Why Doesnt Oral Spironolactone Get Mentioned As Muh Asother Anti-androgens?

[g.i joey]

breast cancer

you got breast cancer?

 

[DHTpolice]

you got breast cancer?

Yes, tumor the size of alexfighterqq's brain.

 

[Jesse Navarro]

hahahahahahaha

 

[DHTpolice]

Jokes aside, I'm out of medicine and waiting for ressuply.

 

[g.i joey]

Jokes aside, I'm out of medicine and waiting for ressuply.

Lmaoo you scared me man

 

[arnoldd]

I been off my regimen for almost 6 days, now testosterone is slowly coming back...
Having a high libido and oily skin again is so depressive, wish antiandrogenic effect lasted much longer

Impossible your testo levels come back to normal in only 6 days..unless you have some problem like hyperthyroidism or something else

 

[DHTpolice]

Do you think taking 100mg spironolactone and 50mg of Cyproterone Acetate would have a better effect than just 200 spironolactone? Also can you take estrogen once every other day or 3 days, or is that not enough for a therapeutic concentration to build up?

It should work better in theory, but it would be overkill in practice, just a huge strain on the liver and kidneys.
No, hormones (pills) should be taken every day, because drastic fluctuations in estrogen levels will cause mood swings, depression and, possibly, chronic Telogen Effluvium.

 

[BetaBoy]

Impossible your testo levels come back to normal in only 6 days..unless you have some problem like hyperthyroidism or something else

Testosterone rebounds are common after stopping CPA suddenly. A fella on HH stopped it cold and he described how most of his hair fell out over the space of a week...

 

[DHTpolice]

You were offended? Go suck some dick you tranny gay. Just feels sick see people like you .

It's hard to be offended by a guy whose "dick is absolute dead as if I am 60 years old impotent".

 

[rclark]

Why is Oral Spironolactone not mentioned as much as finasteride and dutasteride? Is it less effective or not effective enough to take? From what I read it reduced DHT quite significantely.

I was thinking of adding it to my dutasteride, finasteride and minoxidil routine, is anyone else taking it? Do you feel it is effective and worth the sides?

Spironolactone has been studied in females, extensively, and is used as medication to treat female androgen alopecia.

That said, it has BAD side effects for male, as it stops TESTOSTERONE. Of course, it is VERY EFFECTIVE. But,
SO IS CASTRATION!

 

[bobeed]

Why is Oral Spironolactone not mentioned as much as finasteride and dutasteride? Is it less effective or not effective enough to take? From what I read it reduced DHT quite significantely.

I was thinking of adding it to my dutasteride, finasteride and minoxidil routine, is anyone else taking it? Do you feel it is effective and worth the sides?

Dutas and finas? my bro your dick still works?

 

[Jesse Navarro]

Anyone knows how spironolactone works regarding testosterone? Low dose decreases less test or it doesnt matter the dose (the drug builds progressively)? I have the same doubt concerning side effects

 

[Jesse Navarro]

Ok, I'll try. Starting with 50mg, maybe I'll see some results with only 50. I need something stronger, until dutasteride kicks in.

 

[BetaBoy]

Anyone knows how spironolactone works regarding testosterone? Low dose decreases less test or it doesnt matter the dose (the drug builds progressively)? I have the same doubt concerning side effects

Spironolactone like other AA's blocks the effects of androgens by competing for the AR but unlike CPA it doesn't reduce production/synthesis of Testosterone probably explaining why there are higher incidences of gyno in spironolactone users.

 

[IdealForehead]

spironolactone is not popular for a lot of reasons.

Primarily, it is the agent most likely to produce gynecomastia, as it is a SARM.

Roughly, the rates of gyno are as follows:

1) finasteride 1 mg - <1% (case reports only) ref, ref
2) Finasteride 5 mg - 0.3-4.5% ref
3) Dutasteride 0.5 mg - 1.8-2.3% ref
4) Darolutamide 100-900 mg twice daily - 2.4% ref
5) Spironolactone 25-50 mg - 7% ref, ref
6) Spironolactone 75-100 mg - 17% ref, ref
7) Cyproterone - up to 18% ref, ref
8) Flutamide - up to 19% ref
9) Enzalutamide - 49% ref
10) Spironolactone ≥ 150 mg - 52% ref, ref
11) Bicalutamide - 60% ref

Of interest, darolutamide is the strongest antiandrogenic agent on the list yet has the 3rd lowest rate of gyno after finasteride and dutasteride, and that's for daro in massive oral doses.

This has to do primarily with the fact that daro doesn't cross the blood brain barrier and thus doesn't f*** up hormone levels.

spironolactone is also no fun because it makes you piss constantly and it's exhausting. Plus your dick will go mostly limp if you're anything like me.

I really hated spironolactone.

 

[IdealForehead]

Thank you for this, it is very informative. It sucks that rate of gyno for Spironolactone ≥ 150 mg is so high cause that's the dose I'm taking, gyno is the only side I care about so that's a bit worrying. Cyproterone is promising though, requires lower dosages for the therapeutic effect than Spironolactone and has quite a low rate of gyno.

No problem.

Here's the spironolactone dose-gyno incidence rate:

If you want to throw caution to the wind and nuke hair loss, the safest overall option in my opinion is likely topical daro at a dose of 3-6 mg a day (but keep in mind this drug is not even approved for human use yet, and there are no hair studies, so it is purely experimental). Cypro orally would be my next choice. I didn't mind cypro nearly as much as I minded spironolactone.

Cypro was much easier to take. Much less pissing. Stronger castration effects though.

 

[IdealForehead]

What is the recommended dose of Cypro? And is spironolactone at 200mg significantly weaker? Studies Ive read say it can reduce T to female ranges to I was under the impression that it quite strong.

I tried to research extensively cypro vs spironolactone dosing when I was on those agents and found not that much useful info.

In general, probably somewhere between 50-100 mg cypro is roughly equivalent to 200 mg spironolactone.

From my own personal experience 100 mg cypro was definitely stronger than 200 mg spironolactone.

I took 100 mg cypro daily and it completely neutered me, much more strongly than 200 mg spironolactone did. Which was both good and bad. It's actually not that bad being without a sex drive when you're unattractive and have no prospects for sexual activity anyway. But most people would probably find that disturbing to experience. I still did myself.

Some guys have taken 50 mg cypro and reportedly not had any sexual problems. That's pretty amazing if so.

 

[bridgeburn]

Studies Ive read say it can reduce T to female ranges to I was under the impression that it quite strong

I think the stregnth is not just about the T levels but also how well it blocks the receptors.

 

[bridgeburn]

also the half life as well. cypro has more of a build up effect

 

[IdealForehead]

Did you see vastly greater resuts on cypro than on 200mg spironolactone when it comes to hair not other sides?

I thought spironolactone was a nuclear option but now I'm feeling that cypro makes it look like child's play.

I was only on them each for 2-3 weeks one after another. Then I went on daro and stopped all that craziness.

spironolactone/cypro were just a bridge for me until I could figure out a long term solution, which for me was topical daro.

 

[Jesse Navarro]

If gyno happens, you only have to stop immediately, and it goes away, right?