Newly Discovered Factor in Androgenetic Alopecia. The Cure is Near?

[israelite]

Re: A recently discovered new factor in AA, the cure is near

I have a bad feeling that finasteride will remain our best treatment at least until Histogen or CB-03-01 comes out, which probably will be around 2016-2018.

travis u taking finasteride? your hairline was no more than Norwood 2! finasteride+minoxidil and maybe ru would work

 

[2020]

Re: A recently discovered new factor in AA, the cure is near

PGD2 is linked to COX-2 activity.Although COX-2 activity was found to be necessary for early growth of hair follicle (6), PG injection or PG excess induced anagen to catagen transition and alopecia.

Finasteride inhibit Cox-1 and Cox-2.

..... ALL prostaglandins are linked to COX-2 as it's the one thing that actually produces prostaglandins!

forget about all those other things. THE ONLY THING that's out of whack in us bald people is PGD2. ELIMINATE IT and baldness will be cured.

The best way to eliminate it is by targeting GPR44 receptor. Asthma drugs have been doing just that for a while and it works.

 

[2020]

Re: A recently discovered new factor in AA, the cure is near

im sure i read elsewhere that ceterizine actually increases hairloss.

it decreases PGD2 production, so how can that be?

apparently it does decreases PGD2 production, but where did you read that it increases hair loss? :dunno:

 

[2020]

Re: A recently discovered new factor in AA, the cure is near

I have a bad feeling that finasteride will remain our best treatment at least until Histogen or CB-03-01 comes out, which probably will be around 2016-2018.

how so? Have you been reading this thread? DHT is irrelevant at this point. Prostaglandins is where it's at :whistle:

 

[BrightonBaldy]

Re: A recently discovered new factor in AA, the cure is near

i cant remember, it was when i googled how to reduce PGD2, seemed too good to be true that reducing the production of pgd2 involved walking to the local pharmacy and spending a couple of quid.

cant seem to find the report now.

 

[squeegee]

Re: A recently discovered new factor in AA, the cure is near

PGD2 is linked to COX-2 activity.Although COX-2 activity was found to be necessary for early growth of hair follicle (6), PG injection or PG excess induced anagen to catagen transition and alopecia.

Finasteride inhibit Cox-1 and Cox-2.

..... ALL prostaglandins are linked to COX-2 as it's the one thing that actually produces prostaglandins!

forget about all those other things. THE ONLY THING that's out of whack in us bald people is PGD2. ELIMINATE IT and baldness will be cured.

The best way to eliminate it is by targeting GPR44 receptor. Asthma drugs have been doing just that for a while and it works.

What LOL...man.. you are such a donkey..seriously.. You don't need a PGD2 inhibitor.. You need some brain cells transplant. :shakehead:

 

[2020]

Re: A recently discovered new factor in AA, the cure is near

What LOL...man.. you are such a donkey..seriously.. You don't need a PGD2 inhibitor.. You need some brain cells transplant. :shakehead:

sticks and stones.... :whistle:

instead of calling me an idiot each time, why don't you post a legit argument as to why you think I was wrong in the first place?

 

[squeegee]

Re: A recently discovered new factor in AA, the cure is near

What LOL...man.. you are such a donkey..seriously.. You don't need a PGD2 inhibitor.. You need some brain cells transplant. :shakehead:

sticks and stones.... :whistle:

instead of calling me an idiot each time, why don't you post a legit argument as to why you think I was wrong in the first place?

Start reading and stop yapping like a f*****g Chihuahua..It is all over this thread ..You maybe suffering from ADD or Dyslexia??? PGD2 is elevated which cause inhibition of hair growth.. but PGD2 is also needed for normal hair growth. This is why total inhibition of it doesn't sound right.. but I could be wrong as well.. This is why I will follow this thread and read the feedback from the guinea pigs on here.There is also an inflammation factor linked to male pattern baldness, elevated PGD2 that we know, over-active androgen and problems with the migration of the progenitors cell..All of this have something in common with the over expressed COX-2 enzyme.

 

[utallday]

Re: A recently discovered new factor in AA, the cure is near

has anyone seen the dog and horse liquid aspirin? not sure how safe it is for human use or if it even has the active ingredients, but if it does, it might be a good place to start.

 

[2020]

Re: A recently discovered new factor in AA, the cure is near

PGD2 is elevated which cause inhibition of hair growth..

true

but PGD2 is also needed for normal hair growth.

100% false. OTHER prostaglandins are needed hair growth WHICH IS WHY YOU DON'T WANT TO TOUCH COX-2!

why would a certain number of PGD2 be very good for your hair, but once it goes past some level, it actually destroys hair.

This is why total inhibition of it doesn't sound right.. but I could be wrong as well..

when localized at the scalp - total inhibition is right and it will stop hair from thinning.
You are wrong.

This is why I will follow this thread and read the feedback from the guinea pigs on here.There is also an inflammation factor linked to male pattern baldness, elevated PGD2 that we know, over-active androgen and problems with the migration of the progenitors cell..All of this have something in common with the over expressed COX-2 enzyme.

PGD2 is inflammatory.... messing around with COX-2 will also mess with other prostaglandins which you don't want to do!

hair loss isn't that complicated..... a protein which has a function of INHIBITING HAIR GROWTH is produced in excess. Block that protein entirely and you will stop hair loss.

 

[squeegee]

Re: A recently discovered new factor in AA, the cure is near

PGD2 is elevated which cause inhibition of hair growth..

true

but PGD2 is also needed for normal hair growth.

100% false. OTHER prostaglandins are needed hair growth WHICH IS WHY YOU DON'T WANT TO TOUCH COX-2!

why would a certain number of PGD2 be very good for your hair, but once it goes past some level, it actually destroys hair.

This is why total inhibition of it doesn't sound right.. but I could be wrong as well..

when localized at the scalp - total inhibition is right and it will stop hair from thinning.
You are wrong.

This is why I will follow this thread and read the feedback from the guinea pigs on here.There is also an inflammation factor linked to male pattern baldness, elevated PGD2 that we know, over-active androgen and problems with the migration of the progenitors cell..All of this have something in common with the over expressed COX-2 enzyme.

PGD2 is inflammatory.... messing around with COX-2 will also mess with other prostaglandins which you don't want to do!

hair loss isn't that complicated..... a protein which has a function of INHIBITING HAIR GROWTH is produced in excess. Block that protein entirely and you will stop hair loss.

I cannot fix stupid. :shakehead:

 

[odalbak]

Re: A recently discovered new factor in AA, the cure is near

i cant remember, it was when i googled how to reduce PGD2, seemed too good to be true that reducing the production of pgd2 involved walking to the local pharmacy and spending a couple of quid.

If something reduces PGD2 but also reduces useful prostaglandins like PGF2 and PGE2 then it will have adverse effect on hair growth.

 

[CarlosSL]

Re: A recently discovered new factor in AA, the cure is near

Hi all, (Sorry for my English)
I come from a Spanish forum, where we have 1 month testing with cetirizine. Most of us have noticed good results, less hair fall and decreased fat and itching.

TESTIMONIALS:

robertto1 wrote:
I did not want to be presumptuous and on day 2 ... but I must admit that this is better than the Fairy lol.
I run my fingers over his forehead (which at the end of the day was always oily skin), and now is that there is no trace male!

albertmag wrote:
if not psychological or but I seem to notice an improvement in hair ... 16 days ago and I take cetirizine but I have to clarify that I get minoxidil (2 years ago) and irregularly (10 days ago) I take chia oil (omega 3).

peladono wrote:
I took 11 days, must be early to assess results, which note was less grease on his forehead, and especially the most prominent by far is that: at night lately I grabbed a whole body itch Unbearable and since taking I was magically cetirizine

albertmag wrote:
I took 17 days and cut the grease and almost instantly noticed a slight improvement.

robertto1 wrote:
I will be at least until late June. At the moment the fat, I have observed from day 2 that we nipped in the bud ...

pelonovo wrote:
I took 11 days, I noticed that if the hair has fallen to me are on hand to give me minoxidil ...
I will continue commenting and I,,, I think this product in synergy with the other can give me a little better result ....

Lanjaron wrote:
Another one that adds to the evidence of cetirizine ... I bought 2 boxes of 20 tablets, with the last night and took 3 shots (tonight will be the fourth)

1: Miracle antrigrasa as discussed (from the second shot), it is true that I have been using treatments for excess fat in the face but .. What the hell! if I take one year using these treatments and has hardly changed. So put it down to cetirizine, but not exactly understand the relationship seborrhea leather / face - anti allergen.
2: The Fall ... Well, last night I used minoxidil and it is true that I saw only 2 hairs, but it gave me for noticing, because the truth is that I never fixed, you may always take me out 2/3 hairs. (Also, 3 days of making do not think that is meaningful to the fall, wait at least 20 days)

Artemia wrote:
5 days with Alernix:
- Low significant oiliness on the face.
- Low interest in hair loss.
- I sleep like a baby ..

alexin wrote:
8 days with cetirizine. What is strict hair fall that I can see in my hands, hair dryer and others is very true that it falls less, just nothing. As for fat, of course in the face it shows a lot, the front by example just shows the usual fat, right. On the scalp it is harder to see but I also think there is less sebum. As for side effects only, I have noticed that I sleep better, which is very positive.

Forum: http://foro.recuperarelpelo.com/viewtopic.php?t=39976

 

[Boldy]

Re: A recently discovered new factor in AA, the cure is near

I use Levo cetrizine + cetrizine for my high fever, and i noticed that all the itch goes away. But not sure if it did slowdown my hairloss. I don't think its that effective.

Hi all, (Sorry for my English)
I come from a Spanish forum, where we have 1 month testing with cetirizine. Most of us have noticed good results, less hair fall and decreased fat and itching.

TESTIMONIALS:

robertto1 wrote:
I did not want to be presumptuous and on day 2 ... but I must admit that this is better than the Fairy lol.
I run my fingers over his forehead (which at the end of the day was always oily skin), and now is that there is no trace male!

albertmag wrote:
if not psychological or but I seem to notice an improvement in hair ... 16 days ago and I take cetirizine but I have to clarify that I get minoxidil (2 years ago) and irregularly (10 days ago) I take chia oil (omega 3).

peladono wrote:
I took 11 days, must be early to assess results, which note was less grease on his forehead, and especially the most prominent by far is that: at night lately I grabbed a whole body itch Unbearable and since taking I was magically cetirizine

albertmag wrote:
I took 17 days and cut the grease and almost instantly noticed a slight improvement.

robertto1 wrote:
I will be at least until late June. At the moment the fat, I have observed from day 2 that we nipped in the bud ...

pelonovo wrote:
I took 11 days, I noticed that if the hair has fallen to me are on hand to give me minoxidil ...
I will continue commenting and I,,, I think this product in synergy with the other can give me a little better result ....

Lanjaron wrote:
Another one that adds to the evidence of cetirizine ... I bought 2 boxes of 20 tablets, with the last night and took 3 shots (tonight will be the fourth)

1: Miracle antrigrasa as discussed (from the second shot), it is true that I have been using treatments for excess fat in the face but .. What the hell! if I take one year using these treatments and has hardly changed. So put it down to cetirizine, but not exactly understand the relationship seborrhea leather / face - anti allergen.
2: The Fall ... Well, last night I used minoxidil and it is true that I saw only 2 hairs, but it gave me for noticing, because the truth is that I never fixed, you may always take me out 2/3 hairs. (Also, 3 days of making do not think that is meaningful to the fall, wait at least 20 days)

Artemia wrote:
5 days with Alernix:
- Low significant oiliness on the face.
- Low interest in hair loss.
- I sleep like a baby ..

alexin wrote:
8 days with cetirizine. What is strict hair fall that I can see in my hands, hair dryer and others is very true that it falls less, just nothing. As for fat, of course in the face it shows a lot, the front by example just shows the usual fat, right. On the scalp it is harder to see but I also think there is less sebum. As for side effects only, I have noticed that I sleep better, which is very positive.

Forum: http://foro.recuperarelpelo.com/viewtopic.php?t=39976

 

[BrightonBaldy]

Re: A recently discovered new factor in AA, the cure is near

i cant remember, it was when i googled how to reduce PGD2, seemed too good to be true that reducing the production of pgd2 involved walking to the local pharmacy and spending a couple of quid.

If something reduces PGD2 but also reduces useful prostaglandins like PGF2 and PGE2 then it will have adverse effect on hair growth.

Cetirizine was first described as a specific anti-H1 molecule displaying potent antiallergic activity. It was later found that its pharmacological properties extended to cellular actions as on eosinophil recruitment at inflammatory sites in allergic patients. Monocytes and macrophages participate in allergic mechanisms, particularly through high affinity H1 and H2 membrane receptors and generation of pro- and anti-inflammatory agents; among them histamine-induced factors, IL-1 and prostanoids are of importance. The aim of this work was to investigate the effect exerted by various concentrations of cetirizine (0.1-10 micrograms/ml) applied in vitro to human monocytes and peritoneal rat macrophages cultured for 24 h. Peritoneal macrophages were collected either from normal or experimentally inflamed rats. Human monocytes, isolated from peripheral blood, were studied either in a resting state or after stimulation by LPS from Escherichia coli (1 and 10 micrograms/ml). Cetirizine (10 micrograms/ml) significantly enhanced IL-1 release by human monocytes stimulated by a weak LPS concentration (1 microgram/ml) but could not modify the maximal increase of IL-1 release induced by 10 micrograms/ml of LPS. It did not exert any effect on resting cells. Cetirizine (0.1-10 micrograms/ml) enhanced PGE2 release by resting human monocytes. Concentrations of 1 and 10 micrograms/ml enhanced PGE2 release by LPS-stimulated monocytes, and by healthy and inflamed rat macrophages. This effect was concentration-dependent. Our findings point to an anti-inflammatory action of cetirizine via PGE2 release and histamine H2 interactions. Cetirizine did not directly modify IL-1 generation by resting monocytes but the IL-1 production observed after LPS stimulation could promote the mechanisms by which PGE2 is released.

http://www.mendeley.com/research/vitro- ... monocytes/

not sure about PGF2, at least on rats it doesnt inhibit the useful postandrogens

 

[jonson]

Re: A recently discovered new factor in AA, the cure is near

If is it true than why hair from hair transplant don't fall ?

 

[TravisB]

Re: A recently discovered new factor in AA, the cure is near

The problem with OC000459 might be the topical application. We don't even know if it will work that way, and also don't know the vehicle!

 

[2020]

Re: A recently discovered new factor in AA, the cure is near

I cannot fix stupid. :shakehead:

which part was stupid? go on...

 

[BrightonBaldy]

Re: A recently discovered new factor in AA, the cure is near

10mg cetirizine tablets, 14 for 1 pound in a shop near me.

there must be some way to use this at that price, think itd be worth trying to make a topical?

 

[BrightonBaldy]

Re: A recently discovered new factor in AA, the cure is near

for the first time ever ive decided to just do something without having somebody else try it out first.


for hayfever it says to take 10mg or 1 tablet per day orally, ive no need for that, im trying to stop my hair falling out, nevermind sneezing.

so ive decided that using 30mg per day topically really should be enough, if it doesnt work then so be it, ill just be a few puny hairs and a little bit lighter in the wallet. this drug was not designed to be used in this way, i dont live in fear.

so for a month id need about 90 tablets, instead i just bought 6 packets, so ive now got 84 tablets (840mg) of cetirizine. 840mg over 30 days is 28mg per day average.

ive mixed all of them in with an entire bottle of alpecin liquid, usually lasts a month per bottle when used once daily. ive got 3 bottles of this stuff here anyway, its a fairly useless product in my opinion but its one of the best topical vehicles ive ever used. costs are reasonable aswell, money in itself isnt a huge issue but ive no idea what will happen in the future. the cheaper the regime i can muster then the more likely itll be futureproof.. last thing id ever want to be doing is getting locked into a 50-100 quid a month regime that i might be forced to quit one day.

to mix them i sterilized my blender, dried it totally, poured in the entire contents of an alepcin bottle and then the 84 pills. i blasted it for a good few minutes until it was totally saturated. i was left with a milky white liquid that ive then poured into an empty bottle to last me the month.

anyway, i tried it once on my scalp and as expected the entire dose was absorbed within about 10 minutes, my scalp is now bone dry. there was an almost instant tingling sensation as i applied the topical on my male pattern baldness areas, so good or bad its doing something.

hopefully me and the spanairds can grow some f*cking hair