baldnesssadness
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this is getting more and more complicated 
Newly Discovered Factor in Androgenetic Alopecia. The Cure is Near?
- Thread starter yassin
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here is a theory .. kind of outside the square thinking .. why not use excess Cox-2 to our advantage ?
literature states the the pathway from Arachodonic Acid to the PG's go like this
Arachodonic Acid => (Cox1/2) =>PGH2 => (H-PGDS) => PGD2
Arachodonic Acid => (Cox1/2) =>PGH2 => (PTGESx) => PGE2
Rather than concern ourselves with excess Cox-2, why not inhibit the enzyme H-PGDS which will reduce PGD2 and leave more PGH2 to be coverted to the good PG's PGe2 and PGf2a.
There is one H-PGDS inhibitor out there called HQL-79, but difficult to source and doesnt look cheap
literature states the the pathway from Arachodonic Acid to the PG's go like this
Arachodonic Acid => (Cox1/2) =>PGH2 => (H-PGDS) => PGD2
Arachodonic Acid => (Cox1/2) =>PGH2 => (PTGESx) => PGE2
Rather than concern ourselves with excess Cox-2, why not inhibit the enzyme H-PGDS which will reduce PGD2 and leave more PGH2 to be coverted to the good PG's PGe2 and PGf2a.
There is one H-PGDS inhibitor out there called HQL-79, but difficult to source and doesnt look cheap
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Dennis Bergkamp
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chaps. please see below. we need to increase synthesis to PGe2 and PGf2, whilst inhibiting HPGDS/LPGDS
(Hematopoietic prostaglandin D synthase (HPGDS) is primarly expressed in mast cells, antigen-presenting cells, and Th-2 cells. HPGDS converts PGH[SUB]2[/SUB] into PGD[SUB]2[/SUB], a mediator thought to play a pivotal role in airway allergy and inflammatory processes)
ALLERGIC RESPONSE PEOPLE! BALDNESS IS A FREAKIN INFLAMMATORY RESPONSE. To free radicals/allergens whatever.
OH, and TBHQ the antioxidant people sh*t themselves about in chicken nuggets increases AKR1C1 and AKR1C2 expression.
We do however need increased AKR1C3 expression to synthesize PGd2 to 11beta-PGF2alpha- more potent than PGDF btw. Just dont swollow that sheet because it promotes cancer cell survival: Microarray and bioinformatics analysis suggested that overexpression of AKR1C3 in PC-3 cells modulates estrogen and androgen metabolism, activates insulin-like growth factor (IGF)-1 and Akt signaling pathways, as well as promotes tumor angiogenesis and aggressiveness
Funny how whats good for your body is bad for hair and visa versa huh? hairloss is your body being too freakin good at what it does and not caring about your vanity.
How do we increase AKR1c3? fudge knows! but if it diverts PGH2 towards PGF2 and not PGD2 or the deadlier PGJ2, then great!
Im looking into AT-56 and HQL; doubt there is much to it as asthma meds would be using it.
(Hematopoietic prostaglandin D synthase (HPGDS) is primarly expressed in mast cells, antigen-presenting cells, and Th-2 cells. HPGDS converts PGH[SUB]2[/SUB] into PGD[SUB]2[/SUB], a mediator thought to play a pivotal role in airway allergy and inflammatory processes)
ALLERGIC RESPONSE PEOPLE! BALDNESS IS A FREAKIN INFLAMMATORY RESPONSE. To free radicals/allergens whatever.
OH, and TBHQ the antioxidant people sh*t themselves about in chicken nuggets increases AKR1C1 and AKR1C2 expression.
We do however need increased AKR1C3 expression to synthesize PGd2 to 11beta-PGF2alpha- more potent than PGDF btw. Just dont swollow that sheet because it promotes cancer cell survival: Microarray and bioinformatics analysis suggested that overexpression of AKR1C3 in PC-3 cells modulates estrogen and androgen metabolism, activates insulin-like growth factor (IGF)-1 and Akt signaling pathways, as well as promotes tumor angiogenesis and aggressiveness
Funny how whats good for your body is bad for hair and visa versa huh? hairloss is your body being too freakin good at what it does and not caring about your vanity.
How do we increase AKR1c3? fudge knows! but if it diverts PGH2 towards PGF2 and not PGD2 or the deadlier PGJ2, then great!
Im looking into AT-56 and HQL; doubt there is much to it as asthma meds would be using it.
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Yeah, it is interesting but, why this process only affect at certain scalp hairs?
The key at common baldness, in my opinion, is the special pattern of hairloss,...., genetics perhaps? I doubt it because all healthy scalp hair are equals,
The key at common baldness, in my opinion, is the special pattern of hairloss,...., genetics perhaps? I doubt it because all healthy scalp hair are equals,
Dennis Bergkamp
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my theory is that the galea becomes tighter in some than others. Genetically, where the relevant muscles maybe stronger?!
however i do know that in a hypoxic environment, test is converted to DHT more readily rather than to estradiol via aromatase. so all you guy putting rubber bands on your heads- STOP IT! Peruvians are not bald!
(DHT-induced AR transcriptional activity was dramatically increased by hypoxia)
I hope nobody now gives me the oestrogen is bad for hair crap. look at women (higher up than usual) they have bloody good hair.
INFLAMMATION-INDUCED TLR4 EXPRESSION AND REACTIVE OXYGEN SPECIES ARE
ATTENUATED BY DIHYDROTESTOSTERONE IN HUMAN PRIMARY VASCULAR SMOOTH
MUSCLE CELLS
Inflamation people. iv recently started on cetrizine (80 tabs (filtered) in a 250ml water/minoxidil/keto mix) and i also exfoliate my scalp weekly with a salt and lemon juice. oh and try vinegar too.
At first crazy amounts of dead skin will come away, but this will increase topical absorption as well as upregulate WNT.
I have hair 'dots' growing which where smooth skin before. I depilated this week to see if i could speed up the hair cycle; which i know is risky!
I also notice that the pores of these dots are smaller than those with terminal hairs. lemon juice should help with the fibrosis/calcification.
cant be arsed to take before pics until i see enough to warrant a proper test. Signs are good though!
however i do know that in a hypoxic environment, test is converted to DHT more readily rather than to estradiol via aromatase. so all you guy putting rubber bands on your heads- STOP IT! Peruvians are not bald!
(DHT-induced AR transcriptional activity was dramatically increased by hypoxia)
I hope nobody now gives me the oestrogen is bad for hair crap. look at women (higher up than usual) they have bloody good hair.
INFLAMMATION-INDUCED TLR4 EXPRESSION AND REACTIVE OXYGEN SPECIES ARE
ATTENUATED BY DIHYDROTESTOSTERONE IN HUMAN PRIMARY VASCULAR SMOOTH
MUSCLE CELLS
Inflamation people. iv recently started on cetrizine (80 tabs (filtered) in a 250ml water/minoxidil/keto mix) and i also exfoliate my scalp weekly with a salt and lemon juice. oh and try vinegar too.
At first crazy amounts of dead skin will come away, but this will increase topical absorption as well as upregulate WNT.
I have hair 'dots' growing which where smooth skin before. I depilated this week to see if i could speed up the hair cycle; which i know is risky!
I also notice that the pores of these dots are smaller than those with terminal hairs. lemon juice should help with the fibrosis/calcification.
cant be arsed to take before pics until i see enough to warrant a proper test. Signs are good though!
2020
Experienced Member
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not this again....
as for male pattern baldness being an allergy, women would go bald too but they don't
Dennis Bergkamp
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Im new here, but dont question my intelligence, I would blow you out of the water.
Is the exact shape of every male pattern baldness man a coincidence? If we were to test the theory, it would almost certainly be statistically significant to 99.99% confidence level.
Perhaps i didn't explain my theory very well. there is a possibility that the galea is restricing microvascularisation which is leading to a hypoxic state of the affected areas. whether this is a small cog in male pattern baldness; i do not know. but almost certainly the density of androgenic receptors in this area would indicate that these have been up-regulated in response to a negative feedback loop.
It could even be that the galea is thicker on those with male pattern baldness, who the fudge knows. but it is an element which i am not ignorant enough to ignore.
DHT is fine on its own, but coupled with a hypoxic environment is when it causes the trouble.
Is the exact shape of every male pattern baldness man a coincidence? If we were to test the theory, it would almost certainly be statistically significant to 99.99% confidence level.
Perhaps i didn't explain my theory very well. there is a possibility that the galea is restricing microvascularisation which is leading to a hypoxic state of the affected areas. whether this is a small cog in male pattern baldness; i do not know. but almost certainly the density of androgenic receptors in this area would indicate that these have been up-regulated in response to a negative feedback loop.
It could even be that the galea is thicker on those with male pattern baldness, who the fudge knows. but it is an element which i am not ignorant enough to ignore.
DHT is fine on its own, but coupled with a hypoxic environment is when it causes the trouble.
baldnesssadness
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in a way it seems baldness is a alergic condition since pgd2 in the lungs and blood causes asthma on scalp it causes baldness. I guess the ones that are balding gets these pgd2 geneticly . So Dennis what kinda side effects have you seen yet?
Dennis Bergkamp
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no sides. i used to get mad brain fog on finasteride so stopped many years ago. Rather go bald than stupid with a floppy member!
Nizoral helped slow down the loss. im norwood 3/4 maybe. depends on my optimism on the day!
Citrizine soaks in within seconds (its not the fillers in the tablets as i filtered this after leaving to dissolve). my scalp is dry and clean, no sebum at all!
These hair dots are certainly there and were not before. As we have learned, the follicles and hair remain, they are just covered over by calcification/fibrosis.
oh and google topical curcumin effects: reduces PGD2 to 35%, whilst increasing PGE2 and PGF2 by 15% or so. only problem is a yellow scalp is not sexy.
All these wives tales and PGD2 are starting to link up. Im interested in indometacin, but im reluctant to throw a nuclear bomb on my scalp!
Nizoral helped slow down the loss. im norwood 3/4 maybe. depends on my optimism on the day!
Citrizine soaks in within seconds (its not the fillers in the tablets as i filtered this after leaving to dissolve). my scalp is dry and clean, no sebum at all!
These hair dots are certainly there and were not before. As we have learned, the follicles and hair remain, they are just covered over by calcification/fibrosis.
oh and google topical curcumin effects: reduces PGD2 to 35%, whilst increasing PGE2 and PGF2 by 15% or so. only problem is a yellow scalp is not sexy.
All these wives tales and PGD2 are starting to link up. Im interested in indometacin, but im reluctant to throw a nuclear bomb on my scalp!
2020
Experienced Member
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this has been debunked over and over and over and over and over and over and over and over again. STOP POSTING THIS GALEA ****. That is not the reason why people go bald. Also, what wouldn't this happen to women?
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then how come only men get it?
odalbak
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How do you explain hypoxia on the scalp is only present in the galea area?
http://journals.lww.com/plasreconsu..._Male_Pattern_Baldness_with_Botulinum.79.aspx
btw, men are not the only ones with hormone related hair loss, and this hair loss happens mostly on the galea region in women…
baldnesssadness
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damn 2020 you really like to argue dont you? your like in every forum arguing with someone. Thing is we each give a different thought and theory. You dont have be mad because some thinks different then you do,and yes women get this too just like odalbak said.Mr cotsarelis said this pgd2 will work on women as well
2020
Experienced Member
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where does it say it's only in galea region and not just in NW6 pattern area?
botox is anti-inflammatory.... almost any anti-inflammatory(given that it's strong enough) would have positive effects on hair growth
yes I know... how come men get galea problems and not women?
it's ALL BEEN DEBUNKED ALREADY!!! Too tired of arguing with you people again, just read this thread:
http://www.baldtruthtaIk.com/showthread.php?t=8514
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a theory is either proven true or false. Galea theory has been already proven to be false a million times over. Why can't you people let it go? Read this thread:
http://www.baldtruthtaIk.com/showthread.php?t=8514
or should I just start pasting relevant quotes?
baldnesssadness
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yes we do give theories, since no one here is a scientist , we give logical theories that can or not work, we are trying to help each other here to find a way to stop balding? because thats why we are here right? and im sorry i wrote mr cotsarelis said this will work in women as well, what i meant was can work on women as well.
2020
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right except that the theory you provided has already been suggested before and since then been proved to be false. Why is it so hard to understand?
baldnesssadness
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hehe dont take my word for it , im sure those guys havent done spoken yet.
squeegee
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baldnesssadness
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seems i misunderstood , i was talking about pgd2 and the theory that baldness can be allergicly genetic condition., im using gingko biloba to increase my blood circulation. It has been 3 months now , and it galea theory were true than this would have worked.