Exploring The Hormonal Route. Hair=life.

[sg2000]

enanthcypionate

 

[sg2000]

*take both

 

[pentobean]

Okay so I’ve been on 12.5mg cpa, 2mg of estrabet and 60mg of raloxifene daily for 1 month now.

No breast growth, hair has been regrowing.
However my sleep is absolute messy, I try to sleep at 10:30 and then I wake up around 3am-5am and can’t sleep, until 5:30am-8:30am. I think it’s the cpa that’s f*****g my sleep up. I also usually take cpa before sleep so I don’t feel tired the whole day

So I’m going to switch to 50mg of bica + estrobet 2mg and see what happens. I will also likely add .5mg of dutasteride for extra crown protection.

 

[losingbattle88]

Okay so I’ve been on 12.5mg cpa, 2mg of estrabet and 60mg of raloxifene daily for 1 month now.

No breast growth, hair has been regrowing.
However my sleep is absolute messy, I try to sleep at 10:30 and then I wake up around 3am-5am and can’t sleep, until 5:30am-8:30am. I think it’s the cpa that’s f*****g my sleep up. I also usually take cpa before sleep so I don’t feel tired the whole day

So I’m going to switch to 50mg of bica + estrobet 2mg and see what happens. I will also likely add .5mg of dutasteride for extra crown protection.

Tiddies will be growing and u will look fabulous queen!!!! Daddy wants your ***.

 

[sg2000]

Tiddies will be growing and u will look fabulous queen!!!! Daddy wants your ***.

goated youre the goat broo

 

[Adri23]

I've finally made my new dutateride solution today. Will be taking it and after 2 week I'll do a blood test. Hope the DHT gets lower and the solution works. I have spent a lot of time and effort on this lol(and some money along the way too).

 

[Adri23]

I think I saw a little improvement on my hair even tho my mid scalp is still fucked, but the hair feels thicker and darker and the temples are kinda regrowing. I will have the blood test results today or tuesday but I hope DHT gets finally low.

Btw I didnt mean to do a 5 month update but I was bored today and decided to read this thread from November to now to see if I could find any pic from 6 months ago. It seems like my hair has improved a lot in the last 5 months wtf!?

 

[Adri23]

I've had to reduce avodart from 1 mg daily to 0.5 mg every other day tho, and next week I will be without dutas for 6 days till I get my prescription again. I lost access to 1 mg dutasteride again so I am with 0.5 mg now sadly, so I rely almost entirely on my solution cause 0.5 mg avodart is placebo for me, only 1 mg avodart does work on me.

 

[BeardCombover]

Hello, guys. Reporting some updates on my regimen, incase someone is interested.
It so happened that I hopped back on HRT (not because of hair).

Instead of E mono, I decided to add Metformin as some kind of AA. Also taking Omega-3, D3+K2, Q10 and B complex, which all theoretically could help with decreasing cholesterol/insulin and androgen steroidogenesis as a result.
Why Metformin? Firstly, because my glucose was kinda high on my last blood tests, and i even gained some weight. Secondly, because it lowers insulin resistance, which theoretically could help with my low IGF-1 problem (btw, increasing IGF-1 sensitivity might help someone with poor breast development, but thats another topic). Finally, it downregulates HSD3B2 and CYP17A1 enzymes, which are responsible for DHEA and Androstenedione production. Metformin inhibits human androgen production by regulating steroidogenic enzymes HSD3B2 and CYP17A1 and complex I activity of the respiratory chain

Also, just got blood tests, that I decided to do after 2 weeks on this regime.

Not many tests for now, only those that bothered me the most, mainly Prolactin and DHEA-S. On last tests my prolactin was at 940 mIU/l and DHEA-S at 9 umol/l, now both are almost 2 times less. Not sure if Metformin caused that, or lowering EEn dose (was 8mg EEn, now 5.5mg), because high prolactin can also elevate DHEA-S as can be seen here: Prolactin modulation of dehydroepiandrosterone sulfate secretion.
Anyways, happy with the results for now, hope they stay like this. I plan to do many more tests in about a month, after I get out of Russia, including dynamic cortisol and free DHT (which can't be properly done here).
Also planning to do genetic testing, including karyotype, because beside unstable ACTH, I also have some symptoms of either 21-Hydroxylase or 11β-Hydroxylase deficiency when my ACTH is in normal range. Learned about symptoms from this post by Austin Powers:

https://www.reddit.com/r/DrWillPowers/comments/1ctrlyu

Btw, for fellow DHT mutants, that also suspect having CAH, there is a great article, which includes mostly everything you need to know about it:
Challenges in treatment of patients with non-classic congenital adrenal hyperplasia

 

[BeardCombover]

Forgot to mention that Im off aspirin for now, because of stomach issues. But i still believe that its pretty good for some people and internal bleeding thing is IMO rare and overblown, especially on low dose. Moreover, its one of the best inhibitors of COX-1 and COX-2, enzymes which produce PGD-2 aka scalp ashbringer.

Irreversible inhibition means that it fully deactivates the enzymes.
Btw, regarding stomach issues. Im now pretty sure that scalp is interconnected with guts. Did gastroscopy 4 days ago and it showed irritated duodenum, caused by H.pylori (HP++). Gastro told me to take antibiotics and after taking them for 3 days, my scalp already seems less red on crown! Bad thing is, I'll need to take them for at least 2 more weeks on top of all the other meds, hope i'll live through this. =)

 

[Adri23]

Hello, guys. Reporting some updates on my regimen, incase someone is interested.
It so happened that I hopped back on HRT (not because of hair). View attachment 190128
Instead of E mono, I decided to add Metformin as some kind of AA. Also taking Omega-3, D3+K2, Q10 and B complex, which all theoretically could help with decreasing cholesterol/insulin and androgen steroidogenesis as a result.

Seems like a solid regimen honestly

Why Metformin? Firstly, because my glucose was kinda high on my last blood tests, and i even gained some weight. Secondly, because it lowers insulin resistance, which theoretically could help with my low IGF-1 problem (btw, increasing IGF-1 sensitivity might help someone with poor breast development, but thats another topic). Finally, it downregulates HSD3B2 and CYP17A1 enzymes, which are responsible for DHEA and Androstenedione production. Metformin inhibits human androgen production by regulating steroidogenic enzymes HSD3B2 and CYP17A1 and complex I activity of the respiratory chain
View attachment 190126

But doesn't metformin lower IGF-1? I remember I wanted to use it in the past for anti aging but read in many studies it lowers igf-1 and I suspected it could be bad for hair growth cause it also depends on IGF-1

Also, just got blood tests, that I decided to do after 2 weeks on this regime.
View attachment 190127
Not many tests for now, only those that bothered me the most, mainly Prolactin and DHEA-S. On last tests my prolactin was at 940 mIU/l and DHEA-S at 9 umol/l, now both are almost 2 times less. Not sure if Metformin caused that, or lowering EEn dose (was 8mg EEn, now 5.5mg), because high prolactin can also elevate DHEA-S as can be seen here: Prolactin modulation of dehydroepiandrosterone sulfate secretion.
Anyways, happy with the results for now, hope they stay like this. I plan to do many more tests in about a month, after I get out of Russia, including dynamic cortisol and free DHT (which can't be properly done here).

About DHEA-S I think lowering Prolactin could have helped. I used to have higher prolactin even after 3 months of stopping CPA(714 mIU/L) (I dont want to imagine how high could it had been while using it...) and my DHEA-S was on 240μg/dl. After months of not using CPA and changing to injections and bica my DHEA-S started to decrease and now it is between 180 to 199 μg/dl, so yeah metformin could have helped but I think reducing prolactin has 100% helped there too.

Also planning to do genetic testing, including karyotype, because beside unstable ACTH, I also have some symptoms of either 21-Hydroxylase or 11β-Hydroxylase deficiency when my ACTH is in normal range. Learned about symptoms from this post by Austin Powers:

https://www.reddit.com/r/DrWillPowers/comments/1ctrlyu

Btw, for anyone, that also suspects having CAH, there is a great article, which includes mostly everything you need to know about it:
Challenges in treatment of patients with non-classic congenital adrenal hyperplasia

Interesting article, According to that article many of us here are already treating NCCAH. Seems like corticosteroids are to harsh and antiandrogens/5arI and suppressing LH is better than taking corticosteroids especially for long term use, but yea for Classical CAH corticosteroids remain the gold standard

Btw seems like you have everything under control

 

[sg2000]

Btw I didnt mean to do a 5 month update but I was bored today and decided to read this thread from November to now to see if I could find any pic from 6 months ago. It seems like my hair has improved a lot in the last 5 months wtf!?

i think you should add a good multivitamin to your d3 k2 supplementation.
Its certanly a good ally paired with an healty diet 100%

 

[sg2000]

Btw I didnt mean to do a 5 month update but I was bored today and decided to read this thread from November to now to see if I could find any pic from 6 months ago. It seems like my hair has improved a lot in the last 5 months wtf!?

what caused this improvement?

 

[BeardCombover]

Seems like a solid regimen honestly

Ye, kinda seems that way. But as always, only future will tell. =)

But doesn't metformin lower IGF-1? I remember I wanted to use it in the past for anti aging but read in many studies it lowers igf-1 and I suspected it could be bad for hair growth cause it also depends on IGF-1

Seems like a double-edged sword situation. As I understand, its dependant on both insulin amount and insulin resistance, and in adults (unlike chilldren) the resistance influences IGF more. I saw some indepth video about it fron Ninja Nerd, but cant find it for some reason. This study kinda proves the point tho: https://www.sciencedirect.com/science/article/abs/pii/S104366181932081X
"We found in children, intervention duration <12 weeks yielded significant reductions in IGF-1, whilst paradoxically, in participants >18 years old, metformin intake significantly increased IGF-1. We suggest that caution be taken when interpreting the findings of this review, particularly given the discordant supplementation practices between children and adults."
Also, body weight is a pretty big factor. In theory, if you don't lose much weight on Metformin, your IGF will only benefit.

About DHEA-S I think lowering Prolactin could have helped. I used to have higher prolactin even after 3 months of stopping CPA(714 mIU/L) (I dont want to imagine how high could it had been while using it...) and my DHEA-S was on 240μg/dl. After months of not using CPA and changing to injections and bica my DHEA-S started to decrease and now it is between 180 to 199 μg/dl, so yeah metformin could have helped but I think reducing prolactin has 100% helped there too.

Nice, your DHEA-S now seems around the same as mine, seems like a decent amount. Ye, i too think that both could contribute somehow. Just hope it stays like that. =)

Interesting article, According to that article many of us here are already treating NCCAH. Seems like corticosteroids are to harsh and antiandrogens/5arI and suppressing LH is better than taking corticosteroids especially for long term use, but yea for Classical CAH corticosteroids remain the gold standard

Ye, I was on a low dose of the weakest corticosteroid and it still sucked in many ways. Im on remission from ACTH deficiency for now, but ready for its return any time, and i dont even know what causes it. I have a suspicion that either Bica or UDCA caused it last time, cause I was on both when that happened, so I'll stay away from these 2 at least. Hope Metformin will help with CAH tho, even if just a little bit. I have some other meds in mind, but will stick to it for now.

Btw seems like you have everything under control

I try, because every time I doze off even a little bit, it all goes off the rails.
But you too btw

 

[exwhyyou]

Btw I didnt mean to do a 5 month update but I was bored today and decided to read this thread from November to now to see if I could find any pic from 6 months ago. It seems like my hair has improved a lot in the last 5 months wtf!?

yes bro we're so f*****g back

 

[exwhyyou]

Tiddies will be growing and u will look fabulous queen!!!! Daddy wants your ***.

my tits mogggggg

 

[BRezende]

Anyone here ever tried to do a scalp byopsy? i wonder if the other people, like me, who suffer from "reflex hyperandrogenicity" and people who dont respond to 5ari has only androgenetic alopecia and not others imune conditions like Lichen Plano Pilaris

 

[Adri23]

yes bro we're so f*****g back

For now** I am on 0.5 mg dutasteride again and that sh*t sucks for me. I will prob lose my gains if my DIY solution doesnt work

 

[losingbattle88]

For now** I am on 0.5 mg dutasteride again and that sh*t sucks for me. I will prob lose my gains if my DIY solution doesnt work

Ur officially the duta king.

 

[sg2000]

For now** I am on 0.5 mg dutasteride again and that sh*t sucks for me. I will prob lose my gains if my DIY solution doesnt work

lets wait for the blood test