone and DHT with intracellular androgen receptors in target tissues (van Zuuren et al., 2012, Yazdabadi and Sinclair, 2011). Spironolactone also weakly inhibits androgen synthesis (Price, 2003). The anti-androgen effect is more commonly used in hirsutism and acne but has been used successfully at 100- to 200-mg daily doses to treat FPHL (Sinclair et al., 2005). One retrospective study of survey data showed that nearly 75% of women reported stabilization or improvement of their hair loss after treatment with spironolactone (Famenini et al., 2015). Similar results were obtained in an open intervention study from 2005 (Sinclair et al., 2005). While the vast majority of published data discusses adult patients, one case report described the visible improvement of FPHL in a 9-year-old patient after 6 months of therapy (Yazdabadi et al., 2009)."

"Cyproterone acetate works in several ways. It not only competitively blocks DHT from binding to its receptors at target tissue (Gilman et al., 1990), but it is also a progestogen that lowers testosterone levels by decreasing the release of luteinizing and follicle-stimulating hormones through pituitary-mediated supression (Gilman et al., 1990, Varothai and Bergfeld, 2014). "


Dht has a stronger effect on sexual activity than testosterone. And testosterone has a stronger effect on hair loss than Dht. Is it safer and effective to minimize testosterone levels? ex.: 25mg Spironolactone. without fina / duta and estradiol.

 

[Yar]

Hey,

I used 5mg finasteride and 1,5mg topical estradiol for 1y. (2018 aug. - 2019 sep.), but it doesn't work.
I don't want to use Dutasteride because of the negative stronger sexual effects. The exact role of hormones is uncertain. + Dutasteride doesn't work for everyone.

There may be a correlation between higher testosterone levels and hair loss in Androgenetic Alopecia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419033/

"It is logical that some reduction in hair loss and miniaturization may occur if the conversion of testosterone to its stronger androgen, DHT, is prevented......."

"Spironolactone is a potassium-sparing diuretic that functions as a competitive aldosterone antagonist and inhibits the interaction of testosterone and DHT with intracellular androgen receptors in target tissues (van Zuuren et al., 2012, Yazdabadi and Sinclair, 2011). Spironolactone also weakly inhibits androgen synthesis (Price, 2003). The anti-androgen effect is more commonly used in hirsutism and acne but has been used successfully at 100- to 200-mg daily doses to treat FPHL (Sinclair et al., 2005). One retrospective study of survey data showed that nearly 75% of women reported stabilization or improvement of their hair loss after treatment with spironolactone (Famenini et al., 2015). Similar results were obtained in an open intervention study from 2005 (Sinclair et al., 2005). While the vast majority of published data discusses adult patients, one case report described the visible improvement of FPHL in a 9-year-old patient after 6 months of therapy (Yazdabadi et al., 2009)."

"Cyproterone acetate works in several ways. It not only competitively blocks DHT from binding to its receptors at target tissue (Gilman et al., 1990), but it is also a progestogen that lowers testosterone levels by decreasing the release of luteinizing and follicle-stimulating hormones through pituitary-mediated supression (Gilman et al., 1990, Varothai and Bergfeld, 2014). "


Dht has a stronger effect on sexual activity than testosterone. And testosterone has a stronger effect on hair loss than Dht. Is it safer and effective to minimize testosterone levels? ex.: 25mg Spironolactone. without fina / duta and estradiol.

it won’t work! Use trans means spironolactone, cyproterone acetate, estradiol. Use a full transgender regimen.

 

[Yar]

Hey,

I used 5mg finasteride and 1,5mg topical estradiol for 1y. (2018 aug. - 2019 sep.), but it doesn't work.
I don't want to use Dutasteride because of the negative stronger sexual effects. The exact role of hormones is uncertain. + Dutasteride doesn't work for everyone.

There may be a correlation between higher testosterone levels and hair loss in Androgenetic Alopecia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419033/

"It is logical that some reduction in hair loss and miniaturization may occur if the conversion of testosterone to its stronger androgen, DHT, is prevented......."

"Spironolactone is a potassium-sparing diuretic that functions as a competitive aldosterone antagonist and inhibits the interaction of testosterone and DHT with intracellular androgen receptors in target tissues (van Zuuren et al., 2012, Yazdabadi and Sinclair, 2011). Spironolactone also weakly inhibits androgen synthesis (Price, 2003). The anti-androgen effect is more commonly used in hirsutism and acne but has been used successfully at 100- to 200-mg daily doses to treat FPHL (Sinclair et al., 2005). One retrospective study of survey data showed that nearly 75% of women reported stabilization or improvement of their hair loss after treatment with spironolactone (Famenini et al., 2015). Similar results were obtained in an open intervention study from 2005 (Sinclair et al., 2005). While the vast majority of published data discusses adult patients, one case report described the visible improvement of FPHL in a 9-year-old patient after 6 months of therapy (Yazdabadi et al., 2009)."

"Cyproterone acetate works in several ways. It not only competitively blocks DHT from binding to its receptors at target tissue (Gilman et al., 1990), but it is also a progestogen that lowers testosterone levels by decreasing the release of luteinizing and follicle-stimulating hormones through pituitary-mediated supression (Gilman et al., 1990, Varothai and Bergfeld, 2014). "


Dht has a stronger effect on sexual activity than testosterone. And testosterone has a stronger effect on hair loss than Dht. Is it safer and effective to minimize testosterone levels? ex.: 25mg Spironolactone. without fina / duta and estradiol.

take 100 mg, 50 morning and 50 evening spironolactone and 1-2 mg estradiol

 

[Capone]

[QUOTE = "LEXUS, post: 1836026, member: 139951"] Не может быть. без финастерида или дутастерида волосы не будут расти. Вы не могли отрастить волосы на CPA и эстрадиоле. cypro не блокирует dht. без блока DHT невозможно лечить волосы. [/ QUOTE]

I do not use any dht inhibitors. Against this, by inhibiting 5a you inhibit other metabolites. Example: 5a dihydroprogesterone because it acts on 5a reductase which makes other hormone metabolites. Progesterone - 5a - dihydroprogesterone. Study all the hormones and their metabolites that pass through 5a. Inhibit 5a, you inhibit other metabolites. Transits using only testosterone inhibitors and using estradiol grow very beautiful hair. At the moment, I generally switched to Shemale mode.

Doesn’t estrogen inhibit 5ar.. both can’t be high at the same time. Either or

 

[mryellowman]

This is regrowth i suppose ?

 

[Louisa]

looks like it to me

Are you still using Dutaresteride?

 

[Yar]

[QUOTE = "Капоне, пост: 1836200, член: 29953"] Не ингибирует эстроген 5ar .. оба не могут быть высокими одновременно. Либо или [/ QUOTE]

Doesn’t estrogen inhibit 5ar.. both can’t be high at the same time. Either or

it does not need to be suppressed, 5a does not need to be suppressed. It makes other hormone metabolites.

 

[Yar]

Doesn’t estrogen inhibit 5ar.. both can’t be high at the same time. Either or

it does not need to be suppressed, 5a does not need to be suppressed. 5a does other metabolites. Use a dihydrotestosterone antagonist.

 

[Derelict]

Ok im definitely stopping spironolactone until i have lost quite a bit of weight then restart it again, the gyno is seriously bad. Because im overweight it's hard to tell how bad it really is so once i lose a few stone i will try it again. My gyno is wayyy worse than bridgeburns for example.

 

[Mr. Grey]

I think Dutasteride was unnecessary, My hair was growing back just fine on CPA + Estradiol, i added Dutasteride because i was impatient, and I got the Telogen Effluvium that usually comes with starting drugs like Finasteride or Dutasteride, Im still recovering from my Telogen Effluvium.

CPA blocks DHT pretty effectively:

"Cyproterone acetate works in several ways. It not only competitively blocks DHT from binding to its receptors at target tissue (Gilman et al., 1990), but it is also a progestogen that lowers testosterone levels by decreasing the release of luteinizing and follicle-stimulating hormones through pituitary-mediated supression (Gilman et al., 1990, Varothai and Bergfeld, 2014)."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419033/


also with a Testosterone level of 25 ng/dl, there is hardly any DHT being converted at all, which means that 100% of DHT is blocked.

Dutasteride is not cause telogen. It is working fine for a lot of people. How I know you break down with minoxidil, which cause telogen for 100%

 

[Peace]

Yes, anyone who wants to join the discord, please PM me!

I can't figure out how to PM, but may I have an invite?

 

[Derelict]

I didn't really notice much of a shed with dutasteride but i started oral minoxidil very close to when starting it, i shed a ton, maybe the oral minoxidil and dutasteride sheds happened roughly at the same time. Anyway, hope your hair recovers noah.

 

[Yar]

use estradiol, it is a dihydrotestosterone antagonist. Cancel inhibitors 5a, they are harmful.

 

[Father_of_Shiseido]

it won’t work! Use trans means spironolactone, cyproterone acetate, estradiol. Use a full transgender regimen.

Adding estradiol will cost a lot.

 

[baba_yaga]

Would real micro dosing (<0.05 mg) of finasteride and building the dose up, avoid Telogen Effluvium?

 

[Jacob Williams]

I don’t want to jinx myself but I think bicalutamide is working now.