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male
Exploring The Hormonal Route. Hair=life.
- Thread starter bridgeburn
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A veritable wealth of information on the applications and benefits of metformin, also including some points of concern such as the fact that it suppresses adenosine monophosphate.
www.ncbi.nlm.nih.gov
Metformin - For the dermatologist - PMC
Metformin though primarily an antidiabetic drug, has found to play an important role in a number of cutaneous disorders. Because of its role in improving hyperinsulinemia, it has proven beneficial in hormonal acne, hidradenitis suppurativa (HS) and ...
www.ncbi.nlm.nih.gov
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Thank you very much my friend for enriching our debateA veritable wealth of information on the applications and benefits of metformin, also including some points of concern such as the fact that it suppresses adenosine monophosphate.
Metformin - For the dermatologist - PMC
Metformin though primarily an antidiabetic drug, has found to play an important role in a number of cutaneous disorders. Because of its role in improving hyperinsulinemia, it has proven beneficial in hormonal acne, hidradenitis suppurativa (HS) and ...
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What does inhibiting 5ar activation mean? and to what extent does it inhibit. Also I can't imagine reducing IGF-1 would be in any way beneficial to hair.
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The study is not so specific, I do not know how to tell you or physiologically how it works, I just copied and pasted the study.
Maybe AMPK?
Maybe IGF-1 influences in any way?
this is infinite content if you start researching metformin interacts with our body like rampamycin.
IGF-1 in high dosages is bad, for several different reasons and that would give another very big post, but that has already been discussed here, and in the context of treatment where an outbreak of testosterone because of medication is fair to use a medication to regulate your IGF-1 since high testosterone levels result in high IGF-1
But these are just ramblings, I'm just commenting and posting something pertinent that I just read from our source.
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I'm sure supraphysiological levels of IGF-1 aren't beneficial but drugs that increase circulating IGF-1 by upto 2 fold like Ibutamoren and CsA often have the reported side effect of increased hair growth.
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Nice information
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Rapamycin extends life- and health span because it slows aging - PMC
Making headlines, a thought-provocative paper by Neff, Ehninger and coworkers claims that rapamycin extends life span but has limited effects on aging. How is that possibly possible? And what is aging if not an increase of the probability of death ...
www.ncbi.nlm.nih.gov
"Some age-related alterations actually counteract aging. For example, although RNA/protein synthesis is decreased with aging in model organisms, yet its further inhibition prolongs life span further [138-141]. As shown by Neff et al, rapamycin did not prevent anti-aging alterations such as a decrease in testosterone levels. Noteworthy, testosterone activates mTOR"
In other words, testosterone stimulates Mtor by binding to the AR receptor, that is, high levels of testosterone will result in premature aging.
AMPK inhibits mTor.
Metformin stimulate AMPK
That is infinite content does not end.
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Hey cool. And start with a thesis to prove as it will make it more coherent in terms of topics you approach. You can have several but mine was basically "people need to use more estradiol to regrow hair" and that has sort of been my guiding principle but I go much broader too.
Jug-A-Lug
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YES! Exactly, IMO especially in adults there is a correlation between adult acne or proneness to the hormonal causes of acne and people with a vulnerability to hair loss. Even if you don't have acne or just perhaps oily skin, that's still an indicator of hormonal activity that is probably not desirable for your hair.
Thanks for posting this.
I guess the only major concern for me being as that I have addison's disease is the suppression of adrenal hormones, but I'm literally on hormone replacement for aldosterone and cortisol anyhow.
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Yeah, that's a weird paradox but I think it a 50/50 whether you're going to get the benefit or you're just going to get awful acne and hair loss due to upregulated sebum production and the fact that IGF-1 increases go hand in hand with an increase in other androgens.
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My IGF-1 has for some reason gone up as of late and all I can tell you is it has done nothing but cause a nightmare for my skin and hair.
It's not good to have it too low, but my IGF-1 is a matter of points above the reference range and my skin in some ways was worse then during puberty, I never had scalp acne during puberty, and IGF-1 can upregulate hormones that just f*** with hair. I know far better ways to take care of my skin now, so I'm not the mess I was when I was 15, but the scalp acne is a hard one, the estrogel saved me on that account.
5AR inhibition is basically the standard that most people resort to when responding to androgenetic alopecia, it prevents the enzyme from converting testosterone to DHT, which is why some people with whom finasteride works - see a precipitous rise in estrogen because instead that testosterone is in part at least converted into estrogen.
This is why I think finasteride largely works when taken orally, I think that topical finasteride has some other kind of mechanism of action that may be related, but it seems like having the drug applied directly to sensitive tissues just locally blocks the effects of androgens.
Basically I would call the mechanism of topical finasteride basically a controlled application of PFS, which sounds crazy but I do think the accumulation of finasteride in tissues itself where it is not wanted is the cause of PFS, but if you're just applying it to the skin and it is mostly staying there, you're generating the same effect albeit controlled and localized.
It's good to have enough IGF-1, but having too much has been nothing but a skin and hair nightmare for me.
thankfully applying estrogel directly to my scalp seems to have calmed a lot of that down and offset it, but I still have to deal with unreasonably oily skin that that I have to constantly attend to throughout the day, and that is 100% a proven side effect of high IGF-1, I have literally nuked my testosterone and DHT and my skin is still oily because of IGF-1.
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SMILE upregulated by metformin inhibits the function of androgen receptor in prostate cancer cells
Metformin, a diabetes drug, has been reported to inhibit the growth of prostate cancer cells. In this study, we investigated the effect and action mec…
"Metformin treatment reduced cell viability and enhanced apoptosis for both cell lines and additive effects were observed when LNCaP cells were treated with combined metformin and bicalutamide. Metformin down‐regulated full‐length AR protein in LNCaP cells. Both full‐length and the truncated AR (AR‐v7) were down‐regulated by metformin in CWR22Rv1 cells. In both LNCaP and CWR22Rv1 cells, metformin repressed AR signaling pathway not by affecting AR protein degradation/stability, but rather through DOWN-REGULATING the levels of AR mRNAs."
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Wow tf, great find. Metformin alone could help a lot with VERY mild hair loss.Error - Cookies Turned Off
onlinelibrary.wiley.com
SMILE upregulated by metformin inhibits the function of androgen receptor in prostate cancer cells
Metformin, a diabetes drug, has been reported to inhibit the growth of prostate cancer cells. In this study, we investigated the effect and action mec…www.sciencedirect.com
"Metformin treatment reduced cell viability and enhanced apoptosis for both cell lines and additive effects were observed when LNCaP cells were treated with combined metformin and bicalutamide. Metformin down‐regulated full‐length AR protein in LNCaP cells. Both full‐length and the truncated AR (AR‐v7) were down‐regulated by metformin in CWR22Rv1 cells. In both LNCaP and CWR22Rv1 cells, metformin repressed AR signaling pathway not by affecting AR protein degradation/stability, but rather through DOWN-REGULATING the levels of AR mRNAs."