Exploring The Hormonal Route. Hair=life.

[Stephen788]

check out my thread(https://www.gourmetstylewellness.com/interact/threads/how-much-t-dht-does-bicalutamide-block.123281/) on how I calculated my bicalutamide dosage

what is ur regimen btw and what do u want to change to?

If you don't use raloxifene/tamoxifene then 50mg will be more than enough

My regimen is:
10mg oral min (started April 2019 was on topical min for 6 years before that)
0.5mg duta (started in April 2018 was on finasteride for 3 years before that)

I was on 200mg of spironolactone for almost 4 months (started in jan 2019). I got gyno bad and had to stop as it really did bother me.
Hopefully bica improves my hair (I’ll start it at 25mg and see how I react and I’ll increase it from there). I didn’t really know what to expect with gyno as a lot of these new guys on this thread probably don’t. But I’ve experienced it now and I can spot it from a mile away. I will always have a couple of packs of raloxifine and letro on hand though. That’s the best advice I can give.

 

[Ikarus]

Maave doesn't have that aggressive of hairloss though, he is non-binary

He still has hair loss though, otherwise he wouldn’t have been on a hair loss website if it was just as therapy for his non-binary identity. There is many contradicting opinions on its effect on DHT; on the transgender part of reddit, there have been people who say since it blocks the androgen receptors, DHT can’t be formed. And then there are some who say it doesn’t have an effect on DHT because of whatever reason. In my opinion, I think it does block DHT. If the androgen receptors are blocked, then how can T convert to DHT?

 

[Stephen788]

Using bicalutamide alone isn’t an ideal situation; there doesn’t seem to be sufficient information on its effect on DHT. People have different opinions, but there isn’t a solid answer. It’s just safer to use dutasteride with it, just in case. Although, I believe Maave uses bicalutamide without 5AR inhibitors/estradiol yet is having results. I am using bicalutamide along with dutasteride and estradiol, with dutasteride just having a supporting role. If you are using bicalutamide along with dutasteride and oral minoxidil, you will have great results.

I hope so haha. Cheers for your reply. I will keep you guys posted on my results.

 

[Stephen788]

Why letrozole dude? It's f*****g powerful AI. And you can't stop it cold turkey and don't suffer any sides. It completely slashes estrogen. I don't know why did you prefer it over tamoxifen/ralox. Even Dht cream would have been a better option.

I did stop I cold turkey and I didn’t get any sidesand it’s been just over 2 weeks now. I did lower the dosage to 2.5mg for a few days but I doubt that made any difference. Letrozole got my gyno down to a size where it’s unnoticeable.

 

[DHTcel]

He still has hair loss though, otherwise he wouldn’t have been on a hair loss website if it was just as therapy for his non-binary identity. There is many contradicting opinions on its effect on DHT; on the transgender part of reddit, there have been people who say since it blocks the androgen receptors, DHT can’t be formed. And then there are some who say it doesn’t have an effect on DHT because of whatever reason. In my opinion, I think it does block DHT. If the androgen receptors are blocked, then how can T convert to DHT?

DHT has a Kd(binding affinity of 0.25-0.5nM) and T has a Kd(binding affinity of 0.4-1.0)nM for the Androgen Receptor

so by using dutasteride u reduce the needed dosage of bicalutamide to block androgens since T has a lower binding affinity than DHT

 

[DHTcel]

When u started balding:
Age: <19 - Super Agressive Hair Loss
<25 - Agressive Hair Loss
<30 - Normal male pattern baldness
<40 - At least you are married buddy

I started at 14-15

 

[I'mme]

I did stop I cold turkey and I didn’t get any sidesand it’s been just over 2 weeks now. I did lower the dosage to 2.5mg for a few days but I doubt that made any difference. Letrozole got my gyno down to a size where it’s unnoticeable.

Lower the dosage to 2.5mg???!!!! 2.5mg is a proper dose for it. If you took more than 2.5mg and are still not bald, you should be thankful to God! Not only will it decrease your gyno it will diminish it completely, together with your hair.

 

[I'mme]

When u started balding:
Age: <19 - Super Agressive Hair Loss
<25 - Agressive Hair Loss
<30 - Normal male pattern baldness
<40 - At least you are married buddy

I started at 14-15

Same dude. I also started at 14 but I tell people 15 just to make myself feel better.

BTW, I'm going on a regimen to get a inch or two (highly unlikely). If I choose to add aromasin, arimidex, or letrozole, what measure should I take to avoid their impact on hair? RU, bicalutamide, anything??

 

[DHTcel]

Lower the dosage to 2.5mg???!!!! 2.5mg is a proper dose for it. If you took more than 2.5mg and are still not bald, you should be thankful to God! Not only will it decrease your gyno it will diminish it completely, together with your hair.

My hair part moved half a centimeter in the month that I was on tamoxifen, I wonder what would've happened if I used letrozole...

 

[DHTcel]

Same dude. I also started at 14 but I tell people 15 just to make myself feel better.

BTW, I'm going on a regimen to get a inch or two (highly unlikely). If I choose to add aromasin, arimidex, or letrozole, what measure should I take to avoid their impact on hair? RU, bicalutamide, anything??

arimidex is the most hair safe drug I've ever used out of all AI/SERM, its more safe than raloxifine in my opinion

 

[Ikarus]

DHT has a Kd(binding affinity of 0.25-0.5nM) and T has a Kd(binding affinity of 0.4-1.0)nM for the Androgen Receptor

so by using dutasteride u reduce the needed dosage of bicalutamide to block androgens since T has a lower binding affinity than DHT

But what effect does bicalutamide have on DHT? If bicalutamide has an effect on DHT, then there isn’t a point of me using dutasteride in all honesty...

 

[Ikarus]

When u started balding:
Age: <19 - Super Agressive Hair Loss
<25 - Agressive Hair Loss
<30 - Normal male pattern baldness
<40 - At least you are married buddy

I started at 14-15

At least your hair didn’t end up like mine! Mine seems to have been similar to Bridges starting point in terms of density, except my hair is longer...

 

[Stephen788]

Lower the dosage to 2.5mg???!!!! 2.5mg is a proper dose for it. If you took more than 2.5mg and are still not bald, you should be thankful to God! Not only will it decrease your gyno it will diminish it completely, together with your hair.

Letrozole didn’t alter how much hair I am shedding. I’m still shedding the same amount as before. Maybe I’m lucky but what it did do for me is get my gyno to an unnoticeable size and I am so much more happy now because of it.

 

[Stephen788]

This is my current hair. The green circle is where I apply toppick. The hair in front is my fringe. As you can see letrozole has done nothing to my hair. I was on it 1.5 months at 5mg.
The miniature hairs I started to grow on spironolactone where in the temple regions. The centre of the green circle is only slightly less then normal density. I’m a Norwood 3 but I had a hair transplant in 2014 so I can put toppick in my hair so it looks normal.

Lower the dosage to 2.5mg???!!!! 2.5mg is a proper dose for it. If you took more than 2.5mg and are still not bald, you should be thankful to God! Not only will it decrease your gyno it will diminish it completely, together with your hair.

 

[I'mme]

Letrozole didn’t alter how much hair I am shedding. I’m still shedding the same amount as before. Maybe I’m lucky but what it did do for me is get my gyno to an unnoticeable size and I am so much more happy now because of it.

Yes. But I would still request to proceed with caution now. Rather than raloxifene take metformin with Bicalutamide to prevent gyno. Metformin is breast specific aromatase inhibitor having many other benefits as well. If you still get gyno, take raloxifene.

 

[Obsessive]

I meant: if it ends up systematic nonetheless, and poses the risk of typical side effects, then what’s the point of using it topically? It just defeats the purpose of using topicals, which is to avoid the possibility of side effects...

THe point of topical is to provide a huge local concentration of drug (at the follicle/AR) as opposed to a lower concentration at AR achieved from oral dosing. Yes, some systemic absorption always occurs. But, since you are saturating the follicle and AR via local administration less drug can be used vs. oral dosing. Some of the topical will be metabolized within the dermal layer, some will go systemic, and some will not penetrate at all. So if you're dosing topically with 50 mg drug, you should achieve better AR receptor coverage and less systemic absorption when compared to oral dosing of equiv. amount of drug.

 

[Obsessive]

Yes. But I would still request to proceed with caution now. Rather than raloxifene take metformin with Bicalutamide to prevent gyno. Metformin is breast specific aromatase inhibitor having many other benefits as well. If you still get gyno, take raloxifene.

Are you actually using Metformin? I thought the jury was still our regarding its effects on hair. Possibly detrimental? Any reports of people incorporating metformin into their regimen?

 

[I'mme]

THe point of topical is to provide a huge local concentration of drug (at the follicle/AR) as opposed to a lower concentration at AR achieved from oral dosing. Yes, some systemic absorption always occurs. But, since you are saturating the follicle and AR via local administration less drug can be used vs. oral dosing. Some of the topical will be metabolized within the dermal layer, some will go systemic, and some will not penetrate at all. So if you're dosing topically with 50 mg drug, you should achieve better AR receptor coverage and less systemic absorption when compared to oral dosing of equiv. amount of drug.

So you're ready to become Guinea pig for topical Bicalutamide? :-D

 

[I'mme]

Are you actually using Metformin? I thought the jury was still our regarding its effects on hair. Possibly detrimental? Any reports of people incorporating metformin into their regimen?

Yes, Ein took it and he had fantastic results.
Why would it be detrimental to hair?
(Maybe people thought it increases IGF1 but it doesn't ; Infact, researches show it decreases it.)

Also, as against tamoxifen, it's effects are largely/completely breast specific.

 

[Obsessive]

So you're ready to become Guinea pig for topical Bicalutamide? :-D

I'm waiting to see more bical success stories before using it. I don't fear side effects, but am more concerned with using something that has (possibly) worked for only 3-4 people.