Does prolonged use of estradiol downregulate the androgen receptors or upregulate them? And can a high enough dosage of estradiol overcome the binding affinity of DHT? While on 50mg bica, and 10mg EV every 5 days, my hairloss only stopped after adding finasteride.
Estradiol will downregulate AR expression. Not sure why you still needed finasteride, but maybe it was a coincidence. It shouldn't have been necessary on bica and ev.
It's strange I know, that high a dosage of both should be enough. But as soon as the sides from finasteride emerge (depression brain fog etc.), the hair loss stopped and my face became a lot smoother as if the transition moved along.
What about beard growth? I guess dutasteride has a long half-life but I haven't filled it in a while. I go back and forth between thinking that it is still worthwhile when already hitting female targets but if it has to do with repairing damage maybe that makes sense. But in general, I think that anything that raises estrogen levels and lowers T levels to adult female targets will "work" as a protocol even if some or several of the elements are superfluous. With all the stuff that @bridgeburn was taking, he had to be hitting targets pretty quickly and without missing the entire time interval that he blogged.
It's ineteresting what you say about lower estradiol levels and breast growth. During my T spike, when I lowered my E2 levels my hair started falling out again, but breast growth defintely increased. As for Bridgeburn, I guess everyone is different. I know for sure that I couldn't tolerate 50mg of cypro everyday.
Well, hopefully I am putting my money where my mouth is here and my hair doesn't stall without any AA's. I thought about trying bica but I don't want to ruin the experiment. Oral minoxidil shouldn't change the results but rather speed them up, I think. Usually you would have the age factor, but my experience with estrogen is that all tissue created is essentially brand new tissue meaning I expect better results than a cis-female of my age.
Also, if there is any method that might increase breast growth but probably only temporarily, it is estrogen deprivation or possibly topical application which I think worked for me but there's no way to know. It too might be temporary as is progesterone. Thank Goddess, I am not obsessed with both hair and breasts.
I think if daro or enza ever become financially viable, they will be our saviour from AR upregulation and adrenal T. I think someone on this forum mentioned excessive sugar consumption and it's effect on the AR. I don't know exactly what the mechanism was, do you know anything on this subject?
It's hard to tell, but you hide it well
guess i'm out of luck
Yes thanks. I had long wanted to transition anyway prior to realizing hrt could be beneficial to hair loss, so 2 birds with one stone kinda worked for the best in my case.
That hairline is actually amazing, i never had that even when i was 10
I do take vitamin D 200 µg a day. I did have some dandruff issues in the past in that area, but not currently.
