Exploring The Hormonal Route. Hair=life.

[JaneyElizabeth]

I am wondering if folks have any thoughts about cellulite. Many MtFs actually like cellulite as it is an all but universal (80% to 90%) female artifact. Cellulite is also interesting in that it is a type of collagen issue related to a change or deterioration in the lattice pattern normally found in skin. In this sense, it might respond well for those seeking to eliminate it but either derma-rolling or via mechanical massage. I don't like the perfect hair health massages but scalp massage with a mechanical Shibari-type device might be easier than either derma-rolling or harsh massages that seek to bring the sides of the hair towards the middle:

Cellulite - Wikipedia

en.wikipedia.org

I think that cellulite might be relevant in that it is a highly sexually-dimorphic trait that appears to come on when hormonal levels of estrogen reach adult cis-female levels.

 

[JaneyElizabeth]

Wire brushing?

Has anyone tried wired brushing in place of derma-rolling or scalp massage? I seem to recall some news about folks claiming success with using a wire brush for approximately five minutes a day but maybe this is for balding scalp. It seems awfully harsh to longer hair but soft bristle brushing, at least up to some point seems healthy.

 

[JaneyElizabeth]

Figured I'd post my progress here since this thread inspired me to even start HRT/transitioning. My hairline is slowly improving but my overall density is staying absolute trash. Really praying for my density to fill in cause I'm really worried about it, not so much worried about hairline since I'll get FFS / hair transplant.

6mg estrofem (3 times a day at random times due to my shitty work/sleep schedule so not really optimised), 50mg bica, 1.25mg finasteride daily; nizoral 5%, dermaroll 1.5mm once a week but I must not be doing it right cause its only sore for a few hours afterwards whereas other people report it hurting for day(s). Dermapen in the mail so hopefully fixing that soon.View attachment 149181

In my opinion, you are on the best regimen possible from what I have seen and observed. For some reason very few seem to be going single-shot on estradiol and I continue to believe that that is essentially always the best regimen. The whole reason that people use AA's appears to be quite dated from what the history of HRT indicates. When people were only swallowing tablets and using either synthetics or CEE's, there was a marked increase in liver issues. Therefore, physicians were quite wary and stingy in terms of how much Premarin/Ethinylestradiol they were willing to prescribe. Hence, the theory is that circulating levels of estrogen were not enough to reverse calcification/fibrosis of dormant follicles without adding an AA/Progestin:

and https://en.wikipedia.org/wiki/Ethinylestradiol

These liver issues seem to be remote for people swallowing pure estradiol and many/most now seem to be using much safer ingestion methods such as parenteral methods like injections, the patch, estrogel, and now buccal and sublingual dosing is safe and efficient as well while being perhaps the least convenient method of all, but quite cheap in cost. In my opinion, swallowing E2 pills remains the gold standard in terms of price and efficacy and convenience. The patch might be the best method for those who don't care about price and the slight inconvience of their wrinkling; this is what I am using now @ 2 Climara 100's weekly but I would go to estrofem without hesitation once I worry less about maintaining targets and so long as the psychological feelings continue to be good, i.e. nice estrogen high and higher, better but different libido. Injections are best for micro-managers, although I personally doubt monitoring prolactin, DHT, estrone, SBHG or anything but T and E really provides profitable information. MtFs also have hormonal issues related to the psychological effects of estrogen in that they often act similarly to SSRI's for many of us which might call for even higher levels of estrogen.

I think that the higher the levels of estrogen used/circulating, the better the hair growth without exception. The spanner in the works is that high levels of estrogen at least during the initial stages of HRT seem to halt breast growth. This is the article that I have basically been using to inform myself related to AA's, which may be needed by some MtFs, and pure estradiol which is probably all that most need:

Scalp Hair Regrowth in Hormone-Treated Transgender Woman - PMC

Evidence of androgenetic alopecia, or male pattern baldness, can be distressing for transgender women. Here we present the case of a transgender woman with scalp hair regrowth after ∼6 months on oral estradiol and spironolactone therapy achieving ...

www.ncbi.nlm.nih.gov

In terms of micro-needling, I have done so similarly to you. What I have found in my case is that the longer mm needles work far better and are likely to cause distress to the scalp that is much less severe and which fully heals in 8 to 12 hours. The extra length makes it so I don't have to press so hard and for people like you and me with hair that is fairly long but with diffuse thinning, you can micro-needle everything, the entire scalp without blood or excess inflammation. Derma-rolling to me, appears to require personal bio-feedback and one shouldn't go by the results of others in terms of inflammation or pseudo-damage done to the top two skin levels. The longer needles also seem to help me be done in five minutes or so, or even two minutes really. Doing it more often with less damage appears to be a viable hair regrowth path as well according to what I have seen on youtube.

 

[Androgenic Alpaca]

Figured I'd post my progress here since this thread inspired me to even start HRT/transitioning. My hairline is slowly improving but my overall density is staying absolute trash. Really praying for my density to fill in cause I'm really worried about it, not so much worried about hairline since I'll get FFS / hair transplant.

6mg estrofem (3 times a day at random times due to my shitty work/sleep schedule so not really optimised), 50mg bica, 1.25mg finasteride daily; nizoral 5%, dermaroll 1.5mm once a week but I must not be doing it right cause its only sore for a few hours afterwards whereas other people report it hurting for day(s). Dermapen in the mail so hopefully fixing that soon.View attachment 149181

Solid results so far. Hair regrowth takes a lot of time - how long have you been on your regimen? And any particular reason you're not using minoxidil?

 

[JaneyElizabeth]

Solid results so far. Hair regrowth takes a lot of time - how long have you been on your regimen? And any particular reason you're not using minoxidil?

Welcome.

 

[John Difool]

What's good for hrt is not necessarily good for hair. You can try Bica 50mg, CPA 12.5mg, spironolactone 100mg bid while on E2. E2 is essential.

Levels to measure: T, E2, DHEA, SHBG, P4 and DHT. Free T & E2 can be calculated with good precision out of SHBG and total T and E2 respectively. That saves money. Keep doing blood work monthly while you adjust dosages. More bioidentical E2 should take precedence over increasing AA for safety reasons. You can combo spironolactone and CPA while building your E2 levels (but should drop it asap) and taking Duta to help with hairloss if DHT is still high (don't bother with Fina). Don't switch drugs abruptly unless you enjoy shedding. You can't correlate T levels while taking spironolactone or Bica (only CPA lowers T) but you can check DHEA-S for adrenal activity. Too low T will transform you into a zombie so keep enough while you target DHT undetectable level. Then drop Duta. Then AA after a few checks.

Don't forget supplements to combat hair shed and keep skin healthy. Topical E2 on scalp also helps a lot but it's important to keep skin hydrated because Ethanol will cause hair strands to dry up and break (after all you are doing all of this to get nice looking hair not just a stainless sponge looking mane on your head. I use collagen, cholesterol and ceramides mid day while I apply Estrogel 6 hours before and after. Essential oils are also a cheap way to keep an healthy skin. E2 & P4 are magical on face. I stopped apply it on scalp and taking it oral because lack of evidence on its benefits. Tretinoid on face but I avoid touching hair follicles with that stuff some people reported hair loss while using it. Oral minoxidil only (spironolactone is a diuretic and helps with water retention.) Anedoctally my hormonal triggered shed stopped as soon as I poked my belly with peptides (GHK-Cu, TB-500, BPC-157, IGF-1, Biotin Tripeptide-1)

 

[JaneyElizabeth]

What's good for hrt is not necessarily good for hair. You can try Bica 50mg, CPA 12.5mg, spironolactone 100mg bid while on E2. E2 is essential.

Levels to measure: T, E2, DHEA, SHBG, P4 and DHT. Free T & E2 can be calculated with good precision out of SHBG and total T and E2 respectively. That saves money. Keep doing blood work monthly while you adjust dosages. More bioidentical E2 should take precedence over increasing AA for safety reasons. You can combo spironolactone and CPA while building your E2 levels (but should drop it asap) and taking Duta to help with hairloss if DHT is still high (don't bother with Fina). Don't switch drugs abruptly unless you enjoy shedding. You can't correlate T levels while taking spironolactone or Bica (only CPA lowers T) but you can check DHEA-S for adrenal activity. Too low T will transform you into a zombie so keep enough while you target DHT undetectable level. Then drop Duta. Then AA after a few checks.

Don't forget supplements to combat hair shed and keep skin healthy. Topical E2 on scalp also helps a lot but it's important to keep skin hydrated. I use collagen, cholesterol and ceramides mid day while I apply Estrogel 6 hours before and after. Essential oils are also a cheap way to keep an healthy skin. E2 & P4 are magical on face. I stopped apply it on scalp and taking it oral because lack of evidence on its benefits. Tretinoid on face but I avoid touching hair follicles with that stuff some people reported hair loss while using it. Oral minoxidil only (spironolactone is a diuretic and helps with water retention.) Anedoctally my hormonal triggered shed stopped as soon as I poked my belly with peptides (GHK-Cu, TB-500, BPC-157, IGF-1, Biotin Tripeptide-1)

This is way too complicated in my viewpoint for the vast majority of people. As you say, E2 is essential and perhaps nothing else. FtMs might use two ingestion methods, clitoral and injection but they basically only use testosterone or DHT if available. I don't see any reason why hair regrowth or HRT wouldn't work best in terms of convenience, cost, side-effects and results for hair as well using estrogen alone. I am literally in a hurry with a transition deadline coming up in terms of socialization so I am trying to maximize effects by adding retin-A, derma-rolling, oral minoxidil and large amounts of topical estrogel but I doubt that it is necessary in the longer run.

I already follow your posts but that is a remarkable list to keep track of. You are absolutely right about the mixed effects of AA's and this site along with my own experience with spironolactone hammered that home. AA's must only be used with extreme caution and respect for their systemic-wide jarring of hormones and they have, in my experience for more deleterious effects on strength than estradiol. The only reason why I might touch bica ceteris paribus would be because it seems to be by far be touted most of all for good hair results but all three AA's and certain progestins are likely to have similar effects when used in large enough amounts. I continue to believe that the hair effects of AA's are impure and often not indicative of any cosmetically significant regrowth similar to the restoration of cueball scalps when estrogen is part of the mix or the only medication used.

In a new age-y way, HRT to me related to feminization is about grace and seemless or at least semi-seemless change and it shouldn't be jarring to the system or cause mad hair sheds. MtFs however seem to change AA's willy-nilly and they are often also changing things that might not hurt results but when combined with AA's might be jarring such as changing injection methods or failing to titrate upwards and downwards careful. When HRT comes completely together, we can all agree that the results can be astonishing so at the time time, gingerly use is perhaps best but I am learning and ready along with everyone else.

Sexually dimorphic things like scalp hair, beard and body hair growth and breast growth might be very tightly integrated and difficult to adjust and we sort of know this already, since cis-females don't appear able to increase breast size or improve their hair using estrogen at least until they experience a significant reduction in circulating estrogen levels as they age or increased production when they become pregnant and that seems to be temporary and in the case of breasts, also something that combined with breast feeding can deflate the breasts post-pregnancy.

I think that cis-males are often fascinated by the science of this and comparing our MtF sites to FtM sites seems to highlight this. The MtF sites are swarming with gals who actually welcome complexity even when you factor in the DIY aspect.

Certainly, many/most MtFs never go to hormonal sites or necessarily question the credentials of their doctors and they might even accept that HRT has limitations but not on AskMtFHRT. I have learned lots but still nobody is increasing nipple size on purpose and I see little evidence that anything is different related to breast development. On GourmetStyleWellness, if anything people are using much more suspect stuff to the point that it is fun to sort of make fun of ourselves. Not MtFs on their HRT sites. It is deadly serious and people pout if you tell them that there is no evidence that progesterone up the butt builds breasts. They will just stick more up there and I am willing to bet that many, many MtFs who do DIY use huge amounts of estrogen starting off, in excess of what is recommended and then spend years with the disturbing reality that "I hosed my breasts before they even started". Oh wait, I don't have to bet; there are currently multiple posts up like that along with the ones like, "Help. I started HRT 24 days ago and I don't see any difference." Aaaarggh. I can't take answering those anymore because they infuriate me.

 

[John Difool]

I am not trying to address the audience with low iq. When dealing with these things by yourself you need to learn and study hard. If these simple steps are to complicated for some folks then I suppose they are welcome to follow their endo and dermatologist advices. After all most do with variable success rates. I came disappointed and désillusioned with some parts of modern medicine practices. So I decided to invest my time in this. I am sharing if someone feels the same about it and had similar experience and goals. I have tons of powders in my freezer I tried and discarded. I just want to avoid others willing to invest to make the same mistakes.

 

[John Difool]

RetinA unproven. Try Progesterone topical instead. Large amounts of E2? Lol. If only this was the answer... SHH and Wnt signaling are the bomb when added to PGE2 & SW. Vellus goes terminal at light speed (thanks @pegasus2) That stuff got me back on track in no time. You want to accelerate things: get HGH & IGF peptides and start scalp injections. You have extra money add TB-500.

Ymmv!

 

[JaneyElizabeth]

I am not trying to address the audience with low iq. When dealing with these things by yourself you need to learn and study hard. If these simple steps are to complicated for some folks then I suppose they are welcome to follow their endo and dermatologist advices. After all most do with variable success rates. I came disappointed and désillusioned with some parts of modern medicine practices. So I decided to invest my time in this. I am sharing if someone feels the same about it and had similar experience and goals. I have tons of powders in my freezer I tried and discarded. I just want to avoid others willing to invest to make the same mistakes.

Nobody is saying differently but it seems impossible to replicate for others. Even adding one or another in the wrong order might be counterproductive as I often wonder when I see multiple stacks of things not scientifically shown to be efficacious at the margin.

The same thing with powers. What if I switch form buccal too soon or too late or my estrone levels are off or I switch too late with injections or I don't added my estrone booster pills? Is IV'ing progesterone better or is provera actually more effective just less healthy in the long run? How about boron? It goes on and on without even the most minimal pictoral evidence or data compilation except Dr. Powers says or conjectures, and people eat it up. Even for extreme measures, I think that most can probably handle best say, a reductase inhibitor, minoxidil, a dandruff shampoo/keto, an AA and estrogen. Once one gets into different estrogen ingestion methods, complexity goes up greatly and then people get into spikes, troughs and peaks and steady state and half-lives, all of which probably matter for the psychological effects but probably in my viewpoint, not at all for hair growth. None of this is generally compiled data-wise or in terms of order of addition and so forth but I am a guinea pig and if I am convinced that E2 only isn't enough, then I will probably add bica, which I might also do if I have some other reason for lowering estrogen amounts since that can emulate in some ways the E2 only experience.

But I stand in the way of no one and encourage all exploration. At the same time, those of us who find simpler is better have a story to tell as well to the extent that anecdotal experiences are helpful which in the field of HRT, they appear often not to be and non-replicable.

 

[JaneyElizabeth]

RetinA unproven. Try Progesterone topical instead. Large amounts of E2? Lol. If only this was the answer... SHH and Wnt signaling are the bomb when added to PGE2 & SW. Vellus goes terminal at light speed (thanks @pegasus2) That stuff got me back on track in no time. You want to accelerate things: get HGH & IGF peptides and start scalp injections. You have extra money add TB-500.

Ymmv!

I am pretty happy already so I am going to keep going forward essentially with E-2 only and without monitoring any levels of anything as long as I am hitting standard E and T adult female targets. Using estrogel the way that I do is extreme in that I apply it on days when I am home maybe ten times a day to scalp face and other targets. I haven't the bandwidth for anything else.

I get plenty of email related to my below the neck and facial results, which is all surgery free except for hair removal which in my view, facially, is likely to have significant positive effects but then again, I might just be cute generally, male or female, lucky or blessed by my Goddess in heaven but I am not capable of monitoring any further aspects of hair/HRT medications or results and I don't think that it works in HRT and I live on the redditt transfeminine science thread with everything bookmarked. I am also somewhat down on complexity because it seems to only discourage gals without "results". And gal after gal after gal, particularly it seems the taller ones and the broader ones seem to indicate that their external results are all but non-existent/inconsequential.

 

[baldingyoungsucks]

Hey everyone what’s better for regrowing hair and thinning body hair? Bicalutamide or Spirolactone? I’m a Norwood 2. Please help

 

[John Difool]

I think you should take the time to read this thread from A-Z and make up your mind.

 

[Androgenic Alpaca]

I am not trying to address the audience with low iq. When dealing with these things by yourself you need to learn and study hard. If these simple steps are to complicated for some folks then I suppose they are welcome to follow their endo and dermatologist advices. After all most do with variable success rates. I came disappointed and désillusioned with some parts of modern medicine practices. So I decided to invest my time in this. I am sharing if someone feels the same about it and had similar experience and goals. I have tons of powders in my freezer I tried and discarded. I just want to avoid others willing to invest to make the same mistakes.

RetinA unproven. Try Progesterone topical instead. Large amounts of E2? Lol. If only this was the answer... SHH and Wnt signaling are the bomb when added to PGE2 & SW. Vellus goes terminal at light speed (thanks @pegasus2) That stuff got me back on track in no time. You want to accelerate things: get HGH & IGF peptides and start scalp injections. You have extra money add TB-500.

Ymmv!

Medical doctors have different goals than us. Doctors are scientists, after all, and they are interested in establishing safe and scientifically proven therapies. This takes a long time with lots of research. The people on this forum are seeking out results, even if that means using untested research chemicals. As much as some of the people on this forum might like to think of themselves as amateur scientists, what happens on here is not science.

Truthfully, I personally would not want to use a lot of the therapies that you and pegasus use. Shh agonists, WNT modulators, HGH, PGE2, etc. act on pathways that have been linked to carcinogenesis. I'm not saying that the particular chemicals are carcinogenic, just that those therapies might carry risk as there is no scientific evidence on their safety. Moreso than even HRT. HRT therapies are relatively safe. Yes, they may cause permanent infertility, but they are mostly proven to be safe and effective (to be fair, CPA carries some risks). Personally, I think that I will save some of Pegasus's methods for a last resort if all other options prove unsuccessful. Nonetheless, I think its great that you and Pegasus are doing these therapies and posting results here for everyone to see.

I think we can all agree that anyone who may want to try any of the unproven therapies mentioned on this forum need to do as much research as possible before trying things out.

 

[JaneyElizabeth]

Hey everyone what’s better for regrowing hair and thinning body hair? Bicalutamide or Spirolactone? I’m a Norwood 2. Please help

Most say bicalutamide but it depends also on whether you are using estrogen or not. Both work well for many people. Bica presents more long-term concerns while spironolactone often smacks people in the face with non-life-threatening sides that can be hard to endure.

 

[JaneyElizabeth]

Here's my screed about HRT meds being used improperly and without caution, and as I mention, I was guilty of being dismissive of the strong and pervasive side-effects and jarring effects of using AA's improvidently or in the case of MtFs, without cause. This applies as written only to HRT when done intentionally to feminize. If it serves as a warning to cis-males to avoid AA's then people often say that we on this thread might be reckless and each has to make their own decision. Cis-males have different goals and estrogen in the amounts needed by MtFs for hair growth appears to be a no-go for essentially all of them.

HUGE T increase on spironolactone

This started as a comment on a great post asking for advice about Bica vs. spironolactone, which I want to hear about, but I'm a little bit freaked out and have seen a ton of great knowledge shared here, so here I go.
I started my medical transition 11months ago on 100mg of spironolactone. I only started on t-blockers because I was worried about mental health changes and a trans friend suggested it. I was also a little unsure to some degree. My T was still hovering at the same place it started around 700 after a couple months, so we upped my dose to 200mg.
By this summer it became clear I needed Estrogen. I started on 1mg two months ago with the intention to titrate up, which I am currently doing at 2mg, soon 3mg. I made this decision with my NP just the other day based off my Metabolic panel and my Estradiol levels, which was 43. There was an issue with the labs coming in late, so we didn't have the Testosterone to reference. however when it came back later today, it was 1053 and my free testosterone was 92.3.
Since starting spironolactone, I have no motivation. Not to cook, not to clean, barely to work, not to socialize, and I'm always angry. I thought this was because I was so low on sex hormones. Here's what I think I understand and some questions:
My testosterone could be getting blocked from binding with my receptors, but still being produced. The lack of Estradiol might have even exacerbated that, so my dosage change could help. However, is this in any way normal?
spironolactone v. Bica - Tell me everything. It seems like women who started on spironolactone but changed to bica have had success. Please advise. I'm in the US so cypro is not really an option and doesn't sound right to me.
Again, my motivation is sh*t and my generally manageable mental health goes from seemingly impossible and suicidal to so angry I have to close myself in my room and literally get in a fighting match with my bed and pillows so I don't scare my dog. When I read about testosterone issues happening in men due to anabolic steroids, I felt like that really described my experience. What do people think or have to say?
Thank you everyone and anyone who answers this post.

Comment as JaneyElizabeth
JaneyElizabeth

1 point · 23 minutes ago

I find what you recount disturbing not only in terms of advice from someone who, I mean, I am sort of doing the same thing, as I am no doctor but I try to only synthesize what we don't know mostly since we know so little but I never recommend anyone not use estrogen, even non-binary folks.

Again and again and again when I read complaints both here and on a hair loss thread related to HRT, AA's are involved. I think that for the most part for most people, AA's are yesterday's trash. They have been incorporated due to stasis in medication procedures and the failure by many to realize that the only point of AA's is when someone can't hit targets and you don't need to hit targets for up to years. Things like the Powers program even though he touts bicalutamide, are only more of the same stacking of potent medications without having a full handle on what or why except, "hmm, maybe adding this and switching ingestion methods of estrogen three times using different metabolites would work...." But we are the ones being experimented on on and suffering the consequences and at the very least, I want to see some data compiled instead of Tony Robbins-type hoopla. Where are the pictures? I digress a bit because I am infuriated about all of this over-medication when none of us are sick!

In the olden days, many gals never could get to targets because the meds, largely swallowed synthetic and non-human estrogens could cause significant liver artifacts the longer they were used. Due to this fear, physicians refused to prescribe enough estrogen in these forms and of course, MtF's didn't fully feminize in the long run and specifically in terms of what might be called hair and above the neck results. Breast growth can come right at the beginning or not; we are all different.

AA's in my experience impact sharply on strength and fatigue and cause much more weakness than using estrogen alone without any payback. Bica is said to be great for this and that, particularly hair but where's the evidence that it is better than just estradiol? I don't think that there is any. There could be triggering mechanisms related to hair growth and other aspects but we don't know and the risks and sides are often life-crippling. For spironolactone, people mention weakness, fatigue, brain fog (which I think is the same as the first too, largely, i.e., too tired to think). spironolactone is a potassium-sparing diuretic and causes excessive urination and the need to increase NaCl uptake. I had a shaker on my nightstand because I often awoke wanting table salt. In certain situations these potassium-raising aspects can be quite serious.

I am not saying that spironolactone doesn't work in certain circumstances but usually there are indeed reasons why targets can't be hit otherwise or there should be. If it is merely a question of speed, then I wouldn't touch the stuff. I went completely bald and I was sweating uncontrollably last summer and felt as weak as a kitten. None of that hurt results but who wants to lose all of her hair in her quest to regrow it? Higher T is a widely known and common, if not likely occurrence from using spironolactone and bica.

These are strong, jarring meds that derive from prostate cancer research which doesn't mean that they don't work but estrogen seems to work for almost all of us in a non-jarring way. The goal probably should be to be on the fewest different types of medications possible and not stacking med after med in the search of better "physical" results.

Less is more; simpler is often better especially when unlike in prostate cancer, we aren't receiving real-time or semi-real time readings to evaluate and adjust to. I think HRT has gotten out of control in the search for a la carte "results" and I become less and less sanguine about the lack of reasonable expectations and even what appears to be anger by some MtFs when they don't see happen what they though was a certainty, at least something positive results-wise. Maybe this is too bleak but these are powerful meds and not to be used without caution and respect for what they can do, and I was no different leaping to 200mg of spironolactone well ahead of what my doctor recommended and she never even recommended any spironolactone until I basically told her I would buy it offshore otherwise. She had me on tiny amounts of estrogen and she was right and I was wrong and I owe her great thanks for my "results" and I recently emailed and told her so.

I know that you can get this resolved and I hope that you will report back with your improvement.

Goddess bless.

 

[baldingyoungsucks]

Bicalutamide is the stronger AA but spironolactone has its own benifits. I thing you should read this thread like @John said or read the clinical study papers written about each drug.

I have read both and it seems like both have its ups and downs but bica seems to be the safest. I’m still wondering which is better for hairloss? Also I heard bica causes t levels to rise in the beginning. Can that cause a lot of hairloss?

 

[Father_of_Shiseido]

Obviously it's not a regimen for cis men. Maybe bridgeburn used his hair as an excuse to transition, this is the first I'm hearing of it. Either way he messed himself up pretty severely. He does look better now than he did before regardless of how he wants to identify.

I wish he would come back and let us know how things are going now. I would like to see a cis man try this, grow back his hair in a few months and then see if he can reverse the feminization and get his sperm back all while keeping the hair.

At a time I was on 400 mg of spironolactone. I got pretty bad gyno and erectile dysfunction plus facial feminization. For some people it doesn't matter. But I realized that putting my manhood at stake just for the shake of hair was not worth it.

 

[Father_of_Shiseido]

i’m coming to the end of a 3 month Telogen Effluvium shed, it’s beginning to fill back in.

View attachment 149157

You look good...

 

[JaneyElizabeth]

I was wondering if we could get some feedback on the following from someone regarding this since I have very little knowledge regarding these meds. I know that John, Pegasus and some others are likely to know something about this. Thanks everyone:

Hi janey, it's fchopin from Reddit.
Sorry for the late reply, I have to go to bed early. I'm currently on a zoladex injection and going through the t flare stage, and so was wondering how effective topical bicalutamide in a dmso solution would be. Being trans, the drug going systemic wouldn't be an issue, and bica dissolves well in DMSO. The worry I have is dosing, and would it be dangerous having bica shoot straight into the blood stream. Others on the forum have explored the idea, but were wary of systemic absorption, and were only using an ethanol based solution. If I were to try this, it would be by crushing 150mg casodex pills.