Exploring The Hormonal Route. Hair=life.

[John Difool]

There is a good paper on the role of Estrogen with hair foliicles.
https://www.researchgate.net/publication/7486010_Estrogens_and_the_hair_follicle

 

[Rysteve93]

Ok guys, I’m using avodart .5 mg daily (1.5years) and Loniten 15mg daily (3 months).

I need to be more aggressive, is Bicalutamide and topical E worth adding to my regime? I need results!

I was thinking 100mg bic, Estrogel, and novadex 10mg

 

[Stephen788]

A lot of your are taking estrogen (as I’m thinking about possibly to) but do any of Yous actually have Good regrowth? Very few people.

If you take E alone the chances are you won’t get the regrow much. You need to combine E with an AA for decent results. If you do not wish to nuke your T then you are like me. I am on 100mg - 150mg of spironolactone. I alternate the amount because it prevents in T levels from getting to low. My T is at a level where I can get an erection And still ejaculate although it’s much smaller quantity of sperm. In terms of regrowth. I am definitely regrowing. But a lot slower then if you were to go on e + spironolactone for example. Be aware that gyno is an issue. I take letro when it starts playing up for about a week until it subsides.

 

[pegasus2]

Ok guys, I’m using avodart .5 mg daily (1.5years) and Loniten 15mg daily (3 months).

I need to be more aggressive, is Bicalutamide and topical E worth adding to my regime? I need results!

I was thinking 100mg bic, Estrogel, and novadex 10mg

That's a big commitment, and not seeing it through will only make things worse. You better be sure you're prepared to handle the very serious sides before doing it. There are so many other things you can try first besides dutasteride and minoxidil.

 

[Father_of_Shiseido]

Ok guys, I’m using avodart .5 mg daily (1.5years) and Loniten 15mg daily (3 months).

I need to be more aggressive, is Bicalutamide and topical E worth adding to my regime? I need results!

I was thinking 100mg bic, Estrogel, and novadex 10mg

Bicalutamide that too on 100 mg is not a joke. You will definitely see feminizing side effects. If you don't respond to 50 mg, then you will not respond to 100 mg either.

 

[Father_of_Shiseido]

If you take E alone the chances are you won’t get the regrow much. You need to combine E with an AA for decent results. If you do not wish to nuke your T then you are like me. I am on 100mg - 150mg of spironolactone. I alternate the amount because it prevents in T levels from getting to low. My T is at a level where I can get an erection And still ejaculate although it’s much smaller quantity of sperm. In terms of regrowth. I am definitely regrowing. But a lot slower then if you were to go on e + spironolactone for example. Be aware that gyno is an issue. I take letro when it starts playing up for about a week until it subsides.

Don't you see the feminizing face on spironolactone?

 

[Rysteve93]

That's a big commitment, and not seeing it through will only make things worse. You better be sure you're prepared to handle the very serious sides before doing it. There are so many other things you can try first besides dutasteride and minoxidil.

What would you suggest, RU?

 

[Stephen788]

Don't you see the feminizing face on spironolactone?

I don’t think my face has changed at all really. I have recently shaved my beard. My face may have feminised, because an AA should feminise you, but not noticeable to me.
I’ve been on spironolactone since January 2019. I switched to bica briefly for a few months in jan 2020 but went back in spironolactone again.

 

[Rysteve93]

I don’t think my face has changed at all really. I have recently shaved my beard. My face may have feminised, because an AA should feminise you, but not noticeable to me.
I’ve been on spironolactone since January 2019. I switched to bica briefly for a few months in jan 2020 but went back in spironolactone again.

Any results? Stabilisation, density improvement? Overall experience?

 

[Father_of_Shiseido]

I don’t think my face has changed at all really. I have recently shaved my beard. My face may have feminised, because an AA should feminise you, but not noticeable to me.
I’ve been on spironolactone since January 2019. I switched to bica briefly for a few months in jan 2020 but went back in spironolactone again.

What about the others? Do they notice any changes to your face?

 

[Jacob Williams]

Anyone using bica or cypro instead of spironolactone should also be using eplerenone to block the mineralocorticoid receptor. Bica and cypro won't cover that, and that's probably why they don't seem to grow as much hair as spironolactone.

Can you elaborate? I’ve never even heard of eplerenone or the mineralcorticoid receptor before.

 

[Jacob Williams]

Also after a bit of research I’m very close to fully convinced that Vitamin D absorption/VDR play a major role in alopecia.

 

[Jacob Williams]

Also after a bit of research I’m very close to fully convinced that Vitamin D absorption/VDR play a major role in alopecia.

Has anyone experimented with VDR agonists?

 

[John Difool]

Can you elaborate? I’ve never even heard of eplerenone or the mineralcorticoid receptor before.

Elaborate yourself. Google. First result typing Eplerenone & Mineralcorticoid

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157540/

 

[John Difool]

Also after a bit of research I’m very close to fully convinced that Vitamin D absorption/VDR play a major role in alopecia.

Can't wait to read your research paper. Are you starting to experiment with vitamin D?

 

[pegasus2]

Can you elaborate? I’ve never even heard of eplerenone or the mineralcorticoid receptor before.

The mineralocorticoid receptor is responsible for fibrosis. Eplerenone and spironolactone are MCR antagonists, blocking the negative effects of aldosterone and cortisol, downregulating GPER, and reversing fibrosis. Spironolactone is also an androgen antagonist, while eplerenone is not.

Has anyone experimented with VDR agonists?

Lots of people have. It is only a major issue in alopecia areata.

 

[John Difool]

Did you mean Minor

 

[pegasus2]

What would you suggest, RU?

Before you go full HRT, RU is the bare minimum of what you can try. Topical darolutamide, ASC-J9(very messy, you must be dedicated), Wnt agonists, microneedling. If you're a cis male HRT is not a trivial thing. You should exhaust all other options before trying it.

Did you mean Minor

No, it plays a significant role in immune-related hair loss. In androgenetic alopecia it is minor.

 

[Rysteve93]

Let’s just say one was to go down the anti Androgen route, is Spironolactone the better choice? I see a lot of yous guys using it. From what I’ve read it’s extremely harsh on the liver, not really sustainable long term & weaker in comparison to others. Also it is total shut down of production of T, Where as Bic is a lot more potent and safer to use. Doesn’t directly shut down T production but it binds to androgen receptors.

I’m no expert and I’m pretty novice when it comes to this route I’m just trying to understand it clearly before choosing to do anything.

can any of you guys weigh pros and cons of..

Cpa
spironolactone
Bic

 

[NorwoodingMyWay]

Let’s just say one was to go down the anti Androgen route, is Spironolactone the better choice? I see a lot of yous guys using it. From what I’ve read it’s extremely harsh on the liver, not really sustainable long term & weaker in comparison to others. Also it is total shut down of production of T, Where as Bic is a lot more potent and safer to use. Doesn’t directly shut down T production but it binds to androgen receptors.

I’m no expert and I’m pretty novice when it comes to this route I’m just trying to understand it clearly before choosing to do anything.

can any of you guys weigh pros and cons of..

Cpa
spironolactone
Bic

CPA : very effective at lowering T levels even in low doses. The most common doses used in HRT is 6.25 mg- 25 mg. Not sustainable long term (possible side effects of brain tumours, liver diseases, cardiovascular complications, troubled metabolism ect...)




Spironolactone : quite effective in blocking androgens. Controversial on whether it lowers T levels or not. High doses (>200 mg) may be needed to block a substantial amount of male range T / DHT. The most common doses used in HRT are 50 mg- 200 mg. Carries more common side effects such as dizziness, dehydration, excessive sweating / peeing, low blood pressure, passing out ect... In sever cases, it can lead to death due to hyperkaleamia and kidney failure.




Bica : very effective in blocking androgen. High doses (100 mg and more) may be needed to block male range T / DHT. The most common dosage is 50 mg used in HRT. Minimal common side effects ( hot flashes, dizziness ect...), but carries a significant Gyno probability. Severe side effects are liver failure and seizures.




Choose your poison.