The reason I think bica works for women and not men is that in men it raises T levels but effectively prevents T from binding, so that excess likely converts to DHT which has far more affinity for androgen receptors than bica does. So imo bica should never be used without being in conjunction with a 5ari (or e2 which will prevent much of the increase in T due to hpa axis)
Well I think T might also cause hairloss in people whose receptors are suuuper sensitive. But T has a fraction of the binding affinity that dht does, so doesn't pose nearly the same threat. But that might be to blame in those who get increased hairloss after introducing dutasteride
Won’t a significant portion of that T aromatize in women?
T can be aromatized to E in either sex, and bica generally increases E lvls in cis men taking bica alone. But that increase in T won't occur in cis women (or trans women using E due to its antigonadotropin effect causing negative feedback on the hpg axis).
This assertion is not supported by anything. It's nothing more than your imagination. In Russia, some say that one who has not served in the army is not a man. You are spouting similar nonsense, which is based on nothing. I don't think a man is defined by his fertility and erection lol
Hey... How is ur hair?.. Treatment working?
Yes, I have terminal hair along the Norwood 0 growth line. But it is very thin. I'm waiting for the thickening.
Ur regime?.. I'm currently on 100 mg spironolactone and 4mg estradiol sublingual...
But since starting hrt... My hair has become brittle and wirey... Is it due to hormonal fluctuations?
Click on "My regimen"
Ok ... I don't know y my hair turned fragile overnight...
Spot on. When someone feels adventurous about oral regimens they should first think very hard, and when still feeling adventurous they could maybe try Bicalutamide (after giving Dutasteride sufficient time, of course). Bicalutamide is still relatively benign (in comparison to E2) since it doesn't actually shut down the HPT axis. The effects of Bicalutamide are also (almost) always reversible, which makes a wrong decision more forgiving. Don't mess with E2 when you're male. I'm 100% sure it will be regretted (genuine trans people are an exception, of course).
speaking in absolutes is irresponsible, how could you be 100% sure someone will regret anything.
I have not seen a single example where someone would regret it. The side effects of HRT are overrated, not underestimated, which is why we don't see people who would regret. The fact is that people are well aware of the side effects and resort to it when it becomes clear that the second choice is the complete destruction of life due to baldness. No one thinks that HRT has no consequences, so they are not horrified when they get changes.
My only negative side-effect with E2 do far has been gyno.
I can say the same
Never heard of it. Melatonin does not cure gynecomastia and can cause it, how is that possible?
It DEFINITELY worked for me!
My gland was formed while taking Bicalutamide more than six months ago and was already clearly fibrosing, so I was clearly too late