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Not worth to use bica for 10 ng/dl and i dont think it can block it fully unless you take 50 or more mg per day. It is more expensive than dutasteride and less effective for DHT
Exploring The Hormonal Route. Hair=life.
- Thread starter bridgeburn
- Start date
im becoming so greedy i want my hair healty till i die.I dont care about aging hair loss i just want them to not miniaturize.
What should i do?
So having dht below 10 ng dl can still lead to miniaturization?
bica is healty as far as i know and even 200 mg a day could be safe (?)
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Well as you said tissue dht is unknown unless you do biopsy or something like that. So if you dont want or cant do it 2.5 mg dutasteride or more is your best bet to be safe forever.
No. It is safe at 12.5mg or 25 mg daily and there are no studies long term but some trans have taken it for many years without issues for now. If you take 50 mg or more it start to rise side effects long term, especially liver issues.
E2 + dutasteride 2.5 mg or more + 12.5 mg bica daily + oral min 2.5 mg + tretinoin cream and topical minoxidil 5% in temples and hairline is what I think it can be one of the best hair loss stack we have rn IMO
do you think if you up bica to 25 mg daily again will make things worse? (I doubt)
I need to get a job asap to buy 5 avodart box and take 2.5 mg daily asap
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It's a pretty strong systemic drug, so you'll see effects pretty fast. If not, mb there's another enzyme beside PGD2 causing it. Week is more than enough to find out.
And again, taking more than 100mg is uselss for hair.
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I shared my empirical experience and showed some scientific data, I think thats the better approach than just rambling.
But you do you, if you came here to ramble, nobody can stop you. Sorry if im being mean, getting annoyed pretty fast lately.
- Reaction score
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I dont need bica 25 mg. Im good with 12.5 mg bica and more dutasteride with the rest of the stack
Lol that is a stupid question. You know the answer already
okok,i hope my dht is never going to spike and remain 5,0 ng dl even if i stop cpa…
If thats gonna happen i should up dutasteride dosage asap
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Yeah do it, it is never bad to increase dutasteride if you are anxious and want to get peace of mind
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Okay after reconsideration and looking my scalp I’m switching to Estrogen Cypo injections, since it’s more bioavailable. I don’t know how to inject for sh*t but I’ll figure it out.
I’m going to try out
Bica 50mg
dutasteride .5mg
Estrogen cypo injections
Maybe raloxifene every once in a while
I’m going to try out
Bica 50mg
dutasteride .5mg
Estrogen cypo injections
Maybe raloxifene every once in a while
I think everyone’s treatment is different. If you have reflex estrogen may only make your situation worse same with bica. Some people respond well to finasteride and then terrible to dutasteride. It’s all trial and error. So far estrogen bica and finasteride caused more inflammation and the only thing that works on cooling that down is drugs that are meant/completely for anti inflammation.
25mg daily fucks my hair, i tested this twice. 12.5mg is the right dosage for me personally, which is very low
i got 81mg capsules, hoping this improves my skin and improves this constant sebum production at my temples
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How people here came to conclusion that aspiring can help hair loss, when it’s severely inhibiting both cox-1 and cox-2? LMAO. I mean, you will attack pgd2, but you will reduce pge2 severely which is needed for hair regrowth. If you want to target inflammation, find better ways, Cetirizine for example which it does not affect pge2, but it primarily targets pgd2. Also, aspirin lowers minoxidil potency.
And a fast search from perplexity:
Yes, aspirin, which blocks both COX-1 and COX-2 enzymes, does lower prostaglandin E2 (PGE2) levels. Studies show that orally consumed aspirin inhibits the cyclooxygenase (COX) pathway, resulting in a significant reduction of PGE2 production in human tissues such as skeletal muscle. For example, a single standard dose of aspirin (975 mg) reduced in vivo PGE2 levels by about 44% and ex vivo PGE2 production by about 24% in human skeletal muscle.
Low-dose aspirin also inhibits systemic PGE2 biosynthesis by approximately 45% in healthy volunteers, and both low and standard doses reduce skeletal muscle PGE2 production significantly. The inhibition is due to aspirin's acetylation and permanent inactivation of COX enzymes, which prevents the conversion of arachidonic acid to PGE2, with effects lasting for hours after aspirin is cleared from the circulation.
Well, I will keep checking on and off for this specific approach, just to see your experiences. I really hope it will work for anyone trying it. Personally, I would never touch this.
And a fast search from perplexity:
Yes, aspirin, which blocks both COX-1 and COX-2 enzymes, does lower prostaglandin E2 (PGE2) levels. Studies show that orally consumed aspirin inhibits the cyclooxygenase (COX) pathway, resulting in a significant reduction of PGE2 production in human tissues such as skeletal muscle. For example, a single standard dose of aspirin (975 mg) reduced in vivo PGE2 levels by about 44% and ex vivo PGE2 production by about 24% in human skeletal muscle.
Low-dose aspirin also inhibits systemic PGE2 biosynthesis by approximately 45% in healthy volunteers, and both low and standard doses reduce skeletal muscle PGE2 production significantly. The inhibition is due to aspirin's acetylation and permanent inactivation of COX enzymes, which prevents the conversion of arachidonic acid to PGE2, with effects lasting for hours after aspirin is cleared from the circulation.
Aspirin lowers the potency of minoxidil primarily by inhibiting sulfotransferase enzymes in hair follicles, which are necessary for converting minoxidil into its active form, minoxidil sulfate. Minoxidil is a pro-drug that requires sulfation by these enzymes in the outer root sheath of hair follicles to become effective in treating androgenetic alopecia (Androgenetic Alopecia). Low-dose oral aspirin, a derivative of salicylic acid, has been shown to significantly reduce sulfotransferase activity in hair follicles, thereby decreasing the conversion of minoxidil to its active form and reducing its efficacy. A study found that after 14 days of aspirin administration, the predicted response rate to topical minoxidil dropped from 50% to 27%, indicating a substantial reduction in minoxidil's effectiveness due to aspirin's inhibitory effect on sulfotransferase enzymes. In summary, aspirin reduces minoxidil potency mainly by inhibiting the sulfotransferase enzymes required for minoxidil activation in hair follicles, leading to decreased therapeutic response in hair loss treatment.Well, I will keep checking on and off for this specific approach, just to see your experiences. I really hope it will work for anyone trying it. Personally, I would never touch this.
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