Samumed - SM04554

Min0

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No Pharma is going to go ahead with a drug that can only deliver a 10% improvement. 10% doesn't move the needle enough when you can get the same result from OTC minoxidil or $.50/pill finasteride. To warrant the massive investment in bringing a drug to market, it will have to substantially outperform what's currently available.

there is a market for maintaining without sides my friend. people will stop finasteride as soon as a safer alternative comes.
 

Breyfogle

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Reducing everything to a percentage is almost meaningless.
It's like judging a car based on horsepower. Horsepower sells cars. Torque wins races.
Look at the charts on the phase 2 SM results.
Depending on the hair type, and depending on the hair phase (anagen or telogen), hairloss was halted, and then exponentially regrew over time.
It was only five months, but each hair type began to bell curve upward toward the end of the test. That's a functional cure to me.

Looking for an average regrowth percentage in this instance is foolish.
On "average," all humans have one breast and one testicle.
 

Pavi

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What is going on with this? They deciding whether or not to go to phase III?
 

Afro_Vacancy

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bullshit, no one will refuse to use a safer finasteride.

It annoys me that they have never had competent dosing studies for finasteride. There's just no clinical evidence for 1 mg/day as ideal.
 

NewUser

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people will stop finasteride as soon as a safer alternative comes.

Like topical minoxidil is safer than oral Loniten. I think samumed is trialing their drug using finasteride as a control group if I'm not mistaking it for another drug altogether.

Christiano and Jahoda's discovery that a topical jakinib is more effective than oral might drive new drugs to be trialed using both oral and topical methods. Personally, I would thinK any drug meant for male pattern baldness would better utilized locally at the HF level than in my liver and kidneys.
 

sunchyme1

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Of course they won't refuse to use a safer finasteride, its just that safety isn't the reason they aren't using it, so a safer finasteride won't significantly improve the bottom line.

The market wants a more effective finasteride, not a safer finasteride.

this is why i fear heavy balding motherfuckers like myself

guys are spend more time getting a regrowth product to the market than a maintenance one
 

wilfred

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Has it been confirmed that this drug plateaus at 10% results? I mean what if it keeps improving over the long term? I'd take that.
 

Trouse

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Minoxidil and ketoconazole are effective when used as adjuncts to finasteride/dutasteride.

Minoxidil is a regrowth treatment, it actually isn't great for maintenance at all and it's not a long term solution to hair loss. Ketzo is a proverbial throw-in to a regiment and again, long term, it's simply not strong enough to slow down male pattern baldness to a respectable level.

There's one great maintenance option for hairloss and the side effects are bad enough to deter a decent portion of men from using it.
 

GiveMeAccessToMyAccount

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bullshit, no one will refuse to use a safer finasteride.

The truth is not many people know about finasteride/propecia in the first place. Why? Because the results of finasteride aren't compelling enough to get the attention of the masses. Yes Propecia sells 100s of millions of dollars in the US a year, but if it was actually known to regrow hair it would have sold in the billions of dollars in the US. I understand that some of the people who use/used it and experienced side effects would like a side effect-free product, but let's face it, the buyers of this drug and anti-finasteride consumers of this drug are all the same market, separate from those who do not even care about Propecia/Rogaine. A comparable drug to finasteride with no negative side effects will not attract people who didn't care for propecia before. It would have to be a drug that actually regrows massive amounts of hair. Those NW3-7's who have never used finasteride and don't even know about its side effects are NOT looking for finasteride-like results, side effects or not. They are looking for something that will blow up in the news and social media, that is guaranteed to turn their NW5, 6 or 7 dying little hair follicles into prime Brad Pitt hairline, or Denzel Washington hairline.

I'm not saying it wouldn't be a welcoming drug to you and others who want to use finasteride but suffer from side effects. I'm saying that Occulus is probably right, it's something that is "only on the boards". In reality, people actually want their hair back and that's the type of news they want to hear.
 

Min0

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The truth is not many people know about finasteride/propecia in the first place. Why? Because the results of finasteride aren't compelling enough to get the attention of the masses. Yes Propecia sells 100s of millions of dollars in the US a year, but if it was actually known to regrow hair it would have sold in the billions of dollars in the US. I understand that some of the people who use/used it and experienced side effects would like a side effect-free product, but let's face it, the buyers of this drug and anti-finasteride consumers of this drug are all the same market, separate from those who do not even care about Propecia/Rogaine. A comparable drug to finasteride with no negative side effects will not attract people who didn't care for propecia before. It would have to be a drug that actually regrows massive amounts of hair. Those NW3-7's who have never used finasteride and don't even know about its side effects are NOT looking for finasteride-like results, side effects or not. They are looking for something that will blow up in the news and social media, that is guaranteed to turn their NW5, 6 or 7 dying little hair follicles into prime Brad Pitt hairline, or Denzel Washington hairline.
I'm not saying it wouldn't be a welcoming drug to you and others who want to use finasteride but suffer from side effects. I'm saying that Occulus is probably right, it's something that is "only on the boards". In reality, people actually want their hair back and that's the type of news they want to hear.

minoxidil doesn't stop hairloss like finasteride.
if doctors knew about a safer finasteride, THEY WILL recommend it to the masses who are starting to lose their hair, i think a lot of doctors know that finasteride is not a safe drug this is why they sometimes don't even tell the patients to use it.
 

GiveMeAccessToMyAccount

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minoxidil doesn't stop hairloss like finasteride.
if doctors knew about a safer finasteride, THEY WILL recommend it to the masses who are starting to lose their hair, i think a lot of doctors know that finasteride is not a safe drug this is why they sometimes don't even tell the patients to use it.

My argument wasn't that minoxidil stops hair loss like finasteride. But since we're on that topic now, from my personal experience, minoxidil did stop my hair loss when I started it in Feb 2015, my hair was shedding a lot because I wasn't on anything. The only thing I could buy at the time, being in college and having no money was kirkland's minoxidil. Surprisingly, within a month, minoxidil slowed my hair loss down to basically no shedding. I then got on finasteride and nizoral a month later, when minoxidil alone had already stopped my shedding.

I'm not sure who these doctors are, ever since I was 18, every physician/dermatologist I visited about my hair loss, told me about Propecia. I am from New York, i'm not sure if location had anything to do with it. Maybe doctors in other states keep information like this from their patients. But I never experienced this personally. I remember not being blown away by Propecia results when I went to look it up online. I actually got on it like a year or two after being told about it because what it cost didn't match the results it gave at the time.
 

GiveMeAccessToMyAccount

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I have maintained on minoxidil alone for 19 months and counting

Yeah, I know from experience that minoxidil does stop hair loss. Maybe not for everybody, but neither does finasteride. Minoxidil by itself stopped my aggressive hairloss within a month. And it was BAD, really bad shedding. I was going towards the diffused horseshoe pattern really fast. I'm pretty sure I deleted the before photos I took in disgust.
 
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