Hello guys, I have some updates about my dutasteride solution. I've been reading lot of studies and it seems mct + ethanol alone causes good solubility on dutasteride but the bioavailability remains less than 20% because the ethanol is rapidly absorbed by the body. After that happens most of the dutasteride precipitate from the solution because dutasteride is not very soluble in mct oil. For this reason I have been reading lots of studies and I will incorporate
SEDDS(Self-emulsifying drug delivery system) with this method I will basically be able to form micelles with surfactants that encapsulate the dutasteride in the oil preventing separation of it and increasing bioavailability. I will use a ratio of 43.59% Smix (Smix is surfactants + cosurfactants) which should decrease droplet size to <100 nm as per studies. Basically when you have <100 nm droplets the drug is highly bioavailable and it can absorb pretty good. Also when it reach the small intestine and make contact with bile salts, these can drop the dropplet size to like 30 nm droplet size which would absorb the drug pretty damn easy. With this method i will achieve a bioavailability very similar to Avodart because the solution wont precipitate(cause I wont rely on ethanol to dissolve dutasteride, the solvents of dutasteride will be lecithin and polysorbate 80 which have high solubilty in dutasteride, you can check it here
https://pmc.ncbi.nlm.nih.gov/articles/PMC4232777/#:~:text=of drug without addition of,Figure 2). I will mostly use natural surfactants because surfactants at high amounts are hazardous, the only synthetic one I will use is Tween 80 but in small dosages which is under the ADI(Acceptable Daily Intake) of 25 mg/kg(I will use ~3.8mg/kg).
I wont be able to use the solution for few days till the supplies arrive but it doesnt matter as long as I get a good bioavailability.
