Search gourmetstylewellness.com, many(subjective term) have found success in using higher dose vitamin d either by itself or with other things.
For Your Viewing Pleasure-Vitamin D Deficiency & Hair Loss: A Case Report
- Thread starter OtyMac
- Start date
Stepping thru a few of observations noted in table 1:
1) androgens- already discussed above and dht is used by the body to mitigate vit d deficiency.
2) inflammation- broad topic but interferes with IL-17 and stops peroxynitrite formation too.
Nutraceuticals Targeting Generation and Oxidant Activity of Peroxynitrite May Aid Prevention and Control of Parkinson's Disease - PubMed
Parkinson's disease (PD) is a chronic low-grade inflammatory process in which activated microglia generate cytotoxic factors-most prominently peroxynitrite-which induce the death and dysfunction of neighboring dopaminergic neurons. Dying neurons then release damage-associated molecular pattern...
pubmed.ncbi.nlm.nih.gov
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Vitamin D can regulate the production and degradation of prostaglandin D2 (PD2) and other inflammatory substances, such as prostaglandin E2 (PGE2):
4) microrganism- unknown probably thru sebum
5) fibrosis- inflammation disrupted by vitamin d
6) blood vessel calcification-
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Yes, vitamin D deficiency can contribute to capillary calcification:
- Vitamin D deficiency and CAC
Vitamin D deficiency can increase the risk of developing coronary artery calcification (CAC) in people who don't already have CAC. - 7) sebaceous gland size-
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Vitamin D levels and sebaceous glands are related in several ways:- Sebaceous gland function
Vitamin D can inhibit the proliferation, differentiation, and secretion of sebum, which are all key factors in sebum production.
- Sebaceous gland inflammation
Vitamin D can inhibit the upregulation of inflammatory biomarkers by P. acnes and UVB irradiation.
- Seborrheic dermatitis
Low vitamin D levels are associated with seborrheic dermatitis, and patients with severe vitamin D deficiency develop it earlier.
- Acne
Vitamin D deficiency can potentiate the inflammatory process in severe acne patients.
- Sebaceous gland therapy
Sebaceous glands may be potential targets for therapy with vitamin D analogues.
- Sebaceous gland function
- 8) vascularity-
The relationship between microvascular complications and vitamin D deficiency in type 2 diabetes mellitus
- https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s12902-015-0029-y
9) - APM- unknown but probably inflammation related
- 10) skull shape-
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Vitamin D deficiency can cause a skull shape abnormality in newborns and infants called craniotabes, which is characterized by soft, thin skull bones that deform when pressure is applied:
Other signs of vitamin D deficiency in children include:Craniotabes Description Soft, thin skull bones that deform when pressure is applied Effect Skull bones may remain soft and malleable for a longer period, predisposing the infant to skull deformation Signs Skull bones collapse inward when pressure is applied, but snap back when the pressure is relieved Associated conditions Rickets, congenital syphilis, and osteogenesis imperfecta Treatment Oral cholecalciferol supplementation can normalize serum 25-hydroxyvitamin D levels and resolve the skull softening - Slow growth
- Uneven teeth
- Slow walking and crawling
- Wide fontanelles
- Deformed ribs and rib cage
- Scoliosis and bow legs
11)GA AKA galea aponeurotica- muscle contraction problems occur in muscular dystrophy 1 patients too(who also get Androgenetic Alopecia) and are helped by vit d supplementation and short term effects with botox for Androgenetic Alopecia.
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The galea aponeurotica is a dense fibrous membrane that underlies hair follicles that are prone to androgenic alopecia (Androgenetic Alopecia). Androgenetic Alopecia is a common hair loss disorder that causes progressive, patterned hair thinning in the scalp regions above the galea aponeurotica.
Here's some information about Androgenetic Alopecia and the galea aponeurotica:- Pathogenesis
Androgenetic Alopecia is thought to be caused by a combination of genetics and androgens, particularly dihydrotestosterone (DHT), a metabolite of testosterone. DHT attaches to an androgen receptor in Androgenetic Alopecia-prone hair follicles, which can lead to hair follicle miniaturization.
- Scalp tension
A hypothetical model suggests that chronic scalp tension from the galea aponeurotica can cause an inflammatory response in Androgenetic Alopecia-prone tissues. This response can lead to the thickening of the dermal sheath, perifollicular fibrosis, and calcification, which can restrict the growth space, oxygen, and nutrient supply for hair follicles.
- Pathogenesis
Frontiers | Vitamin D Promotes Skeletal Muscle Regeneration and Mitochondrial Health
Vitamin D is an essential nutrient for maintenance of skeletal muscle and bone health. The vitamin D receptor (VDR) is present in muscle, as is CYP27B1, the ...
www.frontiersin.org
Furthermore, mounting evidence suggests that vitamin D may play an important role during muscle damage and regeneration. Muscle damage is characterized by compromised muscle fiber architecture, disruption of contractile protein integrity(ME:meaning the galea aponeurotic muscle is never/partly contracts hense the effectiveness of botox), and mitochondrial dysfunction
12) muscular- mentioned above:
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When I was living at home my mother would basically always recommend I drink milk which is vitamin d3 fortified . I was never a fan of cow milk and definitely tried to minimize it. I started balding at about age 17 around the age of when I was starting not to prefer milk.
There are some threads around about the association with heavy sweating with male pattern baldness. Here's one but there are more around:
In high school when I started balding and always outsweated my team mates like 3 to 1 that could have been the start of the deficiency. Not to mention it seemed like I had chronic fatigue syndrome too.
www.youtube.com
The thing is...vitamin d3 isn't going to work for everybody about like everything else. I'm pretty sure over 50% of the US population is deficient in vitamin d and I don't even have to take a test because: I eat no fatty fish, don't drink vit d3 enriched milk and not in the sun that much.
Some videos about d3 and K2.
This guys vitamin d3 figures out after conversion to 230 ng/ml which is 2x the upper limit range. 30-100 is supposedly normal. The guys vitamin d3 is off the charts yet he doesn't suffer from hypercalcemia.
Vitamin d3 looks like it didn't work too well for Dr. Mandell:
Yet it looks like it worked for this guy that caught it early:
Worked here too:
www.youtube.com
Don't overdose or especially without K2 this may happen:
So..clearly vitamin d3 is involved with the Androgenetic Alopecia process BUT WHY doesn't it work for everybody? Aside from the always correct genetics answer could it be the capillaries were already too calcified to benefit them?
There are some threads around about the association with heavy sweating with male pattern baldness. Here's one but there are more around:
In high school when I started balding and always outsweated my team mates like 3 to 1 that could have been the start of the deficiency. Not to mention it seemed like I had chronic fatigue syndrome too.
8 Signs Your Body Is Begging for Vitamin D
What are the signs of vitamin D deficiency? Vitamin D greatly influences the systems of our body from ensuring calcium supply to our bones to strengthening o...
www.youtube.com
The thing is...vitamin d3 isn't going to work for everybody about like everything else. I'm pretty sure over 50% of the US population is deficient in vitamin d and I don't even have to take a test because: I eat no fatty fish, don't drink vit d3 enriched milk and not in the sun that much.
Some videos about d3 and K2.
This guys vitamin d3 figures out after conversion to 230 ng/ml which is 2x the upper limit range. 30-100 is supposedly normal. The guys vitamin d3 is off the charts yet he doesn't suffer from hypercalcemia.
Vitamin d3 looks like it didn't work too well for Dr. Mandell:
Yet it looks like it worked for this guy that caught it early:
Worked here too:
HAIR LOSS NIGHTMARE? DISCOVER THE SECRET TO RAPID REGROWTH WITH VITAMIN D
HAIR LOSS NIGHTMARE? DISCOVER THE SECRET TO RAPID REGROWTH WITH VITAMIN DToday, we're examining clinical case studies on vitamin D supplementation for hair r...
www.youtube.com
Don't overdose or especially without K2 this may happen:
So..clearly vitamin d3 is involved with the Androgenetic Alopecia process BUT WHY doesn't it work for everybody? Aside from the always correct genetics answer could it be the capillaries were already too calcified to benefit them?
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So the non-responders to vitamin d probably have a VDR mutation while those who do respond are just low in vitamin D.
Yes, vitamin D receptor (VDR) mutations can cause hair loss, including androgenetic alopecia:
The occurrence of alopecia depends on the location of the VDR mutation. For example, mutations in the VDR-RXR interaction domain can cause alopecia, but mutations in the ligand-binding domain do not.
Children with VDR defects that cause alopecia may require intravenous calcium infusions to bypass the defective VDR. There is no cure for androgenetic alopecia, but holistic therapies may help halt the process and boost hair growth.
Yes, vitamin D receptor (VDR) mutations can cause hair loss, including androgenetic alopecia:
- Alopecia
A clinical feature of hereditary 1,25-dihydroxyvitamin D-resistant rickets (HVDRR), which is caused by VDR gene mutations. Alopecia can include sparse body hair, lack of eyebrows and eyelashes, or total scalp and body alopecia.
- Androgenetic alopecia
Vitamin D deficiency may be associated with early onset androgenetic alopecia.
- Derepressing genes: The unliganded VDR can lose its suppressor activity, which may derepress genes that lead to alopecia.
- Disrupting ligand binding: Mutations can disrupt the VDR's ability to bind to ligands like calcitriol.
- Disrupting DNA binding: Mutations can disrupt the VDR's ability to bind to DNA.
The occurrence of alopecia depends on the location of the VDR mutation. For example, mutations in the VDR-RXR interaction domain can cause alopecia, but mutations in the ligand-binding domain do not.
Children with VDR defects that cause alopecia may require intravenous calcium infusions to bypass the defective VDR. There is no cure for androgenetic alopecia, but holistic therapies may help halt the process and boost hair growth.
There are probably "back doors" to getting around a VDR mutation..Many of the compounds mentioned below have been tried but what was their vitamin d status? Does the success of treatments hinge around vitamin d in adequate levels? What if a person has an adequate vitamin d level but still has inherited resistance?
www.mdpi.com
Vitamin D resistance can be inherited or de novo acquired; in the former case is caused by the mutation of VDR or RXR genes or the genes involved in calcitriol activation, catabolism, and signaling, in the latter case the resistance can be environment-dependent.
The resistance to vitamin D could be overcome by altering the epigenetic control of VDR. In our analysis we considered three molecules, sulforaphane, curcumin, and butyrate produced by the intestinal microbioma, which if added to the diet could enhance the expression of VDR through epigenetic mechanisms, facilitating the transcription of the VDR gene and the activity of this transcriptional factor.
Natural Epigenetic Modulators of Vitamin D Receptor
Vitamin D plays an important role in every tissue due to its differentiating properties and the control of calcium homeostasis. The reversion of the epigenetic repression of the vitamin D receptor (VDR) could lead to an increased sensitivity of the cells to the beneficial activity of the hormone...
www.mdpi.com
Vitamin D resistance can be inherited or de novo acquired; in the former case is caused by the mutation of VDR or RXR genes or the genes involved in calcitriol activation, catabolism, and signaling, in the latter case the resistance can be environment-dependent.
Sulforaphane(brocolli extract)
Because VDR is regulated by epigenetic mechanisms, it would be interesting to carry out a clinical study testing the enhancement of vitamin D efficacy in patients treated with SF. The evidences supporting the hypothesis that SF could be beneficial in incrementing the response to vitamin D are provided by the study of Schwab et al. [88], investigating the anti-inflammatory effect of SF on three different human colorectal cancer cells.Curcumin
Probiotics and Butyrate
The resistance to vitamin D could be overcome by altering the epigenetic control of VDR. In our analysis we considered three molecules, sulforaphane, curcumin, and butyrate produced by the intestinal microbioma, which if added to the diet could enhance the expression of VDR through epigenetic mechanisms, facilitating the transcription of the VDR gene and the activity of this transcriptional factor.
Interesting that retinoic acid(Retin-a) does work to an extent but again what was their vitamin d3 status? I've seen one video claim _90%_ of the world is deficient in vitamin d3.
So if you are supplementing with vitamin d3 also try topical retinoic acid or add sulforaphane, curcumin or butyrate producing probiotics into the mix.
Abnormal VDR protein
Some VDR gene mutations can cause the production of an abnormally short VDR protein, or an abnormal receptor that can't bind to calcitriol, RXR, or DNA.
The retinoid X receptor (RXR) is involved in the nuclear signaling pathways for both retinoic acid and vitamin D. The use of all-trans-retinoic acid (ATRA) or 1,25-dihydroxyvitamin D3 (1,25D) as a differentiation therapy may be a promising treatment for AML.
Topical all-trans-retinoic acid (tretinoin) alone and in combination with 0.5% minoxidil has been tested for the promotion of hair growth in 56 subjects with androgenetic alopecia.
Tretinoin was shown to stimulate some hair regrowth in approximately 58% of the subjects studied. One female subject with pronounced alopecia for more than 20 years had regrowth of hair using only tretinoin for a period of 18 months
So if you are supplementing with vitamin d3 also try topical retinoic acid or add sulforaphane, curcumin or butyrate producing probiotics into the mix.
Abnormal VDR protein
Some VDR gene mutations can cause the production of an abnormally short VDR protein, or an abnormal receptor that can't bind to calcitriol, RXR, or DNA.
The retinoid X receptor (RXR) is involved in the nuclear signaling pathways for both retinoic acid and vitamin D. The use of all-trans-retinoic acid (ATRA) or 1,25-dihydroxyvitamin D3 (1,25D) as a differentiation therapy may be a promising treatment for AML.
Topical all-trans-retinoic acid (tretinoin) alone and in combination with 0.5% minoxidil has been tested for the promotion of hair growth in 56 subjects with androgenetic alopecia.
Tretinoin was shown to stimulate some hair regrowth in approximately 58% of the subjects studied. One female subject with pronounced alopecia for more than 20 years had regrowth of hair using only tretinoin for a period of 18 months
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Butyrate and vitamin D can have synergistic effects on vitamin D receptor (VDR) expression, which can help with disease resistance and may be a potential antibiotic alternative:
If you're taking a vitamin D supplement but aren't seeing improvement, you can try adding a synergistic component like butyrate to help with absorption.
Or maybe even GABA(gamma amino butyric acid) taken sublingually or orally?
www.nature.com
However, emerging evidence has demonstrated that changes in both circulating and brain levels of GABA are associated with changes in gut microbiota composition and that changes in GABA levels and microbiota composition play a role in modulating mental health. This recent research has raised the possibility that GABA may be a potent mediator of the gut–brain axis. This review article will cover up-to-date information about GABA-producing microorganisms isolated from human gut and food sources, explanation why those microorganisms produce GABA, food factors inducing gut–GABA production, evidence suggesting GABA as a mediator linking between gut microbiota and mental health, including anxiety, depression, stress, epilepsy, autism spectrum disorder, and attention deficit hyperactivity disorder, and novel information regarding homocarnosine-a predominant brain peptide that is a putative downstream mediator of GABA in regulating brain functions.
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Butyrate and vitamin D can have synergistic effects on vitamin D receptor (VDR) expression, which can help with disease resistance and may be a potential antibiotic alternative:
- VDR expression
Butyrate and vitamin D can increase VDR mRNA expression in intestinal epithelial cells infected with Salmonella.
- Disease resistance
Butyrate and vitamin D can help make poultry more resistant to disease.
- Antibiotic alternative
Butyrate and vitamin D may be a cost-effective alternative to antibiotics for preventing and controlling diseases.
- Anti-inflammatory
Butyrate and vitamin D can reduce inflammation and the severity of Salmonella colitis.
- Antimicrobial peptides
Butyrate and vitamin D can increase the production of antimicrobial peptides.
If you're taking a vitamin D supplement but aren't seeing improvement, you can try adding a synergistic component like butyrate to help with absorption.
Or maybe even GABA(gamma amino butyric acid) taken sublingually or orally?
Gamma-aminobutyric acid as a potential postbiotic mediator in the gut–brain axis - npj Science of Food
Gamma-aminobutyric acid (GABA) plays a crucial role in the central nervous system as an inhibitory neurotransmitter. Imbalances of this neurotransmitter are associated with neurological diseases, such as Alzheimer’s and Parkinson’s disease, and psychological disorders, including anxiety...
www.nature.com
Nanomedical studies of the restoration of nitric oxide/peroxynitrite balance in dysfunctional endothelium by 1,25-dihydroxy vitamin D3 - clinical implications for cardiovascular diseases
This effect accounts for the reduction of oxidative/
nitroxidative stress and the overall increase in bioavailable
NO – both a highly beneficial effect of vitamin D3 treatment
on endothelium and the cardiovascular system.
The process of restoring bioavailable NO production by vitamin D3 is
more efficient and comprehensive than other possible path-
ways of the restoration of dysfunctional endothelium, like
elevated levels of L-arginine, sepiapterin treatment, scav-
enging or dismutase of O2
−. As shown here, L-arginine, sepiapterin or NADPH inhibition can only partially restore
(20%–30%) endothelial function under physiologically
acceptable concentrations
The effect of vitamin D supplementation on the progression of benign prostatic hyperplasia: A randomized controlled trial
The intervention group received 50 000 units of vitamin D3 and the control group received a placebo every two weeks for six months.
BPH is associated with chronic inflammation and increased expressions of pro-inflammatory cytokines such as interleukin-15 [8] in stromal cells, interleukin-17 in T cells [9], interferon-gamma in basal cells and stromal cells, and IL-8 cells in growth factor-derived epithelial cells [10].
"It has been reported that a 6000 IU dose red(TYPO-per) day of Vitamin D analogs can reduce the prostate volume in BPH patients [17,26]."
Conclusion
In this study, we evaluated the effect of vitamin D supplementation on prostate volume, PSA levels, and patients’ symptoms according to the IPSS questionnaire. We found that vitamin D supplementation significantly reduced prostate volume and serum PSA levels in the intervention group compared to the control group. This effect was independent of age and the presence or absence of diabetes. Both groups had a reduction in clinical symptoms after the end of the study.Cannabidiol (CBD) Upregulates Vitamin D3 Receptors (VDRs) Expression That Modulates Cytokines (TNF-α, IL-6), Tissue Elasticity, Cellular Senescence, and Mitochondrial ATP Generation in Human and Rodent Cell Lines
Conclusion
Our data clearly show that CBD significantly increased VDR expression in human and rodent cell lines. CBD treatment also exerts anti-inflammatory effect, improved tissue elasticity, anti-senescence activity, and enhanced mitochondrial activity. In this study, for the first time, we showed the evidence suggesting that the VDR plays a critical and multifaceted role in various types of human cells.Hair Regrowth with Cannabidiol (CBD)-rich Hemp Extract –A Case Series
Menopause and estrogen deficiency are associated with apparent intestinal resistance to vitamin D, which can be reversed by estrogen replacement
Discussion
In this study, we have assessed not only the effect of aging on steroid hormone interaction in vivo but also the significance of changing estrogens levels on the bioresponse of vitamin D receptors in vitro. By using a ovariectomized model, we have simulated postmenopausal osteoporosis and by using an aging model we have assessed the effect of age-related bone loss in this interaction as well.There is evidence to suggest that estrogens regulate the activity and expression of VDR in target organs
Maybe I overlooked but I believe there was also a seasonal impact on hair growth. Considering vitamin d will be affected through the seasons it could play a factor in it.
I'm imagining low sun light plus heat. Mean less stimulus. More sun and or more cool weather can lead to more vitamin d and more stimuli.
I'm imagining low sun light plus heat. Mean less stimulus. More sun and or more cool weather can lead to more vitamin d and more stimuli.
This paper discusses the failure of vitamin D supplementation without a glutathione precursor which helps metabolize d3 to calcitriol. Also read the several similar articles about 1/3rd the page down about glutathione and Vit d3 deficiency.
I just started taking 1/8th teaspoon of MSM sublingually which can be used to make glutathione.
I read in a psoriasis forum(posted down below) about sublingual sulfur and quite a remarkable turnaround and psoriasis is not easy to control/impossible for many and likely involves a vitamin D deficiency(or resistance) and gut issues maybe just like male pattern baldness? This sublingual 30x sulfur has had many claims too by others of its success in clearing up other skin conditions. It is called "Hyland's 30x sulfur". I've decided on using MSM sublingually instead.
pubmed.ncbi.nlm.nih.gov
Vitamin D receptors are expressed in many organs and tissues, which suggests that vitamin D (VD) affects physiological functions beyond its role in maintaining bone health. Deficiency or inadequacy of 25(OH)VD is widespread globally.
Population studies demonstrate that a positive association exists between a high incidence of VD deficiency and a high incidence of chronic diseases, including dementia, diabetes, and heart disease.
However, many subjects have difficulty achieving the required circulating levels of 25(OH)VD even after high-dose VD supplementation, and randomized controlled clinical trials have reported limited therapeutic success post-VD supplementation.
Thus, there is a discordance between the benefits of VD supplementation and the prevention of chronic diseases in those with VD deficiency. Why this dissociation exists is currently under debate and is of significant public interest.
This review discusses the downregulation of VD-metabolizing genes needed to convert consumed VD into 25(OH)VD to enable its metabolic action exhibited by subjects with metabolic syndrome, obesity, and other chronic diseases.
Research findings indicate a positive correlation between the levels of 25(OH)VD and glutathione (GSH) in both healthy and diabetic individuals.
Cell culture and animal experiments reveal a novel mechanism through which the status of GSH can positively impact the expression of VD metabolism genes.
This review highlights that for better success, VD deficiency needs to be corrected at multiple levels:
(i) VD supplements and/or VD-rich foods need to be consumed to provide adequate VD, and
(ii) the body needs to be able to upregulate VD-metabolizing genes to convert VD into 25(OH)VD and then to 1,25(OH)2VD to enhance its metabolic action.
This review outlines the association between 25(OH)VD deficiency/inadequacy and decreased GSH levels, highlighting the positive impact of combined VD+LC supplementation on upregulating GSH, VD-metabolizing genes, and VDR. These effects have the potential to enhance 25(OH)VD levels and its therapeutic efficacy.
_________________________
Post from psoriasis forum: (also they have some success with CBD too)
I believe "Hylands Sulphur 30x" has cleared the psoriasis on my body. I can't find the article or comment that made me even think of trying it. I ordered it online at swansonvitamins, a bottle of 250 tablets for $5.39. They are tiny pills and you dissolve 4 under your tongue four times a day. I have not taken the dose over twice a day and even only once a day. They dissolve quickly and there is no taste. My spots of psoriasis "deactivated", they turned from red to flesh colored and now some areas are invisible and all are very faded.
I have had scalp "seborrhea dermatitis" for over fifty years and have kept it somewhat in check with coal tar shampoo and betamethasone cream until the last five years and now it covers my entire scalp. Recently I broke out in psoriasis looking spots on my hands, elbows, upper arms, thighs, knees, calves, and ankles. My elbows were solid white and the other spots varied from red to pink with scaliness. My dermatologist said it was psoriasis and the scales on my scalp were psoriasis and not "seb.derm." as he and every dermatologist I have seen over the fifty years had previously thought.
He prescribed clobetasol propionate for the body spots. I used that twice a day for two days and the spots turned even more red, seemed to enlarge a tiny bit, and there seemed to be more of them. I stopped using it. I went back to two Benadryl a night, which had seemed to improve the spots while I was waiting for my doctor’s appointment. The spots improved again, but I only took the Benadryl one night, whereas previously I had taken them five nights in a row with some improvement.
Also while waiting for my appointment, somewhere online I had read about sulphur 30x helping psoriasis and had ordered two bottles. Today I searched the Internet for info on this - sulfur psoriasis - and found none. I searched vitaminshoppe, and could not find the sulfur pills. I even searched swansonvitamins for sulfur and these pills did not come up. Only when I entered the "Item Number" from my invoice, did the bottle come up on the swanson site. It is HY103 and the label reads "Sulphur 30X Rash and Eczema."
Just now I thought to search my "favorites" to see if I had saved the article. Thank goodness I did. It is at livestrong.com and is titled "Homeopathic Treatment for Psoriasis on Scalp". It lists other treatments I have never heard of.
If you try the sulfur, please let us know the results. It is probably available at healthfood stores, but if you can't find it, Swansons delivers quickly and they are reliable. I have taken the four Hylands Sulphur 30X pills about four maybe five days, at most twice a day, and may have even forgotten one day. There is just no other explanation for this stuff disappearing so quickly. I have had it for about two months.
I just started taking 1/8th teaspoon of MSM sublingually which can be used to make glutathione.
I read in a psoriasis forum(posted down below) about sublingual sulfur and quite a remarkable turnaround and psoriasis is not easy to control/impossible for many and likely involves a vitamin D deficiency(or resistance) and gut issues maybe just like male pattern baldness? This sublingual 30x sulfur has had many claims too by others of its success in clearing up other skin conditions. It is called "Hyland's 30x sulfur". I've decided on using MSM sublingually instead.
The Impact of Vitamin D and L-Cysteine Co-Supplementation on Upregulating Glutathione and Vitamin D-Metabolizing Genes and in the Treatment of Circulating 25-Hydroxy Vitamin D Deficiency
The Impact of Vitamin D and L-Cysteine Co-Supplementation on Upregulating Glutathione and Vitamin D-Metabolizing Genes and in the Treatment of Circulating 25-Hydroxy Vitamin D Deficiency - PubMed
Vitamin D receptors are expressed in many organs and tissues, which suggests that vitamin D (VD) affects physiological functions beyond its role in maintaining bone health. Deficiency or inadequacy of 25(OH)VD is widespread globally. Population studies demonstrate that a positive association...
pubmed.ncbi.nlm.nih.gov
Vitamin D receptors are expressed in many organs and tissues, which suggests that vitamin D (VD) affects physiological functions beyond its role in maintaining bone health. Deficiency or inadequacy of 25(OH)VD is widespread globally.
Population studies demonstrate that a positive association exists between a high incidence of VD deficiency and a high incidence of chronic diseases, including dementia, diabetes, and heart disease.
However, many subjects have difficulty achieving the required circulating levels of 25(OH)VD even after high-dose VD supplementation, and randomized controlled clinical trials have reported limited therapeutic success post-VD supplementation.
Thus, there is a discordance between the benefits of VD supplementation and the prevention of chronic diseases in those with VD deficiency. Why this dissociation exists is currently under debate and is of significant public interest.
This review discusses the downregulation of VD-metabolizing genes needed to convert consumed VD into 25(OH)VD to enable its metabolic action exhibited by subjects with metabolic syndrome, obesity, and other chronic diseases.
Research findings indicate a positive correlation between the levels of 25(OH)VD and glutathione (GSH) in both healthy and diabetic individuals.
Cell culture and animal experiments reveal a novel mechanism through which the status of GSH can positively impact the expression of VD metabolism genes.
This review highlights that for better success, VD deficiency needs to be corrected at multiple levels:
(i) VD supplements and/or VD-rich foods need to be consumed to provide adequate VD, and
(ii) the body needs to be able to upregulate VD-metabolizing genes to convert VD into 25(OH)VD and then to 1,25(OH)2VD to enhance its metabolic action.
This review outlines the association between 25(OH)VD deficiency/inadequacy and decreased GSH levels, highlighting the positive impact of combined VD+LC supplementation on upregulating GSH, VD-metabolizing genes, and VDR. These effects have the potential to enhance 25(OH)VD levels and its therapeutic efficacy.
_________________________
Post from psoriasis forum: (also they have some success with CBD too)
I believe "Hylands Sulphur 30x" has cleared the psoriasis on my body. I can't find the article or comment that made me even think of trying it. I ordered it online at swansonvitamins, a bottle of 250 tablets for $5.39. They are tiny pills and you dissolve 4 under your tongue four times a day. I have not taken the dose over twice a day and even only once a day. They dissolve quickly and there is no taste. My spots of psoriasis "deactivated", they turned from red to flesh colored and now some areas are invisible and all are very faded.
I have had scalp "seborrhea dermatitis" for over fifty years and have kept it somewhat in check with coal tar shampoo and betamethasone cream until the last five years and now it covers my entire scalp. Recently I broke out in psoriasis looking spots on my hands, elbows, upper arms, thighs, knees, calves, and ankles. My elbows were solid white and the other spots varied from red to pink with scaliness. My dermatologist said it was psoriasis and the scales on my scalp were psoriasis and not "seb.derm." as he and every dermatologist I have seen over the fifty years had previously thought.
He prescribed clobetasol propionate for the body spots. I used that twice a day for two days and the spots turned even more red, seemed to enlarge a tiny bit, and there seemed to be more of them. I stopped using it. I went back to two Benadryl a night, which had seemed to improve the spots while I was waiting for my doctor’s appointment. The spots improved again, but I only took the Benadryl one night, whereas previously I had taken them five nights in a row with some improvement.
Also while waiting for my appointment, somewhere online I had read about sulphur 30x helping psoriasis and had ordered two bottles. Today I searched the Internet for info on this - sulfur psoriasis - and found none. I searched vitaminshoppe, and could not find the sulfur pills. I even searched swansonvitamins for sulfur and these pills did not come up. Only when I entered the "Item Number" from my invoice, did the bottle come up on the swanson site. It is HY103 and the label reads "Sulphur 30X Rash and Eczema."
Just now I thought to search my "favorites" to see if I had saved the article. Thank goodness I did. It is at livestrong.com and is titled "Homeopathic Treatment for Psoriasis on Scalp". It lists other treatments I have never heard of.
If you try the sulfur, please let us know the results. It is probably available at healthfood stores, but if you can't find it, Swansons delivers quickly and they are reliable. I have taken the four Hylands Sulphur 30X pills about four maybe five days, at most twice a day, and may have even forgotten one day. There is just no other explanation for this stuff disappearing so quickly. I have had it for about two months.
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Generally from the consensus I've read is that microneedling alone will not work very well. Now, I will not say all his results were from vitamin d3 but he was on a high dose of 5000 IU per day as recommended early in this thread to achieve 50 ng/ml. So, the combination of microneedling, vitamin d3 5000 IU per day and diet definitely helped this guy and also reverted his hair from a grayish to black again.
He Was Microneedling WITHOUT Finasteride/Minoxidil For 4 Months..SHOCKING Results!
Interesting that vitamin d3 is very crucial in the wounding process.
Here is an outstanding find by Benjit in showing toddlers having male pattern baldness. While they were IGF-1 deficient and that could have been entirely the cause, there is another association with Laron Syndrome besides IGF-1.
pmc.ncbi.nlm.nih.gov
We reviewed and analyzed the clinical studies that have considered the relationship between vitamin D and the GH/IGF-1 axis in pediatric populations. We found two main areas of interest: the vitamin D deficiency status in patients affected by GH deficit (GHD) and the relationship between serum vitamin D metabolites and IGF-1. Although limited by some bias, from the analysis of the studies presented in the scientific literature, it is possible to hypothesize a greater frequency of hypovitaminosis D in the subjects affected by GHD, a reduced possibility of its correction with only substitution treatment with recombinant growth hormone (rGH) and an improvement of IGF-1 levels after supplementation treatment with vitamin D.
Vitamin D and growth hormone in children: a review of the current scientific knowledge - PMC
Human growth is a complex mechanism that depends on genetic, environmental, nutritional and hormonal factors. The main hormone involved in growth at each stage of development is growth hormone (GH) and its mediator, insulin-like growth factor 1 ...
pmc.ncbi.nlm.nih.gov
We reviewed and analyzed the clinical studies that have considered the relationship between vitamin D and the GH/IGF-1 axis in pediatric populations. We found two main areas of interest: the vitamin D deficiency status in patients affected by GH deficit (GHD) and the relationship between serum vitamin D metabolites and IGF-1. Although limited by some bias, from the analysis of the studies presented in the scientific literature, it is possible to hypothesize a greater frequency of hypovitaminosis D in the subjects affected by GHD, a reduced possibility of its correction with only substitution treatment with recombinant growth hormone (rGH) and an improvement of IGF-1 levels after supplementation treatment with vitamin D.
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Results of a woman just using vitamin d3 high dose and an iron supplement. I've begun to realize that iron is also a hormetic inducer because it increases free radicals(just like nitric oxide does) at low doses. Iron levels are lower in male pattern baldness vs controls and also for females more so.
pmc.ncbi.nlm.nih.gov
Hormesis is defined operationally as biologic responses to a factor that induces beneficial effects at low doses and harmful effects at high doses. Based on findings from this study and others, we could invoke a role of hormesis to explain iron’s beneficial as well as harmful effects in AKI
Iron Plays a Certain Role in Patterned Hair Loss - PMC
Role of iron in hair loss is not clear yet. The purpose of this study was to evaluate the relationship between iron and hair loss. Retrospective chart review was conducted on patients with female pattern hair loss (FPHL) and male pattern hair loss ...
pmc.ncbi.nlm.nih.gov
Hormesis is defined operationally as biologic responses to a factor that induces beneficial effects at low doses and harmful effects at high doses. Based on findings from this study and others, we could invoke a role of hormesis to explain iron’s beneficial as well as harmful effects in AKI