Exploring The Hormonal Route. Hair=life.

[coco_304]

How people here came to conclusion that aspiring can help hair loss, when it’s severely inhibiting both cox-1 and cox-2? LMAO. I mean, you will attack pgd2, but you will reduce pge2 severely which is needed for hair regrowth. If you want to target inflammation, find better ways, Cetirizine for example which it does not affect pge2, but it primarily targets pgd2. Also, aspirin lowers minoxidil potency.

And a fast search from perplexity:

Yes, aspirin, which blocks both COX-1 and COX-2 enzymes, does lower prostaglandin E2 (PGE2) levels. Studies show that orally consumed aspirin inhibits the cyclooxygenase (COX) pathway, resulting in a significant reduction of PGE2 production in human tissues such as skeletal muscle. For example, a single standard dose of aspirin (975 mg) reduced in vivo PGE2 levels by about 44% and ex vivo PGE2 production by about 24% in human skeletal muscle.
Low-dose aspirin also inhibits systemic PGE2 biosynthesis by approximately 45% in healthy volunteers, and both low and standard doses reduce skeletal muscle PGE2 production significantly. The inhibition is due to aspirin's acetylation and permanent inactivation of COX enzymes, which prevents the conversion of arachidonic acid to PGE2, with effects lasting for hours after aspirin is cleared from the circulation.

​

Aspirin lowers the potency of minoxidil primarily by inhibiting sulfotransferase enzymes in hair follicles, which are necessary for converting minoxidil into its active form, minoxidil sulfate. Minoxidil is a pro-drug that requires sulfation by these enzymes in the outer root sheath of hair follicles to become effective in treating androgenetic alopecia (Androgenetic Alopecia). Low-dose oral aspirin, a derivative of salicylic acid, has been shown to significantly reduce sulfotransferase activity in hair follicles, thereby decreasing the conversion of minoxidil to its active form and reducing its efficacy. A study found that after 14 days of aspirin administration, the predicted response rate to topical minoxidil dropped from 50% to 27%, indicating a substantial reduction in minoxidil's effectiveness due to aspirin's inhibitory effect on sulfotransferase enzymes. In summary, aspirin reduces minoxidil potency mainly by inhibiting the sulfotransferase enzymes required for minoxidil activation in hair follicles, leading to decreased therapeutic response in hair loss treatment.

Well, I will keep checking on and off for this specific approach, just to see your experiences. I really hope it will work for anyone trying it. Personally, I would never touch this.

And what about oral minoxidil..?

 

[BeardCombover]

How people here came to conclusion that aspiring can help hair loss, when it’s severely inhibiting both cox-1 and cox-2? LMAO. I mean, you will attack pgd2, but you will reduce pge2 severely which is needed for hair regrowth. If you want to target inflammation, find better ways, Cetirizine for example which it does not affect pge2, but it primarily targets pgd2. Also, aspirin lowers minoxidil potency.

And a fast search from perplexity:

Yes, aspirin, which blocks both COX-1 and COX-2 enzymes, does lower prostaglandin E2 (PGE2) levels. Studies show that orally consumed aspirin inhibits the cyclooxygenase (COX) pathway, resulting in a significant reduction of PGE2 production in human tissues such as skeletal muscle. For example, a single standard dose of aspirin (975 mg) reduced in vivo PGE2 levels by about 44% and ex vivo PGE2 production by about 24% in human skeletal muscle.
Low-dose aspirin also inhibits systemic PGE2 biosynthesis by approximately 45% in healthy volunteers, and both low and standard doses reduce skeletal muscle PGE2 production significantly. The inhibition is due to aspirin's acetylation and permanent inactivation of COX enzymes, which prevents the conversion of arachidonic acid to PGE2, with effects lasting for hours after aspirin is cleared from the circulation.

​

Aspirin lowers the potency of minoxidil primarily by inhibiting sulfotransferase enzymes in hair follicles, which are necessary for converting minoxidil into its active form, minoxidil sulfate. Minoxidil is a pro-drug that requires sulfation by these enzymes in the outer root sheath of hair follicles to become effective in treating androgenetic alopecia (Androgenetic Alopecia). Low-dose oral aspirin, a derivative of salicylic acid, has been shown to significantly reduce sulfotransferase activity in hair follicles, thereby decreasing the conversion of minoxidil to its active form and reducing its efficacy. A study found that after 14 days of aspirin administration, the predicted response rate to topical minoxidil dropped from 50% to 27%, indicating a substantial reduction in minoxidil's effectiveness due to aspirin's inhibitory effect on sulfotransferase enzymes. In summary, aspirin reduces minoxidil potency mainly by inhibiting the sulfotransferase enzymes required for minoxidil activation in hair follicles, leading to decreased therapeutic response in hair loss treatment.

Well, I will keep checking on and off for this specific approach, just to see your experiences. I really hope it will work for anyone trying it. Personally, I would never touch this.

It has already been mentioned in this thread that Aspirin reduces Minoxidil efficacy. I guess it's a matter of priorities. If you do fine on minoxidil, why would you even consider taking aspirin? The problem is, for some people inflammation causes much more damage than minoxidil can regrow, for those loosing ground, aspirin is pretty decent IMO, because its one the best prostaglandin blockers. You mentioned PGE2 and although it is true that its one of lipids that help with producing some follicle stem cells (although there are bunch of more important factors for hair growth), its also THE most pro-inflammatory prostaglandin actually.
According to PGE2 wiki: "In response to physiologic and psychologic stress, prostaglandin E2 (PGE2) is involved in several inflammation and immunity pathways. As one of the most abundant prostaglandins in the body, PGE2 is involved almost all typical inflammation markers such as redness, swelling, and pain."
Again, I really doubt that it does more good than harm If you're already suffering from inflammation, and lowering its biosynthesis
by half might even be necessary for some.
I personally don't use Minoxidil (due to sides), so basically no risks for hair, but those that use it might want to try Aspirin out for a week and see how it goes. I doubt that minoxidil effect on hair can be neutralised in such short period, especially for those that reached terminal hair.

 

[GRme11]

And what about oral minoxidil..?

Will probably affect it as well. Oral Minoxidil still needs sulfotransferase activity.

 

[GRme11]

It has already been mentioned in this thread that Aspirin reduces Minoxidil efficacy. I guess it's a matter of priorities. If you do fine on minoxidil, why would you even consider taking aspirin? The problem is, for some people inflammation causes much more damage than minoxidil can regrow, for those loosing ground, aspirin is pretty decent IMO, because its one the best prostaglandin blockers. You mentioned PGE2 and although it is true that its one of lipids that help with producing some follicle stem cells (although there are bunch of more important factors for hair growth), its also THE most pro-inflammatory prostaglandin actually.
According to PGE2 wiki: "In response to physiologic and psychologic stress, prostaglandin E2 (PGE2) is involved in several inflammation and immunity pathways. As one of the most abundant prostaglandins in the body, PGE2 is involved almost all typical inflammation markers such as redness, swelling, and pain."
Again, I really doubt that it does more good than harm If you're already suffering from inflammation, and lowering its biosynthesis
by half might even be necessary for some.
I personally don't use Minoxidil (due to sides), so basically no risks for hair, but those that use it might want to try Aspirin out for a week and see how it goes. I doubt that minoxidil effect on hair can be neutralised in such short period, especially for those that reached terminal hair.

Well, yes, if you are not on minoxidil you could give a try and see how it goes. The same can be said by trying other cox inhibitors rather than aspirin, for example. But being on minoxidil while you are a responder, it is a red flag! Also, from all these years that I am reading about hair loss, it’s seems that pge2/pgf2a are promoters/balancers of hair regrowth, at least on scalp tissue. Then, the inflammation comes from pgd2, pro inflammatory cytokines, ROS, TGF beta, etc.

 

[BeardCombover]

Well, yes, if you are not on minoxidil you could give a try and see how it goes. The same can be said by trying other cox inhibitors rather than aspirin, for example. But being on minoxidil while you are a responder, it is a red flag! Also, from all these years that I am reading about hair loss, it’s seems that pge2/pgf2a are promoters/balancers of hair regrowth, at least on scalp tissue. Then, the inflammation comes from pgd2, pro inflammatory cytokines, ROS, TGF beta, etc.

Well, aspirin can also regulate cytokines via pge2 reduction, but... you know what, fair enough!
After a sober look, I guess it was pretty arrogant of me to advise aspirin to people on minoxidil, considering I wasn't even on minoxidil when it worked great on me. Mere speculations atp.
Learned my mistake, not gonna advise any meds to anyone here from now on, only share my own experience.
Also, gonna be busy, so brb with blood tests updates in like a month.

 

[exwhyyou]

damn i guess its my last day on asprin then wtfff

 

[exwhyyou]

how do i lower my inflammation if i wanna keep taking minoxidil

 

[Adri23]

how do i lower my inflammation if i wanna keep taking minoxidil

Have you ever tested dht? I feel more inflamed in general when my DHT is higher. I always know if something is working lowering DHT not only for hair but my inflammation ceases. With 0.5 mg dutasteride I had lot of scalp pains and inflammation. With 1 mg it all went away suddenly and my hair started to improve

 

[sg2000]

Have you ever tested dht? I feel more inflamed in general when my DHT is higher. I always know if something is working lowering DHT not only for hair but my inflammation ceases. With 0.5 mg dutasteride I had lot of scalp pains and inflammation. With 1 mg it all went away suddenly and my hair started to improve

lol my scalp pain(when touching hair) and inflammation went away when i nuked T.When i was only on dutasteride it was basically the same and i doubt adding 1 capsule a day would make any differance

 

[sg2000]

at this point i think it was T all along

 

[Adri23]

lol my scalp pain(when touching hair) and inflammation went away when i nuked T.When i was only on dutasteride it was basically the same and i doubt adding 1 capsule a day would make any differance

Lol you didnt understand my point. I obviously talk about dutasteride while on hrt. dutasteride alone is useless for many ppl when they start balding young. In any case I think only high dosages could help those cases as I said, but for young ppl maybe even T could cause hair loss so yes androgens in general are gargbage

 

[sg2000]

just applied hydrocortisone you can see how bad my diffuse thinning is…
I really hope that the corticosteroid paired with vit d (cause i had deficiency 23 ngdl) and multivitamins can give me more thickness and improve the strands…
I dont know how much e2 is heping without the corticosteroid cause just like 10 days ago my hair was absolutely sh*t and low density so im afraid to drop it.
Wait did you had scalp pain too even with hrt and 0.5 of dutasteride and went away on 1mg?
Was it painful and intense like pre hrt?

 

[Adri23]

just applied hydrocortisone you can see how bad my diffuse thinning is…
I really hope that the corticosteroid paired with vit d (cause i had deficiency 23 ngdl) and multivitamins can give me more thickness and improve the strands…
I dont know how much e2 is heping without the corticosteroid cause just like 10 days ago my hair was absolutely sh*t and low density so im afraid to drop it.
Wait did you had scalp pain too even with hrt and 0.5 of dutasteride and went away on 1mg?
Was it painful and intense like pre hrt?

Yes the pain was still there. It was not coincidence that it always used to hurt when my dht was higher

 

[GRme11]

just applied hydrocortisone you can see how bad my diffuse thinning is…
I really hope that the corticosteroid paired with vit d (cause i had deficiency 23 ngdl) and multivitamins can give me more thickness and improve the strands…
I dont know how much e2 is heping without the corticosteroid cause just like 10 days ago my hair was absolutely sh*t and low density so im afraid to drop it.
Wait did you had scalp pain too even with hrt and 0.5 of dutasteride and went away on 1mg?
Was it painful and intense like pre hrt?

You need to fix the prolactin levels asap, too….

 

[sg2000]

You need to fix the prolactin levels asap, too….

yeah im slowing tapering cpa off

 

[sg2000]

Yes the pain was still there. It was not coincidence that it always used to hurt when my dht was higher

i doubt it was intense as it was pre hrt,when i nukes T scalp pain went away.Pre hrt dht was 22 ng dl and T maybe very high... and after hrt, t was 0,24 ng dl and dht 5,0 ng dl .For me i think it was all due to T i doubt a difference of 15 ng dl in dht could have saved my scalp pain

 

[GRme11]

i doubt it was intense as it was pre hrt,when i nukes T scalp pain went away.Pre hrt dht was 22 ng dl and T maybe very high... and after hrt, t was 0,24 ng dl and dht 5,0 ng dl .For me i think it was all due to T i doubt a difference of 15 ng dl in dht could have saved my scalp pain

17 ng/dl reduction in DHT is big! Definitely can make a difference.

 

[losingbattle88]

lol my scalp pain(when touching hair) and inflammation went away when i nuked T.When i was only on dutasteride it was basically the same and i doubt adding 1 capsule a day would make any differance

Yep adri is a hypochondriac sadly like most here.

 

[Adri23]

i doubt it was intense as it was pre hrt,when i nukes T scalp pain went away.Pre hrt dht was 22 ng dl and T maybe very high... and after hrt, t was 0,24 ng dl and dht 5,0 ng dl .For me i think it was all due to T i doubt a difference of 15 ng dl in dht could have saved my scalp pain

I think you have no idea how more potent dht is vs T. 2.5 to 10 times more potent so imagine

 

[Adri23]

Yep adri is a hypochondriac sadly like most here.

Bro not to be this guy but I have experienced with more drugs than you ever did and prob read more studies too. Also did many many hormone blood tests