Newly Discovered Factor in Androgenetic Alopecia. The Cure is Near?

[2020]

Re: A recently discovered new factor in AA, the cure is near

I have a question, squeegee posted earlier that thyme oil reduces COX-2 Enzymatic activity now while that reduces good Prostaglandins would combining thyme oil with minoxidill (presuming that minoxidil
up-regulates PGE2) be a good start until we can see the results from this OC000459 experiment.

probably.... btw, emu oil which I assume you're still using, is a weak PGD2 blocker.

 

[2020]

Re: A recently discovered new factor in AA, the cure is near

http://academic.research.microsoft.com/Paper/6827994

....To better understand the role of COX-2 in tumorigenesis, we generated transgenic mice that overexpress COX-2 under control of the human keratin 14 promoter, which allows for expression in the epidermis and some other epithelia. Transgenic mice, referred to as K14.COX2 mice, were readily distinguished from their nontransgenic littermates by the appearance of significant alopecia. Administration of a specific COX-2 inhibitor restored hair growth, indicating that the alopecia was attribut- able to elevated COX-2 enzymatic activity......

Any arthritis drug should restore hair then I guess..... :whistle:



This guy from HairSite had it all right:
http://www.hairsite.com/hair-loss/board ... ory-0.html

...From research all over it has been learned that WNT signalling plays a very important role in hair growth. Increasing prostaglandin increases WNT signalling....

correcting prostaglandins === FULL REGROWTH unk:

 

[zeroes]

Re: A recently discovered new factor in AA, the cure is near

http://academic.research.microsoft.com/Paper/6827994

....To better understand the role of COX-2 in tumorigenesis, we generated transgenic mice that overexpress COX-2 under control of the human keratin 14 promoter, which allows for expression in the epidermis and some other epithelia. Transgenic mice, referred to as K14.COX2 mice, were readily distinguished from their nontransgenic littermates by the appearance of significant alopecia. Administration of a specific COX-2 inhibitor restored hair growth, indicating that the alopecia was attribut- able to elevated COX-2 enzymatic activity......

Any arthritis drug should restore hair then I guess..... :whistle:



This guy from HairSite had it all right:
http://www.hairsite.com/hair-loss/board ... ory-0.html

[quote:2rci6nrl]...From research all over it has been learned that WNT signalling plays a very important role in hair growth. Increasing prostaglandin increases WNT signalling....

correcting prostaglandins === FULL R

EGROWTH unk:[/quote:2rci6nrl]

Do you have a theory on pgd2 and cox-2 regarding castrated men? If this is the cure we need to at least think about that.

 

[2020]

Re: A recently discovered new factor in AA, the cure is near

btw, anyone remember this study:

Stress-blocking drug restores hair in bald mice
http://www.reuters.com/article/2011/02/ ... AT20110216

^ that's how Astressin-B was born....

Well, Cortisol is a stress hormone and guess what: CORTISOL ACTUALLY INHIBITS PROSTAGLANDIN PRODUCTION.

Stress === PROSTAGLANDIN INBALANCE === HAIR LOSS.

 

[2020]

Re: A recently discovered new factor in AA, the cure is near

Do you have a theory on pgd2 and cox-2 regarding castrated men? If this is the cure we need to at least think about that.

not sure about that.... I'm also surprised that castrated men are not regrowing ALL of their hair, it only halts further loss :jackit:

 

[zeroes]

Re: A recently discovered new factor in AA, the cure is near

Good point.

My only worry is mice, they can regrow hair with just about anything, so doing the opposite for experimenting shouldn't be that hard.

 

[2020]

Re: A recently discovered new factor in AA, the cure is near

Excessive sebum? PGD2 is responsible for that too:

Characteristic of the steps of baldness in humans, the mice who had applied levels of prostaglandin in their skin for purposes of the study, lost their hair, their follicles got smaller and the sebaceous gland got larger.

.... so who else thinks that this is just another "sensational" study? :innocent:

 

[TravisB]

Re: A recently discovered new factor in AA, the cure is near

It seems that this discovery makes a lot of sense regarding hairloss. Someone must try this OC000459 ASAP.

 

[squeegee]

Re: A recently discovered new factor in AA, the cure is near

male pattern baldness is just a chronic inflammation condition.

Read this page over and over: http://themedicalbiochemistrypage.org/eicosanoids.php


PGD2 is 3X the norm because of the inflammation: PGD2 Major biological activities: inhibits platelet and leukocyte aggregation, decreases T-cell proliferation and lymphocyte migration and secretion of IL-1? and IL-2; induces vasodilation and production of cAMP

 

[BrightonBaldy]

Re: A recently discovered new factor in AA, the cure is near

Almost every new post makes me more confident about this, I guess it will all just take time with our experiments to find out.

You know... while you were all out reading those reports and fighting; your hair was falling out, time to move on.... can any of the best read posters here list some or all of the available theoretical treatments?

 

[Boldy]

Re: A recently discovered new factor in AA, the cure is near

Do you have a theory on pgd2 and cox-2 regarding castrated men? If this is the cure we need to at least think about that.

not sure about that.... I'm also surprised that castrated men are not regrowing ALL of their hair, it only halts further loss :jackit:

Maybe due to the Lack of COX2? Testosterone also up regulates COX, these men might have a lack of good prostaglandins like E2 and F2a..

I guess they could regrowth once PGE2+F2a is added.

 

[zeroes]

Re: A recently discovered new factor in AA, the cure is near

I thought we had to reduce cox-2.

 

[Fight Your Genes]

Re: A recently discovered new factor in AA, the cure is near

This study is certainly filling the gaps in our knowledge of male pattern baldness, why the pattern occurs the way it does is still a mystery though. Great quote regarding excessive sebum and prostaglandins 2020. It seems that PGD2 is connected to all the pathways for male pattern baldness.

It would be great If we could get a good list of PGD2 inhibitors and PGE2 up regulators. Another questions for you guys, are we looking to lower our total serum levels of PGD2 or just localized levels in the scalp......and which method would work best?

 

[2020]

Re: A recently discovered new factor in AA, the cure is near

male pattern baldness is just a chronic inflammation condition.

Read this page over and over: http://themedicalbiochemistrypage.org/eicosanoids.php


PGD2 is 3X the norm because of the inflammation: PGD2 Major biological activities: inhibits platelet and leukocyte aggregation, decreases T-cell proliferation and lymphocyte migration and secretion of IL-1? and IL-2; induces vasodilation and production of cAMP

speaking of inflammation....

"Reversal of male-pattern baldness, hypertrichosis, and accelerated hair and nail growth in patients receiving benuxaprofen"
http://www.ncbi.nlm.nih.gov/pmc/article ... 3-0024.pdf

In 1982, 5 people accidentally reversed their hair loss by taking benuxaprofen which is an anti-inflammatory drug.... :woot:


also: male pattern baldness itch == Inflammation? :dunno:

 

[2020]

Re: A recently discovered new factor in AA, the cure is near

This study is certainly filling the gaps in our knowledge of male pattern baldness, why the pattern occurs the way it does is still a mystery though. Great quote regarding excessive sebum and prostaglandins 2020. It seems that PGD2 is connected to all the pathways for male pattern baldness.

some guy on HairSite had this theory:

Another interesting obversvation... the question we all ask... Why does hairloss begin in a horshoe pattern? Well because since some people due to genetic or other stimuli/factors stop producing good prostaglandin or not enough the hair stem cells shut down and than the cells around also react to their deaths and its a chain cycle that spreads.

 

[Fight Your Genes]

Re: A recently discovered new factor in AA, the cure is near

This study is certainly filling the gaps in our knowledge of male pattern baldness, why the pattern occurs the way it does is still a mystery though. Great quote regarding excessive sebum and prostaglandins 2020. It seems that PGD2 is connected to all the pathways for male pattern baldness.

some guy on HairSite had this theory:

Another interesting obversvation... the question we all ask... Why does hairloss begin in a horshoe pattern? Well because since some people due to genetic or other stimuli/factors stop producing good prostaglandin or not enough the hair stem cells shut down and than the cells around also react to their deaths and its a chain cycle that spreads.

Makes sense. I guess the opposite should be true for reactivating them so.. The regrowth on the arthritis drugs seems quite dramatic, they must lower COX-2 significantly. OC000459 hopefully will work even better as it targets the receptor directly.

 

[odalbak]

Re: A recently discovered new factor in AA, the cure is near

also: male pattern baldness itch == Inflammation? :dunno:

That's an excellent question. If we stop the inflammation process by removing excess of PGD2, would that stop the male pattern baldness itch or not? In other words is inflammation the consequence of male pattern baldness itch or the cause of it?

Another related question I have is why do I always feel male pattern baldness itch (in the vertex area) after applying Nizoral ?

 

[CarlosSL]

Re: A recently discovered new factor in AA, the cure is near

Hi all, I am very depressed, I cry a lot, I'm sad. sh*t alopecia.

There is hope for us? ... someday really will get a solution for alopecia? ... I'm sorry, but I'm depressed.

 

[2020]

Re: A recently discovered new factor in AA, the cure is near

Hi all, I am very depressed, I cry a lot, I'm sad. sh*t alopecia.

There is hope for us? ... someday really will get a solution for alopecia? ... I'm sorry, but I'm depressed.

do you have alopecia areata or just male pattern baldness?

right, now I'm almost 100% positive that you can grow back every single hair if you corrected your prostaglandin levels.
You can regrow everything. No need for Replicel, Histogen, etc... :innocent:

 

[CarlosSL]

Re: A recently discovered new factor in AA, the cure is near

I have androgenic alopecia. I have 20 years and I feel very bad. I do not want false hope, just know how many years left for a solution. sorry for my english