Flutagel

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cmudave

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squeegee said:
Where can I buy legit Flutagel in North America??I wanna try that! :punk:

I know there is http://www.sinere.com/shop/304SP2_relea ... dukte.html


31.00 EUR = 48.5521 USD
Euro United States Dollars
1 EUR = 1.56620 USD 1 USD = 0.638490 EUR

Thats not even including shipping, which for the US is 12.50 EUR....which is about 19.50 USD which all together comes out to about 68 USD. youuuch.

And to answer your question i don't think it is possible to buy flutagel in North America. I think the only place as of right now is the actual sinere website.
 

squeegee

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How long can we go approximately with one bottle with one application a day?? This stuff is expensive but people started to get results with it..so..why not? What type of gel are they using?? Too easy to go buy flutamide and mix it with a gel application...
 

Matt27

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squeegee said:
How long can we go approximately with one bottle with one application a day?? This stuff is expensive but people started to get results with it..so..why not? What type of gel are they using?? Too easy to go buy flutamide and mix it with a gel application...

I've been using it for just over 2 months and still have over half a bottle left, maybe 65% or so. I only apply it on my temples but I use a lot each application. Sinere doesn't "use" any gel, they create theirs from scratch. If you simply "buy flutamide and mix it with a gel application" you will have absolutely nothing close to the formula Sinere makes which is extremely similar to the one used in the Sintov experiment.
 

billythekid

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any update matt27?

it seems many people are reporting shedding or thinning of hair whilst on flutagel.
 

hairsucks

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I've been using it for just over 2 months now, I seem to have started shedding last week or so. The shed is either due to the flutagel working or me dropping my other treatments - spironolactone, nizoral, tricomin, topical finasteride. :dunno:

I'm using Flutagel and that's it on it's own, I'll give it a good 6 months to see if it works. I shave my head once a week so I should be able to see regrowth pretty quick.

As it stands, my scalp is in good condition but my hair is now at the worst it's ever been due to the recent shedding.
 

Matt27

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billythekid said:
any update matt27?

it seems many people are reporting shedding or thinning of hair whilst on flutagel.

Hardly any change. Definitely not growing back a bunch of hair. It's weird tho, I've got several new hairs out in front of my hairline but now I can't tell if my actual hairline is getting weaker or if it's just the new hairs being out in front just making it appear that way. That or if my hairline hairs are starting to thicken up at all. It's been about 10 weeks now. I took pics back on Dec. 17 and started Flutagel on Feb. 22 so I will take another set of pics on June 17 and decide what to do after that. If I don't see any improvement, but no loss, I will probably stay on it. However, if I see noticeable loss in just 6 months ti me I will probably get off and switch to Nanominox FMS or something. That and start back up with the Nizoral and Alpecin shampoo's which I dropped once I started using Flutagel.
 

el_duterino

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Matt, are you using Flutagel alone ? I would strongly recommend using it combined to an oral DHT inhibitor if you have aggressive/advanced hairloss.
I seriousely doubt 1 % of flutamide will be enough on its own,... unless you are a Hamster.

Cheers
El Duterino
 

Matt27

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Unfortunately that is not an option as I get severe and aggressive hyperandrogenicity whenever I take any internal anti-androgens, even Saw Palmetto or EGCG will trigger it.
 

el_duterino

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I see. then perhaps you could try using this Flutagel 2 or 3 times a day. One could imagine that some DHT binds to the AR during that "free" time when Flut is not on the scalp, after washing the hair before the next appliction.

That could be perhaps enough to continue loosing ground.

One question is: HOW LONG does flutamide STAYS binded to the AR..is it just a few hours or longer..? because DHT is constantly created. finasteride/dutasteride is constanlty inhibiting it (with half-life variations) during the 24 hours, if I am correct.

Any thoughts ?

El Duternino
 

moter

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I've been on Flutagel for 2 months and just started my first shed a few days ago. The shed is lessening every day now.

As far as regrowth, a few stray hairs have come in around the hairline where I'm using the gel. I certainly need more to call this a successful experiment. I have a starting pic, and will post if there's a noticeable change.

I'm also using a quarter milligram of finasteride and Activ M shampoo.

As I understand it, shed is necessarry for thickening. Can anyone confirm or deny this?
 

Matt27

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el_duterino said:
I see. then perhaps you could try using this Flutagel 2 or 3 times a day. One could imagine that some DHT binds to the AR during that "free" time when Flut is not on the scalp, after washing the hair before the next appliction.

That could be perhaps enough to continue loosing ground.

One question is: HOW LONG does flutamide STAYS binded to the AR..is it just a few hours or longer..? because DHT is constantly created. finasteride/dutasteride is constanlty inhibiting it (with half-life variations) during the 24 hours, if I am correct.

Any thoughts ?

El Duternino

There have been studies done that show AR's die off after about 3 hours if they do not bond with an androgen. However, the Flutamide *should* remain active in the skin for at least 6-7 hours, which would give a 6-7 hour window of effectiveness. One would probably have to apply it 3 times a day for complete protection, which might render the gel very unpractical as not many people I know have time to apply a gel 3 times a day, especially one that immediately dries into a flaky white substance like Flutagel.

On another note I got a haircut yesterday and there is definite thinning in the general areas of application. It's either working and hairs are in the process of regrowth or it's not doing anything at all. I guess another couple of months will tell. I don't know if I can hold out that much longer tho if it continues to thin. A big part of me wants to go back to my regular regimin thinking I'm crazy to expect things to suddenly get better after 10 consecutive weeks of getting worse. Then again maybe just the weaker/already dead or dying folicles shed and only the strong ones remain?? I don't know, it's literally like splitting hairs trying to ration if things are good or getting beter or bad and getting worse.
 

hairsucks

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I know exactly what you mean Matt27,

I'm in the same boat, I'm really starting to thin out all over the top of my head where i'm applying the flutagel every night.

I find myself on these boards a lot more often when this happens. Already thinking about what to have as my next regime, I know 2 months is too little to know if it's a good shed or a bad one so I'm going to stick with it for another 4 months.

If I keep going the way I am I'll be slick bald soon!
 

el_duterino

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Ok, so these early reports show that the people having some results with 1% Flutagel, including myself, are using it with a DHT inhibitor (finasteride or dutasteride). It seems too mild to halt aggressive hairloss on its own, at one application a day at least.

I did not experience any shedding. In fact, "daily usual shedding" decreased a lot

The proposed MDF solution is using 2% of Flutamide and a good dose of Dutasteride, which seems like a good mix then.

Cheers
El Duterino
 

Newbaldy84

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Fluta does work. I don't know about effectivness but it was able to reduce my beard just after 2 weeks. and it keeps getting thinner and thinner
 

cmudave

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Newbaldy84 said:
Fluta does work. I don't know about effectivness but it was able to reduce my beard just after 2 weeks. and it keeps getting thinner and thinner

thats awesome! wouldn't it take more than 2 weeks though?
 

hairsucks

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I think 2 months is too soon to know what's going on yet. The shedding could well be a good sign.

I seem to be getting some new hairs on my hairline popping up but the rest of my hair is getting thinner. Strange.
 

kamui

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alkulk said:
Side effects with topical fluta are not likely:
the usual dose of oral Flutamide is 750 mg (1-1-1). The minimum dose which lead to side effect was I think 125 mg. If you take 1ml of Flutagel you have about 20 mg on your head. And surely not all of these 20 mg go systemically.



I think the math here is wrong.

Flutagel is 1% in a 100mL solution. So that means there is 1000mg of Flutamide per 100mL. So if you use 1mL of it, you would be getting 10mg of Flutamide NOT 20mg.

Correct me if I am wrong.
 

alkulk

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Thats right. If you use the Flutagel. If you use Genhair's Lotion which is 2%, then it is 20mg. :)
 

Matt27

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Based on studies done with hydroalcoholic solutions, the absorption rate of flutamide is approx. 17%. With a gel based vehicle like Sinere's I would imagine it would be much less, probably closer to 3-5%, if even that. I haven't heard of one person getting sides from Sinere's gel.
 

Newbaldy84

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damn I don't like the consistency of that new flutagel. The old one was more like a liquid and this one and like a paste. I have rather longer hair and this just doesn't cut it. Can I add water or something that will make it more watery? plus I applied this gel yesterday and today I had a lot of flakes on my scalp much much more than when I was using liquid version of flutagel. Do you think if I contacted sinere they could send me the liquid one ?
 
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