Why Doesnt Oral Spironolactone Get Mentioned As Muh Asother Anti-androgens?

[IdealForehead]

If gyno happens, you only have to stop immediately, and it goes away, right?

Yes according to all the studies I read. If it's med induced just stop the med and it resolves.

 

[bridgeburn]

Aren't those 2 things one of the same? Isn't the production of T dependent on the antagonist? So if the receptors are blocked doesn't that there is less T in the serum?

well, I think depending on the type of antiandrogen, they all have slightly differnet mechanisms of action other than receptor attachment. cypro is considered a progestin and activates the progesterone receptor too, Im not sure if that is part of its antiandrogenic effects but it could be since several other progestins also have antiandrogen effects, like MPA. Cypro is primarily medically used as an anti androgen but spironolactone on the other hand, the anti androgen effects are considered a side effect and to use it as an antiandrogen is off label use.
Also cypro raises prolactin, and prolactin itself lowers T levels as well and if you take cypro for a prolonged period of time you should monitor your prolactin levels in case of developing a prolactin producing tumor.

what you said may also be true in a way but not just attaching to the receptor but attaching to the receptor AND causing some activity on it. because both spironolactone and cypro actually dont really just block the receptor, they very weakly activate the androgen receptor. So cypro and spironolactone are actually like very weak androgens. much better for them to be attached than real androgens.
Bicalutimide on the other hand is a pure antiandrogen. it blocks the receptor and doesn't activate and the body actually increases the production of T. Im afraid to take bic though, it doesnt stay on the receptor nearly as long as Dht.

also as i said, cypro has a long half life and it also builds up in your fat. If your body decides to process your drugs one day faster than usually or invrease its metabolism or upregulate itself then in theory you should be safer from T fluctactions on cypro.

so yeah, i think that the slight activating of the AR is what tricks the body to produce less. but the prolactin increase of cypro and the build up effect, and possibly the progestin effects may also be a part of why its stronger.

 

[IdealForehead]

All that may be true bridgeburn (I don't know - never went that far in my research) but one other factor to add is that spironolactone has a greater potential than cyproterone to truly activate the androgen receptor. This is why it is not used in prostate cancer, while cyproterone can be it. Some men die faster if they take spironolactone with prostate cancer.

https://www.ncbi.nlm.nih.gov/pubmed/22665559

While cyproterone is a common treatment for prostate cancer (in combo with other meds). This is one of its primary uses.

 

[bridgeburn]

All that may be true bridgeburn (I don't know - never went that far in my research) but one other factor to add is that spironolactone has a greater potential than cyproterone to truly activate the androgen receptor. This is why it is not used in prostate cancer, while cyproterone can be it. Some men die faster if they take spironolactone with prostate cancer.

https://www.ncbi.nlm.nih.gov/pubmed/22665559

While cyproterone is a common treatment for prostate cancer (in combo with other meds). This is one of its primary uses.

hmmm, good to know. thanks

 

[BaldingGuy]

It’s not mentioned because it’s kind of a taboo. Most guys are under the impression that you will turn into a girl while taking it. While there are higher risks of side effects that can seriously effect someone it wouldn’t turn you into a female without adding estrogen. However transsexuals M2F do take oral spironolactone to start their transformation by it androgen blocking abilities. It’s also hard to get because you will need to visit your doctor regularly because it can effect your heart. So try finding a doctor that will willingly put you on something as serious as this when you’re a healthy guy.
But from experience it does work. At least has for me. I’ve been on it for 2 years with no gyno and no sides. I’m healthy male with no problem los having sex or anything. I wrote a post about my whole experience and pics are in the thread of you want to read it and maybe investigate spironolactone for yourself. All the information is in the thread. Hope this helps.

https://www.gourmetstylewellness.com/interact/threads/you-might-be-interested-in-reading-this.110443/

Did you get a prescription for it? If so, how did you manage to convince your doctor? I have an appointment early Jan and I don't really know how I'm going to ask for it without him calling me crazy. I'm on fina and minoxidil for 9 months now and losing hair even faster than before the treatment so I don't think it's working.. My itch never went away neither...

 

[Jesse Navarro]

What blood tests should one take while on spironolactone? And how frequent? I know I should be careful with the potassium

 

[bridgeburn]

Do you think taking 100/150mg of spironolactone and 25mg of Cypro will be effective or is that too low of an amount for cypro to build an effective therapeutic concentration?

25mg is usually enough to knock down T quite a lot.

 

[DHTpolice]

Do you think taking 100/150mg of spironolactone and 25mg of Cypro will be effective or is that too low of an amount for cypro to build an effective therapeutic concentration?

You're underestimating the power of cypro. Try 1/4 of 50 mg pill, you will be amazed... I felt its effect in a matter of hours: dull testicular pain, much stronger than from finasteride or spironolactone (it was bearable and pain gradually faded, so don't be scared), zero sexual functions, absolute numbness... Maybe I am a very good responder to it, though.

 

[DHTpolice]

Ive had those responses (dull testicular pain and zero libido) with 150mg spironolactone, but I think it may be a placebo as I felt similar feelings when I started finasteride, not as strong tho.

How did you split the Cypro pill? I am only managing to find 50mg and I don't know if I can split that into 4. Its promising that it worked for you with 12.5, since I feel sypro is working well at only 100 maybe I'm sensitive to strong antiandrogens.

I split it with knife, it's not hard at all.

 

[bridgeburn]

I just found something else out about CPA. According to this it reduces 5ar in the skin? https://www.ncbi.nlm.nih.gov/pubmed/12600226

"Chlormadinone acetate, cyproterone acetate and dienogest are potent, orally active progestogens, which have antiandrogenic instead of partial androgenic activity. They act mainly by blocking androgen receptors in target organs, but also reduce the activity of skin 5alpha-reductase, the enzyme responsible for converting testosterone to the more potent androgen, 5alpha-dihydrotestosterone, in sebaceous glands and hair follicles."

 

[DHTpolice]

Yes, my density has significantly improved, still far from what it used to be in my teens, though. Temples are regrowing too, but it's a slow process. I started estrogen not so long ago, so it will take some time.

 

[rclark]

Anyone knows how spironolactone works regarding testosterone? Low dose decreases less test or it doesnt matter the dose (the drug builds progressively)? I have the same doubt concerning side effects

There are some guys here who use it. I would never use it, but some guys do and have success (and erections, but
I don't ask).

 

[bridgeburn]

As spironolactone has a short half life would taking it as 75mg three times daily 8 hours apart make more sense than 100mg every 12 hours?

2x a day works great for most. spironolactone itself has a short half life but its metabolites have a longer half life and they are part of its clinical effects.

 

[ElTioLaBota]

Estrogen seems like it gives great response. You females are so lucky you can take all this and not worry about gyno. Do you take estrogen orally or apply it?

Estrogen is breast cancer fuel so its not that easy

 

[ElTioLaBota]

I split it with knife, it's not hard at all.

Do you take any hormone test?

 

[stachu]

Oral spironolactone is awfull sh*t, i would never ever touch it. Seen a transgender in my city on it, i would take being bald.

 

[DHTpolice]

Estrogen seems like it gives great response. You females are so lucky you can take all this and not worry about gyno. Do you take estrogen orally or apply it?

I take Diane 35, 1 pill a day.

 

[DHTpolice]

Do you take any hormone test?

No, ha-ha.