Exploring The Hormonal Route. Hair=life.

[Ikarus]

[QUOTE = "Ikarus, post: 1813331, member: 139443"] Тогда почему мой FSH значительно ниже типичных мужских диапазонов? [/ QUOTE]
[QUOTE = "Икарус, пост: 1813339, участник: 139443"] Бикалутамид не влияет на ФСГ ... Это, скорее всего, из-за эстрогена. [/ QUOTE]
[QUOTE = "Икарус, пост: 1813339, участник: 139443"] Бикалутамид не влияет на ФСГ ... Это, скорее всего, из-за эстрогена. [/ QUOTE]

cpa + estradiol, in general, spironolactone in a dose of 50/50 is safe. You can try. If you feel that you cancel the drug.

CPA is not a safe drug for long-term use... I would not recommend that!

 

[Yar]

Just joined this gargantuan thread with a question; I’m at the point where I need to make a decision between spironolactone and bicalutamide due to the uselessness of finasteride/dutasteride alone.

I’m swaying more towards bicalutamide due to the potassium increase in spironolactone which would make me want to go through the formal prescription route due to monitoring potassium levels.

However the one thing that slightly puts me off Bica is the upregulution of T therefore how much estradiol would be necessary to balance 50mg bica and 0.5 duta? Would 1mg be sufficient as I want to limit the use of extraneous drugs.

that dutasterid, that finasteride increase testosterone, they inhibit dgt, but increase testosterone. In order to avoid testosterone, add estradiol to the mode so that the pituitary gland sees estradiol and does not increase testosterone.

 

[Yar]

CPA is not a safe drug for long-term use... I would not recommend that!

it is used everywhere, it is added to all combined drugs. it is a progestin, based on progesterone. Nothing dangerous !!! It is the progestins that are added to the combination with ethinyl estradiol in order to avoid cancer.

 

[Yar]

You should definitely go for bicalutamide over spironolactone, since spironolactone is a diuretic and it will have a negative impact on your body and mood. It's a weak anti-androgen, whilst having a greater rate of side effects and being harsher on the body.

You should use 2MG/day if possible, since it will aid in other aspects when using bicalutamide. Although, 1MG/day would be fine too.

I would consider Spironolankton less safe. So how should I monitor the level of potassium! This is potassium-saving diuretic

 

[Yar]

CPA is not a safe drug for long-term use... I would not recommend that!

progestins are added to avoid cancer from the carcinogenic effect of estradiol.

 

[Father_of_Shiseido]

[QUOTE = "Ikarus, post: 1813331, member: 139443"] Тогда почему мой FSH значительно ниже типичных мужских диапазонов? [/ QUOTE]
[QUOTE = "Икарус, пост: 1813339, участник: 139443"] Бикалутамид не влияет на ФСГ ... Это, скорее всего, из-за эстрогена. [/ QUOTE]
[QUOTE = "Икарус, пост: 1813339, участник: 139443"] Бикалутамид не влияет на ФСГ ... Это, скорее всего, из-за эстрогена. [/ QUOTE]

cpa + estradiol, in general, spironolactone in a dose of 50/50 is safe. You can try. If you feel that you cancel the drug.

50/50=1. What do you mean?

 

[Yar]

50/50=1. What do you mean?

50 in the morning 50 in the evening

 

[Ikarus]

it is used everywhere, it is added to all combined drugs. it is a progestin, based on progesterone. Nothing dangerous !!! It is the progestins that are added to the combination with ethinyl estradiol in order to avoid cancer.

You are talking about Diane 35

 

[Yar]

You are talking about Diane 35

Not only, there are many combination drugs containing progestins

 

[Ikarus]

Not only, there are many combination drugs containing progestins

You are particularly talking about medications which are Diane 35 or similar... We are talking about CPA in doses such as 12.5mg/day, 25mg/day or 50mg/day.

 

[Yar]

[QUOTE = "Икарус, пост: 1813452, участник: 139443"] Вы говорите о Диане 35 [/ QUOTE]
Дроспиренон-этинилэстрадиол

You are talking about Diane 35

A lot of different progestins are used, they all have different effects androgenic activity, estrogenic activity, progestin activity .....

 

[Ikarus]

[QUOTE = "Икарус, пост: 1813452, участник: 139443"] Вы говорите о Диане 35 [/ QUOTE]
Дроспиренон-этинилэстрадиол

A lot of different progestins are used, they all have different effects androgenic activity, estrogenic activity, progestin activity .....

It’s in Russian or something... I can’t understand that.

 

[Yar]

Just joined this gargantuan thread with a question; I’m at the point where I need to make a decision between spironolactone and bicalutamide due to the uselessness of finasteride/dutasteride alone.

I’m swaying more towards bicalutamide due to the potassium increase in spironolactone which would make me want to go through the formal prescription route due to monitoring potassium levels.

However the one thing that slightly puts me off Bica is the upregulution of T therefore how much estradiol would be necessary to balance 50mg bica and 0.5 duta? Would 1mg be sufficient as I want to limit the use of extraneous drugs.

Try mode 2.5 finasteride + 2 estradiol

 

[Yar]

It’s in Russian or something... I can’t understand that.

I showed you how many different progestins in Russia. Different activities, progestin, antiandrogenic, androgenic, antiestrogenic, estrogenic

 

[Ikarus]

Yes CPA works really well, however you must be aware of the increase in prolactin with the use of CPA which can result in prolactinomas and meningiomas(benign brain tumors) as it's most threatening possible side effect. which makes it unsafe for long term use, i think its use should only be short term if it's your current AA of choice. Bicalutamide is a newer AA derived from Flutamide as a 2nd generation NSAA and it works extremely well, with a higher safety profile and less liver toxicity, safer than spironolactone, CPA, Flutamide etc, and i probably would have never found it if it weren't for @Ikarus bringing it up a while back 'cuase i didn't even know what NSAA's were. Bicalutamide is the strongest and safest AA so far that I've found. @itsyaboi the upregulation in T won't matter because it wont be able to bind to its receptors anyway, encase that's what you're worried about, but 2mg E will balance it out so in the case you have to stop Bicalutamide your T will be normal-ish. and you have to use E with Bicalutamide or you'll likely get hot flashes, dizziness, dowdiness and other hormone imbalance symptoms anyway. Bicalutamide usually presents little to no side effects in users who have a female hormone profile, males experience the things i mentioned above if they don't use E while blocking all their T and same goes for other AAs.

Along with the issues with tumours, it appears to have a greater possibility of hepatic incidences with prolonged use. It is helpful within transgender women, in terms of ‘speeding up the process’, but it poses greater risks. It has a significant rate of depression, which isn’t mentioned frequently; that’s an automatic no-no for me...

Hot flashes, and those other particular symptoms of androgen deprivation, generally disappear in time. Although, it’s definitely better to use bicalutamide with estrogen.

 

[Father_of_Shiseido]

Ever since I stared dutasteride 2.5 mg, I feel like my facial structure has changed. It has grown bigger. Anyone else has the same experience?

 

[Ikarus]

Ever since I stared dutasteride 2.5 mg, I feel like my facial structure has changed. It has grown bigger. Anyone else has the same experience?

Probably feminisation... My cheekbones have become larger, and significantly more defined...

 

[Yar]

Probably feminisation... My cheekbones have become larger, and significantly more defined...

cheekbones is the prerogative of men wide cheekbones, I had wide cheekbones to hormone therapy, right now everything is smoothed out, they are almost gone

 

[Yar]

Probably feminisation... My cheekbones have become larger, and significantly more defined...

they had been wider before

 

[Ikarus]

cheekbones is the prerogative of men wide cheekbones, I had wide cheekbones to hormone therapy, right now everything is smoothed out, they are almost gone

What? Fuller cheeks, which are more defined, is a particularly female trait. I did have more prominent cheekbones to begin with, but estrogen has added more to it.