Exploring The Hormonal Route. Hair=life.

[John Difool]

I can't find the quotation a member made back then, but it's better using Finasteride, what I gathered from a few users.

Better using Fina than Duta? I'd like to hear the explanation.

Most doctors don't even know what is Bica.

 

[Pls_NW-1]

Better using Fina than Duta? I'd like to hear the explanation.

Most doctors don't even know what is Bica.

I was just saying. I try to find the stuff members added back then, I saw, but I can't find it to proof that...

Either way, I actually can't seem to find a probelm of using Dutasteride and Bicalutamide together...

No and yes, most doctors don't know what Bicalutamide is, but happily my andrologist knows, lol!

 

[John Difool]

Then you are in better hands than most. Dr Powers prescription includes both Duta & Bica for trans patients with male pattern baldness.

 

[Pls_NW-1]

Then you are in better hands than most. Dr Powers prescription includes both Duta & Bica for trans patients with male pattern baldness.

I am not transgender, however haha.
I think the threads' name gives you a little insight into my personality.

 

[John Difool]

On reddit, transtimelines, I read that DHT gets formed through 3 (/4 pathways), and sometimes... the other pathways tank the lost DHT (through the adrenal androgens and other precursors (DHEA-S, P, T (gonadal) and T (from DHEA-S (adrenal))).

I have problems with my adrenal gland and I just HOPE Bicalutamide will work for me, if not, then I am done lol. I will try using Resveratrol and maybe Metformin.

The following protocol emerged: (credit /r/estrogen)

Each step should be separated by a few weeks to find the minimal set of changes needed:

• [1] Stop progesterone to starve the backdoor pathway
• [2a] If not on bicalutamide, replace your current AA by just bicalutamide
• [2b] If already on bicalutamide, try to raise bicalutamide dose (given the binding affinity)
• [3] Add dutasteride to bicalutamide. do not use finasteride as an alternative to dutasteride as it doesn't block all isoforms of 5AR
• [4] If the problem persist, check DHEA levels or the androsterone to etiocholanolone ratio to confirm the adrenal origin through the frontdoor pathway which shouldn't be operating
• [5] WORK IN PROGRESS

At step 5, if the adrenal origin is confirmed, adding spironolactone or low dose dexamethosone are being investigated as alternatives to abiraterone. Nothing of that can be recommended yet as a step 5. We will know more after the literature review

Still, if you suffer from high DHT or signs of remasculinization, please try this.

 

[Pls_NW-1]

The following protocol emerged: (credit /r/estrogen)

Each step should be separated by a few weeks to find the minimal set of changes needed:

• [1] Stop progesterone to starve the backdoor pathway
• [2a] If not on bicalutamide, replace your current AA by just bicalutamide
• [2b] If already on bicalutamide, try to raise bicalutamide dose (given the binding affinity)
• [3] Add dutasteride to bicalutamide. do not use finasteride as an alternative to dutasteride as it doesn't block all isoforms of 5AR
• [4] If the problem persist, check DHEA levels or the androsterone to etiocholanolone ratio to confirm the adrenal origin through the frontdoor pathway which shouldn't be operating
• [5] WORK IN PROGRESS

At step 5, if the adrenal origin is confirmed, adding spironolactone or low dose dexamethosone are being investigated as alternatives to abiraterone. Nothing of that can be recommended yet as a step 5. We will know more after the literature review

Still, if you suffer from high DHT or signs of remasculinization, please try this.

Yes, but buddy, I think Abiraterone Acetat would be too much for a cis-men wanting to get nuclear, or?

I will save this post and mark it, thank you soo much John!

 

[Pls_NW-1]

Abiaterone would be dangerous, really. it's not worth it for the sake of hair. Sure, if you got resistant PC, then you NEED it, but for hair... then you should rather visit a psychologist.

I just hope so much that Bica + finasteride/duta will help me, even Resveratrol... oof

 

[franzliszt]

The following protocol emerged: (credit /r/estrogen)

Each step should be separated by a few weeks to find the minimal set of changes needed:

• [1] Stop progesterone to starve the backdoor pathway
• [2a] If not on bicalutamide, replace your current AA by just bicalutamide
• [2b] If already on bicalutamide, try to raise bicalutamide dose (given the binding affinity)
• [3] Add dutasteride to bicalutamide. do not use finasteride as an alternative to dutasteride as it doesn't block all isoforms of 5AR
• [4] If the problem persist, check DHEA levels or the androsterone to etiocholanolone ratio to confirm the adrenal origin through the frontdoor pathway which shouldn't be operating
• [5] WORK IN PROGRESS

At step 5, if the adrenal origin is confirmed, adding spironolactone or low dose dexamethosone are being investigated as alternatives to abiraterone. Nothing of that can be recommended yet as a step 5. We will know more after the literature review

Still, if you suffer from high DHT or signs of remasculinization, please try this.

How was your experience with betamethasone, and would you reccomend it in addition to a full hrt regimen?

 

[John Difool]

Adding spironolactone could work as a cheap replacement to AC Dex could be used to lower DHEA. I am not a doctor. But as it stands there 3 ways you can get DHT in your blood. Cutting physically or chemically on of them works for 96% of the people transitioning.

 

[Norwoody]

Adding spironolactone could work as a cheap replacement to AC Dex could be used to lower DHEA. I am not a doctor. But as it stands there 3 ways you can get DHT in your blood. Cutting physically or chemically on of them works for 96% of the people transitioning.

Perhaps another reason that fina/duta only block 40-60% of scalp DHT specifically

 

[Pls_NW-1]

Perhaps another reason that fina/duta only block 40-60% of scalp DHT specifically

DHT does not get formed only by 5AR. It gets formed in the tissue from DHEA-S to, well, DHT. And many more ways.bicalutamide should anyways block that DHT, but in some rare cases, the other DHT pathways tank all the lost DHT and you remasculinize and continue to lose hair, as John explained.

I wonder how you can reduce the ACTH signaling ...

 

[Norwoody]

Btw, with spironolactone, can it be used topically or orally?

 

[Pls_NW-1]

Btw, with spironolactone, can it be used topically or orally?

Only orally, there is no reason for topical use.

It needs to pass the liver to prosper lol

 

[Norwoody]

Only orally, there is no reason for topical use.

It needs to pass the liver to prosper lol

Thanks. What do you think about its safety/side effect profile?

 

[Pls_NW-1]

I really dislike spironolactone because of its effect on many things like the electrolyte imbalance effect and many more, just no. Especially of the fact that you need to increase dosage after time to make it "still work"... Thats really a pain in the *** for people trying to fight hair loss for life. You can't take huge amounts of a SAA, like spironolactone, just no, don't do it if you appreciate your health.

 

[John Difool]

Orally only. It needs to be synthesized in your digestive system. All the spironolactone creams out there are snake oil.

 

[Pls_NW-1]

Thats why I would choose Bicalutamide. Tho I would consider taking Eplerenone or any other MCR agonist with Bicalutamide as it seems that the regrowth on spironolactone is superior to Bica, reason may be to the MCR properties spironolactone has. And Eplerenone has the MCR properties, but no AA properties.

 

[John Difool]

I really dislike spironolactone because of its effect on many things like the electrolyte imbalance effect and many more, just no. Especially of the fact that you need to increase dosage after time to make it "still work"... Thats really a pain in the *** for people trying to fight hair loss for life. You can't take huge amounts of a SAA, like spironolactone, just no, don't do it if you appreciate your health.

I am not aware of increase dosage for spironolactone under hrt. The dosages I have seen range from 100-200

 

[Norwoody]

Yeah if my current regimen doesn't get regrowth then I will definitely have to just get some kind of transplant. There is a cure, but it's all about how far you are willing to go.

 

[Pls_NW-1]

I am not aware of increase dosage for spironolactone under hrt. The dosages I have seen range from 100-200

Yes, thats the dose you need, especially for hair, however, users on this forum proved all the time again that they needed to increase their dosage.