What if that man was a full blown norwood 7 before ? just sayin..
I think he was a Norwood 8.5 before oral jakinibs.
New Hair Growth Mechanism Discovered
- Thread starter c_super2
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I think he was a Norwood 8.5 before oral jakinibs.
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What if that man was a full blown norwood 7 before ? just sayin..
Then he'd be a NW7 after.
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I guess this is his actuall norwood before JAK notice on the before pic one white terminal hair standing in the middle and some black hair in the front, If he was norwood 7 this hair would not be there.What if that man was a full blown norwood 7 before ? just sayin..
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look at the before pic closely you will notice there is some hair in the back and one white hair in the middle and a few in the front, and don't forget to put your glasses on.
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I'm not arguing with you man!
I'm just saying, I saw hair on that mans head, maybe it's just hair stuck on my phone, or maybe you are too old to see that, anyway I'm happy now.
All of this faith people put in JAK and now "tregs" and other stuff is pure, unpasteurized cope.
It's extremely simple in concept: The androgens cause your follicles to shrink and shorten their anagen phase until it's too tiny to produce hair (microscopic according to some studies) and after a few years fibrosis sets in and your hair is like Han Solo at the end of Empire Strikes Back only hit with some "Honey, I Shrunk The Kids" after.
The fact that every one of these researchers who makes a discovery like this and the hairloss sufferers who read it get hyped about "it's implications for other types of hairloss" or whatever, demonstrates how both the public and medical community at large don't understand Androgenetic Alopecia on even the most basic level.
Cool, turning on or off X type of immune cell or whatever made hair start or stop growing in a mouse! Yeah, I'm not surprised when that mouse actually still has normal hair follicles under there — they just weren't producing hair.
My advice to everyone in this shared hell is to give your full attention and support to groups like Tsuji, RepliCel, TissUse, HairClone, L'Oreal and Follica because the only way we're making it out is with a method that is capable of growing hair where none previously existed.
I think Tsuji's method will be an important breakthrough in hair restoration and should be a future option for burn victims and all manner of scalp conditions not suitable for cell therapy, drugs etc.
People in future will refer to this time we are living in now as the pre-genetic engineering era or "pre-GE". And as Robert Hoffman of Anticancer suggests, perhaps an imperfect but effective solution will suffice. It could be they will identify just enough genes for switching on or off with small molecule or nano-drugs to grow hair. The cure for common pattern baldness will come in a tube or a bottle, like so much striped toothpaste was a manufacturing marvel last century.
And with these latest discoveries for tregs and proteins SCF And KROX20, it's making more sense than the old theory that says normal levels of DHT sometimes but not always kills HFs to death with a high probability of maybe. Hippocrates was among the first to associate disease and hereditary. The medical community is only now acknowledging the importance of genetics and its relevance to leading edge medicine.
People in future will refer to this time we are living in now as the pre-genetic engineering era or "pre-GE". And as Robert Hoffman of Anticancer suggests, perhaps an imperfect but effective solution will suffice. It could be they will identify just enough genes for switching on or off with small molecule or nano-drugs to grow hair. The cure for common pattern baldness will come in a tube or a bottle, like so much striped toothpaste was a manufacturing marvel last century.
And with these latest discoveries for tregs and proteins SCF And KROX20, it's making more sense than the old theory that says normal levels of DHT sometimes but not always kills HFs to death with a high probability of maybe. Hippocrates was among the first to associate disease and hereditary. The medical community is only now acknowledging the importance of genetics and its relevance to leading edge medicine.
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It's really like those guys taking out the spark plug of an engine and then saying: the engine doesn't run without the spark plugs!
Then replacing the spark plugs in and engine that previously exploded and wonder why it doesn't help.
Spark plugs being prostaglandins.
Then replacing the spark plugs in and engine that previously exploded and wonder why it doesn't help.
Spark plugs being prostaglandins.
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That sounds like the soon to be obsolete medieval theory of male pattern baldness. ~~ Well we denatured him with finasteride and even cut off his testicles, but he's still topless. Hmm? We will call it "dht sensitivity" and tell the poor slobs to rock it.
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Possibly relevant: Cotsarelis, Yang and Garza showed that there are marked differences in stem cell activity between bald and non-bald scalps. Could defective tregs be causing this?
Either way, stem cells are needed for HF to regenerate in normal hair cycling. If tregs increase these stem cells, it could be useful in treating other hairloss disorders and possibly Androgenetic Alopecia.
DHT inhibitors are known to slow Androgenetic Alopecia. But on the growth side of problem, newer studies of PRP, derma rolling and hair plucking, the techniques apparently work by increasing stem cell activity in Balding scalps. Perhaps if tregs increase stem cells, it could lead to a treatment for growing hair in Androgenetic Alopecia if researchers find out that tregs are deficient in pattern balding scalps.
Either way, stem cells are needed for HF to regenerate in normal hair cycling. If tregs increase these stem cells, it could be useful in treating other hairloss disorders and possibly Androgenetic Alopecia.
DHT inhibitors are known to slow Androgenetic Alopecia. But on the growth side of problem, newer studies of PRP, derma rolling and hair plucking, the techniques apparently work by increasing stem cell activity in Balding scalps. Perhaps if tregs increase stem cells, it could lead to a treatment for growing hair in Androgenetic Alopecia if researchers find out that tregs are deficient in pattern balding scalps.
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Some recent studies of the effects of NAD+, nicotinamide riboside on stem cells, such as this one,
http://science.sciencemag.org/content/early/2016/04/27/science.aaf2693, has me tempted to go to the Bro'Science Lab with my 100mg capsules and a Dermastamp. Hmmm, nothing to lose, I guess. Except maybe more hair. Anyone else care to speculate?
http://science.sciencemag.org/content/early/2016/04/27/science.aaf2693, has me tempted to go to the Bro'Science Lab with my 100mg capsules and a Dermastamp. Hmmm, nothing to lose, I guess. Except maybe more hair. Anyone else care to speculate?
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There are many possibly explanations for this. For example, this is exactly what you would expect to see with defective Wnt signaling. Hair follicle stem cells activated in the absence of Wnt signaling become sebocytes and form large sebaceous glands instead of large hair follicles. Without any evidence for Treg dysfunction in A.G.A, and with a great deal of evidence for Wnt signaling involvement in A.G.A, wouldn't that be the first place to look for explaining this?
S Foote.
Experienced Member
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This tregs idea that immune cells are necessary to enlarge hair follicles, is typical of the bad science in this field. The only study where actual Human male pattern baldness follicles significantly enlarged, was when these were transplanted into immune deficient mice. This throws this idea right out of the window.
http://www.jaad.org/article/S0190-9622(02)61499-9/pdf
If nothing else this study demonstrates that Human male pattern baldness follicles can significantly re-enlarge given the right "external" conditions.
S. Foote, Rosenblum said that in addition to tregs increasing in numbers in HFSC and directing them to regenerate, tregs are also found in lymph nodes. I thought you'd find that interesting. Lymph and immune system work together, yes? I think the lymphatic system is also poorly understood.
InBeforeTheCure, yes I am aware of the studies on Wnt and BMP signalling for hfSC differentiation. A number of researchers have identified importance of Wnt signalling in skin and HF. Cotsarelis et al discovered that Fgf9 originates from gamma delta T cells, a subset of T cells involved in the immune response. Fgf9 is a catalyst for a signal sent by a Wnt pathway.
InBeforeTheCure, yes I am aware of the studies on Wnt and BMP signalling for hfSC differentiation. A number of researchers have identified importance of Wnt signalling in skin and HF. Cotsarelis et al discovered that Fgf9 originates from gamma delta T cells, a subset of T cells involved in the immune response. Fgf9 is a catalyst for a signal sent by a Wnt pathway.
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S Foote.
Experienced Member
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Well yes, lymphatic function is closely linked to immune function. That is why in my opinion DHT induced lymphatic insufficiency in the male pattern baldness area, also creates the recognised changes in immunology and fibrosis in this area. Such changes are recognised in tissues subject to lymphedema as I reference in my article.
My point here is that the only study to demonstrate a significant re-enlargement of male pattern baldness follicles, clearly demonstrates that there is no cellular or molecullar problem with the follicles themselves. The important factor must be external, and these studies that suggest a faulty hair cycle and other internal factors are just not relevant.
This important significant re-enlargement of male pattern baldness follicles in this study ( What people here want), has to be explained! The evidence for my explanation is in my article.
And more studies are pointing to links between Androgenetic Alopecia and:
- Heart problems
- Insulin resistance
- Prostate cancer
- Metabolic disorder
- Polycystic ovarIan disorder
havent we always really known male pattern baldness is more than just DHT? We just never understood what that is, and if you have insulin resistance or other issues there is not a lot of things that can be practically done today to fix that anyway. DHT is one thing we can alter with propecia, and is proven to make a big difference where we can actually use a molecule to change that. We always knew its more then hormones in a deeper level, but there has to be a practical way to address the problem or its pointless theory.
From theory to practical application that can fix or alter the problem is a very huge leap.
Good point because, yes, according to a British study, type II diabetes was reversed in 12 of 30 patients who lost weight through diet and, more importantly, lost fat in their pancreas, about one gram of pancreatic fat loss apparently enough to relieve stress on the organ. Other studies have shown that insulin resistance in muscle cells (and insulin sensitivity in fat cells) can be reversed with diet and exercise. Type 2 doesn't always have to lead to the more serious type I condition. Is it possible to reverse baldness through diet and exercise similarly? Or as S. Foote says possibly by increasing blood flow and reducing the hydraulic effect with lymph drainage in and around the scalp?
This study of botox injections into the scalps of Balding men revealed similar results to Merck's propecia. I tbink iy suggests that increasing blood flow in the scalp is just as effective as blocking DHT and tends to support S. Foote's theory for a hostile environment in general. Why does DHT have the exact opposite effect on HF everywhere else on the body beginning at puberty?
http://journals.lww.com/plasreconsu..._Botulinum.79.aspx?WT.mc_id=HPxADx20100319xMP<br%20/>
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