Exploring The Hormonal Route. Hair=life.

[Pls_NW-1]

Wow, great find Tato! I will definitely add now Metformin to Bicalutamide in a few months, when the Doctor approves!

 

[tato123]

if i’m not wrong ein use 1000 mg metformin, i Will think about add 500 mg for my scheme

 

[tato123]

As said in the study it will cause apoptosis in some types of AR receptors defective , this seems to be very interesting, anti oxidant, anti inflammatory , anti cancer, by inhibiting the NK pathway, and it has plus with bicalutamide Its a very intrigue

 

[tato123]

acts in the same way as rampamycin (an imussupressor used for transplant recipients, where it is proven that it increases life expectancy in healthy rats, and the same study proved in vivo and decreases age-related diseases, maintains skin quality bla bla bla)

Maybe in a very crazy thought here maybe metformin alone can help with hair loss.

 

[tato123]

Stimulation of Hair Growth by Small Molecules that Activate Autophagy

Hair plays important roles, ranging from the conservation of body heat to the preservation of psychological well-being. Hair loss or alopecia affects …

www.sciencedirect.com

"Hair plays important roles, ranging from the conservation of body heat to the preservation of psychological well-being. Hair loss or alopecia affects millions around the world, but there is a lack of methods that can be used to grow hair. We report that quiescent hair follicles (telogens) can be stimulated to initiate anagen and hair growth by small molecules that activate autophagy, including the metabolites α-ketoglutarate (α-KG) and α-ketobutyrate (α-KB), and the drugs prescribed rapamycin and metformin, which interfere with mTOR and AMPK signaling. Stimulation of hair growth by these agents is blocked by specific inhibitors of autophagy, suggesting a mechanistic link between autophagy and hair regeneration. Consistently, increased autophagy is detected at the entrance of anagen during the natural hair follicle cycle, and oral α-KB prevents hair loss in elderly mice."

Was i say , maybe metformim alone can help hair

 

[Norwoody]

I'd say give finasteride at least 6-12 months before considering dutasteride. Do needling for sure. I'd hop on OM as soon as possible just because I know that it works, even at low doses. Or at least do the foam because it really seems to help most people with vertex issues.

 

[tato123]

 

[KNemo]

AKG thread https://www.gourmetstylewellness.com/intera...arate-for-adipose-tissue-rejuvenation.129511/

 

[JaneyElizabeth]

Considering we're not talking about therapeutic dosages which the estrogen gel is measured for, I simply apply as much as I need for coverage and if the sides are too much I dilute it in a distilled water/solvent solution.

I really haven't had to do that with the estrogel, so it really is one of those things just like minoxidil where you take your metered concentration (5% 2% whatever) and apply for coverage, then if you have sides, lower your concentration, that's really all you can do, that or apply it only once every other day.

Every day. I never go without applying it at least twice a day, once all over like hair mousse and then throughout the day at the hairline and formerly on the crown but that's filled in now. Don't worry about "wasting it on the hair" just mix it with a little minoxidil and that should put it into circulation. Apparently, Estrogel forms crystals when it dries so it will still be there so people might want to use a little topical to help it blend in.

 

[Almas]

Has anyone tried testing different areas of E application? What evidence is there that Estradiol works better on the scalp? Maybe applying on the wrist would have exactly the same effect.
If you mix it with Minoxidil, how can you be sure that it is doing anything at all ...

 

[JaneyElizabeth]

Has anyone tried testing different areas of E application? What evidence is there that Estradiol works better on the scalp? Maybe applying on the wrist would have exactly the same effect.
If you mix it with Minoxidil, how can you be sure that it is doing anything at all ...

You would have to start one and then wait a couple of months. I haven't a complete idea of what is doing what in my own case but it's all together powerful.

 

[JaneyElizabeth]

You would have to start one and then wait a couple of months. I haven't a complete idea of what is doing what in my own case but it's all together powerful.

E2 is absorbed perhaps up to five times more via the scrotum because the skin is thin, I would used it on the scalp as well since it might have localized effects too.

 

[Almas]

You would have to start one and then wait a couple of months. I haven't a complete idea of what is doing what in my own case but it's all together powerful.

Due to the fact that no one tries it solo, there is little information on effectiveness. I am always angry when someone uses minoxidil: it is not clear what is the effectiveness of each individual drug

 

[Pls_NW-1]

@tato123 So what is your pov for the treatment we elaborated together in the last few weeks? (finasteride,bica,metf.,resveratrol,etc.)
?

What do you think, how long can we stay on it, and what would you say about efficacy, how long are you personally on these drugs?

 

[Pls_NW-1]

Would you guys say I have inflammation!? Doesn't look like... idk

 

[JaneyElizabeth]

Due to the fact that no one tries it solo, there is little information on effectiveness. I am always angry when someone uses minoxidil: it is not clear what is the effectiveness of each individual drug

Yeah but I couldn't wait any longer. I have a ball to attend. I know oral Min is working though because it has made my beard scratchier and things like my scant arm hair more resilient. It kicked in right away for me last October at 12.5mg and now at 6.25mg because of the hypertrichinosis.

 

[JaneyElizabeth]

I used to like to grow weed and it's like that. Every day I would run to the basement to see if my plants had grown. I should have been growing a couple this winter but now, its checking my hair growth.

 

[JaneyElizabeth]

Know how to get a Brazilian person pissed off? Just say that Ayrton Senna sucked as a race car driver....

That's for Tato.

 

[DogoDiLaurentiis]

Metformin enhances the antiproliferative and apoptotic effect of bicalutamide in prostate cancer - Prostate Cancer and Prostatic Diseases

Prostate cancer incidence and mortality vary dramatically by geographical location. Both are higher in developed countries. Some attribute this to westernized lifestyles of high-energy diets and limited physical activity with consequent obesity. Obesity and obesity-related diseases like diabetes...

www.nature.com

Guys check this out.

Can't wait to get on metformin, I feel like that will be one of the final pieces of my metabolic/hormonal puzzle for me to really pull ahead of whatever is dragging me down.

 

[2TameDHT]

I have been doing a lot of reading on the subject on Reddit, and I see quite a few posts from trans women saying that HRT did little to improve their hair loss. I was wondering how that would be possible. Like, under what circumstances would it NOT work. I read earlier in this thread that one reason is that the person had already gone through at least five years of hair loss, but others who were at an advanced stage of balding seem to have recovered, at least, somewhat.

I am, essentially, interested in the odds of it working versus not working.