Exploring The Hormonal Route. Hair=life.

Almas

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[UPDATE] I received my hormone blood-work results.

Testosterone: 4.7 nmol/L (with the normal male range being 8.6 to 29.0 nmol/L)
Estradiol: 719 pmol/L (with the normal male range being 41 to 159 pmol/L)

After receiving this information, I can gather that my testosterone levels are significantly lower than the normal male range; although they are slightly higher than normal female ranges. Furthermore, my estradiol levels are significantly higher than the normal male range; they are within normal female ranges.

Within transgender women, the goal is to have estradiol levels within the range of 300 to 600 pmol/L. In that sense, my estradiol levels are slightly higher than the ranges which are aimed at transgender women. I can suspect this is due to the bicalutamide having a synergetic effect with estrogen.

I do have to wait slightly longer for my other hormone blood-work results, since I am not really allowed to know the results until my endocrinologist inspects them.

View attachment 122249
Perhaps, in this case, 0.75mg E per day is sufficient.
 

Pls_NW-1

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Pls-Nw1, why are you praising bicalutamide and you’re not in it yet ? Just asking, no offense
Bicalutamide is the "safest" Anti Androgen you could take. Its a NSAA.
People, who's balding is that aggressive, shouldn't only rely on 5ARi's, but much rather aa well on AA's and in the worst case as well on E for a period of time.
 

Pls_NW-1

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Bicalutamide and E have a synergistic effect, Ikarus destroyed its T and raised E to huge values by only 2 mg E. For me these are excessive levels, so I think about 0.75
I wonder if someone has some new photos of Ikarus. I dont have him on social medias.

@Derelict You once said you have him on snap?! Is it possible that you could send me a PM of his situation nowadays. It's such a shame he vanished from here, a great source.
 

Derelict

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I wonder if someone has some new photos of Ikarus. I dont have him on social medias.

@Derelict You once said you have him on snap?! Is it possible that you could send me a PM of his situation nowadays. It's such a shame he vanished from here, a great source.

No, i was a member of his discord before it was deleted, i don't know how he is doing now but i hope he is doing well. I do vaugely remember the pics he posted though and his results from 0.5mg dutasteride, 50mg bica, 2mg estradiol and 5mg oral min were amazing given the extent of his hair loss before starting. He seemed to me to be a much better responder to oral min than i am, i don't know if that is because of estradiol or not.
 

DogoDiLaurentiis

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I've been trying bi-estro for six weeks now although sometimes I have taken days off just because my nipples are itchy as. All I can report is a large shed. I'll probably go to 3 months and if nothing happens taper off. Also derma rolling with HLS peptides and using keto cream twice a week but I think it has just exasperated the shed.

I used bi-est for about a month, and straight estriol for a month prior, I would say nothing even comes close to what I'm experiencing with straight 17b estradiol, nothing else.

Estriol made my skin nice, and stabilized my hair but did not induce intense regrowth and and a marked improvement in scalp and hair texture the way estradiol has.

However that being said a shed is indicative of starting a new growth cycle, however with estrogen that should basically stop after a point and new growth should come in strongly afterward.

I don't know what keto is whether you're mentioning ketorolac, but I do also use anti-inflammatories, but I use them sparingly as using them constantly deprives your body of the good inflammation necessary to induce hair growth.

If you're getting the dreaded breast area tingling indicative of gyno, what you need to do is start taking magnesium, as it increases excretion of estrogen from your body. This is something I did not learn until very recently and was probably in some way contributing to my reduced natural estrogen over the years.

Also, beta sitosterol will inhibit aromatase which might seem like that's counterintuitive, but what you want is the beneficial effects of site application of estrogen without it overloading you in vivo.

Also consider using betamethasone topical if you have any scalp inflammation as it increases estrogen receptor sensitivity meaning you will require less circulating estrogen to do it's job at the hair follicle receptor level.
 

Almas

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If anyone has Ikarus contacts - give them to me. I do not know which is better: increase the dosage of Bicalutamide to 75mg-100mg, or add 0.75E estrogel to 50mg. I would like to ask him
 

Norwoody

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If anyone has Ikarus contacts - give them to me. I do not know which is better: increase the dosage of Bicalutamide to 75mg-100mg, or add 0.75E estrogel to 50mg. I would like to ask him
I'd imagine some of this would depend on individual aromatization. If you are a good aromatizer, probably more bica would serve you well. If you don't aromatize well then E is probably necessary. Thoughts?
 

Almas

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I'd imagine some of this would depend on individual aromatization. If you are a good aromatizer, probably more bica would serve you well. If you don't aromatize well then E is probably necessary. Thoughts?
Yes, that's right. But if we talk about guaranteed treatment, then it's more about estradiol. However, I will have to monitor the E and T levels and get tested. It's more troublesome

I am currently taking 50mg. My skin produces less oil, but it's still not dry, closer to oily. This probably suggests that androgens continue to work.
 

Norwoody

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Yes, that's right. But if we talk about guaranteed treatment, then it's more about estradiol. However, I will have to monitor the E and T levels and get tested. It's more troublesome

I am currently taking 50mg. My skin produces less oil, but it's still not dry, closer to oily. This probably suggests that androgens continue to work.
Have you tried dutasteride?
 

Pls_NW-1

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I'd imagine some of this would depend on individual aromatization. If you are a good aromatizer, probably more bica would serve you well. If you don't aromatize well then E is probably necessary. Thoughts?
Yeah I stated that once. Ein seems like he has impressive aromatization genes.
 

Norwoody

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Too expensive. The difference between him and finasteride is not worth such an overpayment, for this money I would rather increase the dosage of Bicalutamide if necessary
Just wondering. Some have reported much less sebum on dutasteride since it blocks the type I enzyme. I've never heard of someone getting on finasteride and reporting reduced sebum.

You probably are a poor aromatizer like myself. Good to get tested for sure though.
 

Almas

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Just wondering. Some have reported much less sebum on dutasteride since it blocks the type I enzyme. I've never heard of someone getting on finasteride and reporting reduced sebum.

You probably are a poor aromatizer like myself. Good to get tested for sure though.
I think testing will not tell a lot, because the sensitivity to E can also be different
Perhaps now my E is just rising and will peak in a month. I still have acne so androgens are still working
 

Ticken

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Holy, thats much! With only 2mg... and bica.

Ikarus's estradiol level of 719 pmol/L converts to 195 pg/ml. (pg/ml is the unit of measurement that is mostly used in US and in clinical studies)
I've read accounts of male hair growth that was kickstarted with E2 levels of 90-100pg/ml.
The male reference range for estradiol is 10-60 pg/ml just for perspective. EDIT: ref range for estradiol is 10-40 pg/ml
There's a basic conversion calculator for E2 here:
 
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Almas

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Ikarus's estradiol level of 719 pmol/L converts to 195 pg/ml. (pg/ml is the unit of measurement that is mostly used in US and in clinical studies)
I've read accounts of male hair growth that was kickstarted with E2 levels of 90-100pg/ml.
The male reference range for estradiol is 10-60 pg/ml just for perspective.
There's a basic calculator for E2 here:
So, for guaranteed regrowth, my E must be at the level of 90-100? Does it give significant feminization? Bica raises E to 30-45pg / ml, according to the charts on the internet. A dose of 150 mg increases E by 1.5-2.5 times.
 
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