Exploring The Hormonal Route. Hair=life.

[Gergely]

There's someone who's already pretty much done what you're describing

/femgen/ Mad Science

Summary The purpose of this document is to provide information on an experimental drug combination. This aim of this combo is to stop masculinization and provide slight feminization while avoiding breast growth and retaining genital function. Basically HRT-lite. As of 9/16/2018, I have discontin...

docs.google.com

This was the document i mentioned earlier, i couldn't find it

 

[Pls_NW-1]

There's someone who's already pretty much done what you're describing

/femgen/ Mad Science

Summary The purpose of this document is to provide information on an experimental drug combination. This aim of this combo is to stop masculinization and provide slight feminization while avoiding breast growth and retaining genital function. Basically HRT-lite. As of 9/16/2018, I have discontin...

docs.google.com

Yeah, know him already. Tho his protocol might not work for us. But we can clearly see here the effect of bica systemically. The dude went from a rough and aggressive 19-year old boy to a cute 12 yo femboy lol

 

[Pls_NW-1]

Bicalutamide 50-100mg + 1mg finasteride more optimal

I would prefer this then:
100mg Bicalutamide
1mg Finasteride
+optional 5mg Minoxidl

++GYNO SURGERY lol

Edit: I dont think 50mg Bica will be sufficient enough.

 

[Almas]

If 50mg has even a tiny effect, I'll switch to 75mg. If they don't change anything at all, I'll jump to 100mg right away.

 

[Pls_NW-1]

If 50mg has even a tiny effect, I'll switch to 75mg. If they don't change anything at all, I'll jump to 100mg right away.

When do you plan to test your T?

 

[deathdiss]

im thinking of giving pharmacy estriol a shot. cream wise specifically that could replace bi-estro cream.


because bi-estro is far lower in dosage...but applied on the scalp it doesnt produce any systemic effect. So I'm wondering if this could be the same for estriol cream from pharma?

 

[Pls_NW-1]

im thinking of giving pharmacy estriol a shot. cream wise specifically that could replace bi-estro cream.


because bi-estro is far lower in dosage...but applied on the scalp it doesnt produce any systemic effect. So I'm wondering if this could be the same for estriol cream from pharma?

Many on this thread rated Estriol as pretty much; pregnant horse-piss.

Hope this clarifies, I think you would do much better on the bi-estro cream.

 

[Pls_NW-1]

He really got pretty skinny and slim, on the before he looked really well "shaped" lol.

•Possible facial feature softening and muscle atrophy
Looks like a 11 year old tomboy

 

[tato123]

There's someone who's already pretty much done what you're describing

/femgen/ Mad Science

Summary The purpose of this document is to provide information on an experimental drug combination. This aim of this combo is to stop masculinization and provide slight feminization while avoiding breast growth and retaining genital function. Basically HRT-lite. As of 9/16/2018, I have discontin...

docs.google.com

CPA + BICALUTAMIDA is the most fucked up nuclear bomb it has, along with raloxifene yet.


Come on let's analyze.

CPA in addition to antiandrogen is an LH / FSH inhibitor.


In some cases bicalutamide is prescribed with LH / FSH inhibitors most of the time in fact to prevent peak testosterone in patients with prostate cancer.

However, the list of side effects would give 3 pages here including I don’t know, urinating blood, failure of several organs, all drugs that will f*** your liver in 4 will be in the scheme .


There was no hormonal response without T without E

And CPA will block ER too.

He didn't use any estrogen, but the photos are terrible too, you can't see how bad his baldness was before.

But here's another example of a therapeutic scheme imprababily of regrowth , the guy suppressed everything in his body and grew hair

placebo effect?
Androgenic alopecia?
Who knows ?

 

[Pls_NW-1]

CPA + BICALUTAMIDA is the most fucked up nuclear bomb it has, along with raloxifene yet.


Come on let's analyze.

CPA in addition to antiandrogen is an LH / FSH inhibitor.


In some cases bicalutamide is prescribed with LH / FSH inhibitors most of the time in fact to prevent peak testosterone in patients with prostate cancer.

However, the list of side effects would give 3 pages here including I don’t know, urinating blood, failure of several organs, all drugs that will f*** your liver in 4 will be in the scheme .


There was no hormonal response without T without E

And CPA will block ER too.

He didn't use any estrogen, but the photos are terrible too, you can't see how bad his baldness was before.

But here's another example of a therapeutic scheme imprababily of regrowth , the guy suppressed everything in his body and grew hair

placebo effect?
Androgenic alopecia?
Who knows ?

It wasn't even meant for hair. He now takes Bica + E injections. He's non-binary I think, and he dropped Ralox and is growing now huge milker-tittieesss.

 

[tato123]

It wasn't even meant for hair. He now takes Bica + E injections. He's non-binary I think, and he dropped Ralox and is growing now huge milker-tittieesss.

I got it, I thought it was a regimen for hair regrowth.

 

[Pls_NW-1]

My best bet is to take bica 100mg + finasteride 1mg. If regrowth does not happen, but halt, then minoxidil, and if still unhappy, try cycling in E for a period of time, if you are willing all its effects.

I still try to find some infos on Eplerenone.

 

[Pls_NW-1]

"However, the role of mineralocorticoid receptor (MR) signaling is now known to extend beyond the kidney, with human skin, including the hair follicle (HF), expressing the MR. Using microdissected female HFs treated ex vivo with MR agonists and antagonists, we sought to determine the effects of MR-mediated signaling in the cutaneous context. Indeed, not only did the skin and HF epithelium express the MR at both the gene and protein level, but its expression was hair cycle dependent. Moreover, the selective MR antagonist eplerenone promoted hair shaft elongation and hair matrix keratinocyte proliferation whilst delaying catagen (HF regression)."

Mineralocorticoid Receptor Antagonists Stimulate Human Hair Growth ex vivo - PubMed

Whilst topical steroids represent one of the most frequently administered treatments for skin and hair diseases, predominantly based on their glucocorticoid receptor-mediated anti-inflammatory effects, the mineralocorticoid effects of topical steroids have received surprisingly little attention...

pubmed.ncbi.nlm.nih.gov

TL; DR:

MCR antagonists elongate anagen phase and prevent/reverse fibrosis.

Spironolactone inhibits MCR as a side effect as well, this might explain why spironolactone is sometimes for some people even more effective than Bicalutamide. I think we should combine Eplerenone to our cocktail.

I will research about this drug even more; effectivness, hepatotoxicity, side effects, interactions.

 

[Pls_NW-1]

Eplerenone:

Mechanism:

"Eplerenone (e pler' e none) is a competitive antagonist of aldosterone at the mineralocorticoid receptor. The aldosterone receptor in the late distal tubules and collecting ducts of the kidneys induces sodium reabsorption and potassium excretion in the distal tubule. Inhibition of this receptor promotes a sodium diuresis, but maintains body potassium levels. Eplerenone has a higher affinity for the aldosterone receptor than spironolactone and is claimed to have fewer anti-androgenic effects (gynecomastia, hair loss). However, the two molecules are structurally quite similar."

Eplerenone - LiverTox - NCBI Bookshelf

www.ncbi.nlm.nih.gov

Hepatotoxicity:

clinically apparent liver injury from eplerenone has yet to be reported. The similarity in structure to spironolactone suggests that it may share susceptibility to the acute liver injury reported rarely with that agent.

Likelihood score: E* (unproven but suspect rare cause of clinically apparent liver injury).

Eplerenone - LiverTox - NCBI Bookshelf

www.ncbi.nlm.nih.gov

Cool drug, a shame I didn’t knew earlier. Works like spironolactone without AA properties. In combo with bica, this would be cool, ngl.

 

[Yar]

If someone wants to restore hair growth welcome to contact me in private messages

 

[Pls_NW-1]

If someone wants to restore hair growth welcome to contact me in private messages

Yar, I would love to hear your hair loss journey and your story.

 

[Yar]

Yar, I would love to hear your hair loss journey and your story.

My journey started like everyone else with finasteride,it didn't give me any results for several months,even the temples began to leave.I am a supporter of the fact that if I drink the drug, it should show a result in a week,but the weeks went by and there was no result and there were even deterioration.Then I switched to ciproterone 12.5-25 and 2-4mg of estrophem alternating doses of 2/4, this brought results my temples began to show results but still remained insignificant.I was faced with the fact that my hair began to get greasy.And my seborrhea at that time worsened.Seborrheic fat flowed out of my head.I stopped taking ciproterone because I came to the conclusion that it lowers the liver shbg and there are more free androgens.I switched to spironolactone and started taking it at a dose of 50 / 100mg per day,this showed a very good result and my seborrhea disappeared as free androgens became scarce due to an increase in liver shbg.I have overgrown my temples a little.I was happy with my result.Then I came across information about progesterone, in addition to this, I learned information about progesterone from a knowledgeable person and switched to progesterone.I don't take Spironolactone anymore.It made me lose weight quickly, and my wrinkles sharpened and became clearer.And so I started using progesterone and it gives me great results.All the side effects that I earned I experienced before taking progesterone namely this small breast.If I had started taking it initially, I wouldn't have had such small breasts.But it does not prevent me from living, since at any time I can switch to testosterone to experience the growth of muscles in my chest and it will be a normal male breast, of course I will stop taking progesterone and start taking testosterone in gel.

 

[Pls_NW-1]

My journey started like everyone else with finasteride,it didn't give me any results for several months,even the temples began to leave.I am a supporter of the fact that if I drink the drug, it should show a result in a week,but the weeks went by and there was no result and there were even deterioration.Then I switched to ciproterone 12.5-25 and 2-4mg of estrophem alternating doses of 2/4, this brought results my temples began to show results but still remained insignificant.I was faced with the fact that my hair began to get greasy.And my seborrhea at that time worsened.Seborrheic fat flowed out of my head.I stopped taking ciproterone because I came to the conclusion that it lowers the liver shbg and there are more free androgens.I switched to spironolactone and started taking it at a dose of 50 / 100mg per day,this showed a very good result and my seborrhea disappeared as free androgens became scarce due to an increase in liver shbg.I have overgrown my temples a little.I was happy with my result.Then I came across information about progesterone, in addition to this, I learned information about progesterone from a knowledgeable person and switched to progesterone.I don't take Spironolactone anymore.It made me lose weight quickly, and my wrinkles sharpened and became clearer.And so I started using progesterone and it gives me great results.All the side effects that I earned I experienced before taking progesterone namely this small breast.If I had started taking it initially, I wouldn't have had such small breasts.But it does not prevent me from living, since at any time I can switch to testosterone to experience the growth of muscles in my chest and it will be a normal male breast, of course I will stop taking progesterone and start taking testosterone in gel.

You are not transgender, right?

I really like your story! But don't you think taking Testosterone again might hurt your hair?? What's your plan?

And how can I increase liver SHBG without using Spironolactone. Does Eplerenone raise SHBG levels as well?

 

[Yar]

Яр, я хотел бы услышать ваше путешествие по выпадению волос и вашу историю.

P/s. I will not stop taking progesterone ,but I will connect testosterone in a gel to test whether it is possible to take only progesterone and testosterone not to earn side effects and return the growth of hair on the head, the perfect hairstyle as in my youth.

 

[Yar]

You are not transgender, right?

I really like your story! But don't you think taking Testosterone again might hurt your hair?? What's your plan?

And how can I increase liver SHBG without using Spironolactone. Does Eplerenone raise SHBG levels as well?

No I'm not afraid the testosterone will destroy my hair is,they will be under the protection of progesterone.I don't know the medicines except spironolactone and oral estradiol, which is able to increase SHBG in the liver.