Why Not Estrogen When You're Trying To Avoid Systemic Absorption Anyway?

[Follisket]

I mean, I know the obvious answer is you wouldn't want to feminize your body.

But due to the high incidence of side effects, a lot of treatments in development right now are focused on topical application, aiming to limit the effects of AAs to the scalp, anyway.

So if you're trying to avoid the same issue of systemic side effects, why not try and apply whatever mechanism is necessary for that localization to something that is proven to give you massive regrowth rather just maintenance – such as estrogen?

It seems to me you'd be trying to solve the same problem but with much greater payoff. Or would estrogen for some reason be that much harder to confine to a specific area?

 

[GoldenMane]

All topical go systemic to a certain degree so that's probably why. I would totally give a topical estrogen treatment a go though. I'm pretty sure estrogen topical do already exist...

 

[GoldenMane]

Just had a look on eBay, there's a few creams with photo estrogens, estradiol and/or estriol. Seem to be designed for menopausal women but might be worth trying.

 

[Ikkaku]

What about DGLA?

PS: Oups, I did a mistake, I was thinking about cationic liposome carrier system

 

[Grasshüpfer]

Just had a look on eBay, there's a few creams with photo estrogens, estradiol and/or estriol. Seem to be designed for menopausal women but might be worth trying.

Grow boobs! (As long as you are not going over 40 pg/mL you should be ok.)

So if you're trying to avoid the same issue of systemic side effects, why not try and apply whatever mechanism is necessary for that localization to something that is proven to give you massive regrowth rather just maintenance – such as estrogen?

Something as a liposomal Estradiol? I think this is actually a very smart idea. However something like this is too compicated to mix in your bathroom and big pharma doesnt seem to be interested. But its still a very valid direction of thinking.

 

[plisk]

is estradiol "proven" to give massive regrowth? For every tranny we see who has massive regrowth theres about 3 others who look like gollum and end up needing to wear wigs.

If im not mistaken, many transgenders also make use of progesterone, which might be the significant factor.

 

[Grasshüpfer]

is estradiol "proven" to give massive regrowth? For every tranny we see who has massive regrowth theres about 3 others who look like gollum and end up needing to wear wigs.
If im not mistaken, many transgenders also make use of progesterone, which might be the significant factor.

Once the cells are sensecent no amount of MtF treatment revives them. If you still have vellus, it will return though.

All this hormonal medication is working very different from person to person. Progesterone reduces both Estradiol and Dht. In many balding males and females its actually very high estradiol levels that cause balding. It s unclear though, if too much estradiol is directly inhibiting hair growth, eg. by blocking the amount of testosterone that is needed in hair growth, or if it upregulates the AR response or the local Dht production.

Unfortualtely there is very little research on this, as every endoctrinal system in every human being operates slightly different. Also it is hard to measure as the result of a hormone change on the hair has a delay from 4 weeks to 12 Months, as we see on finasteride.

 

[Follisket]

Mind you, I'm not suggesting people start experimenting with estrogen on their own, I'm just wondering why companies aren't looking into this when they're facing the same challenges with topical antiadrogens anyway.

 

[WMQ]

This is what estrogen gives you.

(Read that man's story in the other video, it's heart breaking)

 

[Grasshüpfer]

Mind you, I'm not suggesting people start experimenting with estrogen on their own, I'm just wondering why companies aren't looking into this when they're facing the same challenges with topical antiadrogens anyway.

+1

Btw. the guy looks all around better after his estrogen treatment. the facial features are more feminie but way more pronounced.

I am waiting for my alpicort f. I have no estrogen anyway in my system (less than 5 pg/mL).

 

[WMQ]

+1

Btw. the guy looks all around better after his estrogen treatment. the facial features are more feminie but way more pronounced.

I am waiting for my alpicort f. I have no estrogen anyway in my system (less than 5 pg/mL).

Does anyone know if estradiol has any anti-androgenic effect?

 

[Grasshüpfer]

Does anyone know if estradiol has any anti-androgenic effect?

Not directly. Dht is lowering the estradiol levels, however when dht is low, too much estradiol lowers testosterone production, which is dangerous in men.

Progesterone controls both dht and estradiol levels, so it makes sense to take progesterone and a bit of estradiol. Estradiol pretty much guarantees gyno, so it is advisable to dose very low.

 

[hilbert]

on 17-alpha-estradiol 0.025 or 0.05% and proge 1% since 2002.
no miracles, but no systemic effects.

 

[GoldenMane]

Saw some progesterone cream on eBay, considering buying... In addition. To finasteride and minoxidil of course. Would progesterone cream need to have estradiol too?

 

[opti]

It would be better to create a topical estrogen lotion with no systemic effects, however this seems to be very difficult to create. Even anti-androgens like CB go systemic. If you have temple loss or are one of those people with full vertex and full forehead balding, estrogen may be the way to regrow that. I don't think any anti androgen can regrow temple. On the other side AA's are more efficient on vertex balding.

I also saw some docu about a trans girl who wanted to become a muscular men. Injecting T have him/her a big beard but her nw0 went to nw1,5-2 with T injections...

 

[Marconi]

what do you think about Follicept? Instead of IGF-1 put estrogen .

 

[rupture]

Not directly. Dht is lowering the estradiol levels, however when dht is low, too much estradiol lowers testosterone production, which is dangerous in men.

Progesterone controls both dht and estradiol levels, so it makes sense to take progesterone and a bit of estradiol. Estradiol pretty much guarantees gyno, so it is advisable to dose very low.

So not true Estro does not guarantee gyno nor does it guarantee regrowth.

 

[Beowulf]

Grow boobs! (As long as you are not going over 40 pg/mL you should be ok.)




Something as a liposomal Estradiol? I think this is actually a very smart idea. However something like this is too compicated to mix in your bathroom and big pharma doesnt seem to be interested. But its still a very valid direction of thinking.

But what about Kane?

 

[Jim lahey]

what do you think about Follicept? Instead of IGF-1 put estrogen .

Follicept? you mean that scam company that was torn appart into oblivion like a year ago?

 

[kiwipilu]

Follicept? you mean that scam company that was torn appart into oblivion like a year ago?

I'm still curious about the vehicle they were using