f*** Propecia

the_swami

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westcovinajoe said:
I emailed Merck. Hopefully they get back to me so we can get to the bottom of this mysterious guy who could have been a "pharmacist" but wasn't.

LOL :lol:
 

kalbo

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westcovinajoe said:
Just thought I would add as an aside:

Since Propecia has been available as a hair loss medication, many more people have died using aspirin, Tylenol, and well let's not even mention alcohol.
wow... I see absolutely no flaws in that comparison :!:

Not only do tylenol and aspirin users vastly out-number propecia users, but they've both been out over 40 years longer (aspirin being out 93 years before propecia).


westcovinajoe said:
Here is a link for some unbiased, non-paranoid info: http://en.wikipedia.org/wiki/Finasteride

Chill out,
Joe.
First of all, why would you even post this? It almost seems as if it were just copied from Merck's website. Plus it does nothing to debunk any allegations pertaining to some of the lesser-known long-term side effects like the one being discussed here.

Secondly, I wouldn't consider wikipedia to be a reliable source of information by any stretch of the imagination. This is the same site where I wrote an entry about my brother and how he was known as the village idiot in the town I grew up in. Heck, right now I can even add a line into the Finasteride entry saying, "Caution: may cause you to grow an extra finger or two".



Anyways, I'm not saying I fully believe the story about the "pharmacist". I just think finasteride users shouldn't brush aside such claims and go about in ignorant bliss. Plus, I don't know where many of you are getting the idea that this is just some unsubstantiated claim made by one wacko. A different poster already provided two links that support those claims and I can also contribute by adding another quote/link that supports the idea of finasteride causing complications with the immune system:

The other possible mechanism by which hormonal changes may affect prostate cancer development is the capacity of sex hormones to modulate immune response. Androgen and estrogen receptors are present on most immune competent cells, and sex hormones are known to affect T helper 1 (Th1)/Th2 cell balance (5, 6). Th1 response is associated with cell-mediated immunity, e.g. elimination of cancerous cells, whereas Th2 response is credited with immune tolerance such as fetus survival during pregnancy. Therefore, finasteride could potentially be involved in alteration of immune surveillance against cancer in aging males.
http://jcem.endojournals.org/cgi/content/full/89/12/6359

Again, I'm not saying that we should all stop using finasteride blah blah blah... Just saying that if you choose to use it, you must also be aware of the risks involved.
 

westcovinajoe

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I am aware of the risks involved.

As people are aware of the risks of driving drunk and shooting heroin.

Sure makes a difference huh...

Post cautionary tales all you like, let us just avoid the outright fictional fear mongering shall we?

Joe.
 

StoptheMadness

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Quote:
The other possible mechanism by which hormonal changes may affect prostate cancer development is the capacity of sex hormones to modulate immune response. Androgen and estrogen receptors are present on most immune competent cells, and sex hormones are known to affect T helper 1 (Th1)/Th2 cell balance (5, 6). Th1 response is associated with cell-mediated immunity, e.g. elimination of cancerous cells, whereas Th2 response is credited with immune tolerance such as fetus survival during pregnancy. Therefore, finasteride could potentially be involved in alteration of immune surveillance against cancer in aging males.

http://jcem.endojournals.org/cgi/conten ... 89/12/6359

This is serious news to me. It seems that finasteride, when taken long term, can seriouly f*** us up. Many people with male pattern baldness, such as myself, seem to not care about our long term health (side note - imho, it's entirely egregious for posters to advocate dutasteride, its infinitely more potent than propecia)
 

kalbo

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westcovinajoe said:
I am aware of the risks involved.

As people are aware of the risks of driving drunk and shooting heroin.

Sure makes a difference huh...
Yes, the difference being that people who drive drunk and shoot heroin are idiots......

Dude, I have no idea where you're going with that one.... are you claiming that the risks involved in using propecia are equivalent to that of drunk driving and shooting heroin??
 

westcovinajoe

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kalbo said:
westcovinajoe said:
I am aware of the risks involved.

As people are aware of the risks of driving drunk and shooting heroin.

Sure makes a difference huh...
Yes, the difference being that people who drive drunk and shoot heroin are idiots......

Dude, I have no idea where you're going with that one.... are you claiming that the risks involved in using propecia are equivalent to that of drunk driving and shooting heroin??

No, I am saying so what!

Who needs you or anybody else scaring people into paralysis.

I am also saying to keep a proper perspective.

How many people on here smoke pot, or shoot steroids or drink until they pass out?

Much of what is posted here is nonsense! Just fear-based crap.

If you want to say we should be careful, that is fine.

That is way DIFFERENT than saying you know someone who knows for a fact that the company that makes this stuff KNOWS it is harmful.

You know red meat and cheese are killing people too.

I am sure there is some paranoia forum for that too...

Understand that?
 

kalbo

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Hey, if you just came out and compared the risks of using propecia to that of eating red meat and cheese instead of driving drunk and shooting heroin, then that would've been completely fine with me. But since you didn't do that, what kind of reaction would've you expected from me??

Anyways, I completely understand the problems people have with someone creating a thread and expecting us to believe some outlandish story such as that one. But the difference now is that other people came on and brought evidence that support his claims, and despite that, some people still refuse to consider the things being discussed. It's kind of corny to say "ignorance is bliss", but at the moment, it seems like an appropriate statement.
 

powersam

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that is misleading information you have posted above. you have used a selected part of the text to try and support your case when in fact it does not.

it is well known that while on finasteride your chances of developing prostate cancer are decreased, but if you are one of the few unlucky ones who do develop cancer then it will most probably be of a more aggressive type. none of this is news and has been known for quite some time.
 

stax

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Bottom line, EVERYBODY taking drugs of anykind dont know the potential future risks, especially hormone altering drugs. Who the f*** knows if this rogaine we put on our heads is safe long-term? I dont know if i beleive the story here, but i wont rule it out, your going against your natual internal hormones when your hormones were perfectly fine and normal to begin with. Its not like you had a health problem or your hormones were naturally out of whack causing you problems. DHT is damn important to a man. Its funny people who take the sh*t are so offended when somebody mentiones there could be long-term problems with its use. It may help you keep your hair, but it degrades your personality and quality of life. Topical anti-adrogens are where its at.
 

Aplunk1

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This thread was initiated to provide for scare tactics against our current hairloss treatments.

Propecia & Rogaine - the only two FDA-approved substances for treating hairloss have been proven, OVER AND OVER, in regards to their long-term safety and efficacy.

Nothing but fearmongering.

I suggest that this thread be closed.
 

hairhaircomeagain

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Aplunk1 said:
This thread was initiated to provide for scare tactics against our current hairloss treatments.

Propecia & Rogaine - the only two FDA-approved substances for treating hairloss have been proven, OVER AND OVER, in regards to their long-term safety and efficacy.

Nothing but fearmongering.

I suggest that this thread be closed.

Dude...Dont post junk sh*t....If Propecia has not been proven to cause harm in the long term...it also hasnt been proven that they are safe long term. Show me one study that has shown Propecia is safe for long term...Fuckin the medicine itself has not been in existence long term..How can anyone prove its safe.

Please refrain from posting what you THINK here.
 

powersam

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once again, this thread is full of unsubstantiated claims and rumours. there could most definately be long term consequences of finasteride use, however the drug has been in use 14 years and none have been reported. so what is the point of this thread? until there are reported cases of long term side effects, of whatever nature, there is no point speculating about it.

this is the one time i'd advocate a thread being deleted as it contains absolutely nothing beneficial.
 

kalbo

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PowerSam said:
that is misleading information you have posted above. you have used a selected part of the text to try and support your case when in fact it does not.
How so? :pensativo:
The whole quote is basically saying that sex hormones control Th1/Th2 cell balance, which is associated with cell-mediated immunity. So any alterations in the production of sex hormones could potentially compromise the effectiveness of the immune system. The highlighted part is merely the gist of the whole paragraph. This isn't evidence that will cause one to say, "good god, I must inform the authorities to put an end to such an awful drug!!", but it does add to the credibility of that wacky story we all read.


And for those wishing to lock this thread, well I propose a different solution. How about we just change the title to something like "Potential long-term effects of finasteride"? That way there will be no misconceptions as to the nature of the matter being discussed. It's main purpose would be to raise awareness of potential long-term sides as opposed to scaring the $h!t out of finasteride users.
 

Solo

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The pseudohermaphrodite´s are a living proof that there´s no long term risk.



Enough said.
 

the_swami

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Solo said:
The pseudohermaphrodite´s are a living proof that there´s no long term risk.

Almost enough said :lol:

Keep in mind that finasteride may not *only affect* 5-alpha reductase. It is *possible* that it has unknown effects on other enzymes / organ systems / etc. I think that overall the evidence is fairly strong that it is safe and that what side effects *sometimes* arise will diminish upon discontinuation.

Hmm, I guess another issue is finasteride affects 5-alpha reductase type 1 but the pseudohermaphrodites have type 2 gene defects.

http://en.wikipedia.org/wiki/5-alpha-re ... deficiency
(yeesh that's spooky stuff)

Another issue entirely is whether it is safe in teenagers and young adults (who may sometimes take it for MPH). Given how important DHT is for sexual dev during fetal developement, it may play a role even later in life.

As far as crazy stuff like autoimmune illnesses and alien abductions, I'm not too worried.
 

Bryan

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the_swami said:
Hmm, I guess another issue is finasteride affects 5-alpha reductase type 1 but the pseudohermaphrodites have type 2 gene defects.

Finasteride is a 5a-reductase type 2 inhibitor. It has only a very very slight effect on type 1.

Bryan
 

powersam

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kalbo - that quote was an excerpt from a letter of opinion and theory not proven fact.
 

westcovinajoe

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This thread is not about Propecia being danger free as nothing we eat or swallow is danger free. Too much water drinking can kill you.

This thread is about an alleged meeting with a former employee of Merck.

If you have thoughts or comments about that, make them here.

If you have links, comments, or thoughts about the dangers associated with long term use of Propecia, please post them in the thread most appropriate.

I am not trying to act as a moderator, but it seems the outrageousness of the claims made by the thread originator are being forgotten.

Thanks,
Joe.
 
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